pmedpharmФармация и фармакологияPharmacy & Pharmacology2307-92662413-2241Pyatigorsk Medical and Pharmaceutical Institute - branch of Volgograd State Medical Univer10.19163/2307-9266-2022-10-6-500-514pmedpharm-1216Research ArticleОБЗОРЫ, ЛЕКЦИИREVIEWS, LECTURESМОЛЕКУЛЯРНЫЕ МЕХАНИЗМЫ, ЛЕЖАЩИЕ В ОСНОВЕ ТЕРАПЕВТИЧЕСКОГО ДЕЙСТВИЯ ВИТАМИНА В6MOLECULAR MECHANISMS UNDERLYING THERAPEUTIC ACTION OF VITAMIN B6https://orcid.org/0000-0001-6623-6938ЗагубнаяО. А.ZagubnayaO. A.

младший научный сотрудник сектора математического моделирования и статистической обработки результатов НИИ цитохимии и молекулярной фармакологии, Москва, Россия; научный сотрудник, группы биомедицинских исследований, BiDiPharma GmbH, Германия.

115404, Россия, г. Москва, ул. 6-я Радиальная, д. 24, стр. 14

22962, Германия, Зик, Бюльтбек, 5

Junior Researcher, Department of Mathematical Modeling and Statistical Processing of Results, Institute of Cytochemistry and Molecular Pharmacology, Moscow, Russia; Research Fellow, Biomedical Research Group, BiDiPharma GmbH, Germany

Bldg 14, 24, 6th Radialnaya St., Moscow, Russia, 115404

5, Bültbek, Siek, Germany, 22962

oz_brg@icmph.orghttps://orcid.org/0000-0001-9020-7686НарциссовЯ. Р.NartsissovY. R.

кандидат физико-математических наук, доцент по специальности «Биофизика», заведующий сектором математического моделирования и статистической обработки результатов НИИ цитохимии и молекулярной фармакологии, Москва, Россия; руководитель группы биомедицинских исследований, BiDiPharma GmbH, Германия

115404, Россия, г. Москва, ул. 6-я Радиальная, д. 24, стр. 14

E-mail: yn_brg@icmph.org

Candidate of Sciences (Physics and Mathematics), Associate Professor in Biophysics, Head of the Sector of Mathematical Modeling and Statistical Processing of Results, Institute of Cytochemistry and Molecular Pharmacology, Moscow, Russia; Head of Biomedical Research Group, BiDiPharma GmbH, Germany

Bldg 14, 24, 6th Radialnaya St., Moscow, Russia, 115404

5, Bültbek, Siek, Germany, 22962

 

yn_brg@icmph.orgНаучно-исследовательский институт цитохимии и молекулярной фармакологии; Группа биомедицинских исследований (BiDiPharma GmbH)ГерманияInstitute of Cytochemistry and Molecular Pharmacology; Biomedical Research Group, BiDiPharma GmbHGermany202212022023106500514Copyright © Загубная О.А., Нарциссов Я.Р., 20232023Загубная О.А., Нарциссов Я.Р.Zagubnaya O.A., Nartsissov Y.R.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pharmpharm.ru/jour/article/view/1216Цель

Цель. Анализ молекулярных механизмов, определяющих возможность использования витамина B6 в клинической практике для коррекции различных патологических состояний.

Материалы и методы

Материалы и методы. В качестве инструментов проведения исследования использовались информационно-поисковые (Scopus, PubMed) и библиотечные (eLibrary) базы данных. В ряде случаев для семантического поиска использовалось приложение ResearchGate. В работе осуществлялся анализ и обобщение научной литературы по теме исследования, охватывающей период с 1989 по настоящее время.

Результаты

Результаты. Показано, что все химические формы витамина В6 способны проникать через мембраны большинства клеток путем свободной диффузии, при этом внутри формируют фосфорилированные формы. Пиридоксальфосфат является биологически важным метаболитом, непосредственно участвующим в качестве кофактора во множестве внутриклеточных реакций. Потребности в данном кофакторе зависят от возраста, пола и состояния пациента. Особую роль в потреблении витамина В6 играет беременность и период лактации. В большинстве случаев сбалансированное питание позволяет обеспечить приемлемый уровень данного витамина. В то же время его дефицит приводит к развитию целого ряда патологических состояний, включающих нейродегенеративные заболевания, воспаление и диабет. Также возможны негативные проявления со стороны центральной нервной системы при избыточном потреблении В6.

Заключение

Заключение. Восполнение уровня витамина В6 при его выявленном дефиците является необходимым условием успешной терапии заболеваний центральной нервной системы, диабета и коррекции иммунного статуса пациентов. При этом необходимо соблюдать сбалансированный прием данного кофактора во избежание негативных эффектов на метаболизм при его переизбытке.

The aim of the study was to analyze the molecular mechanisms that determine the possibility of using vitamin B6 in clinical practice for the correction of various pathological conditions.

Materials and methods

Materials and methods. Information retrieval (Scopus, PubMed) and library (eLibrary) databases were used as research tools. In some cases, the ResearchGate application was used for a semantic search. The analysis and generalization of the scientific literature on the topic of research, covering the period from 1989 to the present, has been carried out in the work.

Results

Results. It has been shown that all chemical forms of vitamin B6 are able to penetrate the membranes of most cells by free diffusion, while forming phosphorylated forms inside. Pyridoxal phosphate is a biologically important metabolite that is directly involved as a cofactor in a variety of intracellular reactions. Requirements for this cofactor depend on the age, sex and condition of the patient. Pregnancy and lactation play a special role in the consumption of vitamin B6. In most cases, a balanced diet will provide an acceptable level of this vitamin. At the same time, its deficiency leads to the development of a number of pathological conditions, including neurodegenerative diseases, inflammations and diabetes. Negative manifestations from the central nervous system are also possible with an excessive consumption of B6.

Conclusion

Conclusion. Replenishment of the vitamin B6 level in case of its identified deficiency is a necessary condition for the successful treatment of the central nervous system diseases, diabetes and correction of patients’ immune status. At the same time, it is necessary to observe a balanced intake of this cofactor in order to avoid negative effects on metabolism in case of its excess.

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The authors declare that there are no conflicts of interest present.