pmedpharmФармация и фармакологияPharmacy & Pharmacology2307-92662413-2241Pyatigorsk Medical and Pharmaceutical Institute - branch of Volgograd State Medical Univer10.19163/2307-9266-2022-10-4-308-319pmedpharm-1164Research ArticleОБЗОРЫ, ЛЕКЦИИREVIEWS, LECTURESОЦЕНКА ПОТЕНЦИАЛА РАСТИТЕЛЬНЫХ UV-ФИЛЬТРОВ В СВЕТЕ СОВРЕМЕННОЙ КОНЦЕПЦИИ ФОТОЗАЩИТЫ КОЖИEVALUATION OF PLANT-BASED UV FILTERS POTENTIAL IN MODERN CONCEPT VIEW OF SKIN PHOTOPROTECTIONhttps://orcid.org/0000-0001-5933-2120НемятыхО. Д.NemyatykhO. D.

доктор фармацевтических наук, доцент, профессор кафедры управления и экономики фармации

197376, Россия, г. Санкт-Петербург, ул. Проф. Попова, д. 14, лит. А

Doctor of Sciences (Pharmacy), Associate Professor, Professor of Management and Economics Department of Pharmacy

14, Prof. Popov Str., Saint-Petersburg, Russia, 197376

oksana.nemyatyh@pharminnotech.comhttps://orcid.org/0000-0002-2942-1015ТернинкоИ. И.TerninkoI. I.

доктор фармацевтических наук, доцент, начальник структурного подразделения Испытательной лаборатории (Центр контроля качества лекарственных средств) ФГБОУ ВО СПХФУ Минздрава России; профессор кафедры фармацевтической химии ФГБОУ ВО СПХФУ Минздрава России

197376, Россия, г. Санкт-Петербург, ул. Проф. Попова, д. 14, лит. А

 

Doctor of Sciences (Pharmacy), Associate Professor, Head of the Structural Subdivision, Testing Laboratory (Medicines Quality Control Center)

14, Prof. Popov Str., Saint-Petersburg, Russia, 197376

 

inna.terninko@pharminnotech.comhttps://orcid.org/0000-0001-8101-2123СабитовА. С.SabitovA. S.

преподаватель школы фармации, КазНМУ имени С.Д. Асфендиярова

050000, Республика Казахстан, г. Алматы, ул. Толе Би, д. 88, корп. 4

Teacher of the School of Pharmacy

Bld. 4, 88, Tole Bi Str., Almaty, Republic of Kazakhstan, 050000

acxam78@gmail.comhttps://orcid.org/0000-0001-9534-0398ЛяшкоА. И.LyashkoA. I.

кандидат фармацевтических наук, доцент кафедры управления и экономики фармации

197376, Россия, г. Санкт-Петербург, ул. Проф. Попова, д. 14, лит. А

 

Candidate of Sciences (Pharmacy), Associate Professor of Management and Economics Department of Pharmacy

14, Prof. Popov Str., Saint-Petersburg, Russia, 197376

anastasia.fitisova@pharminnotech.comhttps://orcid.org/0000-0003-4477-4051СакиповаЗ. Б.SakipovaZ. B.

доктор фармацевтических наук, профессор, декан Школы фармации

050000, Республика Казахстан, г. Алматы, ул. Толе Би, д. 88, корп. 4

Doctor of Sciences (Pharmacy), Professor, Dean of the School of Pharmacy

Bld. 4, 88, Tole Bi Str., Almaty, Republic of Kazakhstan, 050000

sakipova.z@kaznmu.kzФедеральное государственное бюджетное образовательное учреждение высшего образования «Санкт-Петербургский государственный химико-фармацевтический университет» Министерства здравоохранения Российской ФедерацииРоссияSaint-Petersburg State Chemical and Pharmaceutical UniversityRussian FederationФедеральное государственное бюджетное образовательное учреждение высшего образования «Санкт-Петербургский государственный химико-фармацевтический университет» Министерства здравоохранения Российской Федерации; Испытательная лаборатория (Центр контроля качества лекарственных средств) федерального государственного бюджетного образовательного учреждения высшего образования «Санкт-Петербургский государственный химико-фармацевтический университет» Министерства здравоохранения Российской ФедерацииРоссияSaint-Petersburg State Chemical and Pharmaceutical UniversityRussian FederationКазахский национальный медицинский университет имени С.Д. АсфендияроваКазахстанAsfendiyarov Kazakh National Medical UniversityKazakhstan202229102022104308319Copyright © Немятых О.Д., Тернинко И.И., Сабитов А.С., Ляшко А.И., Сакипова З.Б., 20222022Немятых О.Д., Тернинко И.И., Сабитов А.С., Ляшко А.И., Сакипова З.Б.Nemyatykh O.D., Terninko I.I., Sabitov A.S., Lyashko A.I., Sakipova Z.B.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pharmpharm.ru/jour/article/view/1164

Терапевтический потенциал растений основан на фармакологических эффектах, обусловленных их фитохимическим профилем. Сегодня научный интерес к растительным объектам возрастает в результате последних исследований, в которых рассматривается перспектива применения данного сырья для косметической отрасли в качестве средств для защиты кожи от пагубного воздействия УФ-лучей.

Цель

Цель. Оценка потенциала растительных UV-фильтров в свете современной концепции фотозащиты кожи.

Материалы и методы

Материалы и методы. Систематический поиск литературы проводился с помощью электронных информационных массивов PubMed, Scopus, Google Scholar, eLibrary. Глубина поиска составила 10 лет (период с 2010 по 2021 гг). Поиск проводили по ключевым словам: антиоксиданты, косметические средства, фотозащита, химический состав, фармакологическое действие.

Результаты

Результаты. В работе рассмотрены и научно обоснованы современные принципы фотозащиты кожи, базирующиеся на применении химических или физических UV-фильтров. Отмечена тенденция использования растительного сырья и его компонентов в рецептуре фотопротекторов, что связано с широким спектром активности, отсутствием ксенобиотического эффекта и высокой биодоступностью органических растительных соединений.

Заключение

Заключение. Анализ данных научных публикаций продемонстрировал потенциальную фотопротекторную активность биологически активных веществ растений, обусловленную антиоксидантным, противовоспалительным и антирадикальным эффектами. Результаты исследования являются теоретическим базисом для дальнейшего всестороннего экспериментального изучения растительных объектов с целью получения пула доказательных данных в области фотопротекции в опытах in vivo.

A therapeutic plants potential is based on the pharmacological effects due to their phytochemical profile. Today, scientific interest in botanicals is increasing as a result of recent research that looks at the prospect of using these raw materials for the cosmetic industry as a means to protect the skin from the harmful effects of UV rays.

The aim of the study was to evaluate a potential of plant-based UV-filters in modern concept view of skin photoprotection.

Materials and methods

Materials and methods. A systematic literature search was carried out using the electronic information arrays PubMed, Scopus, Google Scholar, eLibrary. The search depth was 10 years (the period from 2010 to 2021). The search was carried out by the following keywords: antioxidants, cosmetics, photoprotection, chemical composition, pharmacological action.

Results

Results. In the paper, modern principles of skin photoprotection based on the use of chemical or physical UV-filters are considered and scientifically substantiated A trend for the use of plant-based materials and their components in the formulation of photoprotectors was notified. That is associated with a wide activity spectrum, the absence of a xenobiotic effect, and a high bioavailability of organic plant compounds.

Conclusion

Conclusion. The data analysis from scientific publications demonstrated a potential photoprotective activity of plant-based biologically active substances due to antioxidant, anti-inflammatory and anti-radical effects. The results of the study are a theoretical basis for a further comprehensive experimental study of plant objects in order to obtain a pool of evidence in the field of photoprotection in in vivo experiments.

растительные UV-фильтрыфотопротекцияконцепция современной фотозащиты кожиplant-based UV filtersphotoprotectionconcept of modern skin photoprotectionДанное исследование не имело финансовой поддержки от сторонних организацийThis study did not receive financial support from outside organizationsReferencesWolf P. [UV-Filter. State of the Art] // Hautarzt. – 2009. – Vol. 60, No. 4. – Р. 285–293. DOI: 10.1007/s00105-008-1623-y. GermanWolf P. UV-Filter. State of the Art [UV Filters. State of the art]. Hautarzt. 2009 Apr;60(4):285–93. DOI: 10.1007/s00105-008-1623-y. GermanHe Н., Li А., Li Sh., Tang J., Li L., Xiong L. Natural components in sunscreens: Topical formulations with sun protection factor (SPF) // Biomedicine & Pharmacotherapy. – 2021. – Vol. 134. – Art. ID: 111–161. DOI: 10.1016/j.biopha.2020.111161He H, Li A, Li S, Tang J, Li L, Xiong L. Natural components in sunscreens: Topical formulations with sun protection factor (SPF). Biomed Pharmacother. 2021 Feb;134:111161. DOI: 10.1016/j.biopha.2020.111161Westfall A., Sigurdson G.T., Giusti M.M. Antioxidant, UV protection, and antiphotoaging properties of anthocyanin-pigmented lipstick formulations // J. Cosmet. Sci. – 2019. – Vol. 70, No. 2. – Р. 63–76.Westfall A, Sigurdson GT, Giusti MM. Antioxidant, UV Protection, and Antiphotoaging Properties of Anthocyanin-Pigmented Lipstick Formulations. J Cosmet Sci. 2019 Mar/Apr;70(2):63–76.Korać R.R., Khambholja K.M. Potential of herbs in skin protection from ultraviolet radiation // Pharmacogn. Rev. – 2011. – Vol. 5, No. 10. – Р. 164–173. DOI: 10.4103/0973-7847.91114Korać RR, Khambholja KM. Potential of herbs in skin protection from ultraviolet radiation. Pharmacogn Rev. 2011 Jul;5(10):164–73. DOI: 10.4103/0973-7847.91114Lohézic-Le Dévéhat F., Legouin В., Couteau С., Boustie J., Coiffard L. Lichenic extracts and metabolites as UV filters // J. Photochem. Photobiol. B. – 2013. – Vol. 120. – Р. 17–28. DOI: 10.1016/j.jphotobiol.2013.01.009Lohézic-Le Dévéhat F, Legouin B, Couteau C, Boustie J, Coiffard L. Lichenic extracts and metabolites as UV filters. J Photochem Photobiol B. 2013 Mar 5;120:17–28. DOI: 10.1016/j.jphotobiol.2013.01.009Vostálová J., Tinková Е., Biedermann D., Kosina P., Ulrichová J., Rajnochová Svobodová A. Skin protective activity of silymarin and its flavonolignans // Molecules. – 2019. – Vol. 24, No. 6. – Р. 1022–2406. DOI: 10.3390/molecules24061022Vostálová J, Tinková E, Biedermann D, Kosina P, Ulrichová J, Rajnochová Svobodová A. Skin Protective Activity of Silymarin and its Flavonolignans. Molecules. 2019 Mar 14;24(6):1022. DOI: 10.3390/molecules24061022Álvarez-Gómez F., Korbee N., Casas V., Teófilo Abdala-Díaz R., Figueroa F. UV photoprotection, cytotoxicity and immunology capacity of red algae extracts // Molecules. – 2019. – Vol. 24, No. 2. – Art. No. 341. DOI: 10.3390/molecules24020341Álvarez-Gómez F, Korbee N, Casas-Arrojo V, Abdala-Díaz RT, Figueroa FL. UV Photoprotection, Cytotoxicity and Immunology Capacity of Red Algae Extracts. Molecules. 2019 Jan 18;24(2):341. DOI: 10.3390/molecules24020341Ahmady A., Amini H. M., Zhakfar A.M., Babak G., Sediqi M.N. Sun protective potential and physical stability of herbal sunscreen developed from afghan medicinal plants // Turk. J. Pharm. Sci. – 2020. – Vol. 17, No. 3. – P. 285–292. DOI: 10.4274/tjps.galenos.2019.15428Ahmady A, Amini MH, Zhakfar AM, Babak G, Sediqi MN. Sun Protective Potential and Physical Stability of Herbal Sunscreen Developed from Afghan Medicinal Plants. Turk J Pharm Sci. 2020 Jun;17(3):285–92. DOI: 10.4274/tjps.galenos.2019.15428Baldisserotto A., Buso P., Radice M., Dissette V., Lampronti I., Gambari R., Manfredini S., Vertuani S. Moringa oleifera leaf extracts as multifunctional ingredients for “natural and organic” sunscreens and photoprotective preparations // Molecules. – 2018. – Vol. 23, No. 3. – Art. No. 664. DOI: 10.3390/molecules23030664Baldisserotto A, Buso P, Radice M, Dissette V, Lampronti I, Gambari R, Manfredini S, Vertuani S. Moringa oleifera Leaf Extracts as Multifunctional Ingredients for “Natural and Organic” Sunscreens and Photoprotective Preparations. Molecules. 2018 Mar 15;23(3):664. DOI: 10.3390/molecules23030664Cefali L.C., Ataide J.A., Fernandes A.R., Sanchez-Lopez E., Sousa I.M.O., Figueiredo M.C., Ruiz A.L.T.G., Foglio M.A., Mazzola P.G., Souto E.B. Evaluation of In Vitro Solar Protection Factor (SPF), Antioxidant Activity, and Cell Viability of Mixed Vegetable Extracts from Dirmophandra mollis Benth, Ginkgo biloba L., Ruta graveolens L., and Vitis vinífera L. // Plants (Basel). – 2019. – Vol. 8, No. 11. – Art. ID: 453. DOI: 10.3390/plants8110453Cefali LC, Ataide JA, Fernandes AR, Sanchez-Lopez E, Sousa IMO, Figueiredo MC, Ruiz ALTG, Foglio MA, Mazzola PG, Souto EB. Evaluation of In Vitro Solar Protection Factor (SPF), Antioxidant Activity, and Cell Viability of Mixed Vegetable Extracts from Dirmophandra mollis Benth, Ginkgo biloba L., Ruta graveolens L., and Vitis vinífera L. Plants (Basel). 2019 Oct 26;8(11):453. DOI: 10.3390/plants8110453Kiralan M., Yildirim G. Rosehip (Rosa canina L.) Oil // Fruit Oils: Chemistry and Functionality. – 2019. – Р. 803–814. DOI: 10.1007/978-3-030-12473-1_43Kiralan M, Yildirim G. Rosehip (Rosa canina L.) Oil. Fruit Oils: Chemistry and Functionality. 2019: 803–14. DOI: 10.1007/978-3-030-12473-1_43Fascella G., D’Angiolillo F., Mammano M., Amenta M., Romeo F., Rapisarda P., Ballistreri G. Bioactive compounds and antioxidant activity of four rose hip species from spontaneous Sicilian flora // Food Chemistry. – 2019. – Vol. 289. – P. 56–64. DOI: 10.1016/j.foodchem.2019.02.127Fascella G, D’Angiolillo F, Mammano MM, Amenta M, Romeo FV, Rapisarda P, Ballistreri G. Bioactive compounds and antioxidant activity of four rose hip species from spontaneous Sicilian flora. Food Chem. 2019 Aug 15;289:56-64. DOI: 10.1016/j.foodchem.2019.02.127Jiménez P.P., Masson S.L., Quitral R.V. Chemical composition of chia seed, flaxseed and rosehip and its contribution in fatty acids omega-3 // Revista Chilena De Nutricion. – 2013. – Vol. 40, No. 2. – P. 155–160. DOI:10.4067/S0717-75182013000200010Jiménez PP, Masson SL, Quitral RV. Chemical composition of chia seed, flaxseed and rosehip and its contribution in fatty acids omega-3. Revista Chilena De Nutricion. 2013;40(2):155–60. DOI: 10.4067/S0717-75182013000200010Pashazadeh H., Özdemir N., Zannou O., Koca I. Antioxidant capacity, phytochemical compounds, and volatile compounds related to aromatic property of vinegar produced from black rosehip (Rosa pimpinellifolia L.) juice // Food Bioscience. – 2021. – Vol. 44, No. 9. – Art. ID: 101318. DOI: 10.1016/j.fbio.2021.101318Pashazadeh H, Özdemir N, Zannou O, Koca I. Antioxidant capacity, phytochemical compounds, and volatile compounds related to aromatic property of vinegar produced from black rosehip (Rosa pimpinellifolia L.) juice. Food Bioscience. 2021;44(9):101318. DOI: 10.1016/j.fbio.2021.101318Dąbrowska M., Maciejczyk E., Kalemba D. Rose hip seed oil: Methods of extraction and chemical composition // European Journal of Lipid Science and Technology. – 2019. – Vol. 121, No. 8. – Art. ID: 1800440. DOI: 10.1002/ejlt.201800440Dąbrowska M, Maciejczyk E, Kalemba D. Rose hip seed oil: Methods of extraction and chemical composition. European Journal of Lipid Science and Technology. 2019;121(8):1800440. DOI: 10.1002/ejlt.201800440Duru N., Karadeniz F., Erge H.S. Changes in bioactive compounds, antioxidant activity and HMF formation in rosehip nectars during storage // Food and Bioprocess Technology. – 2012. – Vol. 5, No. 7. – P. 2899–2907. DOI: 10.1007/s11947-011-0657-9Duru N, Karadeniz F, Erge HS. Changes in bioactive compounds, antioxidant activity and HMF formation in rosehip nectars during storage. Food and Bioprocess Technology. 2012;5(7):2899–907. DOI: 10.1007/s11947-011-0657-9Kayath H., Dhawan S., Nanda S. In-vitro Estimation of Photo-Protective Potential of Rosehip Seed Oil and QbD Based Development of a Nanoformulation // Current Nanomedicine. – 2019. – Vol. 9, No. 3. – P. 216–231. DOI: 10.2174/2468187309666190126112141Kayath H, Dhawan S, Nanda S. In-vitro Estimation of Photo-Protective Potential of Rosehip Seed Oil and QbD Based Development of a Nanoformulation. Current Nanomedicine. 2019;9(3):216–31. DOI: 10.2174/2468187309666190126112141Kulaitienė J., Medveckienė B., Levickienė D., Vaitkevičienė N., Makarevičienė V., Jarienė E. Changes in fatty acids content in organic rosehip (Rosa spp.) seeds during ripening // Plants. – 2020. – Vol. 9, No. 12. – Art. No. 1793. DOI: 10.3390/plants9121793Kulaitienė J, Medveckienė B, Levickienė D, Vaitkevičienė N, Makarevičienė V, Jarienė E. Changes in Fatty Acids Content in Organic Rosehip (Rosa spp.) Seeds during Ripening. Plants (Basel). 2020 Dec 17;9(12):1793. DOI: 10.3390/plants9121793Bhave A., Schulzova V., Chmelarova H., Mrnka L., Hajslova J. Assessment of rosehips based on the content of their biologically active compounds // J. Food Drug. Anal. – 2017. – Vol. 25, No. 3. – P. 681–690. DOI: 10.1016/j.jfda.2016.12.019Bhave A, Schulzova V, Chmelarova H, Mrnka L, Hajslova J. Assessment of rosehips based on the content of their biologically active compounds. J Food Drug Anal. 2017 Jul;25(3):681–90. DOI: 10.1016/j.jfda.2016.12.019Дубцова Г.Н., Негматуллоева Р.Н., Бессонов В.В., Байков В.Г., Шевякова Л.В., Махова Н.Н., Передеряев О.И., Богачук М.Н., Байгарин Е.К. Состав и содержание биологически активных веществ в плодах шиповника // Вопросы питания. – 2012. – Т. 81, № 6. – P. 84–88.Dubtsova GN, Negmatulloeva RN, Bessonov VV, Baĭkov VG, Sheviakova LV, Makhova NN, Perederiaev OI, Bogachuk MN, Baĭgarin EK. [Composition and content of biologically active substances in rose hips]. Vopr Pitan. 2012;81(6):84–8. RussianChu C.C., Nyam K.L. Application of seed oils and its bioactive compounds in sunscreen formulations // Journal of the American Oil Chemists’ Society. – 2021. – Vol. 98, No. 7. – P. 713–726. DOI: 10.1002/aocs.12491Chu CC, Nyam KL. Application of seed oils and its bioactive compounds in sunscreen formulations. Journal of the American Oil Chemists’ Society. 2021;98(7):713–26. DOI: 10.1002/aocs.12491Radice M., Manfredini S., Ziosi P., Dissette V., Buso P., Fallacara A., Vertuani S. Herbal extracts, lichens and biomolecules as natural photo-protection alternatives to synthetic UV filters. A systematic review // Fitoterapia. – 2016. – Vol. 114. – Р. 144–162. DOI: 10.1016/j.fitote.2016.09.003Radice M, Manfredini S, Ziosi P, Dissette V, Buso P, Fallacara A, Vertuani S. Herbal extracts, lichens and biomolecules as natural photo-protection alternatives to synthetic UV filters. A systematic review. Fitoterapia. 2016 Oct;114:144–62. DOI: 10.1016/j.fitote.2016.09.003Олисова О.Ю., Владимирова Е.В., Бабушкин А.М. Кожа и солнце // Российский журнал кожных и венерических болезней. – 2012. – Т. 15, № 6. – C. 57–62. DOI: 10.17816/dv36783Olisova OY, Vladimirova EV, Babushkin AM. The skin and the sun. Russian Journal of Skin and Venereal Diseases. 2012;15(6):57–62. DOI: 10.17816/dv36783. RussianСвиридова А.А., Ищенко А.А. Солнцезащитные средства. I. Классификация и механизм действия органических фильтров // Химия и химическая технология. – 2006. – Т. 49, № 11 – С. 3–14.Sviridova AA, Ischenko AA. Sun protective materials i. classification and interaction mechanism for organic UV-filters. ChemChemTech. 2006;49(11):3–14. RussianCavinato M., Jansen-Dürr P. Molecular mechanisms of UVB-induced senescence of dermal fibroblasts and its relevance for photoaging of the human skin // Exp. Gerontol. – 2017. – Vol. 94. – P. 78–82. DOI: 10.1016/j.exger.2017.01.009Cavinato M, Jansen-Dürr P. Molecular mechanisms of UVB-induced senescence of dermal fibroblasts and its relevance for photoaging of the human skin. Exp Gerontol. 2017 Aug;94:78–82. DOI: 10.1016/j.exger.2017.01.009Wu S., Han J., Laden F., Qureshi A.A. Long-term ultraviolet flux, other potential risk factors, and skin cancer risk: a cohort study // Cancer Epidemiol. Biomarkers Prev. – 2014. – Vol. 23, No. 6. – Р. 1080–1089. DOI: 10.1158/1055-9965.EPI-13-0821Wu S, Han J, Laden F, Qureshi AA. Long-term ultraviolet flux, other potential risk factors, and skin cancer risk: a cohort study. Cancer Epidemiol Biomarkers Prev. 2014 Jun;23(6):1080–9. DOI: 10.1158/1055-9965.EPI-13-0821Fitzpatrick T.B. The validity and practicability of sun-reactive skin types I through VI // Arch. Dermatol. – 1988. – Vol. 124, No. 6. – Р. 869–871. DOI: 10.1001/archderm.124.6.869Fitzpatrick TB. The validity and practicality of sun-reactive skin types I through VI. Arch Dermatol. 1988 Jun;124(6):869–71. DOI: 10.1001/archderm.124.6.869Smanalieva J., Iskakova J., Oskonbaeva Z., Wichern F., Darr D. Investigation of nutritional characteristics and free radical scavenging activity of wild apple, pear, rosehip, and barberry from the walnut-fruit forests of Kyrgyzstan // European Food Research and Technology. – 2020. – Vol. 246, No. 5. – P. 1095–1104. DOI: 10.1007/s00217-020-03476-1Smanalieva J, Iskakova J, Oskonbaeva Z, Wichern F, Darr D. Investigation of nutritional characteristics and free radical scavenging activity of wild apple, pear, rosehip, and barberry from the walnut-fruit forests of Kyrgyzstan. European Food Research and Technology. 2020;246(5):1095–104. DOI: 10.1007/s00217-020-03476-1Ácsová A., Hojerová J., Janotková L., Bendová H., Jedličková L., Hamranová V., Martiniaková S. The real UVB photoprotective efficacy of vegetable oils: in vitro and in vivo studies // Photochem. Photobiol. Sci. – 2021. – Vol. 20, No. 1. – P. 139–151. DOI: 10.1007/s43630-020-00009-3Ácsová A, Hojerová J, Janotková L, Bendová H, Jedličková L, Hamranová V, Martiniaková S. The real UVB photoprotective efficacy of vegetable oils: in vitro and in vivo studies. Photochem Photobiol Sci. 2021 Jan;20(1):139–51. DOI: 10.1007/s43630-020-00009-3Charles Dorni A.I., Amalraj A., Gopi S., Varma K., Anjana S.N. Novel cosmeceuticals from plants- аn industry guided review // Journal of Applied Research on Medicinal and Aromatic Plants. – 2017. – Vol. 7. – P. 1–26. DOI: 10.1016/j.jarmap.2017.05.003Charles Dorni AI, Amalraj A, Gopi S, Varma K, Anjana SN. Novel cosmeceuticals from plants- аn industry guided review. Journal of Applied Research on Medicinal and Aromatic Plants. 2017;7:1–26. DOI: 10.1016/j.jarmap.2017.05.003Baumann L. How to use oral and topical cosmeceuticals to prevent and treat skin aging // Facial Plast. Surg. Clin. North. Am. – 2018. – Vol. 26, No. 4. – P. 407–413. DOI: 10.1016/j.fsc.2018.06.002Baumann L. How to Use Oral and Topical Cosmeceuticals to Prevent and Treat Skin Aging. Facial Plast Surg Clin North Am. 2018 Nov;26(4):407–13. DOI: 10.1016/j.fsc.2018.06.002Akbarzadeh A., Rezaei-Sadabady R., Davaran S., Joo S.W., Zarghami N., Hanifehpour Y., Samiei M., Kouhi M., Nejati-Koshki K. Liposome: classification, preparation, and applications // Nanoscale Res. Lett. – 2013. – Vol. 8, No. 1. – Art. No. 102. DOI: 10.1186/1556-276X-8-102Akbarzadeh A, Rezaei-Sadabady R, Davaran S, Joo SW, Zarghami N, Hanifehpour Y, Samiei M, Kouhi M, Nejati-Koshki K. Liposome: classification, preparation, and applications. Nanoscale Res Lett. 2013 Feb 22;8(1):102. DOI: 10.1186/1556-276X-8-102Fivenson D., Sabzevari N, Qiblawi S., Blitz J, Norton B, Norton S. Sunscreens: UV filters to protect us: Part 2-Increasing awareness of UV filters and their potential toxicities to us and our environment // International Journal of Women’s Dermatology. – 2021. – Vol. 7, Issue 1. – P. 45–69. DOI: 10.1016/j.ijwd.2020.08.008Fivenson D, Sabzevari N, Qiblawi S, Blitz J, Norton B, Norton S. Sunscreens: UV filters to protect us: Part 2-Increasing awareness of UV filters and their potential toxicities to us and our environment. International Journal of Women’s Dermatology. 2021;7(Issue 1. – P. 45–69. DOI: 10.1016/j.ijwd.2020.08.008Takshak S., Agrawal S.B. Defense potential of secondary metabolites in medicinal plants under UV-B stress // J. Photochem. Photobiol. B: Biology. – 2019. – Vol. 193. – P. 51–88. DOI: 10.1016/j.jphotobiol.2019.02.002Takshak S, Agrawal SB. Defense potential of secondary metabolites in medicinal plants under UV-B stress. J Photochem Photobiol B: Biology. 2019;193:51–88. DOI: 10.1016/j.jphotobiol.2019.02.002Shikov A.N., Narkevich I.A., Akamova A.V., Nemyatykh O.D., Flisyuk E.V., Luzhanin V.G., Povydysh M.N., Mikhailova Y.V., Pozharitskaya O.N. Medical Species Used in Russia for the Management of Diabetes and Related Disorders // Front. Pharmacol. – 2021. – Vol. 12. – Art. ID: 697411. DOI: 10.3389/fphar.2021.697411Shikov AN, Narkevich IA, Akamova AV, Nemyatykh OD, Flisyuk EV, Luzhanin VG, Povydysh MN, Mikhailova IV, Pozharitskaya ON. Medical Species Used in Russia for the Management of Diabetes and Related Disorders. Front Pharmacol. 2021 Jul 20;12:697411. DOI: 10.3389/fphar.2021.697411Zhang S., Zhang L., Zou H, Qiu1 L., Zheng Y., Yang D., Wang Y. The effect of developmental and environmental factors on secondary metabolites in medicinal plants // Plant Physiol. Biochem. – 2020. – Vol. 148. – P. 80–89. DOI: 10.3389/fpls.2021.781236Li Y, Kong D, Fu Y, Sussman MR, Wu H. The effect of developmental and environmental factors on secondary metabolites in medicinal plants. Plant Physiol Biochem. 2020 Mar;148:80–9. DOI: 10.1016/j.plaphy.2020.01.006Verdaguer D., Jansen M., Llorens L., Morales L., Neugart S. UV-A radiation effects on higher plants: Exploring the known unknown // Plant Sci. – 2017. – Vol. 255. – P. 72–81. DOI: 10.1016/j.plantsci.2016.11.014Verdaguer D, Jansen MA, Llorens L, Morales LO, Neugart S. UV-A radiation effects on higher plants: Exploring the known unknown. Plant Sci. 2017 Feb;255:72–81. DOI: 10.1016/j.plantsci.2016.11.014Cefali L.C., Ataide J.A., Moriel P., Foglio M.A., Mazzola P.G. Plant-based active photoprotectants for sunscreens // Int. J. Cosmet.Sci. – 2016. – Vol. 38, No 4. – P. 346–353. DOI: 10.1111/ics.12316Cefali LC, Ataide JA, Moriel P, Foglio MA, Mazzola PG. Plant-based active photoprotectants for sunscreens. Int J Cosmet Sci. 2016 Aug;38(4):346–53. DOI: 10.1111/ics.12316Piovesana de Souza F., Campos G.R., Packer J.F. Determinação da atividade fotoprotetora e antioxidante em emulsões contendo extrato de Malpighia glabra L. // Acerola. J. Basic. Appl. Pharm. Sci. – 2013. – Vol. 34, No. 1. – P. 69–77.Piovesana de Souza F, Campos GR, Packer JF. Determinação da atividade fotoprotetora e antioxidante em emulsões contendo extrato de Malpighia glabra L. Acerola J Basic Appl Pharm Sci. 2013;34(1):69-77.Kumar N., Jose J. Current developments in the nanomediated delivery of photoprotective phytochemicals // Environ. Sci. Pollut. Res. – 2020. – Vol. 27, No. 31. – P. 38446–38471. DOI: 10.1007/s11356-020-10100-yKumar N, Jose J. Current developments in the nanomediated delivery of photoprotective phytochemicals. Environ Sci Pollut Res. 2020;27(31): 38446–71. DOI:10.1007/s11356-020-10100-yAvila Acevedo J.G., Castañeda C.M., Benitez F.J., Durán D.A., Barroso V.R., Martínez C.G., Muñoz L.J., Martínez C.A., Romo de Vivar A. Photoprotective activity of Buddleja scordioides // Fitoterapia. – 2005. – Vol. 76, No. 3–4. – P. 301–309. DOI: 10.1016/j.fitote.2005.03.009Avila Acevedo JG, Castañeda CM, Benitez FJ, Durán DA, Barroso VR, Martínez CG, Muñoz LJ, Martínez CA, Romo de Vivar A. Photoprotective activity of Buddleja scordioides. Fitoterapia. 2005 Jun;76(3–4):301–9. DOI: 10.1016/j.fitote.2005.03.009Velasco M.V.R., Balogh T.S., Pedriali C.A., Sarruf F.D., Pinto C.A.S.O., Kaneko T.M., Rolim Baby A. [Association of rutin with octyl p-methoxycinnamate and benzophenone-3: in vitro evaluation of photoprotective efficacy by reflectance spectrophotometry] // Lat. Am. J. Pharm. – 2008. – Vol. 27, No. 1. – P. 23–27. PortugueseVelasco MVR, Balogh TS, Pedriali CA, Sarruf FD, Pinto CASO, Kaneko TM, Rolim Baby A. Association of rutin with octyl p-methoxycinnamate and benzophenone-3: in vitro evaluation of photoprotective efficacy by reflectance spectrophotometry [Associação da rutina com p-metoxicinamato de octila e benzofenona-3: avaliação in vitro da eficácia fotoprotetora por espectrofotometria de refletância]. Lat Am J Pharm. 2008;27(1): 23–7. PortugueseVelasco M.V., Sarruf F.D., Salgado-Santos I.M., Haroutiounian-Filho C.A., Kaneko T.M., Baby A.R. Broad spectrum bioactive sunscreens // Int. J. Pharm. – 2008. – Vol. 363, No. 1–2. – P. 50–57. DOI: 10.1016/j.ijpharm.2008.06.031Velasco MV, Sarruf FD, Salgado-Santos IM, Haroutiounian-Filho CA, Kaneko TM, Baby AR. Broad spectrum bioactive sunscreens. Int J Pharm. 2008 Nov 3;363(1–2):50–7. DOI: 10.1016/j.ijpharm.2008.06.031Netto MPharm G., Jose J. Development, characterization, and evaluation of sunscreen cream containing solid lipid nanoparticles of silymarin // J. Cosmet. Dermatol. – 2018. – Vol. 17, No. 6. – P. 1073-1083. DOI: 10.1111/jocd.12470Netto MPharm G, Jose J. Development, characterization, and evaluation of sunscreen cream containing solid lipid nanoparticles of silymarin. J Cosmet Dermatol. 2018 Dec;17(6):1073-1083. DOI: 10.1111/jocd.12470Shanuja S.K., Iswarya S., Sridevi J., Gnanamani A. Exploring the UVB-protective efficacy of melanin precursor extracted from marine imperfect fungus: Featuring characterization and application studies under in vitro conditions // Int. Microbiol. – 2018. – Vol. 21, No. 1–2. – P. 59–71. DOI: 10.1007/s10123-018-0005-2Shanuja SK, Iswarya S, Sridevi J, Gnanamani A. Exploring the UVB-protective efficacy of melanin precursor extracted from marine imperfect fungus: Featuring characterization and application studies under in vitro conditions. Int Microbiol. 2018 Jun;21(1-2):59–71. DOI: 10.1007/s10123-018-0005-2Cefali L.C. Franco J.G., Nicolini G.F., Ataide J.A., Mazzola P.G. In vitro antioxidant activity and solar protection factor of blackberry and raspberry extracts in topical formulation // J. Cosmet. Dermatol. – 2019. – Vol. 18, No. 2. – P. 539–544. DOI: 10.1111/jocd.12842Cefali LC, Franco JG, Nicolini GF, Ataide JA, Mazzola P.G. In vitro antioxidant activity and solar protection factor of blackberry and raspberry extracts in topical formulation. J Cosmet Dermatol. 2019;18(2):539-44. DOI: 10.1111/jocd.12842Young A.R., Narbutt J., Harrison G.I., Lawrence K.P., Bell M., O’Connor C., Olsen P., Grys K., Baczynska K.A., Rogowski-Tylman M., Wulf H.C., Lesiak A., Philipsen P.A. Optimal sunscreen use, during a sun holiday with a very high ultraviolet index, allows vitamin D synthesis without sunburn // Br. J. Dermatol. – 2019. – Vol. 181, No. 5. – P. 1052–1062. DOI: 10.1111/bjd.17888Young AR, Narbutt J, Harrison GI, Lawrence KP, Bell M, O’Connor C, Olsen P, Grys K, Baczynska KA, Rogowski-Tylman M, Wulf HC, Lesiak A, Philipsen PA. Optimal sunscreen use, during a sun holiday with a very high ultraviolet index, allows vitamin D synthesis without sunburn. Br J Dermatol. 2019 Nov;181(5):1052–62. DOI: 10.1111/bjd.17888Li S.X., Li M.F., Bian J., Wu X.F., Peng F., Ma M.G. Preparation of organic acid lignin submicrometer particle as a natural broad-spectrum photo-protection agent // Int. J. Biologic. Macromolecul. – 2019. – Vol. 132. – P. 836–843. DOI: 10.1016/j.ijbiomac.2019.03.177Li SX, Li MF, Bian J, Wu XF, Peng F, Ma MG. Preparation of organic acid lignin submicrometer particle as a natural broad-spectrum photo-protection agent. Int J Biologic Macromolecul. 2019;132:836–43. DOI: 10.1016/j.ijbiomac.2019.03.177Cefali L.C., Ataide J.A., Fernandes A.R., Sousa I.M.O., Gonçalves F.C.D.S., Eberlin S., Dávila J.L., Jozala A.F., Chaud M.V., Sanchez-Lopez E., Marto J., d’Ávila M.A., Ribeiro H.M., Foglio M.A., Souto E.B., Mazzola P.G. Flavonoid-Enriched Plant-Extract-Loaded Emulsion: A Novel Phytocosmetic Sunscreen Formulation with Antioxidant Properties // Antioxidants (Basel). – 2019. – Vol. 8, No. 10. – Art. No. 443. DOI: 10.3390/antiox8100443Cefali LC, Ataide JA, Fernandes AR, Sousa IMO, Gonçalves FCDS, Eberlin S, Dávila JL, Jozala AF, Chaud MV, Sanchez-Lopez E, Marto J, d’Ávila MA, Ribeiro HM, Foglio MA, Souto EB, Mazzola PG. Flavonoid-Enriched Plant-Extract-Loaded Emulsion: A Novel Phytocosmetic Sunscreen Formulation with Antioxidant Properties. Antioxidants (Basel). 2019 Oct 1;8(10):443. DOI: 10.3390/antiox8100443Cho Y.H., Bahuguna A., Kim H.H., Kim D.I., Kim H.J., Yu J.M., Jung H.G., Jang J.Y., Kwak J.H., Park G.H., Kwon O.J., Cho Y.J., An J.Y., Jo C., Kang S.C., An B.J. Potential effect of compounds isolated from Coffea arabica against UV-B induced skin damage by protecting fibroblast cells // J. Photochem. Photobiol. B. – 2017. – Vol. 174. – P. 323–332. DOI: 10.1016/j.jphotobiol.2017.08.015Cho YH, Bahuguna A, Kim HH, Kim DI, Kim HJ, Yu JM, Jung HG, Jang JY, Kwak JH, Park GH, Kwon OJ, Cho YJ, An JY, Jo C, Kang SC, An BJ. Potential effect of compounds isolated from Coffea arabica against UV-B induced skin damage by protecting fibroblast cells. J Photochem Photobiol B. 2017 Sep;174:323–32. DOI: 10.1016/j.jphotobiol.2017.08.015Musazzi U.M., Franzè S., Minghetti P., Casiraghi A. Emulsion versus nanoemulsion: how much is the formulative shift critical for a cosmetic product? // Drug Deliv. Transl. Res. – 2018. – Vol. 8, No. 2. – P. 414–421. DOI: 10.1007/s13346-017-0390-7Musazzi UM, Franzè S, Minghetti P, Casiraghi A. Emulsion versus nanoemulsion: how much is the formulative shift critical for a cosmetic product? Drug Deliv Transl Res. 2018 Apr;8(2):414–21. DOI: 10.1007/s13346-017-0390-7

The authors declare that there are no conflicts of interest present.