pmedpharmФармация и фармакологияPharmacy & Pharmacology2307-92662413-2241Pyatigorsk Medical and Pharmaceutical Institute - branch of Volgograd State Medical Univer10.19163/2307-9266-2022-10-1-4-18pmedpharm-1022Research ArticleОБЗОРЫ, ЛЕКЦИИREVIEWS, LECTURESСОВРЕМЕННОЕ СОСТОЯНИЕ ИССЛЕДОВАНИЙ В ОБЛАСТИ ХИМИЧЕСКОГО СОСТАВА И ФАРМАКОЛОГИЧЕСКОГО ДЕЙСТВИЯ КУКУРУЗЫ СТОЛБИКОВ С РЫЛЬЦАМИCURRENT STATE OF RESEARCH IN THE FIELD OF CHEMICAL COMPOSITION AND PHARMACOLOGICAL EFFECTS OF ZEA MAYDIS STYLI CUM STIGMATIShttps://orcid.org/0000-0001-7081-3523НикифороваЕ. Б.NikiforovaE. B.

кандидат фармацевтических наук, доцент, исполняющий обязанности заведующего кафедрой фармации

350063, Россия, г. Краснодар, ул. Митрофана Седина, 4

Candidate of Sciences (Pharmacy), Associate Professor, Acting Head of the Department of Pharmacy

4, Mitrofan Sedin St., Krasnodar, Russia, 350063

elenanik94@mail.ruhttps://orcid.org/0000-0003-3593-2302БатН. М.BatN. M.

доктор фармацевтических наук, профессор, декан фармацевтического факультета

350063, Россия, г. Краснодар, ул. Митрофана Седина, 4

Doctor of Sciences (Pharmacy), Professor, Dean of the Pharmaceutical Faculty

4, Mitrofan Sedin St., Krasnodar, Russia, 350063

batnm@mail.ruhttps://orcid.org/0000-0001-8151-0587ДавитавянН. А.DavitavyanN. A.

кандидат фармацевтических наук, доцент, доцент кафедры фармации

350063, Россия, г. Краснодар, ул. Митрофана Седина, 4

Candidate of Sciences (Pharmacy), Associate Professor, Associate Professor of the Department of Pharmacy

4, Mitrofan Sedin St., Krasnodar, Russia, 350063

davitavyan08@mail.ruФедеральное государственное бюджетное образовательное учреждение «Кубанский государственный медицинский университет» Министерства здравоохранения Российской ФедерацииРоссияKuban State Medical UniversityRussian Federation202206032022101418Copyright © Никифорова Е.Б., Бат Н.М., Давитавян Н.А., 20222022Никифорова Е.Б., Бат Н.М., Давитавян Н.А.Nikiforova E.B., Bat N.M., Davitavyan N.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pharmpharm.ru/jour/article/view/1022

Кукурузы столбики с рыльцами (КСР) (лат. – Zea maydis styli cum stigmatis, англ. – corn silk) хорошо известны в медицинской практике. В научной литературе накоплено немало информации о химическом составе и фармакотерапевтическом действии данного лекарственного растительного сырья. Хронологический анализ этих сведений показывает, что ранее ландшафт научных публикаций был посвящен, главным образом, изучению желчегонной, диуретической, кровоостанавливающей активности КСР и выявлению действующих веществ, ответственных за данные виды активности. В настоящее время отмечается нарастающий научный интерес не только к отдельным индивидуальным природным соединениям в составе КСР, но и к поиску новых аспектов их медицинского применения.

Цель

Цель. Обзор и систематизация современных научных данных в области химического состава и фармакологического действия КСР.

Материалы и методы

Материалы и методы. Для информационно-аналитического поиска использовали научные данные, размещенные на электронных ресурсах PubMed, Web of Science, ScienceDirect, Scopus, Google Scholar, eLibrary. Поиск осуществляли за период с 2005 г. по 2021 г. по ключевым словам: кукуруза обыкновенная; кукурузы столбики с рыльцами; Zea maydis styli cum stigmatis; corn silk; химический состав; фармакологическое действие.

Результаты

Результаты. Обзор посвящен обобщению и анализу современных научных данных о химическом составе и фармакологическом действии КСР. Показано, что по-прежнему наибольшее внимание ученых в составе КСР привлекают флавоноиды. Наряду с ними немаловажное значение для фармакологической активности КСР имеют фенолкарбоновые кислоты, витамин К, фитостерины, летучие соединения и полисахариды. Современные представления о фармакологическом действии КСР расширены за счет обобщения результатов исследования их антиоксидантной, противовоспалительной, антидиабетической, гипотензивной, нейро- и фотопротекторной активности. Опубликованы данные, свидетельствующие об эффективности их применения в составе комплексной терапии опухолевых заболеваний.

Заключение

Заключение. В результате проведенного анализа данных современной научной литературы было установлено, что интерес ученых к КСР не ослабевает. Наряду с флавоноидами данного сырья достаточно активно изучаются и другие группы фармакологически активных веществ. Выявлено, что существенно обновились сведения о потенциально значимых и подтвержденных видах лечебного действия КСР. Результаты данного обзора могут быть полезны для определения перспективных направлений разработки лекарственных средств на основе КСР.

Zea maydis styli cum stigmatis (Engl. corn silk) are well known in medical practice. In the scientific literature, a lot of information has been accumulated about the chemical composition and pharmacotherapeutic actions of this medicinal plant material. A chronological analysis of this information shows that earlier, the scope of scientific publications was mainly devoted to the study of the choleretic, diuretic, hemostatic kinds of Zea maydis styli cum stigmatis activity, and the identification of the active substances responsible for these types of action. Currently, there is a growing scientific interest not only in the individual natural compounds of the Zea maydis styli cum stigmatis composition, but also in the search for new aspects of their medical application.

The aim of the article is a review and systematization of modern scientific data in the field of the Zea maydis styli cum stigmatis chemical composition and their pharmacological action.

Materials and methods

Materials and methods. For the information and analytical search, the scientific data posted on the following electronic resources were used: PubMed, Web of Science, ScienceDirect, Scopus, Google Scholar, eLibrary. The search was carried out in the period from 2005 to 2021 using the following keywords: Zea mays L.; Zea maydis styli cum stigmatis; corn silk; chemical composition; pharmacological action.

Results

Results. The review is devoted to the generalization and analysis of modern scientific data on the Zea maydis styli cum stigmatis chemical composition and their pharmacological action. It has been shown that, as before, the greatest attention of scientists is attracted by flavonoids in the Zea maydis styli cum stigmatis chemical composition. Alongside with them, phenolcarboxylic acids, vitamin K, phytosterols, volatile compounds and polysaccharides are of no small importance for the Zea maydis styli cum stigmatis pharmacological activity. Modern ideas about the Zea maydis styli cum stigmatis pharmacological activity have been expanded by summarizing the study results of their antioxidant, anti-inflammatory, antidiabetic, hypotensive, neuro- and photoprotective activities. The data on the effectiveness of their use as parts of the complex tumor diseases therapy have been published.

Conclusion

Conclusion. As a result of the data analysis of modern scientific literature, it has been found out that Zea maydis styli cum stigmatis are still in the sphere of scientists’ interest. Alongside with the flavonoids of this raw material, other groups of pharmacologically active substances are also being actively studied. It has been revealed that the information about potentially significant and confirmed types of the Zea maydis styli cum stigmatis therapeutic action is significantly updated. The results of this review may be useful for identifying promising directions for the development of the drugs based on Zea maydis styli cum stigmatis.

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The authors declare that there are no conflicts of interest present.