pmedpharmФармация и фармакологияPharmacy & Pharmacology2307-92662413-2241Pyatigorsk Medical and Pharmaceutical Institute - branch of Volgograd State Medical Univer10.19163/2307-9266-2025-13-1-4-19pmedpharm-1675Research ArticleОБЗОРЫREVIEWМозговой нейротрофический фактор как мишень для поиска препаратов, проявляющих антиаддиктивные эффектыBrain-derived neurotrophic factor as a target for the search of anti-addiction drugshttps://orcid.org/0009-0002-2686-4803ХалимановМ. С.KhalimanovM. S.

студент Института фармации им. А.П. Нелюбина, ФГАОУ ВО «Первый МГМУ имени И.М. Сеченова» Минздрава России (Сеченовский Университет). 

119991, Россия, г. Москва, ул. Трубецкая, д. 8, стр. 2.

student of A.P. Nelyubin Institute of Pharmacy of Sechenov First Moscow State Medical University (Sechenov University).

2, Trubetskaya Str., Bldg 8, Moscow, Russia, 119991.

misha-khalimanov@mail.ruhttps://orcid.org/0000-0002-4290-4396ГригоревскихЕ. М.GrigorevskikhE. M.

старший преподаватель кафедры фармакологии Института фармации им. А.П. Нелюбина, ФГАОУ ВО «Первый МГМУ имени И.М. Сеченова» Минздрава России (Сеченовский Университет). 

119991, Россия, г. Москва, ул. Трубецкая, д. 8, стр. 2.

Senior Lecturer of the Department of Pharmacology, A.P. Nelyubin Institute of Pharmacy of Sechenov First Moscow State Medical University (Sechenov University). 

2, Trubetskaya Str., Bldg 8, Moscow, Russia, 119991.

grigorevskikh_e_m@staff.sechenov.ruhttps://orcid.org/0000-0002-4792-7132ЗавадичК. А.ZavadichK. A.

кандидат медицинских наук, доцент кафедры фармакологии Института фармации им. А.П. Нелюбина, ФГАОУ ВО «Первый МГМУ имени И.М. Сеченова» Минздрава России (Сеченовский Университет). 

119991, Россия, г. Москва, ул. Трубецкая, д. 8, стр. 2.

Candidate of Sciences (Medicine), Associate Professor of the Department of Pharmacology, A.P. Nelyubin Institute of Pharmacy of Sechenov First Moscow State Medical University (Sechenov University). 

2, Trubetskaya Str., Bldg 8, Moscow, Russia, 119991.

kzavadich@mail.ruhttps://orcid.org/0009-0001-8420-6852СологовС. И.SologovS. I.

студент Института клинической медицины им. Н.В. Склифосовского, ФГАОУ ВО «Первый МГМУ имени И.М. Сеченова» Минздрава России (Сеченовский Университет). 

119991, Россия, г. Москва, ул. Трубецкая, д. 8, стр. 2.

student of Sklifosovsky Institute of Clinical Medicine of Sechenov First Moscow State Medical University (Sechenov University). 

2, Trubetskaya Str., Bldg 8, Moscow, Russia, 119991.

Sergey.sologov@yandex.ruhttps://orcid.org/0000-0003-3330-0459ТращенковаД. А.TraschenkovaD. A.

ассистент кафедры фармакологии Института Фармации им. А.П. Нелюбина, ФГАОУ ВО «Первый МГМУ имени И.М. Сеченова» Минздрава России (Сеченовский Университет).

119991, Россия, г. Москва, ул. Трубецкая, д. 8, стр. 2.

Assistant of the Department of Pharmacology, A.P. Nelyubin Institute of Pharmacy of Sechenov First Moscow State Medical University (Sechenov University).

2, Trubetskaya Str., Bldg 8, Moscow, Russia, 119991.

trashchenkova_d_a@staff.sechenov.ruhttps://orcid.org/0000-0003-3757-8757ТатжиковаК. А.TatzhikovaK. A.

кандидат медицинских наук, доцент кафедры фармакологии Института фармации им. А.П. Нелюбина, ФГАОУ ВО «Первый МГМУ имени И.М. Сеченова» Минздрава России (Сеченовский Университет). 

119991, Россия, г. Москва, ул. Трубецкая, д. 8, стр. 2.

Candidate of Sciences (Medicine), Associate Professor of the Department of Pharmacology, A.P. Nelyubin Institute of Pharmacy of Sechenov First Moscow State Medical University (Sechenov University). 

2, Trubetskaya Str., Bldg 8, Moscow, Russia, 119991.

tatzhikova_k_a@staff.sechenov.ruhttps://orcid.org/0000-0001-7001-1918ПоликарповЕ. В.PolikarpovE. V.

ассистент кафедры фармакологии Института фармации им. А.П. Нелюбина, ФГАОУ ВО «Первый МГМУ им. И.М. Сеченова» Минздрава России (Сеченовский университет). 

119991, Россия, г. Москва, ул. Трубецкая, д. 8, стр. 2.

Assistant of the Department of Pharmacology, A.P. Nelyubin Institute of Pharmacy of Sechenov First Moscow State Medical University (Sechenov University). 

2, Trubetskaya Str., Bldg 8, Moscow, Russia, 119991.

polikarpov_e_v@staff.sechenov.ruhttps://orcid.org/0000-0002-8526-7147СологоваС. С.SologovaS. S.

кандидат биологических наук, доц., зав. учебной частью кафедры фармакологии Института фармации им. А.П. Нелюбина, ФГАОУ ВО «Первый МГМУ имени И.М. Сеченова» Минздрава России (Сеченовский Университет).

119991, Россия, г. Москва, ул. Трубецкая, д. 8, стр. 2.

Candidate of Sciences (Biology), Associate Professor, Head of the educational part of the Department of Pharmacology, A.P. Nelyubin Institute of Pharmacy of Sechenov First Moscow State Medical University (Sechenov University).

2, Trubetskaya Str., Bldg 8, Moscow, Russia, 119991.

sologova_s_s@staff.sechenov.ruhttps://orcid.org/0000-0003-1878-4467КудлайД. А.KudlayD. A.

доктор медицинских наук, профессор кафедры фармакологии Института фармации им. А.П. Нелюбина, ФГАОУ ВО «Первый МГМУ имени И.М. Сеченова» Минздрава России (Сеченовский Университет); член-корреспондент РАН. 

119991, Россия, г. Москва, ул. Трубецкая, д. 8, стр. 2.

Doctor of Sciences (Medicine), Professor of the Department of Pharmacology, A.P. Nelyubin Institute of Pharmacy of Sechenov First Moscow State Medical University (Sechenov University); Corresponding Member of the Russian Academy of Sciences. 

2, Trubetskaya Str., Bldg 8, Moscow, Russia, 119991.

kudlay_d_a@staff.sechenov.ruhttps://orcid.org/0000-0002-2615-7167СмолярчукЕ. А.SmolyarchukE. A.

кандидат медицинских наук, доцент кафедры фармакологии Института фармации им. А.П. Нелюбина, ФГАОУ ВО «Первый МГМУ имени И.М. Сеченова» Минздрава России (Сеченовский Университет).

119991, Россия, г. Москва, ул. Трубецкая, д. 8, стр. 2.

Candidate of Sciences (Medicine), Associate Professor of the Department of Pharmacology, A.P. Nelyubin Bauman Institute of Pharmacy of Sechenov First Moscow State Medical University (Sechenov University).

2, Trubetskaya Str., Bldg 8, Moscow, Russia, 119991.

smolyarchuk_e_a@staff.sechenov.ruФедеральное государственное автономное образовательное учреждение высшего образования «Первый Московский государственный медицинский университет имени И.М. Сеченова» (Сеченовский Университет)РоссияSechenov First Moscow State Medical University (Sechenov University)Russian Federation202511072025131419Copyright © Халиманов М.С., Григоревских Е.М., Завадич К.А., Сологов С.И., Тращенкова Д.А., Татжикова К.А., Поликарпов Е.В., Сологова С.С., Кудлай Д.А., Смолярчук Е.А., 20252025Халиманов М.С., Григоревских Е.М., Завадич К.А., Сологов С.И., Тращенкова Д.А., Татжикова К.А., Поликарпов Е.В., Сологова С.С., Кудлай Д.А., Смолярчук Е.А.Khalimanov M.S., Grigorevskikh E.M., Zavadich K.A., Sologov S.I., Traschenkova D.A., Tatzhikova K.A., Polikarpov E.V., Sologova S.S., Kudlay D.A., Smolyarchuk E.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pharmpharm.ru/jour/article/view/1675

В данной статье рассматриваются вопросы влияния мозгового нейротрофического фактора (BDNF) на развитие алкоголизма. Рассматриваются возможные пути использования этой молекулы или родственных с ней соединений (миметиков) в качестве мишеней для антиаддиктивного действия.

Цель

Цель. Провести анализ литературных источников с целью выявления потенциальных возможностей применения сигнальных путей BDNF в сфере разработки новых лекарственных препаратов.

Материалы и методы

Материалы и методы. Для поиска информационных материалов использовали реферативные базы данных: PubMed, EMBASE, ResearchGate, elibrary.ru. Ключевые запросы для поиска включали в себя следующие слова и словосочетания: «BDNF», «BDNF TrkB», «BDNF LNGFR», «терапия алкоголизма», «антиаддиктивные препараты», «сигнальные пути», «алкоголизм», «этанол», «отравление». Глубина поиска — 40 лет (1985–2025 гг.). Общее число источников, которые вошли в обзор — 116.

Результаты

Результаты. В данном исследовании проведён анализ молекулярных механизмов действия BDNF, включая его биосинтез, структурные формы (BDNF и про-BDNF), а также функции и особенности рецепторов TrkB и LNGFR. Эти рецепторы играют ключевую роль в регуляции нейрональной пластичности, выживаемости нейронов и апоптотических процессов. Выполненный обзор научной литературы позволил установить, что по состоянию на 2025 год идентифицировано не менее 9 химических соединений с потенциальной антиаддиктивной активностью, которые воздействуют на рецепторы и сигнальные каскады, связанные с BDNF. На основании полученных данных сформулирована гипотеза о перспективах использования BDNF и его сигнальных путей в качестве потенциальных мишеней для разработки новых фармакологических агентов, направленных на лечение алкогольной зависимости. Установленные факты могут существенно расширить терапевтические возможности в борьбе с алкоголизмом и ассоциированными нейротоксическими состояниями.

Заключение

Заключение. Было проанализировано и выявлено, что на 2025 год существует не менее 9 веществ с потенциальной антиаддиктивной активностью, связанной с миметическим действием на рецепторы и сигнальные пути молекулы BDNF.

The relationship between the influence of the brain-derived neurotrophic factor (BDNF) on the development of alcoholism and possible ways of using this molecule or related compounds (mimetics) as targets of anti-addictive action are discusses in the article.

The aim of the work was to carry out a literature review to identify potential applications of the BDNF signaling pathways to assess the feasibility of developing new drugs.

Materials and Methods

Materials and Methods. The following abstract databases were used to search for the information materials: PubMed, EMBASE, ResearchGate, elibrary.ru. The key queries for the search included the following ones: ‘BDNF’, “BDNF TrkB”, “BDNF LNGFR”, “alcoholism therapy”, “anti-addiction drugs”, “signaling pathways”, “alcoholism”, “ethanol”, “poisoning”. The depth of the search was 40 years (1985–2025). The total number of the sources included in the review is 116.

Results

Results. This study analyzed the molecular mechanisms of the action of BDNF, including its biosynthesis, structural forms (BDNF and pro-BDNF), and functions and features of TrkB and LNGFR receptors. These receptors play a key role in the regulation of the neuronal plasticity, a neuronal survival and apoptotic processes. The performed review of the scientific literature made it possible to establish that at least 9 chemical compounds with a potential anti-addictive activity that affect the receptors and signaling cascades associated with BDNF, have been identified as of 2025. Based on the data obtained, a hypothesis about the prospective use of BDNF and its signaling pathways as potential targets for developing new pharmacological agents aimed at the treatment of alcohol dependence, have been formulated. The established facts can significantly expand the therapeutic opportunities in the fight against the alcoholic dependence and associated neurotoxic conditions.

Conclusion

Conclusion. At least 9 compounds with a potential anti-addictive activity associated with a mimetic effect on the receptors and signaling pathways of the BDNF molecule have been analyzed and found to exist as of 2025.

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The authors declare that there are no conflicts of interest present.