pmedpharmФармация и фармакологияPharmacy & Pharmacology2307-92662413-2241Pyatigorsk Medical and Pharmaceutical Institute - branch of Volgograd State Medical Univer10.19163/2307-9266-2022-10-5-404-415pmedpharm-1191Research ArticleОБЗОРЫ, ЛЕКЦИИREVIEWS, LECTURESМОЛЕКУЛЯРНЫЕ МЕХАНИЗМЫ, ОПРЕДЕЛЯЮЩИЕ ПРИМЕНЕНИЕ КОМБИНАЦИИ ГЛИЦИНА И ЦИНКА В КОРРЕКЦИИ ОСНОВНЫХ ПРОЯВЛЕНИЙ СТРЕССА И ТРЕВОГИMOLECULAR MECHANISMS DEFINING APPLICATION OF GLYCINE AND ZINC COMBINATIONIN CORRECTION OF STRESS AND ANXIETY MAIN MANIFESTATIONShttps://orcid.org/0000-0002-1042-4275ШишковаВ. Н.ShishkovaV. N.

доктор медицинских наук, ведущий научный сотрудник, руководитель отдела профилактики когнитивных и психоэмоциональных нарушений ФГБУ «Национальный медицинский исследовательский центр терапии и профилактической медицины» Минздрава России; доцент кафедры терапии и профилактической медицины ФГБОУ ВО МГМСУ имени А.И. Евдокимова Минздрава России

101990, Россия, г. Москва, Петроверигский пер., д. 10, стр. 3; 

127437, Россия, г. Москва, ул. Делегатская, д. 20, стр. 1

Doctor of Sciences (Medicine), Leading Researcher, Head of the Department for the Prevention of Cognitive and Psychoemotional Disorders, National Medical Research Center for Therapy and Preventive Medicine; Associate Professor of the Department of Therapy and Preventive Medicine, Evdokimov Moscow State Medical and Dental University

Bld. 1, 20, Delegatskaya St., Moscow, Russia, 127473

Bld. 3, 10, Petroverigsky Ln., Moscow, Russia, 101000 

veronika-1306@mail.ruhttps://orcid.org/0000-0001-9020-7686НарциссовЯ. Р.NartsissovY. R.

кандидат физико-математических наук, доцент по специальности «Биофизика», заведующий сектором математического моделирования и статистической обработки результатов НИИ цитохимии и молекулярной фармакологии; руководитель группы биомедицинских исследований, BiDiPharma GmbH, Германия

115404, Россия, г. Москва, ул. 6-я Радиальная, д. 24, стр. 14; 

22962, Германия, Зик, Бюльтбек, 5

Candidate of Sciences (Physics and Mathematics), Associate Professor in Biophysics, Head of the Department of Mathematical Modeling and Statistical Processing of Results, Institute of Cytochemistry and Molecular Pharmacology; Head of Biomedical Research Group, BiDiPharma GmbH, Germany

Bldg 14, 24, 6th Radial'naya St., Moscow, Russia, 115404;

5, Bültbek, Siek, Germany, 22962

yarosl@biotic.dol.ruhttps://orcid.org/0000-0002-4741-2331ТитоваВ. Ю.TitovaV. Y.

младший научный сотрудник сектора математического моделирования и статистической обработки результатов НИИ цитохимии и молекулярной фармакологии

115404, Россия, г. Москва, ул. 6-я Радиальная, д. 24, стр. 14

Junior Researcher, Department of Mathematical Modeling and Statistical Processing of Results, Institute of Cytochemistry and Molecular Pharmacology

Bldg 14, 24, 6th Radial'naya St., Moscow, Russia, 115404

victorinchik@gmail.comhttps://orcid.org/0000-0003-1796-3017ШешеговаЕ. В.SheshegovaE. V.

кандидат фармацевтических наук, заведующая сектором экспериментальной фармакологии НИИ цитохимии и молекулярной фармакологии

115404, Россия, г. Москва, ул. 6-я Радиальная, д. 24, стр. 14

Candidate of Sciences (Pharmacy), Head of the Department of Experimental Pharmacology, Institute of Cytochemistry and Molecular Pharmacology

Bldg 14, 24, 6th Radial'naya St., Moscow, Russia, 115404

elshesh@yandex.ruФедеральное государственное бюджетное учреждение «Национальный медицинский исследовательский центр терапии и профилактической медицины» Министерства здравоохранения Российской Федерации; Федеральное государственное бюджетное образовательное учреждение высшего образования «Московский государственный медико-стоматологический университет имени А.И. Евдокимова» Министерства здравоохранения Российской ФедерацииРоссияNational Medical Research Center for Therapy and Preventive Medicine; Evdokimov Moscow State Medical and Dental UniversityRussian FederationНаучно-исследовательский институт цитохимии и молекулярной фармакологии; Группа биомедицинских исследований (BiDiPharma GmbH)ГерманияInstitute of Cytochemistry and Molecular Pharmacology; Biomedical Research Group, BiDiPharma GmbHGermanyНаучно-исследовательский институт цитохимии и молекулярной фармакологииРоссияInstitute of Cytochemistry and Molecular PharmacologyRussian Federation202211122022105404415Copyright © Шишкова В.Н., Нарциссов Я.Р., Титова В.Ю., Шешегова Е.В., 20222022Шишкова В.Н., Нарциссов Я.Р., Титова В.Ю., Шешегова Е.В.Shishkova V.N., Nartsissov Y.R., Titova V.Y., Sheshegova E.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pharmpharm.ru/jour/article/view/1191Цель

Цель. Работа посвящена системному анализу молекулярных механизмов, определяющих возможность комбинированного использования аминокислоты глицин и соединений цинка для лечения пациентов с проявлениями стресса и тревоги.

Материалы и методы

Материалы и методы. В качестве инструментов проведения исследования использовались информационно-поисковые (Scopus, PubMed) и библиотечные (eLibrary) базы данных. В ряде случаев для семантического поиска использовалось приложение ResearchGate. В работе осуществлялся анализ и обобщение научной литературы по теме исследования, охватывающей период с 2000 по настоящее время.

Результаты

Результаты. Показано, что аминокислота глицин, наравне с гамма-аминомасляной кислотой (ГАМК) является ключевым нейромедиатором, регулирующим процессы физиологического торможения в центральной нервной системы (ЦНС) путем увеличения трансмембранной проводимости в специфических гетеропентамерных лигандзависимых хлорных каналах. Введение ионов цинка способно потенцировать открытие данных рецепторов путем увеличения их сродства к глицину, в результате чего происходит усиление процессов торможения в нейронах ЦНС. Восполнение сочетанного дефицита глицина и цинка является важным элементом коррекции постстрессорной дисфункции ЦНС. Сбалансированное потребление цинка и глицина имеет важное значение для большинства людей, ежедневно испытывающих последствия многочисленных стрессов и находящихся в тревожном состоянии. Особенно полезна данная комбинация для лиц, испытывающих состояние хронического психоэмоционального напряжения и дезадаптации, в том числе имеющих сложности с засыпанием. 

Заключение

Заключение. Сбалансированное поддержание концентрации цинка и глицина в организме здорового человека приводит к развитию стойкого противотревожного эффекта, который сопровождается нормализацией ритма сон-бодрствование, что дает возможность полноценного отдыха без потерь работоспособности после пробуждения.

The aim of the work was to carry out a systematic analysis of the molecular mechanisms that determine the possibility of a combined use of amino acid glycine and zinc compounds for the treatment of patients with manifestations of stress and anxiety.

Materials and methods

Materials and methods. Information retrieval (Scopus, PubMed) and library (eLibrary) databases were used as research tools. In some cases, the ResearchGate application was applied for a semantic search. The analysis and generalization of references was carried out on the research topic, covering the period from 2000 to the present time.

Results

Results. It has been shown that amino acid glycine, along with gamma-aminobutyric acid (GABA), is a key neurotransmitter that regulates physiological inhibition processes in the central nervous system (CNS) by increasing transmembrane conductance in specific pentameric ligand-gated ion channels. The introduction of zinc ions can potentiate the opening of these receptors by increasing their affinity for glycine, resulting in an inhibitory processes increase in CNS neurons. The replenishment of the glycine and zinc combined deficiency is an important element in the correction of a post-stress dysfunction of the central nervous system. A balanced intake of zinc and glycine is essential for most people who experience daily effects of multiple stresses and anxiety. This combination is especially useful for the people experiencing a state of chronic psycho-emotional stress and maladaptation, including those who have a difficulty in falling asleep.

Conclusion

Conclusion. A balanced maintenance of the zinc and glycine concentration in the body of a healthy person leads to the development of a stable anti-anxiety effect, which is accompanied by the normalization of the sleep-wake rhythm, which makes it possible to have a good rest without any loss of working efficiency after waking up.

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The authors declare that there are no conflicts of interest present.