A FEW REPRESENTATIVES OF ASTEROIDAE (ASTERACEAE) SUBFAMILY AND GERANIUM (GERANIACEAE) GENUS IN THE BAIKAL REGION (REVIEW)

For citation: E.G. Privalova. A few representatives of Asteroidae (Asteraceae) subfamily and Geranium (Geraniaceae) genus in the Baikal region (review). Pharmacy & Pharmacology. 2021;9(6):426-440. DOI: 10.19163/2307-9266-2021-9-6-426-440 © Е.Г. Привалова, 2021 Для цитирования: Е.Г. Привалова. Некоторые представители подсемейства Asteroidae (Asteraceae) и рода Geranium (Geraniaceae) Прибайкалья (обзор). Фармация и фармакология. 2021;9(6):426-440. DOI: 10.19163/2307-9266-2021-9-6-426-440 A FEW REPRESENTATIVES OF ASTEROIDAE (ASTERACEAE) SUBFAMILY AND GERANIUM (GERANIACEAE) GENUS IN THE BAIKAL REGION (REVIEW)


INTRODUCTION
According to the forecasts of the World Health Organization 1 , the share of herbal medicines is constantly growing and reaches 60% in the total range of medicines. This is ensured by their objective advantages and possibilities [1]. In the medical practice of the Russian Federation, about 20 thousand medicines are used, more than 40% of which are made from medicinal plant materials. Traditional medical systems of numerous national ethnic groups (Tibetan, Buryat, Russian, etc.) rely primarily on natural resources [2][3][4].
Currently, in the scientific literature, a lot of attention is paid to the study of metabolites of plant objects as effective antioxidants. The main representatives of such natural substances are polyphenolic compounds -flavonoids, phenol carboxylic acids, tannides, coumarins. In comparison with other natural compounds, they have the highest prevalence, a significant structural diversity and versatile pharmacological properties. Polyphenolic compounds cause antioxidant, cardiotropic, angioprotective, capillary-strengthening, hepatoprotective, choleretic, diuretic and other important effects [5][6][7]. It should be notified that the plant material contains a mixture of polyphenolic metabolites. This fact affects the specificity of the pharmacological action and forms 1  the scientific basis for modeling and creating new effective herbal preparations [1,[5][6][7][8][9][10].
In this regard, it is urgent to search for new types of plant materials containing polyphenolic compounds, used to treat the most common diseases.
In this context, some species of the Asteraceae or Compositae and Geraniaceae families growing in the Baikal region are of the greatest interest. In particular, these are: Heteropappus altaicus (Willd.) Novopokr., Solidago dahurica L., Leucanthemum vulgare Lam.,  (14). Russian 4 State Register of Medicines. Available from: http://grls.rosminzdrav. ru. Russian montana flores), immunostimulating (Echinaceae purpureae herba) remedies. They are also the sources of drugs that have biological antispasmodic and M-cholinolytic actions (Senecionis platyphylloidis herba), etc. The main groups of biologically active compounds of these plants are vitamins, flavonoids, tannins, essential oils, alkaloids, polysaccharides.
The plants of the Asteroideae and Lactucoideae subfamilies are found in all areas of the Baikal region. The Asteroideae (Tubuliflorae) subfamily prevails: it comprises about 85% of all genera (or 61) of the Asteraceae family. The constancy of their position in the ecological systems of Siberia is the basis for a long-time use of Asteroideae species in folk medicine of this region. About 20 representatives of this subfamily are described as medicinal, mainly from Solidago L., Tripleurospermum Sch.Bip., Leucanthemum Mill., Heteropappus Less., Leontopodium L., Antennaria Gaertn. [15][16][17].
The analysis of the available literature sources showed that H. altaicus, S. dahurica, L. vulgare, T. inodorum, A. dioica, L. conglobatum species have a specific use in folk and traditional medicine, are popular for the treatment of digestive and genitourinary diseases and are objects for study in various scientific fields.
In the process of studying literary sources, information was found on the contents of tannins, flavonoids, vitamin K, resins and bitterness [24].
It was noted that the selenium content can be up to 0.012% of dry phytomass. Thus, A. dioica is considered a source of this element, an important microcomponent in the nutrition of animals and humans [26].
Traditional medicine suggests using the aerial part of A. dioica (D. Don) Greene -the anthode and herb. They are used orally in the form of infusions; externally in the form of powder, gruel made of raw materials, and applications [21]. The extracts from the herb of this plant are astringent. They are taken orally for dysentery, diarrhea, gastritis, stomach and duodenal ulcers. The herb infusion is used as an anti-inflammatory and emollient remedy in the form of rinses and poultices for angina, tonsillitis, stomatitis, goiter, abscesses, septic wounds, breast tumors and as a pain reliever for gout. Fresh herb is applied to the gums to relieve a toothache. Gruel from fresh leaves is applied to the fingers for panaritium, and the wounds are sprinkled with powder from dried leaves. Infusion in the form of applications is used for eye diseases, in the form of douching -for gonorrhea and leucorrhoea. In the past, healers and root doctors advised chewing flowers and taking an infusion for epilepsy and other diseases of the nervous system [21].
Kalinin E.P. et al. confirmed the hemostatic effect of biologically active compounds of A. dioica in vitro and in vivo. It was found out that the anticoagulant activity is manifested by the fraction of the protein-peptide nature [27].
Morphological and anatomical studies of the aerial parts of A. dioica were carried out in order to establish the diagnostic signs of the vegetative organs [28,29].
L. vulgare (L. vulgare (Vaill.) Lam.) is the only species of Leucanthemum genus, represented on the territory of the Baikal region (Eastern Siberia).
The database "The Plant List" contains 37 synonyms for this name, among which 3 have the status of unconfirmed or used without an agreement with the rules of the International Code of Botanical Nomenclature (see paragraphs 1,3,15)   L. vulgare has grey fruits-achenes, up to 2 mm long, with 5-10 distinct ribs, there is no coronet, as a rule, only occasionally the seeds of semiflorets show a unilateral coronet. Representatives with a unilateral coronet of achenes from the Irkutsk region are described for the L. ircutianum DC species and occur sporadically throughout the L. vulgare range in all regions of Siberia. Moreover, the presence of this trait varies even within the population, which makes it possible to consider L. ircutianum as variety or L. vulgare var. ircutianum (DC) Krylov. [13,19].
The L. vulgare range covers the western and southern parts of the Central Siberian Plateau, the Sayans and the Sayan-Baikal region, the Baikal Plateau in its western part, and the northern part of the North-Baikal Plateau. Its habitat is represented by meadows, meadow slopes, 5  forest glades, the border areas; it is often a ruderal species [13]. An assessment of the raw material reserves of this type has been carried out in the Irkutsk region [30].
At the beginning of the previous century, L. vulgare used to spread throughout Europe (excluding the Arctic zone) and in most of Asia (excluding the Arctic zone). Thanks to the anthropogenic activities, including the globalization of migration processes, this species was introduced to other climatic zones and continents (North America). In any case, it is presented as a sun-loving plant that also prefers meadows, forest-steppes, mountainous and subalpine regions. In the places of human farming or in ruderal territories, it occurs along roadsides, on the outskirts of fields, in fallow lands, in crops, in pastures and meadows. It spreads very well on fertile soils; it is characterized as a field weed [31].
It is notified that in the folk medicine of Georgia and the Baikal region, L. vulgare water extracts are used for fevers, colds, coughs, pulmonary tuberculosis, eye diseases, involuntary urination, gastrointestinal colic, migraine, suffocation, pain, etc. Herbs decoction and infusions are prescribed for eye diseases, hernia, hemorrhoids. In addition, the herb and flowers are used externally -for skin rashes, lichen, ulcers, for bathing small children with intestinal spasms and convulsions. For skin diseases, a mixture consisting of crushed herbs together with flowers and rubbed with butter, is applied [15,16,39]. The studies devoted to the crude oil influence on the viability of L. vulgare, have been carried out. It was found out that this species is able not only to survive in soil exposed to crude oil, but also to reduce the concentration of this pollutant in the soil. The roots of L. vulgare successfully formed a symbiosis with mycorrhiza. At the same time, a positive correlation was shown between the concentration of the antioxidant compounds (including polyphenols) and the residual level of the oil concentration in the soil. The results showed that L. vulgare can survive under the conditions of pollution with oil products, and contribute to a decrease in their content in the substrate [40].

Tripleurospermum inodorum (L.)
According to the "Flora of Central Siberia", the Tripleurospermum genus of the Asteroideae subfamily has only one representative -Tripleurospermum inodorum (L.) [18]. According to the floristic summary "Flora of Siberia" [13], the genus has the name of Matricaria L. (Tripleurospermum Sch.Bip.) and includes three sections, two of which are widespread in Siberia with a population of one species -Matricaria perforata = m. Том 9, Выпуск 6, 2021 ОБЗОРЫ, ЛЕКЦИИ inodora = tripleurospermum inodorum from the section of Matricaria (Tripleurospermum), and m. tetragono-sperma= tripleurospermum tetragonosperma from the section of Tetragonosperma. However, the species T. inodorum has been included in "Flora of Siberia" conditionally, since the authors notified its possible presence in the east of Yakutia. The synonyms of the described type [13]  In the Irkutsk Region, T. inodorum is distributed in the western and southern parts of the Central Siberian Plateau and on the southern coast of Lake Baikal. The main habitats are along ditches, riverbanks, along wastelands and near roads, along the edges and glades of light and dark coniferous, as well as small-leaved forests. Since the plant is ecologically unpretentious (xero-mesophyte, mesotroph), this species colonization is often anthropogenic [13,18].
It is carried from one place to another by seeds, while one plant can produce a huge number of achenes, according to various estimates, from 50,000-200,000 to 1.5 million and more. The seeds in the soil retain their germination capacity for a long time (up to 7 years). Due to the cold resistance, the seeds germinate early and amicably enough at low soil temperatures, and overwinter well. T. inodorum is a weedy species in the agricultural production. It infests not only cereals, but also tilled crops. In the Non-Chernozem zone, it is most likely to infest crops of important perennial grasses (clover and lucerne) and winter grains. A negative impact is also reflected in the fact that T. inodorum consumes twice as much moisture as oats and spring wheat, that negatively affects the yield. At the same time, this indicates the ecological stability of the described species. The ecological features of this representative of the Asteroideae subfamily serve as the basis for their rapid introduction into culture, including for the purpose of creating an additional raw material base for medicinal plants [30].
In addition to Eastern Siberia, the main areas of T.
inodorum distribution include Western Europe, Atlantic Europe, the Balkans, Asia Minor, North America, the European part of Russia, the Caucasus, Western Siberia, and the Far East (as an invasive species) [21]. The data analysis from the available literature sources showed that T. inodorum contains essential oil, pyrethrin and related compounds, bitterness, mucus, gum, alkaloids, ascorbic acid; fatty oil (in seeds up to 20%) [21].
In addition, according to the works by a group of cultural Academy, the mineral composition of weeds, including T. inodorum, was studied. As a result, it was found out that in the aerial parts of this species, in the process of the development and growth, sodium, magnesium, phosphorus, sulfur, silicon, manganese, copper, and molybdenum are accumulated in high concentrations [43].
A comparative phytochemical study showed that the amount of flavonoids in T. inodorum flowers exceeds the content of this group BACs in Ch. recutita flowers [44,45].
Taking into account the practical importance of the H. tataricus and H. altaicus species, a further was attention paid to these particular species.
H. tataricus Tamamsch. is the officially accepted name of the species, there are no synonyms [11]. However, there is information about the synonymy of H. biennis (Ledeb.) Tamamsch. ex Grub. (H. tataricus (Lindl.) Tamamsch.) [42]. H. tataricus is distributed in Western and Eastern Siberia, as well as in the Far East. It prefers valleys, steppe and dry meadows, forest edges, steppes. The species is a biennial [11,13].
H. altaicus is a perennial herb. It inhabits the southern part of the Central Siberian plateau, in the mountains of the Eastern Sayans, in the Sayan-Baikal and Barguzinsky regions, Vitim Highlands, it is recorded in the southern part of Buryatia and Dauria. H. altaicus is a sun-loving xeromesophyte, preferring riverbanks, lakes, including saline ones, as well as dry and steppe meadows and steppes [ The species is described in the lists of "Flora of China" [46] as Aster altaicus var. altaicus. The names Aster gmelinii Tausch, Heteropappus altaicus (Willdenow) Novopokrovsky, Kalimeris altaica (Willdenow) Nees, K. altaica var. subincana Avé-Lallemant are marked as synonymous. It is occurs in some China provinces, in addition, in the state of Kashmir (India), Kazakhstan, Mongolia. In the described territories, the species is found in the steppe, in meadows, salt marshes, rocky hillsides, as well as along roadsides and along riverbanks.
A quantitative assessment of some BACs groups of the aerial parts of H. altaicus growing on the territory of Western Transbaikalia, was carried out by Mazur L.V.
In the available literature, the data on the study of H. altaicus in clinical medicine are insufficient; they touch on the period of 1997. The study results of the immunomodulatory and anti-inflammatory effects of triterpene saponins manifested by Solidago virgaurea and biennial species were presented [50]. Moreover, in folk medicine, H. altaicus inflorescences are prescribed for diseases of the gastrointestinal tract. The aerial part of the plant has antibacterial and protistocidal effects. In Tibetan and Mongolian medicine, the herb of this plant is used as an antipyretic, anti-inflammatory agent, for respiratory infections as an expectorant and antitussive remedy, as well as for stomach diseases (including a peptic ulcer disease [51]. The aerial organs are parts of the medicinal herbs mixtures prescribed for the treatment of measles and smallpox. In Chinese medicine, along with other plants, extracts from H. altaicus are used to treat sexual weakness in men, hemoptysis, and chronic bronchitis [21].

Solidago dahurica Kitag.
According to "Flora of Central Siberia" and the Siberian Branch of the Russian Academy of Sciences [18,19], on the territory of Eastern Siberia, the Solidago L. genus has one representative -S. dahurica L. (syn. Solidago dahurica Kitag. S. gebleri Juz. -S. virgaurea var. alpestris Krylov.non. DC.). In its turn, in "Flora of Siberia" [13] it is indicated that two species grow on the territory of Eastern Siberia -S. dahurica and S. spireifolia Fisch. ex Herder. The latter is common only in the Arctic floristic region (Sakha Yakutia). According to the information base of the EL SB RAS [19], S. gebleri, characteristic of the Altai flora, occurs in Eastern Siberia. At the same time, S. canadensis L., which is an officinal species, and S. virgaurea L. are found on the territory of Eastern Siberia. These species belong to the wild and naturalized, and, in practice, typical species of the flora of Eastern Siberia. This is due to their widespread use as cultivated species for landscaping city streets and garden plots, as well as to the sufficient popularity of plants in the practice of traditional medicine [19,21].
According to "The Plant List", S. dahurica is synonymous with S. virgaurea subsp. dahurica (Kitag.) Kitag., for which, in turn, the synonyms are S. gebleri Juz. and S. gebleri var. gebleri [11]. S. dahurica is usually a plain plant; its representatives are tall, up to 1 m, with a large panicle. The leaves are predominantly hairy along the veins. The plants from the Sayans and Stanovoe Highlands have a smaller habitus from 15 to 50 cm and have a simple racemose inflorescence, bare or almost bare leaves. Sometimes this species is distinguished as a special one -S. gebleri Juz. However, these differences are not constant and are not diagnostic signs [13,18,19].
S. dahurica is widespread in Eastern Siberia throughout the Central Siberian Plateau, in the Sayans regions along the Baikal Highlands. It does not form large thickets, but it has a massive habitus, a good supply of raw materials [52]. S. dahurica prefers to settle in thickets of shrubs, in forests, in clearings, along river valleys, on stony and gravelly slopes, pebble and open woodlands.
The hydrolysis of the isolated triterpene saponins revealed eight aglycones, derivatives of virgureagenin, designated by letters A, B, C, D, I, F, G, H. The aglycone virgaureagenin A was identified as oleanolic acid, and virgaureagenin D -as a polygallic acid. The carbohydrate residue consists of glucose, rhamnose and xylose. The presence of glycosides of a polyphenolic nature, in particular, quercetin derivatives -isoquercitrin, has been established, the presence of saponins, tannins, catechins, flavones has been confirmed. The S. dahurica anthodium contains about 0.5% of essential oil, and about 0.7% in the leaves; the presence of saponins, catechins, tannins and flavones has been established [53].
The chemical composition of the aerial organs ensures the use of S. dahurica as an expectorant, diuretic and hypoazotemic agent for the treatment of chronic nephritis and renal failure. In different countries, the Solidago species are used in a similar way. In particular, the herbs S. dahurica, S. virgaurea and S. canadensis have been long prescribed for the diseases of kidneys and bladder, for dissolving kidney and bladder stones, with a high protein content in urine, as a diuretic for dropsy, and also as effective remedies for rheumatism, gout, bronchial asthma, pulmonary tuberculosis, cholelithia-

REVIEWS, LECTURES
sis and other diseases. A successful use of these types externally are for angina rinsing, in gum sponginess, for strengthening sensitive teeth, for purulent wounds applications and bone fractures [24].
From the aerial parts of S. dahurica, mixtures are made -ointments, anatriptics on the basis of cream, pork fat or butter. Such remedies are recommended for skin tuberculosis, dermatitis, burns, rheumatism, and leucorrhoea. The peoples of Komi and Siberia use S. dahurica extracts internally for ulcerative cystitis, hepatitis, prostate adenoma, impotence, frequent emissions and chronic prostatitis (mixed with other plants), as well as externally for rinsing and washing with acute laryngitis, eczema [54].
In the folk medicine of the Caucasus, alcoholic tincture from the underground parts of the plant is used as a wound healing agent [21,54]. The herb S. virgaurea is included in the British Herbal Pharmacopoeia as a diaphoretic and antiseptic [55]. In homeopathy [56], the essence of fresh inflorescences is used for chronic inflammatory diseases of kidneys, accompanied by skin rashes, swelling of the glands, edema, catarrh and rheumatic pains.
The Global Compositae Checklist database, which is an integrated database of nomenclature and taxonomic information of the Asteraceae family, included in the Catalog of Life: 2015 Annual Checklist [57] and "The Plant List" information base [11] indicate that the names   The data presented in the table makes it possible to conclude that an equivalent species is described under the accepted and synonymous names of Leontopodium conglobatum. At the same time, Leontopodium conglobatum has clearly pronounced morphological features, a fairly wide range on the territory of Eastern Siberia, and accessible habitats.
In the available literary sources, there is no information about clinical studies of this species. However, Leontopodium conglobatum (Turcz.) Hand.-Mazz. is included in the arsenal of medicinal plants of Tibetan medicine. For therapeutic purposes, the entire aerial part of the plant is used as a wound healing, expectorant, analgesic and sedative remedy; it is prescribed for cholelithiasis, as well as externally for cauterization during acupuncture [22]. The level of biological activity was studied according to the influence degree of the 1:20 infusion from Leontopodium conglobatum on the foaming reaction in a suspension of Saccharomyces cerevisiae [58]. No data on chemical composition has been found.

Geranium Genus
The Geranium L. (Geraniaceae) genus includes more than 300 species represented by herbs and shrubs. The representatives of the Geranium genus are native to the world and are found in various climatic zones. They can grow in mountains and rocks. More than 20 species of Geranium are cultivated and are the material for the cultivation of highly decorative varieties. The representatives of the Geranium genus form radical leaf rosettes on long petioles. At the same time, the leaf blade is finger-dissected into lobes of various shapes -from rather wide to thin, almost filiform. In the representatives of the Geranium genus, the flowers are actinomorphic, saucer-shaped, usually large and beautiful, and consist of five almost round petals. The petals can grow together to form a flat or calyx shape. In this case, the petals are either bent towards the rim, or, conversely, bent towards the petiole. The color of geranium flowers can be white, purple, blue, violet, lilac of various shades. The fruit is a box of a specific shape with the remaining calyx petals. The shape of the fruit resembles the beak of a crane, hence the name of the genus and the family [60].
The representatives of the Geranium genus of the north-west European Russia flora, were studied by Razarenova K.N. on the basis of the "St. Petersburg State Chemical and Pharmaceutical Academy". The objects of the research were: Geranium prаtense L., G. sylvaticum L., G. palustre L., G. sanguineum L., G. sibiricum L., G. robertianum L., G. pusillum L. and a cultivated G. lividum species [ 59].
The floristic lists and identification guides describe a different number of the representatives of the Geranium genus inhabiting the Baikal region. In particular, in "Flora of Siberia" [61], 20 species are described. In "Flora of Central Siberia" [18], in the Program of the Siberian Branch of the Russian Academy of Sciences [19], there is information about 10 species; a photo guide "Plants of the western coast of Lake Baikal" and a revision summary "Abstract of flora of the Irkutsk region (vascular plants)" [62] contains a description of 4 species.
There is information about the use of geraniums various types in folk medicine as a means of treating insomnia, epilepsy, fever, rheumatism, diarrhea, as a hemostatic in gynecological diseases. In Tibetan medicine, these types are prescribed for the treatment of eye diseases, including cataracts [21,60].
Among the Baikal representatives of the Geranium genus, the most common species have been identified: Geranium eriostemon Fischer., G. pratense L., G. wlassowianum Fischer.

Geranium eriostemon Fischer.
According to the information base [11], the name G. eriostemon is in the Illegitimate status, i.e. the use of this name is not consistent with the rules of the International Code of Botanical Nomenclature. At the same time, the name G. eriostemon is synonymous with the G. platyanthum Duthie species. In the floristic summaries "Flora of Siberia" [61], "Flora of Central Siberia" [18], and the Siberian Branch of of the Russian Academy of Sciences [19], the G. eriostemon species is described as independent.
The habitats are light forests, thickets of bushes, forest edges. The main areas of distribution are the western and southern regions of the Irkutsk region, the Central Siberian plateau, the southwestern outskirts of the Irkutsk region (Eastern Sayan), as well as the southern coast of Lake Baikal [18,19,61,62].
Phytotechnological studies were carried out to obtain an extract containing the maximum amount of flavonoids of the G. eriostemon herb. Based on a comparison of the results obtained on a mathematically predictable model and experimental data, it was found out that the optimal conditions are the ratio "raw material : extractant" = 1 : 40, herewith the extractant was a 60% ethanol and the duration of the extraction was 35 min [63]. The content of tannides was determined by HPLC in some species of geraniums growing in China; the sum of these compounds in the G. eriostemon herb was 0.88% [64].
The aerial parts of G. pratense, which grows in the western part of Russia, were examined for the amino acid composition. In particular, in the aerial parts of G. pratense harvested in the Republic of Bashkortostan, 20 amino acids were identified and their contentss were determined [67,68,71].
The color of geranium flowers is provided by anthocyanin -malvidin diglycoside; leukoanthocyanidin is present in the seeds [68].
The Baikal species G. pratense is one of the first plant objects studied at the Department of Pharmacology of the Irkutsk State Medical Institute in the 60 s of the last century. The studies were related to the effect study of the extract from this plant on the central nervous system and its toxicity [72]. At the same time, in the experiments on laboratory animals, the wound-healing effect of the polysaccharides sum of this plant has been studied. The effect of this group of compounds on the regeneration process of de-epilated animal skin, pretreated with a 20% potassium hydroxide solution, was studied. A noticeable decrease in the area of the wound surface, the acceleration of the regeneration processes and proliferation were found [73]. G. pratense, a species native to Mongolia, has a high antioxidant activity [74,75]. In isolated plasma, methanol extracts inhibited the action of the α-amylase enzymatic activity by more than 40% [74]. The prospect of using the sum of this type polyphenolic compounds against opportunistic microorganisms -strains B. cereus, E. coli, P. aeruginosa, S. aureus -was established [76].
Agrobiological studies of G. pratense were carried out. Was studied the antimicrobial activity of the dried powder from the roots of this plant after the ground application with a potato crop. This procedure reduced a further morbidity of the inoculum. It was found out that the fraction with geraniine exhibits the antimicrobial activity at its content of up to 15% of the dry weight of the root (HPLC method). The antimicrobial activity of this fraction corresponded to 1.25% of the streptomycin effect (a paper disk method). The results of the study indicate that the use of G. pratense as an organic supplement or an accompanying crop for controlling the microbial contamination of potatoes is promising [77].

Geranium wlassowianum Fischer
According to the information database, G. wlassowianum Fischer. has no synonyms [11]. In the Irkutsk region, G. wlassowianum is found in the east and south of the region, more often in the Tulunsky region. It is also ОБЗОРЫ, ЛЕКЦИИ typical for the southern coast of Lake Baikal, is included in the list of vegetation of the Baikal-Lensky reserve, while it prefers habitats similar to the above-listed geraniums species [18,19,62].
Throughout the whole vegetation season, a consistently high content of tannides was noted in the underground and aerial parts of the G. wlassowianum species growing on the territory of Buryatia [69]. The bactericidal activity level of tannins of G. wlassowianum vegetative organs against Staphylococcus aureus, was determined [66].

CONCLUSION
The data presented in the review show that species of the Asteroidae subfamily and the Geranium genus are sources of biologically active compounds of various groups -polyphenols, terpenoids, essential oil components, saturated and unsaturated fatty acids, trace elements, vitamins, etc. The presence of phenolcarboxylic acids, tannides is notified in all species. In folk medicine, the described plant objects are prescribed for the treatment of various diseases. The effect on the central nervous system has been experimentally confirmed. The following types of pharmacological actions -hemostatic, diaphoretic, antiseptic, antioxidant, cytostatic, anti-influenza, antiherpetic, antiprotozoal, antimicrobial and anti-inflammatory -have been confirmed, too.
The ranges of the presented species cover almost all the continents of the globe. This indicates broad adaptive capabilities of the plant objects described. Many of the listed species are the bases for the introduction of varieties with special decorative, economic and biological characteristics into cultivation; the ones with purposefully improved pharmaceutical values have also been included there. In this regard, in relation to the Baikal species Heteropappus altaicus, Solidago dahurica, Leucanthemum vulgare, Tripleurospermum inodorum, Antennaria dioica, Leontopodium conglobatum and Geranium eriostemon, G. pratense, G. wlassowianum, it is advisable to conduct a deep complex phytochemical and pharmacological research in order to create medicines for the treatment of the most common diseases.