pmedpharmФармация и фармакологияPharmacy & Pharmacology2307-92662413-2241Pyatigorsk Medical and Pharmaceutical Institute - branch of Volgograd State Medical Univer10.19163/2307-9266-2023-11-1-4-18pmedpharm-1256Research ArticleОБЗОРЫ, ЛЕКЦИИREVIEWS, LECTURESПодходы к изучению каппа-опиоидных лигандов на моделях нейровоспаленияModels of neuroinflammation for the assessment of kappa-opioid receptor ligandshttps://orcid.org/0000-0002-0079-853XКалитинК. Ю.KalitinK. Yu.

кандидат медицинских наук, доцент, доцент кафедры фармакологии и биоинформатики ФГБОУ ВО ВолгГМУ Минздрава России; научный сотрудник лаборатории экспериментальной фармакологии ГБУ ВМНЦ

400131, Россия, г. Волгоград, пл. Павших Борцов, д. 1

кандидат медицинских наук, доцент; доцент кафедры фармакологии и биоинформатики Волгоградского государственного медицинского университета; научный сотрудник лаборатории экспериментальной фармакологии Волгоградского медицинского исследовательского центра

400131, г. Волгоград, пл. Павших Борцов, 1

kkonst8@ya.ruhttps://orcid.org/0000-0002-7185-4826СпасовА. А.SpasovA. A.

доктор медицинских наук, профессор, академик РАН; заведующий кафедрой фармакологии и биоинформатики ФГБОУ ВО ВолгГМУ Минздрава России; заведующий лабораторией экспериментальной фармакологии ГБУ ВМНЦ

400131, Россия, г. Волгоград, пл. Павших Борцов, д. 1

доктор медицинских наук, профессор, академик РАН; заведующий кафедрой фармакологии и биоинформатики Волгоградского государственного медицинского университета; Заведующая лабораторией экспериментальной фармакологии Волгоградского медицинского исследовательского центра

400131, г. Волгоград, пл. Павших Борцов, 1

aaspasov@volgmed.ruhttps://orcid.org/0000-0002-0429-905XМухаО. Ю.MukhaO. Yu.

студент ФГБОУ ВО ВолгГМУ Минздрава России

400131, Россия, г. Волгоград, пл. Павших Борцов, д. 1

аспирант Волгоградского государственного медицинского университета

400131, г. Волгоград, пл. Павших Борцов, 1

olay.myha14@gmail.com1. Федеральное государственное бюджетное образовательное учреждение высшего образования «Волгоградский государственный медицинский университет» Министерства здравоохранения Российской Федерации 2. Государственное бюджетное учреждение «Волгоградский медицинский научный центр»Россия1. Volgograd State Medical University 2. Volgograd Medical Research CenterRussian Federation1. Федеральное государственное бюджетное образовательное учреждение высшего образования «Волгоградский государственный медицинский университет» Министерства здравоохранения Российской ФедерацииРоссияVolgograd State Medical UniversityRussian Federation202328042023111418Copyright © Калитин К.Ю., Спасов А.А., Муха О.Ю., 20232023Калитин К.Ю., Спасов А.А., Муха О.Ю.Kalitin K.Y., Spasov A.A., Mukha O.Y.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pharmpharm.ru/jour/article/view/1256

Разработка новых препаратов для коррекции нейровоспаления вызывает повышенный интерес, поскольку открывает возможности лечения широкого ряда заболеваний, включая болезнь Альцгеймера, болезнь Паркинсона, эпилепсию, шизофрению, депрессию и др. Каппа-опиоидные агонисты представляют собой перспективный класс соединений, обладающих высоким потенциалом применения при патологических состояниях, сопровождающихся развитием нейровоспаления.

Цель

Цель. Резюмировать информацию о текущих стратегиях, используемых для оценки нейротропных противовоспалительных эффектов каппа-опиоидных лигандов у лабораторных животных с индуцированным нейровоспалением.

Материалы и методы

Материалы и методы. В качестве средств поиска использовались поисковые системы и базы данных Google Scholar, PubMed, ScienceDirect, Scopus, e-Library. Поиск проводился по следующим ключевым словам и словосочетаниям: kappa opioids + neuroinflammation; kappa opioid receptors + neuroinflammation; neuroinflammation models; neuroinflammation models in rat; neuroinflammation models in mice, а также по их русскоязычным аналогам. Были найдены 148 релевантных статей, из которых 122 были включены в настоящий обзор.

Результаты

Результаты. В настоящем обзоре были рассмотрены различные экспериментальные модели нейровоспаления, индуцированного химическими агентами и бактериальным эндотоксином, а также травматические и генетические модели на мышах и крысах. Кроме того, были критически оценены сильные стороны и ограничения каждой модели для определения наиболее подходящей стратегии исследования взаимосвязей между нейровоспалением и сигнальными путями каппа-опиоидной рецепторной системы.

Заключение

Заключение. Рассмотрены особенности нейротропной противовоспалительной активности каппа-опиоидных лигандов. В обзоре обсуждаются как экспериментальные модели, в которых изучались эффекты агонистов каппа-опиоидных рецепторов, так и модели, в которых противовоспалительные свойства агонистов каппа-опиоидов еще не изучены.

The development of new drugs to combat neuroinflammation is highly relevant as it opens up possibilities for the treatment of a wide range of diseases, including Alzheimer’s disease, Parkinson’s disease, epilepsy, schizophrenia, depression, and others. Kappa-opioid agonists represent a promising class of compounds with а high potential to be used in the treatment of neurological conditions accompanied by neuroinflammation.

The aim of the study was to provide a summary of the current strategies employed to evaluate the neurotropic anti-inflammatory effects of kappa-opioid ligands in laboratory animals with induced neuroinflammation.

Materials and methods

Materials and methods. The databases, such as Google Scholar, PubMed, ScienceDirect, Scopus, e-Library were used as search tools. The search comprised the following keywords and phrases in Russian and English: kappa opioids + neuroinflammation; kappa opioid receptors + neuroinflammation; neuroinflammation models; neuroinflammation models in rats, neuroinflammation models in mice. 148 relevant articles were found, 122 were included in this review.

Results

Results. Various experimental models of neuroinflammation, including chemically-induced and bacterial endotoxin-induced neuroinflammation, as well as traumatic and genetic models in mice and rats were evaluated. In addition, the strengths and limitations of each model were critically assessed to identify the most appropriate and reliable approach for investigating the relationship between neuroinflammation and signaling pathways associated with kappa-opioid receptors.

Conclusion

Conclusion. The neurotropic anti-inflammatory activity of kappa-opioid ligands have been comprehensively described. The review discusses both experimental models where the effects of kappa-opioid agonists have been investigated, as well as the models where the anti-inflammatory properties of kappa-opioid agonists have not been studied yet.

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The authors declare that there are no conflicts of interest present.