pmedpharmФармация и фармакологияPharmacy & Pharmacology2307-92662413-2241Pyatigorsk Medical and Pharmaceutical Institute - branch of Volgograd State Medical Univer10.19163/2307-9266-2025-13-3-202-238pmedpharm-1692Research ArticleОБЗОРЫREVIEWКомплексный обзор фармакологических, терапевтических и токсикологических свойств борной кислоты и других борсодержащих соединений: текущее состояние и будущие перспективыA Comprehensive Review of the Pharmacological, Therapeutic, and Toxicological Properties of Boric Acid and Other Boron-Containing Compounds: Current Landscape and Future Perspectiveshttps://orcid.org/0000-0003-1075-9574ЮнусоглуО.YunusogluO.

доцент кафедры медицинской фармакологии медицинского факультета Университета Болу Абант Иззет Байсал (Турция). 

14030, Турция, Болу Меркез/Болу, Кампус Гёлкёй.

Assistant Professor of the Department of Medical Pharmacology in Faculty of Medicine, Bolu Abant Izzet Baysal University. 

Golkoy Campus, Bolu Merkez/Bolu, Turkiye, 14030.

orucfarm@gmail.comhttps://orcid.org/0009-0002-5658-1011КалфаИ.KalfaI.

магистрант кафедры медицинской фармакологии медицинского факультета Университета Болу Абант Иззет Байсал (Турция).

14030, Турция, Болу Меркез/Болу, Кампус Гёлкёй.

Master’s degree student of Medical Pharmacology Department in Faculty of Medicine, Bolu Abant Izzet Baysal University. 

Golkoy Campus, Bolu Merkez/Bolu, Turkiye, 14030.

iremkalfa24@gmail.comhttps://orcid.org/0000-0001-5187-5737ДемирельМ. Э.DemirelM. E.

доктор медицинских наук, преподаватель кафедры неотложной помощи медицинского факультета Университета Болу Абант Иззет Байсал (Турция).

14030, Турция, Болу Меркез/Болу, Кампус Гёлкёй.

Doctor of Sciences (Medicine), Faculty Member of the Department of Emergency in Faculty of Medicine, Bolu Abant Izzet Baysal University. 

Golkoy Campus, Bolu Merkez/Bolu, Turkiye, 14030.

mustafaenesdemirel@ibu.edu.trhttps://orcid.org/0009-0006-4368-6745БинзетМ. А.BinzetM. A.

кандидат медицинских наук, доктор медицинского факультета Университета Болу Абант Иззет Байсал (Турция).

14030, Турция, Болу Меркез/Болу, Кампус Гёлкёй.

Candidate of Sciences (Medicine), Doctor in Faculty of Medicine, Bolu Abant İzzet Baysal University. 

Golkoy Campus, Bolu Merkez/Bolu, Turkiye, 14030.

binzetmuhammedali@gmail.comhttps://orcid.org/0009-0006-4354-8182СевинчУ. З.SevincU. Z.

магистрант кафедры медицинской фармакологии медицинского факультета Университета Болу Абант Иззет Байсал (Турция).

14030, Турция, Болу Меркез/Болу, Кампус Гёлкёй.

 

Master’s degree student of the Department of Medical Pharmacology in Faculty of Medicine, Bolu Abant Izzet Baysal University. 

Golkoy Campus, Bolu Merkez/Bolu, Turkiye, 14030.

uygar.zarif@outlook.comhttps://orcid.org/0000-0001-6614-4347ТюрельИ.TurelI.

доктор медицинских наук, профессор, заведующий кафедрой медицинской фармакологии медицинского факультета Университета Болу Абант Иззет Байсал (Турция).

14030, Турция, Болу Меркез/Болу, Кампус Гёлкёй.

 

Doctor of Sciences (Medicine), Professor, Head of the Department of Medical Pharmacology in Faculty of Medicine, Bolu Abant Izzet Baysal University. 

Golkoy Campus, Bolu Merkez/Bolu, Turkiye, 14030.

idristurel@ibu.edu.trhttps://orcid.org/0000-0003-2940-3172КуртА. Х.KurtA. H.

доктор медицинских наук, профессор, заведующий кафедрой медицинской фармакологии медицинского факультета Университета Болу Абант Иззет Байсал (Турция).

14030, Турция, Болу Меркез/Болу, Кампус Гёлкёй.

Doctor of Sciences (Medicine), Professor of the Department of Medical Pharmacology in Faculty of Medicine, Bolu Abant Izzet Baysal University. 

Golkoy Campus, Bolu Merkez/Bolu, Turkiye, 14030.

hakankurt@ibu.edu.trУниверситет имени Болу Абант Иззет Байсал.ТурцияBolu Abant Izzet Baysal University.Turkey202502082025133202238Copyright © Юнусоглу О., Калфа И., Демирель М., Бинзет М., Севинч У., Тюрель И., Курт А., 20252025Юнусоглу О., Калфа И., Демирель М., Бинзет М., Севинч У., Тюрель И., Курт А.Yunusoglu O., Kalfa I., Demirel M., Binzet M., Sevinc U., Turel I., Kurt A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pharmpharm.ru/jour/article/view/1692Цель

Цель. В этом обзоре собрана информация, полученная в результате комплексного изучения научных ресурсов о последних достижениях в области здравоохранения, касающихся борных кислот и БСС, а также представлены текущие и будущие перспективы.

Материалы и методы

Материалы и методы. Источники литературы были собраны с использованием нескольких баз данных (WOS, PubMed, Scopus, Science Direct, SciVerse, SciELO, Cochrane Library, Embase и Академия Google). Были систематизированы данные о воздействии на здоровье борных кислот и БСС, используемых в доклинических и клинических исследованиях.

Результаты и залючение

Результаты и залючение. Различные природные и синтетические борсодержащие соединения (БСС) все чаще используются в здравоохранении. На сегодняшний день 5 препаратов БСС (бортезомиб, крисаборол, иксазомиб, таваборол и ваборбактам) одобрены Управление по контролю качества пищевых продуктов и лекарственных средств США (FDA) для различных клинических целей. Также известно, что более 10 соединений на основе бора (алабостат, борокаптат натрия, воромицин, TOL-463 и другие) исследуются на различных этапах клинических испытаний. Кроме того, как видно, продолжаются клинические исследования комбинаций различных лекарственных средств с БСС для применения по новым показаниям. Кроме того, отмечается, что бор и борсодержащие соединения широко используются в качестве пищевых добавок. В этом обзоре также представлен анализ последних достижений в области фармакологической активности борных кислот и БСС, включая антиоксидантные, противовоспалительные, антиатеросклеротические, противоопухолевые, антимикробные, противопаразитарные, противовирусные, противопротозойные, кардиопротекторные, гепатопротекторные, нейропротекторные, остеопротекторные, противодиабетические, антиапоптотические, против ожирения, ферроптоз, влияние на иммунную систему, противоэпилептическую, антипаркинсоническую и альцгеймеровскую активность и соответствующие механизмы действия, полученные в ходе исследований как in vitro, так и in vivo.

The aim

The aim. In this review, information obtained through a comprehensive scan of scientific resources on recent developments in the field of health regarding boric acids and BCCs is brought together, and current and future perspectives are presented.

Matherial and methods

Matherial and methods. The literature studies on boron were collected using multiple databases (WOS, PubMed, Scopus, Science Direct, SciVerse, SciELO, Cochrane Library, Embase and Google Scholar). The health effects of boric acids and BCCs used in preclinical and clinical studies were systematically compiled.

Results and conclusion

Results and conclusion. Different natural and synthetic boron-containing compounds (BCCs) are increasingly used in the healthcare sector. To date, five BCCs drugs (bortezomib, crisaborole, ixazomib, tavaborole and vaborbactam) have been approved by the Food and Drug Administration, for diverse clinical applications. It is also understood that more than ten boron-based compounds (alabostat, sodium borocaptate, voromycin, TOL-463 and others) are being investigated in different clinical trial phases. In addition, it is seen that clinical studies are continuing for combinations of various drugs with BCCs for use in new indications. In addition, it is observed that boron and boron-containing compounds are widely used as supplements. This review also provides an overview of recent advances in the pharmacological activities of boric acids and BCCs, including antioxidant, anti-inflammatory, anti-atherosclerotic, anticancer, antimicrobial, antiparasitic, antiviral, antiprotozoal, cardioprotective, hepatoprotective, neuroprotective, osteoprotective, antidiabetic, anti-apoptotic, anti-obesity, ferroptosis properties, effects on immune system, antiepileptic, anti-Parkinson, and anti-Alzheimer’s activities and the mechanisms of action involved, obtained from both in vitro and in vivo studies.

борсодержащие соединенияфармакологический профильборсодержащие лекарственные средствамедицинское применениеboron-containing compoundspharmacological profileboron containing drugsmedical applicationsДанное исследование не имело финансовой поддержки от сторонних организаций.This study did not have financial support from third-party organizations.ReferencesKhaliq H., Juming Z., Ke-Mei P. The Physiological Role of Boron on Health // Biol Trace Elem Res. – 2018. – Vol. 186, No. 1. – P. 31–51. DOI: 10.1007/s12011-018-1284-3Khaliq H, Juming Z, Ke-Mei P. The Physiological Role of Boron on Health. Biol Trace Elem Res. 2018;186(1):31–51. DOI: 10.1007/s12011-018-1284-3Dembitsky V.M., Smoum R., Al-Quntar A.A., Abu Ali H., Pergament I., Srebnik M. Natural occurrence of boron-containing compounds in plants, algae and microorganisms // Plant Science. – 2002. – Vol. 163, No. 5. – P. 931–942. DOI: 10.1016/S0168-9452(02)00174-7Dembitsky VM, Smoum R, Al-Quntar AA, Abu Ali H, Pergament I, Srebnik M. Natural occurrence of boron-containing compounds in plants, algae and microorganisms. Plant Science. 2002;163(5):931–942. DOI: 10.1016/S0168-9452(02)00174-7Elevli B., Yaman İ., Laratte B. Estimation of the Turkish Boron Exportation to Europe // Mining. – 2022. – Vol. 2, No. 2. – P. 155–169. DOI: 10.3390/mining2020009Elevli B, Yaman İ, Laratte B. Estimation of the Turkish Boron Exportation to Europe. Mining. 2022;2(2):155–169. DOI: 10.3390/mining2020009Kabu M., Akosman M.S. Biological effects of boron // Rev Environ Contam Toxicol. – 2013. – Vol. 225. – P. 57–75. DOI: 10.1007/978-1-4614-6470-9_2Kabu M, Akosman MS. Biological effects of boron. Rev Environ Contam Toxicol. 2013;225:57–75. DOI: 10.1007/978-1-4614-6470-9_2Kabu M., Civelek T. The effects of borax on milk yield and selected metabolic parameters in Austrian Simmental (Fleckvieh) cows // Revue de Medecine Veterinaire. – 2012. – Vol. 163. – P. 419–430. DOI: 10.17221/8104-VETMEDKabu M, Civelek T. The effects of borax on milk yield and selected metabolic parameters in Austrian Simmental (Fleckvieh) cows. Revue de Medecine Veterinaire. 2012;163:419–430. DOI: 10.17221/8104-VETMEDDas B.C., Thapa P., Karki R., Schinke C., Das S., Kambhampati S., Banerjee S.K., Van Veldhuizen P., Verma A., Weiss L.M., Evans T. Boron chemicals in diagnosis and therapeutics // Future Med Chem. – 2013. – Vol. 5, No. 6. – P. 653–676. DOI: 10.4155/fmc.13.38Das BC, Thapa P, Karki R, Schinke C, Das S, Kambhampati S, Banerjee SK, Van Veldhuizen P, Verma A, Weiss LM, Evans T. Boron chemicals in diagnosis and therapeutics. Future Med Chem. 2013;5(6):653–676. DOI: 10.4155/fmc.13.38Loomis W.D., Durst R.W. Chemistry and biology of boron // Biofactors. – 1992. – Vol. 3, No. 4. – P. 229–239.Loomis WD, Durst RW. Chemistry and biology of boron. Biofactors. 1992;3(4):229–239.Bernard C.E., Harrass M.C., Manning M.J. Hayes' Handbook of Pesticide Toxicology (Third Edition). New York: Academic Press, 2010. – P. 2033–2053.Bernard CE, Harrass MC, Manning MJ. Hayes' Handbook of Pesticide Toxicology (Third Edition). New York: Academic Press; 2010. P. 2033–2053.Nguyen V.D., Nguyen V.T., Jin S., Dang H.T., Larionov O.V. Organoboron chemistry comes to light: recent advances in photoinduced synthetic approaches to organoboron compounds // Tetrahedron. – 2019. – Vol. 75, No. 5. – P. 584–602. DOI: 10.1016/j.tet.2018.12.040Nguyen VD, Nguyen VT, Jin S, Dang HT, Larionov OV. Organoboron chemistry comes to light: recent advances in photoinduced synthetic approaches to organoboron compounds. Tetrahedron. 2019;75(5):584–602. DOI: 10.1016/j.tet.2018.12.040Wade C.R., Broomsgrove A.E., Aldridge S., Gabbaï F.P. Fluoride ion complexation and sensing using organoboron compounds // Chem Rev. – 2010. – Vol. 110, No. 7. – P. 3958–3984. DOI: 10.1021/cr900401aWade CR, Broomsgrove AE, Aldridge S, Gabbaï FP. Fluoride ion complexation and sensing using organoboron compounds. Chem Rev. 2010;110(7):3958–3984. DOI: 10.1021/cr900401aJelinek R., Kolusheva S. Carbohydrate biosensors // Chem Rev. – 2004. – Vol. 104, No. 12. – P. 5987–6015. DOI: 10.1021/cr0300284Jelinek R, Kolusheva S. Carbohydrate biosensors. Chem Rev. 2004;104(12):5987–6015. DOI: 10.1021/cr0300284Diaz D.B., Yudin A.K. The versatility of boron in biological target engagement // Nat Chem. – 2017. – Vol. 9, No. 8. – P. 731–742. DOI: 10.1038/nchem.2814Diaz DB, Yudin AK. The versatility of boron in biological target engagement. Nat Chem. 2017;9(8):731–742. DOI: 10.1038/nchem.2814Sauvage E., Zervosen A., Dive G., Herman R., Amoroso A., Joris B., Fonzé E., Pratt RF., Luxen A., Charlier P., Kerff F. Structural basis of the inhibition of class A beta-lactamases and penicillin-binding proteins by 6-beta-iodopenicillanate // J Am Chem Soc. – 2009. – Vol. 131, No. 42. – P. 15262–15269. DOI: 10.1021/ja9051526Sauvage E, Zervosen A, Dive G, Herman R, Amoroso A, Joris B, Fonzé E, Pratt RF, Luxen A, Charlier P, Kerff F. Structural basis of the inhibition of class A beta-lactamases and penicillin-binding proteins by 6-beta-iodopenicillanate. J Am Chem Soc. 2009;131(42):15262–15269. DOI: 10.1021/ja9051526Keskin E., Allahverdiyeva S., İzem Özok H., Yunusoğlu O., Yardım Y. Voltammetric Quantification of the Anesthetic Drug Propofol (2,6-Diisopropylphenol) in Pharmaceutical Formulations on a Boron-Doped Diamond Electrode: Scientific Paper // Journal of the Serbian Chemical Society. – 2021. – Vol. 86, No. 7-8. – P. 711–724. DOI: 10.2298/JSC201019017KKeskin E, Allahverdiyeva S, İzem Özok H, Yunusoğlu O, Yardım Y. Voltammetric Quantification of the Anesthetic Drug Propofol (2,6-Diisopropylphenol) in Pharmaceutical Formulations on a Boron-Doped Diamond Electrode: Scientific Paper. Journal of the Serbian Chemical Society. 2021;86(7-8):711–724. DOI: 10.2298/JSC201019017KSutradhar S., Rahaman R., Bhattacharya S., Paul S., Paine T.K. Oxygenolytic cleavage of 1,2-diols with dioxygen by a mononuclear nonheme iron complex: Mimicking the reaction of myo-inositol oxygenase // J Inorg Biochem. – 2024. – Vol. 257. - P. 112611. DOI: 10.1016/j.jinorgbio.2024.112611Sutradhar S, Rahaman R, Bhattacharya S, Paul S, Paine TK. Oxygenolytic cleavage of 1,2-diols with dioxygen by a mononuclear nonheme iron complex: Mimicking the reaction of myo-inositol oxygenase. J Inorg Biochem. 2024;257:112611. DOI: 10.1016/j.jinorgbio.2024.112611Mamedov V.A., Khafizova E.A., Algaeva N.E., Latypov S.K., Sinyashin O.G. Acid-Catalyzed Multicomponent Rearrangements via 2-((Quinoxalin-3(4H)-on-2-yl)(aryl)methylene)malononitriles, Generated In Situ, for Divergent Synthesis of Pyrroles with Different Substitution Patterns // J Org Chem. – 2020. – Vol. 85, No. 15. – P. 9887–9904. DOI: 10.1021/acs.joc.0c01180Mamedov VA, Khafizova EA, Algaeva NE, Latypov SK, Sinyashin OG. Acid-Catalyzed Multicomponent Rearrangements via 2-((Quinoxalin-3(4H)-on-2-yl)(aryl)methylene)malononitriles, Generated In Situ, for Divergent Synthesis of Pyrroles with Different Substitution Patterns. J Org Chem. 2020;85(15):9887–9904. DOI: 10.1021/acs.joc.0c01180Özok H.İ., Keskin E., Yardım Y. First voltammetric procedure for sensing synthetic thyroid hormone liothyronine sodium in tablet dosage form using anionic surfactant media at a boron-doped diamond electrode // Diamond and Related Materials. – 2025. – Vol. 153. – P. 112078. DOI: 10.1016/j.diamond.2025.112078Özok Hİ, Keskin E, Yardım Y. First voltammetric procedure for sensing synthetic thyroid hormone liothyronine sodium in tablet dosage form using anionic surfactant media at a boron-doped diamond electrode. Diamond and Related Materials. 2025;153:112078. DOI: 10.1016/j.diamond.2025.112078Özok H.İ., Kıran M., Oruç Y., Yavuz Y. The First Electroanalytical Study Of Umifenovir (Arbidol) Used As A Potential Antiviral Drug For The Treatment of SARS-CoV-2: A Voltammetric Quantification On The Boron-Doped Diamond Electrode By Using Anionic Surfactant Media // J Electrochem Society. – 2023. – Vol. 170, No. 1. – P. 016501. DOI 10.1149/1945-7111/acafa7Özok Hİ, Kıran M, Oruç Y, Yavuz Y. The First Electroanalytical Study Of Umifenovir (Arbidol) Used As A Potential Antiviral Drug For The Treatment of SARS-CoV-2: A Voltammetric Quantification On The Boron-Doped Diamond Electrode By Using Anionic Surfactant Media. J Electrochem Society. 2023;170(1):016501. DOI 10.1149/1945-7111/acafa7Allahverdiyeva S., Keskin E., Pınar P.T., Yunusoğlu O., Yardım Y., Şentürk Z. Electroanalytical investigation and determination of hepatitis C antiviral drug ledipasvir at a non-modified boron-doped diamond electrode // Diamond and Related Materials. – 2020. – Vol. 108. - P. 107962. DOI: 10.1016/j.diamond.2020.107962Allahverdiyeva S., Keskin E, Pınar PT, Yunusoğlu O, Yardım Y, Şentürk Z. Electroanalytical investigation and determination of hepatitis C antiviral drug ledipasvir at a non-modified boron-doped diamond electrode. Diamond and Related Materials. 2020;108:107962. DOI: 10.1016/j.diamond.2020.107962Wang W., Xiao K., Zheng X., Zhu D., Yang Z., Tang J., Sun P., Wang J., Peng K. Effects of supplemental boron on growth performance and meat quality in African ostrich chicks. J Agric Food Chem. – 2014. – Vol. 62, No. 46. – P. 11024–11029. DOI: 10.1021/jf501789tWang W, Xiao K, Zheng X, Zhu D, Yang Z, Tang J, Sun P, Wang J, Peng K. Effects of supplemental boron on growth performance and meat quality in African ostrich chicks. J Agric Food Chem. 2014;62(46):11024–11029. DOI: 10.1021/jf501789tÇinar M., Küçükyilmaz K., Bozkurt M., Çatli A.U., Bintaş E., Akşit H., Konak R., Yamaner Ç., Seyrek K. Effects of dietary boron and phytase supplementation on growth performance and mineral profile of broiler chickens fed on diets adequate or deficient in calcium and phosphorus // Br Poult Sci. – 2015. – Vol. 56, No. 5. – P. 576–589. DOI: 10.1080/00071668.2015.1079699Çinar M, Küçükyilmaz K, Bozkurt M, Çatli AU, Bintaş E, Akşit H, Konak R, Yamaner Ç, Seyrek K. Effects of dietary boron and phytase supplementation on growth performance and mineral profile of broiler chickens fed on diets adequate or deficient in calcium and phosphorus. Br Poult Sci. 2015;56(5):576–589. DOI: 10.1080/00071668.2015.1079699Fort D.J. Boron deficiency disables Xenopus laevis oocyte maturation events // Biol Trace Elem Res. – 2002. – Vol. 85, No. 2. – P. 157–169. DOI: 10.1385/BTER:85:2:157Fort DJ. Boron deficiency disables Xenopus laevis oocyte maturation events. Biol Trace Elem Res. 2002;85(2):157–169. DOI: 10.1385/BTER:85:2:157Hunt C.D. Dietary boron: progress in establishing essential roles in human physiology // J Trace Elem Med Biol. – 2012. – Vol. 26, No. 2-3. – P. 157–160. DOI: 10.1016/j.jtemb.2012.03.014Hunt CD. Dietary boron: progress in establishing essential roles in human physiology. J Trace Elem Med Biol. 2012;26(2-3):157–160. DOI: 10.1016/j.jtemb.2012.03.014Nielsen F.H. Is boron nutritionally relevant? // Nutr Rev. – 2008. – Vol. 66, No. 4. – P. 183–191. DOI: 10.1111/j.1753-4887.2008.00023.xNielsen FH. Is boron nutritionally relevant? Nutr Rev. 2008;66(4):183–191. DOI: 10.1111/j.1753-4887.2008.00023.xBozkurt M., Küçükyılmaz K., Catlı A.U., Cınar M., Cabuk M., Bintaş E. Effects of boron supplementation to diets deficient in calcium and phosphorus on performance with some serum, bone and fecal characteristics of broiler chickens // Asian-Australas J Anim Sci. – 2012. – Vol. 25, No. 2. – P. 248–255. DOI: 10.5713/ajas.2011.11211Bozkurt M, Küçükyılmaz K, Catlı AU, Cınar M, Cabuk M, Bintaş E. Effects of boron supplementation to diets deficient in calcium and phosphorus on performance with some serum, bone and fecal characteristics of broiler chickens. Asian-Australas J Anim Sci. 2012;25(2):248–255. DOI: 10.5713/ajas.2011.11211Adya R., Tan B.K., Chen J., Randeva H.S. Nuclear factor-kappaB induction by visfatin in human vascular endothelial cells: its role in MMP-2/9 production and activation // Diabetes Care. – 2008. – Vol. 31, No. 4. – P. 758–760. DOI: 10.2337/dc07-1544Adya R, Tan BK, Chen J, Randeva HS. Nuclear factor-kappaB induction by visfatin in human vascular endothelial cells: its role in MMP-2/9 production and activation. Diabetes Care. 2008;31(4):758–760. DOI: 10.2337/dc07-1544Cheng J., Peng K., Jin E., Zhang Y., Liu Y., Zhang N., Song H., Liu H., Tang Z. Effect of additional boron on tibias of African ostrich chicks // Biol Trace Elem Res. – 2011. – Vol. 144, No. 1-3. – P. 538–549. DOI: 10.1007/s12011-011-9024-yCheng J, Peng K, Jin E, Zhang Y, Liu Y, Zhang N, Song H, Liu H, Tang Z. Effect of additional boron on tibias of African ostrich chicks. Biol Trace Elem Res. 2011;144(1-3):538–549. DOI: 10.1007/s12011-011-9024-yBasoglu A., Sevinc M., Birdane F.M., Boydak M. Efficacy of sodium borate in the prevention of fatty liver in dairy cows // J Vet Intern Med. – 2002. – Vol. 16, No. 6. – P. 732–735. DOI: 10.1892/0891-6640(2002)016<0732:eosbit>2.3.co. Erratum in: J Vet Intern Med. – 2003. – Vol. 17, No. 2. – P. 245.Basoglu A, Sevinc M, Birdane FM, Boydak M. Efficacy of sodium borate in the prevention of fatty liver in dairy cows. J Vet Intern Med. 2002;16(6):732–735. DOI: 10.1892/0891-6640(2002)016<0732:eosbit>2.3.co;2. Erratum in: J Vet Intern Med. 2003;17(2):245.Penland J.G. Dietary boron, brain function, and cognitive performance // Environ Health Perspect. – 1994. – Vol. 102, Suppl 7 (Suppl 7). – P. 65–72. DOI: 10.1289/ehp.94102s765Penland JG. Dietary boron, brain function, and cognitive performance. Environ Health Perspect. 1994;102 Suppl 7(Suppl 7):65–72. DOI: 10.1289/ehp.94102s765Devirian T.A., Volpe S.L. The physiological effects of dietary boron // Crit Rev Food Sci Nutr. – 2003. – Vol. 43, No. 2. – P. 219–231. DOI: 10.1080/10408690390826491Devirian TA, Volpe SL. The physiological effects of dietary boron. Crit Rev Food Sci Nutr. 2003;43(2):219–231. DOI: 10.1080/10408690390826491Cortes S., Reynaga-Delgado E., Sancha A.M., Ferreccio C. Boron exposure assessment using drinking water and urine in the North of Chile // Sci Total Environ. – 2011. – Vol. 410–411. – P. 96–101. DOI: 10.1016/j.scitotenv.2011.08.073Cortes S, Reynaga-Delgado E, Sancha AM, Ferreccio C. Boron exposure assessment using drinking water and urine in the North of Chile. Sci Total Environ. 2011;410–411:96–101. DOI: 10.1016/j.scitotenv.2011.08.073Deutsche Gesellschaft für Anthropologie., and Australasian Society for Human Biology. Homo : Internationale Zeitschrift Für Die Vergleichende Forschung Am Menschen. Stuttgart: Enke., 1949.Deutsche Gesellschaft für Anthropologie., and Australasian Society for Human Biology. Homo : Internationale Zeitschrift Für Die Vergleichende Forschung Am Menschen. Stuttgart: Enke., 1949.Scorei R.I., Popa R. Jr. Boron-containing compounds as preventive and chemotherapeutic agents for cancer // Anticancer Agents Med Chem. – 2010. – Vol. 10, No. 4. – P. 346–351. DOI: 10.2174/187152010791162289Scorei RI, Popa R Jr. Boron-containing compounds as preventive and chemotherapeutic agents for cancer. Anticancer Agents Med Chem. 2010;10(4):346–351. DOI: 10.2174/187152010791162289Ozansoy M., AltintaŞ M.Ö., Ozansoy M.B., GÜnay N., KiliÇ E., KiliÇ Ü. Two boron-containing compounds affect the cellular viability of SH-SY5Y cells in an in vitro amyloid-beta toxicity model // Turk J Biol. – 2020. – Vol. 44, No. 4. – P. 208–214. DOI: 10.3906/biy-2001-22Ozansoy M, AltintaŞ MÖ, Ozansoy MB, GÜnay N, KiliÇ E, KiliÇ Ü. Two boron-containing compounds affect the cellular viability of SH-SY5Y cells in an in vitro amyloid-beta toxicity model. Turk J Biol. 2020;44(4):208–214. DOI: 10.3906/biy-2001-22Barrón-González M., Montes-Aparicio A.V., Cuevas-Galindo M.E., Orozco-Suárez S., Barrientos R., Alatorre A., Querejeta E., Trujillo-Ferrara J.G., Farfán-García E.D., Soriano-Ursúa M.A. Boron-containing compounds on neurons: Actions and potential applications for treating neurodegenerative diseases // J Inorg Biochem. – 2023. – Vol. 238. – P. 112027. DOI: 10.1016/j.jinorgbio.2022.112027Barrón-González M, Montes-Aparicio AV, Cuevas-Galindo ME, Orozco-Suárez S, Barrientos R, Alatorre A, Querejeta E, Trujillo-Ferrara JG, Farfán-García ED, Soriano-Ursúa MA. Boron-containing compounds on neurons: Actions and potential applications for treating neurodegenerative diseases. J Inorg Biochem. 2023;238:112027. DOI: 10.1016/j.jinorgbio.2022.112027Christopher R. Ethnobotanical uses, biological activities and phytochemistry of mangrove plant species: A review // Journal of Biologically Active Products from Nature. – 2024. – Vol. 14, No. 5. – P. 581–608. DOI: 10.1080/22311866.2024.2431963Christopher R. Ethnobotanical uses, biological activities and phytochemistry of mangrove plant species: A review. Journal of Biologically Active Products from Nature. 2024;14(5):581–608. DOI: 10.1080/22311866.2024.2431963Penland J.G. Quantitative analysis of EEC effects following experimental marginal magnesium and boron deprivation. Magnesium Res. 1995. – Vol. 8, No. 4. – P. 341–358.Penland JG. Quantitative analysis of EEC effects following experimental marginal magnesium and boron deprivation. Magnesium Res. 1995;8(4):341–358.Penland JG. The importance of boron nutrition for brain and psychological function // Biol Trace Elem Res. 1998. – Vol. 66, No. 1-3. – P. 299–317. DOI: 10.1007/BF02783144Penland JG. The importance of boron nutrition for brain and psychological function. Biol Trace Elem Res. 1998;66(1-3):299–317. DOI: 10.1007/BF02783144Soriano-Ursúa M.A., Farfán-García ED., López-Cabrera Y., Querejeta E., Trujillo-Ferrara JG. Boron-containing acids: preliminary evaluation of acute toxicity and access to the brain determined by Raman scattering spectroscopy // Neurotoxicology. – 2014. – Vol. 40. – P. 8–15. DOI: 10.1016/j.neuro.2013.10.005Soriano-Ursúa MA, Farfán-García ED, López-Cabrera Y, Querejeta E, Trujillo-Ferrara JG. Boron-containing acids: preliminary evaluation of acute toxicity and access to the brain determined by Raman scattering spectroscopy. Neurotoxicology. 2014;40:8–15. DOI: 10.1016/j.neuro.2013.10.005Naghii M.R., Darvishi P., Ebrahimpour Y., Ghanizadeh G., Mofid M., Hedayati M., Asgari A.R. Effect of combination therapy of fatty acids, calcium, vitamin D and boron with regular physical activity on cardiovascular risk factors in rat // J Oleo Sci. – 2012. – Vol. 61, No. 2. – P. 103–111. DOI: 10.5650/jos.61.103Naghii MR, Darvishi P, Ebrahimpour Y, Ghanizadeh G, Mofid M, Hedayati M, Asgari AR. Effect of combination therapy of fatty acids, calcium, vitamin D and boron with regular physical activity on cardiovascular risk factors in rat. J Oleo Sci. 2012;61(2):103–111. DOI: 10.5650/jos.61.103Benderdour M., Bui-Van T., Dicko A., Belleville F. In vivo and in vitro effects of boron and boronated compounds // J Trace Elem Med Biol. – 1998. – Vol. 12, No. 1. – P. 2–7. DOI: 10.1016/S0946-672X(98)80014-XBenderdour M, Bui-Van T, Dicko A, Belleville F. In vivo and in vitro effects of boron and boronated compounds. J Trace Elem Med Biol. 1998;12(1):2–7. DOI: 10.1016/S0946-672X(98)80014-XHenderson K.A., Kobylewski S.E., Yamada K.E., Eckhert C.D. Boric acid induces cytoplasmic stress granule formation, eIF2α phosphorylation, and ATF4 in prostate DU-145 cells // Biometals. – 2015. – Vol. 28, No. 1. – P. 133–141. DOI: 10.1007/s10534-014-9809-5Henderson KA, Kobylewski SE, Yamada KE, Eckhert CD. Boric acid induces cytoplasmic stress granule formation, eIF2α phosphorylation, and ATF4 in prostate DU-145 cells. Biometals. 2015;28(1):133–141. DOI: 10.1007/s10534-014-9809-5Barranco W.T., Eckhert C.D. Boric acid inhibits human prostate cancer cell proliferation // Cancer Lett. – 2004. – Vol. 216, No. 1. – P. 21–29. DOI: 10.1016/j.canlet.2004.06.001Barranco WT, Eckhert CD. Boric acid inhibits human prostate cancer cell proliferation. Cancer Lett. 2004;216(1):21–29. DOI: 10.1016/j.canlet.2004.06.001Usuda K., Kono K., Dote T., Watanabe M., Shimizu H., Tanimoto Y., Yamadori E. An overview of boron, lithium, and strontium in human health and profiles of these elements in urine of Japanese // Environ Health Prev Med. – 2007. – Vol. 12, No. 6. – P. 231–237. DOI: 10.1007/BF02898029Usuda K, Kono K, Dote T, Watanabe M, Shimizu H, Tanimoto Y, Yamadori E. An overview of boron, lithium, and strontium in human health and profiles of these elements in urine of Japanese. Environ Health Prev Med. 2007;12(6):231–237. DOI: 10.1007/BF02898029Herrero M., Ibáñiez E., Cifuentes A. Analysis of natural antioxidants by capillary electromigration methods // J Sep Sci. – 2005. – Vol. 28, No. 9-10. – P. 883–897. DOI: 10.1002/jssc.200400104Herrero M, Ibáñiez E, Cifuentes A. Analysis of natural antioxidants by capillary electromigration methods. J Sep Sci. 2005;28(9-10):883–897. DOI: 10.1002/jssc.200400104Turkez H., Geyikoğlu F., Dirican E., Tatar A. In vitro studies on chemoprotective effect of borax against aflatoxin B1-induced genetic damage in human lymphocytes // Cytotechnology. – 2012. – Vol. 64, No. 6. – P. 607–612. DOI: 10.1007/s10616-012-9454-1Turkez H, Geyikoğlu F, Dirican E, Tatar A. In vitro studies on chemoprotective effect of borax against aflatoxin B1-induced genetic damage in human lymphocytes. Cytotechnology. 2012;64(6):607–612. DOI: 10.1007/s10616-012-9454-1Turkez H., Tatar A., Hacimuftuoglu A., Ozdemir E. Boric acid as a protector against paclitaxel genotoxicity // Acta Biochim Pol. – 2010. – Vol. 57, No. 1. – P. 95–97.Turkez H, Tatar A, Hacimuftuoglu A, Ozdemir E. Boric acid as a protector against paclitaxel genotoxicity. Acta Biochim Pol. 2010;57(1):95–97.Turkez H., Geyikoglu F., Tatar A., Keles M.S., Kaplan I. The effects of some boron compounds against heavy metal toxicity in human blood // Exp Toxicol Pathol. – 2012. – Vol. 64, No. 1-2. – P. 93–101. DOI: 10.1016/j.etp.2010.06.011Turkez H, Geyikoglu F, Tatar A, Keles MS, Kaplan I. The effects of some boron compounds against heavy metal toxicity in human blood. Exp Toxicol Pathol. 2012;64(1-2):93–101. DOI: 10.1016/j.etp.2010.06.011Ustündağ A., Behm C., Föllmann W., Duydu Y., Degen G.H. Protective effect of boric acid on lead- and cadmium-induced genotoxicity in V79 cells // Arch Toxicol. – 2014. – Vol. 88, No. 6. – P. 1281–1289. DOI: 10.1007/s00204-014-1235-5Ustündağ A, Behm C, Föllmann W, Duydu Y, Degen GH. Protective effect of boric acid on lead- and cadmium-induced genotoxicity in V79 cells. Arch Toxicol. 2014;88(6):1281–1289. DOI: 10.1007/s00204-014-1235-5Turkez H. Effects of boric acid and borax on titanium dioxide genotoxicity // J Appl Toxicol. – 2008. – Vol. 28, No. 5. – P. 658–664. DOI: 10.1002/jat.1318Turkez H. Effects of boric acid and borax on titanium dioxide genotoxicity. J Appl Toxicol. 2008;28(5):658–664. DOI: 10.1002/jat.1318Fernandes G.F.S., Denny W.A., Dos Santos J.L. Boron in drug design: Recent advances in the development of new therapeutic agents // Eur J Med Chem. – 2019. – Vol. 179:791–804. DOI: 10.1016/j.ejmech.2019.06.092Fernandes GFS, Denny WA, Dos Santos JL. Boron in drug design: Recent advances in the development of new therapeutic agents. Eur J Med Chem. 2019;179:791–804. DOI: 10.1016/j.ejmech.2019.06.092Ban H.S., Nakamura H. Boron-Based Drug Design // Chem Rec. – 2015. – Vol. 15, No. 3. – P. 616–635. DOI: 10.1002/tcr.201402100Ban HS, Nakamura H. Boron-Based Drug Design. Chem Rec. 2015;15(3):616–635. DOI: 10.1002/tcr.201402100Sharma N., Sharma D. An upcoming drug for onychomycosis: Tavaborole // J Pharmacol Pharmacother. – 2015. – Vol. 6, No. 4. – P. 236–239. DOI: 10.4103/0976-500X.171870Sharma N, Sharma D. An upcoming drug for onychomycosis: Tavaborole. J Pharmacol Pharmacother. 2015;6(4):236–239. DOI: 10.4103/0976-500X.171870Dhillon S. Correction to: Meropenem/Vaborbactam: A Review in Complicated Urinary Tract Infections // Drugs. – 2018. – Vol. 78, No. 13. – P. 1383. DOI: 10.1007/s40265-018-0974-7. Erratum for: Drugs. – 2018. – Vol. 78, No. 12. – P. 1259–1270. DOI: 10.1007/s40265-018-0966-7Dhillon S. Correction to: Meropenem/Vaborbactam: A Review in Complicated Urinary Tract Infections. Drugs. 2018;78(13):1383. DOI: 10.1007/s40265-018-0974-7. Erratum for: Drugs. 2018;78(12):1259–1270. DOI: 10.1007/s40265-018-0966-7Fu Z., Lu C., Zhang C., Qiao B. PSMA5 promotes the tumorigenic process of prostate cancer and is related to bortezomib resistance // Anticancer Drugs. – 2019. – Vol. 30, No. 7. – P. e0773. DOI: 10.1097/CAD.0000000000000773Fu Z, Lu C, Zhang C, Qiao B. PSMA5 promotes the tumorigenic process of prostate cancer and is related to bortezomib resistance. Anticancer Drugs. 2019;30(7):e0773. DOI: 10.1097/CAD.0000000000000773Paller A.S., Tom W.L., Lebwohl M.G., Blumenthal R.L., Boguniewicz M., Call R.S., Eichenfield L.F., Forsha D.W., Rees W.C., Simpson E.L., Spellman M.C., Stein Gold L.F., Zaenglein A.L., Hughes M.H., Zane L.T., Hebert A.A. Efficacy and safety of crisaborole ointment, a novel, nonsteroidal phosphodiesterase 4 (PDE4) inhibitor for the topical treatment of atopic dermatitis (AD) in children and adults // J Am Acad Dermatol. – 2016. – Vol. 75, No. 3. – P. 494–503.e6. DOI: 10.1016/j.jaad.2016.05.046. Erratum in: J Am Acad Dermatol. – 2017. – Vol. 76, No. 4. – P. 777. DOI: 10.1016/j.jaad.2017.01.026Paller AS, Tom WL, Lebwohl MG, Blumenthal RL, Boguniewicz M, Call RS, Eichenfield LF, Forsha DW, Rees WC, Simpson EL, Spellman MC, Stein Gold LF, Zaenglein AL, Hughes MH, Zane LT, Hebert AA. Efficacy and safety of crisaborole ointment, a novel, nonsteroidal phosphodiesterase 4 (PDE4) inhibitor for the topical treatment of atopic dermatitis (AD) in children and adults. J Am Acad Dermatol. 2016;75(3):494–503.e6. DOI: 10.1016/j.jaad.2016.05.046. Erratum in: J Am Acad Dermatol. 2017;76(4):777. DOI: 10.1016/j.jaad.2017.01.026Muz B., Ghazarian R.N., Ou M., Luderer M.J., Kusdono H.D., Azab A.K. Spotlight on ixazomib: potential in the treatment of multiple myeloma // Drug Des Devel Ther. – 2016. – Vol. 10. – P. 217–226. DOI: 10.2147/DDDT.S93602Muz B, Ghazarian RN, Ou M, Luderer MJ, Kusdono HD, Azab AK. Spotlight on ixazomib: potential in the treatment of multiple myeloma. Drug Des Devel Ther. 2016;10:217–226. DOI: 10.2147/DDDT.S93602Das B.C., Adil Shareef M., Das S., Nandwana N.K., Das Y., Saito M., Weiss L.M. Boron-Containing heterocycles as promising pharmacological agents // Bioorg Med Chem. – 2022. – Vol. 63. – P. 116748. DOI: 10.1016/j.bmc.2022.116748Das BC, Adil Shareef M, Das S, Nandwana NK, Das Y, Saito M, Weiss LM. Boron-Containing heterocycles as promising pharmacological agents. Bioorg Med Chem. 2022;63:116748. DOI: 10.1016/j.bmc.2022.116748Marrazzo J.M., Dombrowski J.C., Wierzbicki M.R., Perlowski C., Pontius A., Dithmer D., Schwebke J. Safety and Efficacy of a Novel Vaginal Anti-infective, TOL-463, in the Treatment of Bacterial Vaginosis and Vulvovaginal Candidiasis: A Randomized, Single-blind, Phase 2, Controlled Trial // Clin Infect Dis. – 2019. – Vol. 68, No. 5. – P. 803–809. DOI: 10.1093/cid/ciy554Marrazzo JM, Dombrowski JC, Wierzbicki MR, Perlowski C, Pontius A, Dithmer D, Schwebke J. Safety and Efficacy of a Novel Vaginal Anti-infective, TOL-463, in the Treatment of Bacterial Vaginosis and Vulvovaginal Candidiasis: A Randomized, Single-blind, Phase 2, Controlled Trial. Clin Infect Dis. 2019;68(5):803–809. DOI: 10.1093/cid/ciy554Grégoire V., Evans M., Le Q.T., Bourhis J., Budach V., Chen A., Eisbruch A., Feng M., Giralt J., Gupta T., Hamoir M., Helito J.K., Hu C., Hunter K., Johansen J., Kaanders J., Laskar S.G., Lee A., Maingon P., Mäkitie A., Micciche' F., Nicolai P., O'Sullivan B., Poitevin A., Porceddu S., Składowski K., Tribius S., Waldron J., Wee J., Yao M., Yom S.S., Zimmermann F., Grau C. Delineation of the primary tumour Clinical Target Volumes (CTV-P) in laryngeal, hypopharyngeal, oropharyngeal and oral cavity squamous cell carcinoma: AIRO, CACA, DAHANCA, EORTC, GEORCC, GORTEC, HKNPCSG, HNCIG, IAG-KHT, LPRHHT, NCIC CTG, NCRI, NRG Oncology, PHNS, SBRT, SOMERA, SRO, SSHNO, TROG consensus guidelines // Radiother Oncol. – 2018. – Vol. 126, No. 1. – P. 3–24. DOI: 10.1016/j.radonc.2017.10.016Grégoire V, Evans M, Le QT, Bourhis J, Budach V, Chen A, Eisbruch A, Feng M, Giralt J, Gupta T, Hamoir M, Helito JK, Hu C, Hunter K, Johansen J, Kaanders J, Laskar SG, Lee A, Maingon P, Mäkitie A, Micciche' F, Nicolai P, O'Sullivan B, Poitevin A, Porceddu S, Składowski K, Tribius S, Waldron J, Wee J, Yao M, Yom SS, Zimmermann F, Grau C. Delineation of the primary tumour Clinical Target Volumes (CTV-P) in laryngeal, hypopharyngeal, oropharyngeal and oral cavity squamous cell carcinoma: AIRO, CACA, DAHANCA, EORTC, GEORCC, GORTEC, HKNPCSG, HNCIG, IAG-KHT, LPRHHT, NCIC CTG, NCRI, NRG Oncology, PHNS, SBRT, SOMERA, SRO, SSHNO, TROG consensus guidelines. Radiother Oncol. 2018;126(1):3–24. DOI: 10.1016/j.radonc.2017.10.016Yang H., Wang J., Zhang X., Zhang Y., Qin Z.L., Wang H., Luo X.Y. Application of Topical Phosphodiesterase 4 Inhibitors in Mild to Moderate Atopic Dermatitis: A Systematic Review and Meta-analysis // JAMA Dermatol. – 2019. – Vol. 155, No. 5. – P. 585–593. DOI: 10.1001/jamadermatol.2019.0008. Erratum in: JAMA Dermatol. – 2019. – Vol. 155, No. 7. – P. 865. DOI: 10.1001/jamadermatol.2019.1346Yang H, Wang J, Zhang X, Zhang Y, Qin ZL, Wang H, Luo XY. Application of Topical Phosphodiesterase 4 Inhibitors in Mild to Moderate Atopic Dermatitis: A Systematic Review and Meta-analysis. JAMA Dermatol. 2019;155(5):585–593. DOI: 10.1001/jamadermatol.2019.0008. Erratum in: JAMA Dermatol. 2019;155(7):865. DOI: 10.1001/jamadermatol.2019.1346Rezanka T., Sigler K. Biologically active compounds of semi-metals // Phytochemistry. – 2008. – Vol. 69, No. 3. – P. 585–606. DOI: 10.1016/j.phytochem.2007.09.018Rezanka T, Sigler K. Biologically active compounds of semi-metals. Phytochemistry. 2008;69(3):585–606. DOI: 10.1016/j.phytochem.2007.09.018Chong P.Y., Shotwell J.B., Miller J., Price D.J., Maynard A., Voitenleitner C., Mathis A., Williams S., Pouliot J.J., Creech K., Wang F., Fang J., Zhang H., Tai V.W., Turner E., Kahler K.M., Crosby R., Peat A.J. Design of N-Benzoxaborole Benzofuran GSK8175-Optimization of Human Pharmacokinetics Inspired by Metabolites of a Failed Clinical HCV Inhibitor // J Med Chem. – 2019. – Vol. 62, No. 7. – P. 3254–3267. DOI: 10.1021/acs.jmedchem.8b01719Chong PY, Shotwell JB, Miller J, Price DJ, Maynard A, Voitenleitner C, Mathis A, Williams S, Pouliot JJ, Creech K, Wang F, Fang J, Zhang H, Tai VW, Turner E, Kahler KM, Crosby R, Peat AJ. Design of N-Benzoxaborole Benzofuran GSK8175-Optimization of Human Pharmacokinetics Inspired by Metabolites of a Failed Clinical HCV Inhibitor. J Med Chem. 2019;62(7):3254–3267. DOI: 10.1021/acs.jmedchem.8b01719Diacon A.H., Barry C.E. 3rd, Carlton A., Chen R.Y., Davies M., de Jager V., Fletcher K., Koh G.C.K.W., Kontsevaya I., Heyckendorf J., Lange C., Reimann M., Penman S.L., Scott R., Maher-Edwards G., Tiberi S., Vlasakakis G., Upton C.M., Aguirre D.B. A first-in-class leucyl-tRNA synthetase inhibitor, ganfeborole, for rifampicin-susceptible tuberculosis: a phase 2a open-label, randomized trial // Nat Med. – 2024. – Vol. 30, No. 3. – P. 896–904. DOI: 10.1038/s41591-024-02829-7Diacon AH, Barry CE 3rd, Carlton A, Chen RY, Davies M, de Jager V, Fletcher K, Koh GCKW, Kontsevaya I, Heyckendorf J, Lange C, Reimann M, Penman SL, Scott R, Maher-Edwards G, Tiberi S, Vlasakakis G, Upton CM, Aguirre DB. A first-in-class leucyl-tRNA synthetase inhibitor, ganfeborole, for rifampicin-susceptible tuberculosis: a phase 2a open-label, randomized trial. Nat Med. 2024;30(3):896–904. DOI: 10.1038/s41591-024-02829-7Sun D., Tsivkovski R., Pogliano J., Tsunemoto H., Nelson K., Rubio-Aparicio D., Lomovskaya O. Intrinsic Antibacterial Activity of Xeruborbactam In Vitro: Assessing Spectrum and Mode of Action // Antimicrob Agents Chemother. – 2022. – Vol. 66, No. 10. – P. e0087922. DOI: 10.1128/aac.00879-22Sun D, Tsivkovski R, Pogliano J, Tsunemoto H, Nelson K, Rubio-Aparicio D, Lomovskaya O. Intrinsic Antibacterial Activity of Xeruborbactam In Vitro: Assessing Spectrum and Mode of Action. Antimicrob Agents Chemother. 2022;66(10):e0087922. DOI: 10.1128/aac.00879-22Wall R.J., Rico E., Lukac I., Zuccotto F., Elg S., Gilbert I.H., Freund Y., Alley M.R.K., Field M.C., Wyllie S., Horn D. Clinical and veterinary trypanocidal benzoxaboroles target CPSF3 // Proc Natl Acad Sci U S A. – 2018. – Vol. 115, No. 38. – P. 9616–9621. DOI: 10.1073/pnas.1807915115Wall RJ, Rico E, Lukac I, Zuccotto F, Elg S, Gilbert IH, Freund Y, Alley MRK, Field MC, Wyllie S, Horn D. Clinical and veterinary trypanocidal benzoxaboroles target CPSF3. Proc Natl Acad Sci U S A. 2018;115(38):9616–9621. DOI: 10.1073/pnas.1807915115Karlowsky J.A., Hackel M.A., Wise M.G., Six D.A., Uehara T., Daigle D.M., Cusick S.M., Pevear D.C., Moeck G., Sahm D.F. In Vitro Activity of Cefepime-Taniborbactam and Comparators against Clinical Isolates of Gram-Negative Bacilli from 2018 to 2020: Results from the Global Evaluation of Antimicrobial Resistance via Surveillance , No. GEARS) Program // Antimicrob Agents Chemother. – 2023. – Vol. 67, No. 1. – P. e0128122. DOI: 10.1128/aac.01281-22Karlowsky JA, Hackel MA, Wise MG, Six DA, Uehara T, Daigle DM, Cusick SM, Pevear DC, Moeck G, Sahm DF. In Vitro Activity of Cefepime-Taniborbactam and Comparators against Clinical Isolates of Gram-Negative Bacilli from 2018 to 2020: Results from the Global Evaluation of Antimicrobial Resistance via Surveillance (GEARS) Program. Antimicrob Agents Chemother. 2023;67(1):e0128122. DOI: 10.1128/aac.01281-22Jin W.H., Seldon C., Butkus M., Sauerwein W., Giap H.B. A Review of Boron Neutron Capture Therapy: Its History and Current Challenges // Int J Part Ther. – 2022. – Vol. 9, No. 1. – P. 71–82. DOI: 10.14338/IJPT-22-00002.1Jin WH, Seldon C, Butkus M, Sauerwein W, Giap HB. A Review of Boron Neutron Capture Therapy: Its History and Current Challenges. Int J Part Ther. 2022;9(1):71–82. DOI: 10.14338/IJPT-22-00002.1Uluisik I., Karakaya H.C., Koc A. The importance of boron in biological systems // J Trace Elem Med Biol. – 2018. – Vol. 45. - P. 156–162. DOI: 10.1016/j.jtemb.2017.10.008. Erratum in: J Trace Elem Med Biol. – 2019. – Vol. 55. – P. 215. DOI: 10.1016/j.jtemb.2018.04.001Uluisik I, Karakaya HC, Koc A. The importance of boron in biological systems. J Trace Elem Med Biol. 2018;45:156–162. DOI: 10.1016/j.jtemb.2017.10.008. Erratum in: J Trace Elem Med Biol. 2019;55:215. DOI: 10.1016/j.jtemb.2018.04.001Soriano-Ursúa M.A., Farfán-García E.D., Geninatti-Crich S. Turning Fear of Boron Toxicity into Boron-containing Drug Design // Curr Med Chem. – 2019. – Vol. 26, No. 26. – P. 5005–5018. DOI: 10.2174/0929867326666190327154954Soriano-Ursúa MA, Farfán-García ED, Geninatti-Crich S. Turning Fear of Boron Toxicity into Boron-containing Drug Design. Curr Med Chem. 2019;26(26):5005–5018. DOI: 10.2174/0929867326666190327154954Soriano-Ursúa M.A., Das B.C., Trujillo-Ferrara J.G. Boron-containing compounds: chemico-biological properties and expanding medicinal potential in prevention, diagnosis and therapy // Expert Opin Ther Pat. – 2014. – Vol. 24, No. 5. – P. 485–500. DOI: 10.1517/13543776.2014.881472Soriano-Ursúa MA, Das BC, Trujillo-Ferrara JG. Boron-containing compounds: chemico-biological properties and expanding medicinal potential in prevention, diagnosis and therapy. Expert Opin Ther Pat. 2014;24(5):485–500. DOI: 10.1517/13543776.2014.881472Scorei R. Is boron a prebiotic element? A mini-review of the essentiality of boron for the appearance of life on earth // Orig Life Evol Biosph. – 2012. – Vol. 42, No. 1. – P. 3–17. DOI: 10.1007/s11084-012-9269-2Scorei R. Is boron a prebiotic element? A mini-review of the essentiality of boron for the appearance of life on earth. Orig Life Evol Biosph. 2012;42(1):3–17. DOI: 10.1007/s11084-012-9269-2Song S., Gao P., Sun L., Kang D., Kongsted J., Poongavanam V., Zhan P., Liu X. Recent developments in the medicinal chemistry of single boron atom-containing compounds // Acta Pharm Sin B. – 2021. – Vol. 11, No. 10. – P. 3035–3059. DOI: 10.1016/j.apsb.2021.01.010Song S, Gao P, Sun L, Kang D, Kongsted J, Poongavanam V, Zhan P, Liu X. Recent developments in the medicinal chemistry of single boron atom-containing compounds. Acta Pharm Sin B. 2021;11(10):3035–3059. DOI: 10.1016/j.apsb.2021.01.010Maslah H., Skarbek C., Pethe S., Labruère R. Anticancer boron-containing prodrugs responsive to oxidative stress from the tumor microenvironment // Eur J Med Chem. – 2020. – Vol. 207. – P. 112670. DOI: 10.1016/j.ejmech.2020.112670Maslah H, Skarbek C, Pethe S, Labruère R. Anticancer boron-containing prodrugs responsive to oxidative stress from the tumor microenvironment. Eur J Med Chem. 2020;207:112670. DOI: 10.1016/j.ejmech.2020.112670Baker S.J., Ding C.Z., Akama T., Zhang Y.K., Hernandez V., Xia Y. Therapeutic potential of boron-containing compounds // Future Med Chem. – 2009. – Vol. 1, No. 7. – P. 1275–1288. DOI: 10.4155/fmc.09.71Baker SJ, Ding CZ, Akama T, Zhang YK, Hernandez V, Xia Y. Therapeutic potential of boron-containing compounds. Future Med Chem. 2009;1(7):1275–1288. DOI: 10.4155/fmc.09.71Nunes A.T., Annunziata C.M. Proteasome inhibitors: structure and function // Semin Oncol. – 2017. – Vol. 44, No. 6. – P. 377–380. DOI: 10.1053/j.seminoncol.2018.01.004Nunes AT, Annunziata CM. Proteasome inhibitors: structure and function. Semin Oncol. 2017;44(6):377–380. DOI: 10.1053/j.seminoncol.2018.01.004Soriano-Ursúa M.A., Mancilla-Percino T., Correa-Basurto J., Querejeta E., Trujillo-Ferrara J.G. Give boron a chance: boron containing compounds reach ionotropic and metabotropic transmembrane receptors // Mini Rev Med Chem. – 2011. – Vol. 11, No. 12. – P. 1031–1038. DOI: 10.2174/138955711797247743Soriano-Ursúa MA, Mancilla-Percino T, Correa-Basurto J, Querejeta E, Trujillo-Ferrara JG. Give boron a chance: boron containing compounds reach ionotropic and metabotropic transmembrane receptors. Mini Rev Med Chem. 2011;11(12):1031–1038. DOI: 10.2174/138955711797247743Hunter P. Not boring at all. Boron is the new carbon in the quest for novel drug candidates // EMBO Rep. – 2009. – Vol. 10, No. 2. – P. 125–128. DOI: 10.1038/embor.2009.2Hunter P. Not boring at all. Boron is the new carbon in the quest for novel drug candidates. EMBO Rep. 2009;10(2):125–128. DOI: 10.1038/embor.2009.2Das B.C., Nandwana N.K., Das S., Nandwana V., Shareef M.A., Das Y., Saito M., Weiss L.M., Almaguel F., Hosmane N.S., Evans T. Boron Chemicals in Drug Discovery and Development: Synthesis and Medicinal Perspective // Molecules. – 2022. – Vol. 27, No. 9. – P. 2615. DOI: 10.3390/molecules27092615Das BC, Nandwana NK, Das S, Nandwana V, Shareef MA, Das Y, Saito M, Weiss LM, Almaguel F, Hosmane NS, Evans T. Boron Chemicals in Drug Discovery and Development: Synthesis and Medicinal Perspective. Molecules. 2022;27(9):2615. DOI: 10.3390/molecules27092615Ri C.C., Mf C.., D R.V., T P.C., F T.C., Ir S., A A.G., Ma S.U. Boron-Containing Compounds for Prevention, Diagnosis, and Treatment of Human Metabolic Disorders // Biol Trace Elem Res. – 2023. – Vol. 201, No. 5. – P. 2222–2239. DOI: 10.1007/s12011-022-03346-9Ri CC, Mf CR, D RV, T PC, F TC, Ir S, A AG, Ma SU. Boron-Containing Compounds for Prevention, Diagnosis, and Treatment of Human Metabolic Disorders. Biol Trace Elem Res. 2023;201(5):2222–2239. DOI: 10.1007/s12011-022-03346-9Goldbach H.E., Wimmer M.A. Boron in plants and animals: Is there a role beyond cell-wall structure? // Journal of Plant Nutrition and Soil Science. – 2007. – Vol. 170, No. 1. – P. 39–48. DOI: 10.1002/jpln.200625161Goldbach HE, Wimmer MA. Boron in plants and animals: Is there a role beyond cell-wall structure? Journal of Plant Nutrition and Soil Science. 2007;170(1):39–48. DOI: 10.1002/jpln.200625161Tanaka M., Fujiwara T. Physiological roles and transport mechanisms of boron: perspectives from plants // Pflugers Arch. – 2008. – Vol. 456, No. 4. – P. 671–617. DOI: 10.1007/s00424-007-0370-8Tanaka M, Fujiwara T. Physiological roles and transport mechanisms of boron: perspectives from plants. Pflugers Arch. 2008;456(4):671–617. DOI: 10.1007/s00424-007-0370-8Kohorn B.D., Kohorn S.L., Todorova T., Baptiste G., Stansky K., McCullough M. A dominant allele of Arabidopsis pectin-binding wall-associated kinase induces a stress response suppressed by MPK6 but not MPK3 mutations // Mol Plant. – 2012. – Vol. 5, No. 4. – P. 841–851. DOI: 10.1093/mp/ssr096Kohorn BD, Kohorn SL, Todorova T, Baptiste G, Stansky K, McCullough M. A dominant allele of Arabidopsis pectin-binding wall-associated kinase induces a stress response suppressed by MPK6 but not MPK3 mutations. Mol Plant. 2012;5(4):841–851. DOI: 10.1093/mp/ssr096Matoh T., Ishigaki K., Mizutani M., Matsunaga W., Takabe K. Boron Nutrition of Cultured Tobacco BY-2 Cells: I. Requirement for and Intracellular Localization of Boron and Selection of Cells that Tolerate Low Levels of Boron // Plant Cell Physiology. – 1992. – Vol. 33, No. 8. – P. 1135–1141. DOI: 10.1093/oxfordjournals.pcp.a078365Matoh T, Ishigaki K, Mizutani M, Matsunaga W, Takabe K. Boron Nutrition of Cultured Tobacco BY-2 Cells: I. Requirement for and Intracellular Localization of Boron and Selection of Cells that Tolerate Low Levels of Boron. Plant Cell Physiology. 1992;33(8):1135–1141. DOI: 10.1093/oxfordjournals.pcp.a078365Hu H., Brown P.H. Localization of Boron in Cell Walls of Squash and Tobacco and Its Association with Pectin (Evidence for a Structural Role of Boron in the Cell Wall) // Plant Physiol. – 1994. – Vol. 105, No. 2. – P. 681–689. DOI: 10.1104/pp.105.2.681Hu H, Brown PH. Localization of Boron in Cell Walls of Squash and Tobacco and Its Association with Pectin (Evidence for a Structural Role of Boron in the Cell Wall). Plant Physiol. 1994;105(2):681–689. DOI: 10.1104/pp.105.2.681Hu H., Brown P.H., Labavitch J.M. Species variability in boron requirement is correlated with cell wall pectin // Journal of Experimental Botany. – 1996. – Vol. 47, No. 2. – P. 227–232. DOI: 10.1093/jxb/47.2.227Hu H, Brown PH, Labavitch JM. Species variability in boron requirement is correlated with cell wall pectin. Journal of Experimental Botany. 1996;47(2):227–232. DOI: 10.1093/jxb/47.2.227Sentürk N.B., Kasapoglu B., Sahin E., Ozcan O., Ozansoy M., Ozansoy M.B., Siyah P., Sezerman U., Sahin F. The Potential Role of Boron in the Modulation of Gut Microbiota Composition: An In Vivo Pilot Study // Pharmaceuticals. – 2024. – Vol. 17, No. 10. – P. 1334. DOI: 10.3390/ph17101334Sentürk NB, Kasapoglu B, Sahin E, Ozcan O, Ozansoy M, Ozansoy MB, Siyah P, Sezerman U, Sahin F. The Potential Role of Boron in the Modulation of Gut Microbiota Composition: An In Vivo Pilot Study. Pharmaceuticals. 2024;17(10):1334. DOI: 10.3390/ph17101334Rondanelli M., Faliva M.A., Peroni G., Infantino V., Gasparri C., Iannello G., Perna S., Riva A., Petrangolini G., Tartara A. Pivotal role of boron supplementation on bone health: A narrative review // J Trace Elem Med Biol. – 2020. – Vol. 62. – P. 126577. DOI: 10.1016/j.jtemb.2020.126577Rondanelli M, Faliva MA, Peroni G, Infantino V, Gasparri C, Iannello G, Perna S, Riva A, Petrangolini G, Tartara A. Pivotal role of boron supplementation on bone health: A narrative review. J Trace Elem Med Biol. 2020;62:126577. DOI: 10.1016/j.jtemb.2020.126577Vanderpool R.A., Hoff D., Johnson P.E. Use of inductively coupled plasma-mass spectrometry in boron-10 stable isotope experiments with plants, rats, and humans // Environ Health Perspect. – 1994. – Vol. 102, Suppl 7 (Suppl 7). – P. 13–20. DOI: 10.1289/ehp.94102s713Vanderpool RA, Hoff D, Johnson PE. Use of inductively coupled plasma-mass spectrometry in boron-10 stable isotope experiments with plants, rats, and humans. Environ Health Perspect. 1994;102 Suppl 7(Suppl 7):13–20. DOI: 10.1289/ehp.94102s713Nielsen F.H. Update on human health effects of boron // J Trace Elem Med Biol. – 2014. – Vol. 28, No. 4. – P. 383–387. DOI: 10.1016/j.jtemb.2014.06.023Nielsen FH. Update on human health effects of boron. J Trace Elem Med Biol. 2014;28(4):383–387. DOI: 10.1016/j.jtemb.2014.06.023Dinca L., Scorei I.R. Boron in Human Nutrition and its Regulations Use // Journal of Nutritional Therapeutics. – 2013. – Vol. 2, No. 1. – P. 22–29. DOI: 10.6000/1929-5634.2013.02.01.3Dinca L, Scorei IR. Boron in Human Nutrition and its Regulations Use. Journal of Nutritional Therapeutics. 2013;2(1):22–29. DOI: 10.6000/1929-5634.2013.02.01.3Levêque D., Carvalho M.C., Maloisel F. Review. Clinical pharmacokinetics of bortezomib // In Vivo. – 2007. – Vol. 21, No. 2. – P. 273–278.Levêque D, Carvalho MC, Maloisel F. Review. Clinical pharmacokinetics of bortezomib. In Vivo. 2007;21(2):273–278.Murray F.J. A comparative review of the pharmacokinetics of boric acid in rodents and humans // Biol Trace Elem Res. – 1998. – Vol. 66, No. 1-3. – P. 331–341. DOI: 10.1007/BF02783146Murray FJ. A comparative review of the pharmacokinetics of boric acid in rodents and humans. Biol Trace Elem Res. 1998;66(1-3):331–341. DOI: 10.1007/BF02783146Ciofani G. Potential applications of boron nitride nanotubes as drug delivery systems // Expert Opin Drug Deliv. – 2010. – Vol. 7, No. 8. – P. 889–893. DOI: 10.1517/17425247.2010.499897Ciofani G. Potential applications of boron nitride nanotubes as drug delivery systems. Expert Opin Drug Deliv. 2010;7(8):889–893. DOI: 10.1517/17425247.2010.499897Ocampo-Néstor A.L., Trujillo-Ferrara J.G., Abad-García A., Reyes-López C., Geninatti-Crich S., Soriano-Ursúa M.A. Boron's journey: advances in the study and application of pharmacokinetics // Expert Opin Ther Pat. – 2017. – Vol. 27, No. 2. – P. 203–215. DOI: 10.1080/13543776.2017.1252750Ocampo-Néstor AL, Trujillo-Ferrara JG, Abad-García A, Reyes-López C, Geninatti-Crich S, Soriano-Ursúa MA. Boron's journey: advances in the study and application of pharmacokinetics. Expert Opin Ther Pat. 2017;27(2):203–215. DOI: 10.1080/13543776.2017.1252750Samman S., Naghii M.R., Lyons Wall P.M., Verus A.P. The nutritional and metabolic effects of boron in humans and animals // Biol Trace Elem Res. – 1998. – Vol. 66, No. 1-3. – P. 227–235. DOI: 10.1007/BF02783140Samman S, Naghii MR, Lyons Wall PM, Verus AP. The nutritional and metabolic effects of boron in humans and animals. Biol Trace Elem Res. 1998;66(1-3):227–235. DOI: 10.1007/BF02783140Ku W.W., Chapin R.E., Moseman R.F., Brink R.E., Pierce K.D., Adams K.Y. Tissue disposition of boron in male Fischer rats // Toxicol Appl Pharmacol. – 1991. – Vol. 111, No. 1. – P. 145–151. DOI: 10.1016/0041-008x(91)90143-3Ku WW, Chapin RE, Moseman RF, Brink RE, Pierce KD, Adams KY. Tissue disposition of boron in male Fischer rats. Toxicol Appl Pharmacol. 1991;111(1):145–151. DOI: 10.1016/0041-008x(91)90143-3WHO (World Health Organization), 2009. Boron in Drinking-water. Background document for development of WHO Guidelines for Drinking-water Quality. World Health Organization, Geneva, Switzerland. 28 p.WHO (World Health Organization), 2009. Boron in Drinking-water. Background document for development of WHO Guidelines for Drinking-water Quality. World Health Organization, Geneva, Switzerland. 28 p.Erkeç Ö.E., Huyut Z., Yunusoğlu O., Eren B. Effects of Ghrelin on Brain and Serum Inflammatory Parameters in PTZ-Kindling Model in Rats // Neurochem J. – 2025. – Vol. 19. – P. 74–80. DOI: 10.1134/S1819712425700096Erkeç ÖE, Huyut Z, Yunusoğlu O, Eren B. Effects of Ghrelin on Brain and Serum Inflammatory Parameters in PTZ-Kindling Model in Rats. Neurochem J. 2025;19:74–80. DOI: 10.1134/S1819712425700096Bindu S., Mazumder S., Bandyopadhyay U. Non-steroidal anti-inflammatory drugs (NSAIDs) and organ damage: A current perspective // Biochem Pharmacol. – 2020. – Vol. 180. – P. 114147. DOI: 10.1016/j.bcp.2020.114147Bindu S, Mazumder S, Bandyopadhyay U. Non-steroidal anti-inflammatory drugs (NSAIDs) and organ damage: A current perspective. Biochem Pharmacol. 2020;180:114147. DOI: 10.1016/j.bcp.2020.114147Davis A., Robson J. The dangers of NSAIDs: look both ways // Br J Gen Pract. – 2016. – Vol. 66, No. 645. – P. 172–173. DOI: 10.3399/bjgp16X684433Davis A, Robson J. The dangers of NSAIDs: look both ways. Br J Gen Pract. 2016;66(645):172–173. DOI: 10.3399/bjgp16X684433Cao J., Jiang L., Zhang X., Yao X., Geng C., Xue X., Zhong L. Boric acid inhibits LPS-induced TNF-alpha formation through a thiol-dependent mechanism in THP-1 cells // J Trace Elem Med Biol. – 2008. – Vol. 22, No. 3. – P. 189–195. DOI: 10.1016/j.jtemb.2008.03.005Cao J, Jiang L, Zhang X, Yao X, Geng C, Xue X, Zhong L. Boric acid inhibits LPS-induced TNF-alpha formation through a thiol-dependent mechanism in THP-1 cells. J Trace Elem Med Biol. 2008;22(3):189–195. DOI: 10.1016/j.jtemb.2008.03.005Zhang X., Wang G., Chen S. Boric Acid Alleviates Lipopolysaccharide-Induced Acute Lung Injury in Mice // Biol Trace Elem Res. – 2025. – Vol. 203, No. 3. – P. 1494–1501. DOI: 10.1007/s12011-024-04240-2Zhang X, Wang G, Chen S. Boric Acid Alleviates Lipopolysaccharide-Induced Acute Lung Injury in Mice. Biol Trace Elem Res. 2025;203(3):1494–1501. DOI: 10.1007/s12011-024-04240-2Bozkurt S.B., Hakki S.S., Nielsen F.H. Boric acid alleviates periodontal inflammation induced by IL-1β in human gingival fibroblasts // J Trace Elem Med Biol. – 2024. – Vol. 84. – P. 127466. DOI: 10.1016/j.jtemb.2024.127466Bozkurt SB, Hakki SS, Nielsen FH. Boric acid alleviates periodontal inflammation induced by IL-1β in human gingival fibroblasts. J Trace Elem Med Biol. 2024;84:127466. DOI: 10.1016/j.jtemb.2024.127466Başeğmez M., Doğan M.F. Effects of boric acid on oxidant-antioxidant, proinflammatory cytokine levels, and biochemical parameters in aged rats // Pam Med J. – 2024. – Vol. 17, No. 2. – P. 369–379. DOI: 10.31362/patd.1438593Başeğmez M, Doğan MF. Effects of boric acid on oxidant-antioxidant, proinflammatory cytokine levels, and biochemical parameters in aged rats. Pam Med J. 2024;17(2):369–379. DOI: 10.31362/patd.1438593Gündoğdu A.Ç., Özbayer C., Kar F. Boric Acid Alleviates Gastric Ulcer by Regulating Oxidative Stress and Inflammation-Related Multiple Signaling Pathways // Biol Trace Elem Res. – 2024. – Vol. 202, No. 5. – P. 2124–2132. DOI: 10.1007/s12011-023-03817-7Gündoğdu AÇ, Özbayer C, Kar F. Boric Acid Alleviates Gastric Ulcer by Regulating Oxidative Stress and Inflammation-Related Multiple Signaling Pathways. Biol Trace Elem Res. 2024;202(5):2124–2132. DOI: 10.1007/s12011-023-03817-7Wu J.Y., Lay C.H., Chen C.C., Wu S.Y., Zhou D., Abdula P.M. Textile wastewater bioremediation using immobilized Chlorella sp. Wu-G23 with continuous culture // Clean Techn Environ Policy. – 2021. – Vol. 23. – P. 153–161. DOI: 10.1007/s10098-020-01847-6Wu J-Y, Lay C-H, Chen C-C, Wu S-Y, Zhou D, Abdula PM. Textile wastewater bioremediation using immobilized Chlorella sp. Wu-G23 with continuous culture. Clean Techn Environ Policy. 2021;23;153–161. DOI: 10.1007/s10098-020-01847-6Yamada K.E., Eckhert C.D. Boric Acid Activation of eIF2α and Nrf2 Is PERK Dependent: a Mechanism that Explains How Boron Prevents DNA Damage and Enhances Antioxidant Status // Biol Trace Elem Res. – 2019. – Vol. 188, No. 1. – P. 2–10. DOI: 10.1007/s12011-018-1498-4Yamada KE, Eckhert CD. Boric Acid Activation of eIF2α and Nrf2 Is PERK Dependent: a Mechanism that Explains How Boron Prevents DNA Damage and Enhances Antioxidant Status. Biol Trace Elem Res. 2019;188(1):2–10. DOI: 10.1007/s12011-018-1498-4Ince S., Keles H., Erdogan M., Hazman O., Kucukkurt I. Protective effect of boric acid against carbon tetrachloride-induced hepatotoxicity in mice // Drug Chem Toxicol. – 2012. – Vol. 35, No. 3. – P. 285–292. DOI: 10.3109/01480545.2011.607825Ince S, Keles H, Erdogan M, Hazman O, Kucukkurt I. Protective effect of boric acid against carbon tetrachloride-induced hepatotoxicity in mice. Drug Chem Toxicol. 2012;35(3):285–292. DOI: 10.3109/01480545.2011.607825Chen S., Fan H., Pei Y., Zhang K., Zhang F., Hu Q., Jin E., Li S. MAPK Signaling Pathway Plays Different Regulatory Roles in the Effects of Boric Acid on Proliferation, Apoptosis, and Immune Function of Splenic Lymphocytes in Rats // Biol Trace Elem Res. – 2024. – Vol. 202, No. 6. – P. 2688–2701. DOI: 10.1007/s12011-023-03862-2Chen S, Fan H, Pei Y, Zhang K, Zhang F, Hu Q, Jin E, Li S. MAPK Signaling Pathway Plays Different Regulatory Roles in the Effects of Boric Acid on Proliferation, Apoptosis, and Immune Function of Splenic Lymphocytes in Rats. Biol Trace Elem Res. 2024;202(6):2688–2701. DOI: 10.1007/s12011-023-03862-2Karabağ F., İnce S., Demirel H.H. Boric acid is associated with the suppression of apoptosis and endoplasmic reticulum stress in rat model of paracetamol -induced hepatotoxicity // Journal of Taibah University for Science. – 2023. – Vol. 17, No. 1. – P. 2250565. DOI: 10.1080/16583655.2023.2250565Karabağ F, İnce S, Demirel HH. Boric acid is associated with the suppression of apoptosis and endoplasmic reticulum stress in rat model of paracetamol -induced hepatotoxicity. Journal of Taibah University for Science. 2023;17(1):2250565. DOI: 10.1080/16583655.2023.2250565Sevimli M., Bayram D., Özgöçmen M., Armağan I., Semerci Sevimli T. Boric acid suppresses cell proliferation by TNF signaling pathway mediated apoptosis in SW-480 human colon cancer line // J Trace Elem Med Biol. – 2022. – Vol. 71. – P. 126958. DOI: 10.1016/j.jtemb.2022.126958Sevimli M, Bayram D, Özgöçmen M, Armağan I, Semerci Sevimli T. Boric acid suppresses cell proliferation by TNF signaling pathway mediated apoptosis in SW-480 human colon cancer line. J Trace Elem Med Biol. 2022;71:126958. DOI: 10.1016/j.jtemb.2022.126958Gundogdu K., Gundogdu G., Demirkaya Miloglu F., Demirci T., Tascı S.Y., Abd El-Aty A.M. Anti-Inflammatory Effects of Boric Acid in Treating Knee Osteoarthritis: Biochemical and Histopathological Evaluation in Rat Model // Biol Trace Elem Res. – 2024. – Vol. 202, No. 6. – P. 2744–2754. DOI: 10.1007/s12011-023-03872-0Gundogdu K, Gundogdu G, Demirkaya Miloglu F, Demirci T, Tascı SY, Abd El-Aty AM. Anti-Inflammatory Effects of Boric Acid in Treating Knee Osteoarthritis: Biochemical and Histopathological Evaluation in Rat Model. Biol Trace Elem Res. 2024;202(6):2744–2754. DOI: 10.1007/s12011-023-03872-0Tekeli H., Ekren Asıcı G.S., Bildik A. Anti-inflammatory effect of boric acid on cytokines in ovariectomy-induced rats // Cell Mol Biol (Noisy-le-grand). – 2022. – Vol. 67, No. 4. – P. 313–320. DOI: 10.14715/cmb/2021.67.4.35Tekeli H, Ekren Asıcı GS, Bildik A. Anti- inflammatory effect of boric acid on cytokines in ovariectomy-induced rats. Cell Mol Biol (Noisy-le-grand). 2022;67(4):313–320. DOI: 10.14715/cmb/2021.67.4.35Quintero-Rincón P., Caballero-Gallardo K., Olivero-Verbel J. Natural anticancer agents: prospection of medicinal and aromatic plants in modern chemoprevention and chemotherapy // Nat Prod Bioprospect. – 2025. – Vol. 15, No. 1. – P. 25. DOI: 10.1007/s13659-025-00511-0Quintero-Rincón P, Caballero-Gallardo K, Olivero-Verbel J. Natural anticancer agents: prospection of medicinal and aromatic plants in modern chemoprevention and chemotherapy. Nat Prod Bioprospect. 2025;15(1):25. DOI: 10.1007/s13659-025-00511-0Shahzadi A., Sonmez I., Allahverdiyev O., Onal B., Kandaz C. Cardiac Troponin-I , No. cTnI) a Biomarker of Cardiac Injuries Induced by Doxorubicin Alone and in Combination with Ciprofloxacin, Following Acute and Chronic Dose Protocol in Sprague Dawley Rats // Int J Pharmacol. – 2014. – Vol. 10, No. 5. – P. 258–266. DOI: 10.3923/ijp.2014.258.266Shahzadi A, Sonmez I, Allahverdiyev O, Onal B, Kandaz C. Cardiac Troponin-I (cTnI) a Biomarker of Cardiac Injuries Induced by Doxorubicin Alone and in Combination with Ciprofloxacin, Following Acute and Chronic Dose Protocol in Sprague Dawley Rats. Int J Pharmacol. 2014;10(5):258–266. DOI: 10.3923/ijp.2014.258.266Kahraman E., Göker E. Boric acid exert anti-cancer effect in poorly differentiated hepatocellular carcinoma cells via inhibition of AKT signaling pathway // J Trace Elem Med Biol. – 2022. – Vol. 73. – P. 127043. DOI: 10.1016/j.jtemb.2022.127043Kahraman E, Göker E. Boric acid exert anti-cancer effect in poorly differentiated hepatocellular carcinoma cells via inhibition of AKT signaling pathway. J Trace Elem Med Biol. 2022;73:127043. DOI: 10.1016/j.jtemb.2022.127043Cabus U., Secme M., Kabukcu C., Cil N., Dodurga Y., Mete G., Fenkci I.V. Boric acid as a promising agent in the treatment of ovarian cancer: Molecular mechanisms // Gene. – 2021. – Vol. 796-797. – P. 145799. DOI: 10.1016/j.gene.2021.145799Cabus U, Secme M, Kabukcu C, Cil N, Dodurga Y, Mete G, Fenkci IV. Boric acid as a promising agent in the treatment of ovarian cancer: Molecular mechanisms. Gene. 2021;796-797:145799. DOI: 10.1016/j.gene.2021.145799Çakır Gündoğdu A., Arı N.S., Höbel A., Şenol G., Eldiven Ö., Kar F. Boric Acid Exhibits Anticancer Properties in Human Endometrial Cancer Ishikawa Cells // Cureus. – 2023. – Vol. 15, No. 8. – P. e44277. DOI: 10.7759/cureus.44277Çakır Gündoğdu A, Arı NS, Höbel A, Şenol G, Eldiven Ö, Kar F. Boric Acid Exhibits Anticancer Properties in Human Endometrial Cancer Ishikawa Cells. Cureus. 2023;15(8):e44277. DOI: 10.7759/cureus.44277Bayram D., Özgöçmen M., Çelik D.A., Sarman E., Sevimli M. Does Boric Acid Inhibit Cell Proliferation on MCF-7 and MDA-MB-231 Cells in Monolayer and Spheroid Cultures by Using Apoptosis Pathways? // Biol Trace Elem Res. – 2024. – Vol. 202, No. 5. – P. 2008–2021. DOI: 10.1007/s12011-023-03810-0Bayram D, Özgöçmen M, Çelik DA, Sarman E, Sevimli M. Does Boric Acid Inhibit Cell Proliferation on MCF-7 and MDA-MB-231 Cells in Monolayer and Spheroid Cultures by Using Apoptosis Pathways? Biol Trace Elem Res. 2024;202(5):2008–2021. DOI: 10.1007/s12011-023-03810-0Aydin H.E., Gunduz M.K., Kizmazoglu C., Kandemir T., Arslantas A. Cytotoxic Effect of Boron Application on Glioblastoma Cells // Turk Neurosurg. – 2021. – Vol. 31, No. 2. – P. 206–210. DOI: 10.5137/1019-5149.JTN.30316-20.1Aydin HE, Gunduz MK, Kizmazoglu C, Kandemir T, Arslantas A. Cytotoxic Effect of Boron Application on Glioblastoma Cells. Turk Neurosurg. 2021;31(2):206–210. DOI: 10.5137/1019-5149.JTN.30316-20.1Lin S.Y., Lin C.J., Liao J.., Peir J.J., Chen W.L., Chi C.W., Lin Y.C., Liu Y.M., Chou F.I. Therapeutic efficacy for hepatocellular carcinoma by boric acid-mediated boron neutron capture therapy in a rat model // Anticancer Res. – 2013. – Vol. 33, No. 11. – P. 4799–4809.Lin SY, Lin CJ, Liao JW, Peir JJ, Chen WL, Chi CW, Lin YC, Liu YM, Chou FI. Therapeutic efficacy for hepatocellular carcinoma by boric acid-mediated boron neutron capture therapy in a rat model. Anticancer Res. 2013;33(11):4799–4809.Turkez H., Arslan M.E., Tatar A., Mardinoglu A. Promising potential of boron compounds against Glioblastoma: In Vitro antioxidant, anti-inflammatory and anticancer studies // Neurochem Int. – 2021. – Vol. 149. – P. 105137. DOI: 10.1016/j.neuint.2021.105137Turkez H, Arslan ME, Tatar A, Mardinoglu A. Promising potential of boron compounds against Glioblastoma: In Vitro antioxidant, anti-inflammatory and anticancer studies. Neurochem Int. 2021;149:105137. DOI: 10.1016/j.neuint.2021.105137Scorei R., Ciubar R., Ciofrangeanu C.M., Mitran V., Cimpean A., Iordachescu D. Comparative effects of boric acid and calcium fructoborate on breast cancer cells // Biol Trace Elem Res. – 2008. – Vol. 122, No. 3. – P. 197–205. DOI: 10.1007/s12011-007-8081-8Scorei R, Ciubar R, Ciofrangeanu CM, Mitran V, Cimpean A, Iordachescu D. Comparative effects of boric acid and calcium fructoborate on breast cancer cells. Biol Trace Elem Res. 2008;122(3):197–205. DOI: 10.1007/s12011-007-8081-8Sevimli T.S., Ghorbani A., Gakhiyeva F., Cevizlidere B.D., Sevimli M. Boric Acid Alters the Expression of DNA Double Break Repair Genes in MCF-7-Derived Breast Cancer Stem Cells // Biol Trace Elem Res. – 2024. – Vol. 202, No. 9. – P. 3980–3987. DOI: 10.1007/s12011-023-03987-4Sevimli TS, Ghorbani A, Gakhiyeva F, Cevizlidere BD, Sevimli M. Boric Acid Alters the Expression of DNA Double Break Repair Genes in MCF-7-Derived Breast Cancer Stem Cells. Biol Trace Elem Res. 2024;202(9):3980–3987. DOI: 10.1007/s12011-023-03987-4Sezekler I., Ersoz M., Turan M.A., Coskun Z.M. Investigation of the biochemical and apoptotic changes in breast cancer cells treated with leaf extract from tea (Camellia sinensis L.) grown with added boric acid // Pak J Pharm Sci. – 2020. – Vol. 33, No. 5. – P. 1927–1932.Sezekler I, Ersoz M, Turan MA, Coskun ZM. Investigation of the biochemical and apoptotic changes in breast cancer cells treated with leaf extract from tea (Camellia sinensis L.) grown with added boric acid. Pak J Pharm Sci. 2020;33(5):1927–1932.Aladağ T., Firat F. Comparative effects of boric acid and resveratrol on mcf-7 breast cancer cells metastatic behavior // International Journal of Research –Granthaalayah. – 2022. – Vol. 10, No. 1. – P. 34–46. DOI: 10.29121/granthaalayah.v10.i1.2022.4460Aladağ T, Firat F. Comparative effects of boric acid and resveratrol on mcf-7 breast cancer cells metastatic behavior. International Journal of Research –Granthaalayah. 2022;10(1):34–46. DOI: 10.29121/granthaalayah.v10.i1.2022.4460Hacioglu C., Kar F., Kacar S., Sahinturk V., Kanbak G. High Concentrations of Boric Acid Trigger Concentration-Dependent Oxidative Stress, Apoptotic Pathways and Morphological Alterations in DU-145 Human Prostate Cancer Cell Line // Biol Trace Elem Res. – 2020. – Vol. 193, No. 2. – P. 400–409. DOI: 10.1007/s12011-019-01739-xHacioglu C, Kar F, Kacar S, Sahinturk V, Kanbak G. High Concentrations of Boric Acid Trigger Concentration-Dependent Oxidative Stress, Apoptotic Pathways and Morphological Alterations in DU-145 Human Prostate Cancer Cell Line. Biol Trace Elem Res. 2020;193(2):400–409. DOI: 10.1007/s12011-019-01739-xMorana O., Wood W., Gregory C.D. The Apoptosis Paradox in Cancer // Int J Mol Sci. – 2022. – Vol. 23, No. 3. – P. 1328. DOI: 10.3390/ijms23031328Morana O, Wood W, Gregory CD. The Apoptosis Paradox in Cancer. Int J Mol Sci. 2022;23(3):1328. DOI: 10.3390/ijms23031328Hilal B., Eldem A., Oz T., Pehlivan M., Pirim I. Boric Acid Affects Cell Proliferation, Apoptosis, and Oxidative Stress in ALL Cells // Biol Trace Elem Res. – 2024. – Vol. 202, No. 8. – P. 3614–3622. DOI: 10.1007/s12011-023-03958-9Hilal B, Eldem A, Oz T, Pehlivan M, Pirim I. Boric Acid Affects Cell Proliferation, Apoptosis, and Oxidative Stress in ALL Cells. Biol Trace Elem Res. 2024;202(8):3614–3622. DOI: 10.1007/s12011-023-03958-9Cengiz M., Cetik Yildiz S., Demir C., Şahin İK., Teksoy Ö., Ayhanci A. Hepato-preventive and anti-apoptotic role of boric acid against liver injury induced by cyclophosphamide // J Trace Elem Med Biol. – 2019. – Vol. 53. – P. 1–7. DOI: 10.1016/j.jtemb.2019.01.013Cengiz M, Cetik Yildiz S, Demir C, Şahin İK, Teksoy Ö, Ayhanci A. Hepato-preventive and anti-apoptotic role of boric acid against liver injury induced by cyclophosphamide. J Trace Elem Med Biol. 2019;53:1–7. DOI: 10.1016/j.jtemb.2019.01.013Leśnikowski Z.J. Recent developments with boron as a platform for novel drug design // Expert Opin Drug Discov. – 2016. – Vol. 11, No. 6. – P. 569–578. DOI: 10.1080/17460441.2016.1174687Leśnikowski ZJ. Recent developments with boron as a platform for novel drug design. Expert Opin Drug Discov. 2016;11(6):569–578. DOI: 10.1080/17460441.2016.1174687Ali F., S Hosmane N., Zhu Y. Boron Chemistry for Medical Applications // Molecules. – 2020. – Vol. 25, No. 4. – P. 828. DOI: 10.3390/molecules25040828Ali F, S Hosmane N, Zhu Y. Boron Chemistry for Medical Applications. Molecules. 2020;25(4):828. DOI: 10.3390/molecules25040828Malouff T.D., Seneviratne D.S., Ebner D.K., Stross W.C., Waddle M.R., Trifiletti D.M., Krishnan S. Boron Neutron Capture Therapy: A Review of Clinical Applications // Front Oncol. – 2021. – Vol. 11. – P. 601820. DOI: 10.3389/fonc.2021.601820Malouff TD, Seneviratne DS, Ebner DK, Stross WC, Waddle MR, Trifiletti DM, Krishnan S. Boron Neutron Capture Therapy: A Review of Clinical Applications. Front Oncol. 2021;11:601820. DOI: 10.3389/fonc.2021.601820Nedunchezhian K., Aswath N., Thiruppathy M., Thirugnanamurthy S. Boron Neutron Capture Therapy - A Literature Review // J Clin Diagn Res. – 2016. – Vol. 10, No. 12. – P. ZE01–ZE04. DOI: 10.7860/JCDR/2016/19890.9024Nedunchezhian K, Aswath N, Thiruppathy M, Thirugnanamurthy S. Boron Neutron Capture Therapy - A Literature Review. J Clin Diagn Res. 2016;10(12):ZE01–ZE04. DOI: 10.7860/JCDR/2016/19890.9024Barth R.F., Soloway A.H., Fairchild R.G., Brugger R.M. Boron neutron capture therapy for cancer. Realities and prospects // Cancer. – 1992. – Vol. 70, No. 12. – P. 2995–3007. DOI: 10.1002/1097-0142(19921215)70:12<2995::aid-cncr2820701243>3.0.co;2-#Barth RF, Soloway AH, Fairchild RG, Brugger RM. Boron neutron capture therapy for cancer. Realities and prospects. Cancer. 1992;70(12):2995–3007. DOI: 10.1002/1097-0142(19921215)70:12<2995::aid-cncr2820701243>3.0.co;2-#Sauerwein W.A.G., Sancey L., Hey-Hawkins E., Kellert M., Panza L., Imperio D., Balcerzyk M., Rizzo G., Scalco E., Herrmann K., Mauri P., De Palma A., Wittig A. Theranostics in Boron Neutron Capture Therapy // Life (Basel). – 2021. – Vol. 11, No. 4. – P. 330. DOI: 10.3390/life11040330Sauerwein WAG, Sancey L, Hey-Hawkins E, Kellert M, Panza L, Imperio D, Balcerzyk M, Rizzo G, Scalco E, Herrmann K, Mauri P, De Palma A, Wittig A. Theranostics in Boron Neutron Capture Therapy. Life (Basel). 2021;11(4):330. DOI: 10.3390/life11040330Barth R.F., Zhang Z., Liu T. A realistic appraisal of boron neutron capture therapy as a cancer treatment modality // Cancer Commun (Lond). – 2018. – Vol. 38, No. 1. – P. 36. DOI: 10.1186/s40880-018-0280-5Barth RF, Zhang Z, Liu T. A realistic appraisal of boron neutron capture therapy as a cancer treatment modality. Cancer Commun (Lond). 2018;38(1):36. DOI: 10.1186/s40880-018-0280-5Miyatake S.I., Kawabata S., Hiramatsu R., Kuroiwa T., Suzuki M., Ono K. Boron Neutron Capture Therapy of Malignant Gliomas // Prog Neurol Surg. – 2018. – Vol. 32. – P. 48–56. DOI: 10.1159/000469679Miyatake SI, Kawabata S, Hiramatsu R, Kuroiwa T, Suzuki M, Ono K. Boron Neutron Capture Therapy of Malignant Gliomas. Prog Neurol Surg. 2018;32:48–56. DOI: 10.1159/000469679Yanagie H., Higashi S., Seguchi K., Ikushima I., Fujihara M., Nonaka Y., Oyama K., Maruyama S., Hatae R., Suzuki M., Masunaga S., Kinashi T., Sakurai Y., Tanaka H., Kondo N., Narabayashi M., Kajiyama T., Maruhashi A., Ono K., Nakajima J., Ono M., Takahashi H., Eriguchi M. Pilot clinical study of boron neutron capture therapy for recurrent hepatic cancer involving the intra-arterial injection of a (10)BSH-containing WOW emulsion // Appl Radiat Isot. – 2014. – Vol. 88. – P. 32–37. DOI: 10.1016/j.apradiso.2014.01.014Yanagie H, Higashi S, Seguchi K, Ikushima I, Fujihara M, Nonaka Y, Oyama K, Maruyama S, Hatae R, Suzuki M, Masunaga S, Kinashi T, Sakurai Y, Tanaka H, Kondo N, Narabayashi M, Kajiyama T, Maruhashi A, Ono K, Nakajima J, Ono M, Takahashi H, Eriguchi M. Pilot clinical study of boron neutron capture therapy for recurrent hepatic cancer involving the intra-arterial injection of a (10)BSH-containing WOW emulsion. Appl Radiat Isot. 2014;88:32–37. DOI: 10.1016/j.apradiso.2014.01.014Koivunoro H., Kankaanranta L., Seppälä T., Haapaniemi A., Mäkitie A., Joensuu H. Boron neutron capture therapy for locally recurrent head and neck squamous cell carcinoma: An analysis of dose response and survival // Radiother Oncol. – 2019. – Vol. 137. – P. 153–158. DOI: 10.1016/j.radonc.2019.04.033Koivunoro H, Kankaanranta L, Seppälä T, Haapaniemi A, Mäkitie A, Joensuu H. Boron neutron capture therapy for locally recurrent head and neck squamous cell carcinoma: An analysis of dose response and survival. Radiother Oncol. 2019;137:153–158. DOI: 10.1016/j.radonc.2019.04.033Cammarata F.P., Torrisi F., Vicario N., Bravatà V., Stefano A., Salvatorelli L., D'Aprile S., Giustetto P., Forte G.I., Minafra L., Calvaruso M., Richiusa S., Cirrone G.A.P., Petringa G., Broggi G., Cosentino S., Scopelliti F., Magro G., Porro D., Libra M., Ippolito M., Russo G., Parenti R., Cuttone G. Proton boron capture therapy (PBCT) induces cell death and mitophagy in a heterotopic glioblastoma model // Commun Biol. – 2023. – Vol. 6, No. 1. – P. 388. DOI: 10.1038/s42003-023-04770-wCammarata FP, Torrisi F, Vicario N, Bravatà V, Stefano A, Salvatorelli L, D'Aprile S, Giustetto P, Forte GI, Minafra L, Calvaruso M, Richiusa S, Cirrone GAP, Petringa G, Broggi G, Cosentino S, Scopelliti F, Magro G, Porro D, Libra M, Ippolito M, Russo G, Parenti R, Cuttone G. Proton boron capture therapy (PBCT) induces cell death and mitophagy in a heterotopic glioblastoma model. Commun Biol. 2023;6(1):388. DOI: 10.1038/s42003-023-04770-wCirrone G.A.P., Manti L., Margarone D., Petringa G., Giuffrida L., Minopoli A., Picciotto A., Russo G., Cammarata F., Pisciotta P., Perozziello F.M., Romano F., Marchese V., Milluzzo G., Scuderi V., Cuttone G., Korn G. First experimental proof of Proton Boron Capture Therapy (PBCT) to enhance protontherapy effectiveness // Sci Rep. – 2018. – Vol. 8, No. 1. – P. 1141. DOI: 10.1038/s41598-018-19258-5Cirrone GAP, Manti L, Margarone D, Petringa G, Giuffrida L, Minopoli A, Picciotto A, Russo G, Cammarata F, Pisciotta P, Perozziello FM, Romano F, Marchese V, Milluzzo G, Scuderi V, Cuttone G, Korn G. First experimental proof of Proton Boron Capture Therapy (PBCT) to enhance protontherapy effectiveness. Sci Rep. 2018;8(1):1141. DOI: 10.1038/s41598-018-19258-5Tran N.H., Shtam T., Marchenko Y.Y., Konevega A.L., Lebedev D. Current State and Prospectives for Proton Boron Capture Therapy // Biomedicines. – 2023. – Vol. 11, No. 6. – P. 1727. DOI: 10.3390/biomedicines11061727Tran NH, Shtam T, Marchenko YY, Konevega AL, Lebedev D. Current State and Prospectives for Proton Boron Capture Therapy. Biomedicines. 2023;11(6):1727. DOI: 10.3390/biomedicines11061727Bláha P., Feoli C., Agosteo S., Calvaruso M., Cammarata F.P., Catalano R., Ciocca M., Cirrone G.A.P., Conte V., Cuttone G., Facoetti A., Forte GI., Giuffrida L., Magro G., Margarone D., Minafra L., Petringa G., Pucci G., Ricciardi V., Rosa E., Russo G., Manti L. The Proton-Boron Reaction Increases the Radiobiological Effectiveness of Clinical Low- and High-Energy Proton Beams: Novel Experimental Evidence and Perspectives // Front Oncol. – 2021. – Vol. 11. – P. 682647. DOI: 10.3389/fonc.2021.682647Bláha P, Feoli C, Agosteo S, Calvaruso M, Cammarata FP, Catalano R, Ciocca M, Cirrone GAP, Conte V, Cuttone G, Facoetti A, Forte GI, Giuffrida L, Magro G, Margarone D, Minafra L, Petringa G, Pucci G, Ricciardi V, Rosa E, Russo G, Manti L. The Proton-Boron Reaction Increases the Radiobiological Effectiveness of Clinical Low- and High-Energy Proton Beams: Novel Experimental Evidence and Perspectives. Front Oncol. 2021;11:682647. DOI: 10.3389/fonc.2021.682647Ricciardi V., Bláha P., Buompane R., Crescente G., Cuttone G., Gialanella L., Michaličková K., Pacifico S., Porzio G., Manti L. A New Low-Energy Proton Irradiation Facility to Unveil the Mechanistic Basis of the Proton-Boron Capture Therapy Approach // Applied Sciences. – 2021. – Vol. 11, No. 24. – P. 11986. DOI: 10.3390/app112411986Ricciardi V, Bláha P, Buompane R, Crescente G, Cuttone G, Gialanella L, Michaličková K, Pacifico S, Porzio G, Manti L. A New Low-Energy Proton Irradiation Facility to Unveil the Mechanistic Basis of the Proton-Boron Capture Therapy Approach. Applied Sciences. 2021;11(24):11986. DOI: 10.3390/app112411986Jelínek Michaelidesová A., Kundrát P., Zahradníček O., Danilová I., Pachnerová Brabcová K., Vachelová J., Vilimovský J., David M., Vondráček V., Davídková M. First independent validation of the proton-boron capture therapy concept // Sci Rep. – 2024. – Vol. 14, No. 1. – P. 19264. DOI: 10.1038/s41598-024-69370-yJelínek Michaelidesová A, Kundrát P, Zahradníček O, Danilová I, Pachnerová Brabcová K, Vachelová J, Vilimovský J, David M, Vondráček V, Davídková M. First independent validation of the proton-boron capture therapy concept. Sci Rep. 2024;14(1):19264. DOI: 10.1038/s41598-024-69370-ySamoilov A.V., Ivakin V.A., Rumyantseva T.A., Galanin N.E. Synthesis and Photophysical Properties of a Binuclear Symmetrical Analog of BODIPY with Unconjugated Fluorophores // Russ J Gen Chem. – 2024. – Vol. 94. – P. 2824–2832. DOI: 10.1134/S1070363224110021Samoilov AV, Ivakin VA, Rumyantseva TA, Galanin NE. Synthesis and Photophysical Properties of a Binuclear Symmetrical Analog of BODIPY with Unconjugated Fluorophores. Russ J Gen Chem. 2024;94:2824–2832. DOI: 10.1134/S1070363224110021Spector V., Abramchuk D.S., Bykusov V.V., Zharova A.O., Egorova E.S., Voskresenskaya A.S., Olovyanishnikov A.R., Kuzmichev I.A., Bubley A.A., Antipin R.L., Beloglazkina E.K., Krasnovskaya O.O. BODIPY: synthesis, modification, and applications in sensing and biomedicine // Russ Chem Rev. – 2024. – Vol. 93, No. 10. – P. RCR5136. DOI: 10.59761/RCR5136. Spector V, Abramchuk DS, Bykusov VV, Zharova AO, Egorova ES, Voskresenskaya AS, Olovyanishnikov AR, Kuzmichev IA, Bubley AA, Antipin RL, Beloglazkina EK, Krasnovskaya OO. BODIPY: synthesis, modification, and applications in sensing and biomedicine. Russ Chem Rev. 2024;93(10):RCR5136. DOI: 10.59761/RCR5136Aleksakhina E.L., Ivanova A.S., Pakhrova O.A., Tomilova I.K., Usoltsev S.D., Marfin Yu.S. BODIPY Fluorophores for Evaluating Coagulation Hemostasis Kinetics in Physiological and Pathological States // Russ J Gen Chem. – 2024. – Vol. 94. – P. 1855–1860. DOI: 10.1134/S1070363224070296Aleksakhina EL, Ivanova AS, Pakhrova OA, Tomilova IK, Usoltsev SD, Marfin YuS. BODIPY Fluorophores for Evaluating Coagulation Hemostasis Kinetics in Physiological and Pathological States. Russ J Gen Chem. 2024;94:1855–1860. DOI: 10.1134/S1070363224070296Franke J.M., Raliski B.K., Boggess S.C., Natesan D.V., Koretsky E.T., Zhang P., Kulkarni R.U., Deal P.E., Miller E.W. BODIPY Fluorophores for Membrane Potential Imaging // J Am Chem Soc. – 2019. – Vol. 141, No. 32. – P. 12824–12831. DOI: 10.1021/jacs.9b05912Franke JM, Raliski BK, Boggess SC, Natesan DV, Koretsky ET, Zhang P, Kulkarni RU, Deal PE, Miller EW. BODIPY Fluorophores for Membrane Potential Imaging. J Am Chem Soc. 2019;141(32):12824–12831. DOI: 10.1021/jacs.9b05912Antina E., Bumagina N., Marfin Y., Guseva G., Nikitina L., Sbytov D., Telegin F. BODIPY Conjugates as Functional Compounds for Medical Diagnostics and Treatment // Molecules. – 2022. – Vol. 27, No. 4. – P. 1396. DOI: 10.3390/molecules27041396Antina E, Bumagina N, Marfin Y, Guseva G, Nikitina L, Sbytov D, Telegin F. BODIPY Conjugates as Functional Compounds for Medical Diagnostics and Treatment. Molecules. 2022;27(4):1396. DOI: 10.3390/molecules27041396Loudet A., Burgess K. BODIPY dyes and their derivatives: syntheses and spectroscopic properties // Chem Rev. – 2007. – Vol. 107, No. 11. – P. 4891–4932. DOI: 10.1021/cr078381nLoudet A, Burgess K. BODIPY dyes and their derivatives: syntheses and spectroscopic properties. Chem Rev. 2007;107(11):4891–4932. DOI: 10.1021/cr078381nJang Y., Kim T.I., Kim H., Choi Y., Kim Y. Photoactivatable BODIPY Platform: Light-Triggered Anticancer Drug Release and Fluorescence Monitoring // ACS Appl Bio Mater. – 2019. – Vol. 2, No. 6. – P. 2567–2572. DOI: 10.1021/acsabm.9b00259Jang Y, Kim TI, Kim H, Choi Y, Kim Y. Photoactivatable BODIPY Platform: Light-Triggered Anticancer Drug Release and Fluorescence Monitoring. ACS Appl Bio Mater. 2019;2(6):2567–2572. DOI: 10.1021/acsabm.9b00259Wang R., Dong K., Xu G., Shi B., Zhu T., Shi P., Guo Z., Zhu W.H., Zhao C. Activatable near-infrared emission-guided on-demand administration of photodynamic anticancer therapy with a theranostic nanoprobe // Chem Sci. – 2019. – Vol. 10, No. 9. – P. 2785–2790. DOI: 10.1039/c8sc04854aWang R, Dong K, Xu G, Shi B, Zhu T, Shi P, Guo Z, Zhu WH, Zhao C. Activatable near-infrared emission-guided on-demand administration of photodynamic anticancer therapy with a theranostic nanoprobe. Chem Sci. 2019;10(9):2785–2790. DOI: 10.1039/c8sc04854aMao Z., Kim J.H., Lee J., Xiong H., Zhang F., Kim J.S. Engineering of BODIPY-based theranostics for cancer therapy // Coordination Chemistry Reviews. – 2023. – Vol. 476. – P. 214908. DOI: 10.1016/j.ccr.2022.214908Mao Z, Kim JH, Lee J, Xiong H, Zhang F, Kim JS. Engineering of BODIPY-based theranostics for cancer therapy. Coordination Chemistry Reviews. 2023;476:214908. DOI: 10.1016/j.ccr.2022.214908Zhang J.B., Tong J., Sun D.Y., Fu J.T., Li D.J., Wang P. Targeting ferroptosis in cardio-metabolic-diseases: Mechanisms and therapeutic prospects // Med Res Rev. – 2023. – Vol. 43, No. 3. – P. 683–712. DOI: 10.1002/med.21934Zhang JB, Tong J, Sun DY, Fu JT, Li DJ, Wang P. Targeting ferroptosis in cardio-metabolic-diseases: Mechanisms and therapeutic prospects. Med Res Rev. 2023;43(3):683–712. DOI: 10.1002/med.21934Saraev D.D., Pratt D.A. Reactions of lipid hydroperoxides and how they may contribute to ferroptosis sensitivity // Curr Opin Chem Biol. – 2024. – Vol. 81. – P. 102478. DOI: 10.1016/j.cbpa.2024.102478Saraev DD, Pratt DA. Reactions of lipid hydroperoxides and how they may contribute to ferroptosis sensitivity. Curr Opin Chem Biol. 2024;81:102478. DOI: 10.1016/j.cbpa.2024.102478Jiang X., Stockwell B.R., Conrad M. Ferroptosis: mechanisms, biology and role in disease // Nat Rev Mol Cell Biol. – 2021. – Vol. 22, No. 4. – P. 266–282. DOI: 10.1038/s41580-020-00324-8Jiang X, Stockwell BR, Conrad M. Ferroptosis: mechanisms, biology and role in disease. Nat Rev Mol Cell Biol. 2021;22(4):266–282. DOI: 10.1038/s41580-020-00324-8Feng S., Tang D., Wang Y., Li X., Bao H., Tang C., Dong X., Li X., Yang Q., Yan Y., Yin Z., Shang T., Zheng K., Huang X., Wei Z., Wang K., Qi S. The mechanism of ferroptosis and its related diseases // Mol Biomed. – 2023. – Vol. 4, No. 1. – P. 33. DOI: 10.1186/s43556-023-00142-2Feng S, Tang D, Wang Y, Li X, Bao H, Tang C, Dong X, Li X, Yang Q, Yan Y, Yin Z, Shang T, Zheng K, Huang X, Wei Z, Wang K, Qi S. The mechanism of ferroptosis and its related diseases. Mol Biomed. 2023;4(1):33. DOI: 10.1186/s43556-023-00142-2Maru D., Hothi A., Bagariya C., Kumar A. Targeting Ferroptosis Pathways: A Novel Strategy for Cancer Therapy // Curr Cancer Drug Targets. – 2022. – Vol. 22, No. 3. – P. 234–244. DOI: 10.2174/1568009622666220211122745Maru D, Hothi A, Bagariya C, Kumar A. Targeting Ferroptosis Pathways: A Novel Strategy for Cancer Therapy. Curr Cancer Drug Targets. 2022;22(3):234–244. DOI: 10.2174/1568009622666220211122745Qi X., Wan Z., Jiang B., Ouyang Y., Feng W., Zhu H., Tan Y., He R., Xie L., Li Y. Inducing ferroptosis has the potential to overcome therapy resistance in breast cancer // Front Immunol. – 2022. – Vol. 13. – P. 1038225. DOI: 10.3389/fimmu.2022.1038225Qi X, Wan Z, Jiang B, Ouyang Y, Feng W, Zhu H, Tan Y, He R, Xie L, Li Y. Inducing ferroptosis has the potential to overcome therapy resistance in breast cancer. Front Immunol. 2022;13:1038225. DOI: 10.3389/fimmu.2022.1038225Kar F., Hacioğlu C., Kaçar S. The dual role of boron in vitro neurotoxication of glioblastoma cells via SEMA3F/NRP2 and ferroptosis signaling pathways // Environ Toxicol. – 2023. – Vol. 38, No. 1. – P. 70–77. DOI: 10.1002/tox.23662Kar F, Hacioğlu C, Kaçar S. The dual role of boron in vitro neurotoxication of glioblastoma cells via SEMA3F/NRP2 and ferroptosis signaling pathways. Environ Toxicol. 2023;38(1):70–77. DOI: 10.1002/tox.23662Li X., Wang X., Zhang J., Hanagata N., Wang X., Weng Q., Ito A., Bando Y., Golberg D. Hollow boron nitride nanospheres as boron reservoir for prostate cancer treatment // Nat Commun. – 2017. – Vol. 8. – P. 13936. DOI: 10.1038/ncomms13936Li X, Wang X, Zhang J, Hanagata N, Wang X, Weng Q, Ito A, Bando Y, Golberg D. Hollow boron nitride nanospheres as boron reservoir for prostate cancer treatment. Nat Commun. 2017;8:13936. DOI: 10.1038/ncomms13936Corti A., Dominici S., Piaggi S., Pompella A. Enhancement of ferroptosis by boric acid and its potential use as chemosensitizer in anticancer chemotherapy // Biofactors. – 2023. – Vol. 49, No. 2. – P. 405–414. DOI: 10.1002/biof.1919Corti A, Dominici S, Piaggi S, Pompella A. Enhancement of ferroptosis by boric acid and its potential use as chemosensitizer in anticancer chemotherapy. Biofactors. 2023;49(2):405–414. DOI: 10.1002/biof.1919Hammond Quarcoo F., Appiah Kusi G., Fouemina C.N.J. Nanoparticle-induced Ferroptosis for Cancer Therapy // International Journal of Biological, Physical and Chemical Studies. – 2022. – Vol. 4, No. 2. – P. 30–42. DOI: 10.32996/ijbpcs.2022.4.2.4Hammond Quarcoo F, Appiah Kusi G, Fouemina CNJ. Nanoparticle-induced Ferroptosis for Cancer Therapy. International Journal of Biological, Physical and Chemical Studies. 2022;4(2):30–42. DOI: 10.32996/ijbpcs.2022.4.2.4Arfin S., Jha N.K., Jha S.K., Kesari K.K., Ruokolainen J., Roychoudhury S., Rathi B., Kumar D. Oxidative Stress in Cancer Cell Metabolism // Antioxidants (Basel). – 2021. – Vol. 10, No. 5. – P. 642. DOI: 10.3390/antiox10050642Arfin S, Jha NK, Jha SK, Kesari KK, Ruokolainen J, Roychoudhury S, Rathi B, Kumar D. Oxidative Stress in Cancer Cell Metabolism. Antioxidants (Basel). 2021;10(5):642. DOI: 10.3390/antiox10050642Hunt C.D., Idso J.P. Dietary boron as a physiological regulator of the normal inflammatory response: A review and current research progress // J Trace Elem Exp Med. – 1999. – Vol. 12. – P. 221–233. DOI: 10.1002/(SICI)1520-670X(1999)12:3<221::AID-JTRA6>3.0.CO;2-XHunt CD, Idso JP. Dietary boron as a physiological regulator of the normal inflammatory response: A review and current research progress. J Trace Elem Exp Med. 1999;12:221–233. DOI: 10.1002/(SICI)1520-670X(1999)12:3<221::AID-JTRA6>3.0.CO;2-XPaties Montagner G., Dominici S., Piaggi S., Pompella A., Corti A. Redox Mechanisms Underlying the Cytostatic Effects of Boric Acid on Cancer Cells—An Issue Still Open // Antioxidants. – 2023. – Vol. 12, No. 6. – P. 1302. DOI: 10.3390/antiox12061302Paties Montagner G, Dominici S, Piaggi S, Pompella A, Corti A. Redox Mechanisms Underlying the Cytostatic Effects of Boric Acid on Cancer Cells—An Issue Still Open. Antioxidants. 2023;12(6):1302. DOI: 10.3390/antiox12061302Ke K., Li L., Lu C., Zhu Q., Wang Y., Mou Y., Wang H., Jin W. The crosstalk effect between ferrous and other ions metabolism in ferroptosis for therapy of cancer // Front Oncol. – 2022. – Vol. 12. – P. 916082. DOI: 10.3389/fonc.2022.916082Ke K, Li L, Lu C, Zhu Q, Wang Y, Mou Y, Wang H, Jin W. The crosstalk effect between ferrous and other ions metabolism in ferroptosis for therapy of cancer. Front Oncol. 2022;12:916082. DOI: 10.3389/fonc.2022.916082Forman H.J., Zhang H. Targeting oxidative stress in disease: promise and limitations of antioxidant therapy // Nat Rev Drug Discov. – 2021. – Vol. 20, No. 9. – P. 689–709. DOI: 10.1038/s41573-021-00233-1. Erratum in: Nat Rev Drug Discov. – 2021. – Vol. 20, No. 8. – P. 652. DOI: 10.1038/s41573-021-00267-5Forman HJ, Zhang H. Targeting oxidative stress in disease: promise and limitations of antioxidant therapy. Nat Rev Drug Discov. 2021;20(9):689–709. DOI: 10.1038/s41573-021-00233-1. Erratum in: Nat Rev Drug Discov. 2021;20(8):652. DOI: 10.1038/s41573-021-00267-5Ageeva N.M., Markosov V.A., Muzychenko G.F., Bessonov V.V., Khanferyan R.A. Antioxidant and antiradical properties of red grape wines // Problems of Nutrition. – 2015. – Vol. 84, No. 2. – P. 63–67. EDN: XCEXGBAgeeva NM, Markosov VA, Muzychenko GF, Bessonov VV, Khanferyan RA. Antioxidant and antiradical properties of red grape wines. Problems of Nutrition. 2015;84(2):63–67. EDN: XCEXGBLiu Z., Ren Z., Zhang J., Chuang C.C., Kandaswamy E., Zhou T., Zuo L. Role of ROS and Nutritional Antioxidants in Human Diseases // Front Physiol. – 2018. – Vol. 9. – P. 477. DOI: 10.3389/fphys.2018.00477Liu Z, Ren Z, Zhang J, Chuang CC, Kandaswamy E, Zhou T, Zuo L. Role of ROS and Nutritional Antioxidants in Human Diseases. Front Physiol. 2018;9:477. DOI: 10.3389/fphys.2018.00477Yunusoğlu O., Ayaz İ., Dovankaya E.H. Pharmacological, medicinal and biological properties of flavonoids: A comprehensive review // Journal of Research in Pharmacy. – 2025. – Vol. 29, No. 2. – P. 561–584. DOI: 10.12991/jrespharm.1661054Yunusoğlu O, Ayaz İ, Dovankaya EH. Pharmacological, medicinal and biological properties of flavonoids: A comprehensive review. Journal of Research in Pharmacy. 2025;29(2):561–584. DOI: 10.12991/jrespharm.1661054Misrani A., Tabassum S., Yang L. Mitochondrial Dysfunction and Oxidative Stress in Alzheimer's Disease // Front Aging Neurosci. – 2021. – Vol. 13. – P. 617588. DOI: 10.3389/fnagi.2021.617588Misrani A, Tabassum S, Yang L. Mitochondrial Dysfunction and Oxidative Stress in Alzheimer's Disease. Front Aging Neurosci. 2021;13:617588. DOI: 10.3389/fnagi.2021.617588Riaz M., Yan L., Wu X., Hussain S., Aziz O., Wang Y., Imran M., Jiang C. Boron alleviates the aluminum toxicity in trifoliate orange by regulating antioxidant defense system and reducing root cell injury // J Environ Manage. – 2018. – Vol. 208. – P. 149–158. DOI: 10.1016/j.jenvman.2017.12.008Riaz M, Yan L, Wu X, Hussain S, Aziz O, Wang Y, Imran M, Jiang C. Boron alleviates the aluminum toxicity in trifoliate orange by regulating antioxidant defense system and reducing root cell injury. J Environ Manage. 2018;208:149–158. DOI: 10.1016/j.jenvman.2017.12.008Jackson D.G., Cardwell L.A., Oussedik E., Feldman S.R. Utility of boron in dermatology // J Dermatolog Treat. – 2020. – Vol. 31, No. 1. – P. 2–12. DOI: 10.1080/09546634.2017.1363850Jackson DG, Cardwell LA, Oussedik E, Feldman SR. Utility of boron in dermatology. J Dermatolog Treat. 2020;31(1):2–12. DOI: 10.1080/09546634.2017.1363850Turkez H., Yıldırım S., Sahin E., Arslan M.E., Emsen B., Tozlu O.O., Alak G., Ucar A., Tatar A., Hacimuftuoglu A., Keles M.S., Geyikoglu F., Atamanalp M., Saruhan F., Mardinoglu A. Boron Compounds Exhibit Protective Effects against Aluminum-Induced Neurotoxicity and Genotoxicity: In Vitro and In Vivo Study // Toxics. – 2022. – Vol. 10, No. 8. – P. 428. DOI: 10.3390/toxics10080428Turkez H, Yıldırım S, Sahin E, Arslan ME, Emsen B, Tozlu OO, Alak G, Ucar A, Tatar A, Hacimuftuoglu A, Keles MS, Geyikoglu F, Atamanalp M, Saruhan F, Mardinoglu A. Boron Compounds Exhibit Protective Effects against Aluminum-Induced Neurotoxicity and Genotoxicity: In Vitro and In Vivo Study. Toxics. 2022;10(8):428. DOI: 10.3390/toxics10080428Arslan-Acaroz D., Bayşu-Sozbilir N. Ameliorative effect of boric acid against formaldehyde-induced oxidative stress in A549 cell lines // Environ Sci Pollut Res Int. – 2020. – Vol. 27, No. 4. – P. 4067–4074. DOI: 10.1007/s11356-019-06986-yArslan-Acaroz D, Bayşu-Sozbilir N. Ameliorative effect of boric acid against formaldehyde-induced oxidative stress in A549 cell lines. Environ Sci Pollut Res Int. 2020;27(4):4067–4074. DOI: 10.1007/s11356-019-06986-ySogut I., Oglakci A., Kartkaya K., Ol K.K., Sogut M.S., Kanbak G., Inal M.E. Effect of boric acid on oxidative stress in rats with fetal alcohol syndrome // Exp Ther Med. – 2015. – Vol. 9, No. 3. – P. 1023–1027. DOI: 10.3892/etm.2014.2164Sogut I, Oglakci A, Kartkaya K, Ol KK, Sogut MS, Kanbak G, Inal ME. Effect of boric acid on oxidative stress in rats with fetal alcohol syndrome. Exp Ther Med. 2015;9(3):1023–1027. DOI: 10.3892/etm.2014.2164Gündüz M.K., Bolat M., Kaymak G., Berikten D., Köse DA. Therapeutic Effects of Newly Synthesized Boron Compounds (BGM and BGD) on Hepatocellular Carcinoma // Biol Trace Elem Res. – 2022. – Vol. 200, No. 1. – P. 134–146. DOI: 10.1007/s12011-021-02647-9Gündüz MK, Bolat M, Kaymak G, Berikten D, Köse DA. Therapeutic Effects of Newly Synthesized Boron Compounds (BGM and BGD) on Hepatocellular Carcinoma. Biol Trace Elem Res. 2022;200(1):134–146. DOI: 10.1007/s12011-021-02647-9Ince S., Kucukkurt I., Demirel H.H., Acaroz D.A., Akbel E., Cigerci I.H. Protective effects of boron on cyclophosphamide induced lipid peroxidation and genotoxicity in rats // Chemosphere. – 2014. – Vol. 108. – P. 197–204. DOI: 10.1016/j.chemosphere.2014.01.038Ince S, Kucukkurt I, Demirel HH, Acaroz DA, Akbel E, Cigerci IH. Protective effects of boron on cyclophosphamide induced lipid peroxidation and genotoxicity in rats. Chemosphere. 2014;108:197–204. DOI: 10.1016/j.chemosphere.2014.01.038Kucukkurt I., Ince S., Demirel H.H., Turkmen R., Akbel E., Celik Y. The Effects of Boron on Arsenic-Induced Lipid Peroxidation and Antioxidant Status in Male and Female Rats // J Biochem Mol Toxicol. – 2015. – Vol. 29, No. 12. – P. 564–571. DOI: 10.1002/jbt.21729Kucukkurt I, Ince S, Demirel HH, Turkmen R, Akbel E, Celik Y. The Effects of Boron on Arsenic-Induced Lipid Peroxidation and Antioxidant Status in Male and Female Rats. J Biochem Mol Toxicol. 2015;29(12):564–571. DOI: 10.1002/jbt.21729Kızılay Z., Erken H.A., Çetin N.K., Aktaş S., Abas B.İ., Yılmaz A. Boric acid reduces axonal and myelin damage in experimental sciatic nerve injury // Neural Regen Res. – 2016. – Vol. 11, No. 10. – P. 1660–1665. DOI: 10.4103/1673-5374.193247Kızılay Z, Erken HA, Çetin NK, Aktaş S, Abas Bİ, Yılmaz A. Boric acid reduces axonal and myelin damage in experimental sciatic nerve injury. Neural Regen Res. 2016;11(10):1660–1665. DOI: 10.4103/1673-5374.193247Frei A., Verderosa A.D., Elliott A.G., Zuegg J., Blaskovich M.A.T. Metals to combat antimicrobial resistance // Nat Rev Chem. – 2023. – Vol. 7, No. 3. – P. 202–224. DOI: 10.1038/s41570-023-00463-4Frei A, Verderosa AD, Elliott AG, Zuegg J, Blaskovich MAT. Metals to combat antimicrobial resistance. Nat Rev Chem. 2023;7(3):202–224. DOI: 10.1038/s41570-023-00463-4Hu Z.X., Zhang J., Zhang T., Tian C.Y., An Q., Yi P., Yuan C.M., Zhang Z.K., Zhao L.H., Hao X.J. Aloperine-Type Alkaloids with Antiviral and Antifungal Activities from the Seeds of Sophora alopecuroides L. // J Agric Food Chem. – 2024. – Vol. 72, No. 14. – P. 8225–8236. DOI: 10.1021/acs.jafc.4c00992Hu ZX, Zhang J, Zhang T, Tian CY, An Q, Yi P, Yuan CM, Zhang ZK, Zhao LH, Hao XJ. Aloperine-Type Alkaloids with Antiviral and Antifungal Activities from the Seeds of Sophora alopecuroides L. J Agric Food Chem. 2024;72(14):8225–8236. DOI: 10.1021/acs.jafc.4c00992Sayin Z., Ucan U.S., Sakmanoglu A. Antibacterial and Antibiofilm Effects of Boron on Different Bacteria // Biol Trace Elem Res. – 2016. – Vol. 173, No. 1. – P. 241–246. DOI: 10.1007/s12011-016-0637-zSayin Z, Ucan US, Sakmanoglu A. Antibacterial and Antibiofilm Effects of Boron on Different Bacteria. Biol Trace Elem Res. 2016;173(1):241–246. DOI: 10.1007/s12011-016-0637-zCelebı D., Celebı O., Aydin E., Baser S., Güler M.C., Yildirim S., Taghizadehghalehjoughi A. Boron Compound-Based Treatments Against Multidrug-Resistant Bacterial Infections in Lung Cancer In Vitro Model // Biol Trace Elem Res. – 2024. – Vol. 202, No. 1. – P. 145–160. DOI: 10.1007/s12011-023-03912-9Celebı D, Celebı O, Aydin E, Baser S, Güler MC, Yildirim S, Taghizadehghalehjoughi A. Boron Compound-Based Treatments Against Multidrug-Resistant Bacterial Infections in Lung Cancer In Vitro Model. Biol Trace Elem Res. 2024;202(1):145–160. DOI: 10.1007/s12011-023-03912-9Uzun Yaylacı E. Antibacterial Effects of Boric Acid Against Aquatic Pathogens // Journal of Anatolian Environmental and Animal Sciences. – 2021. – Vol. 6, No. 2. – P. 240–244. DOI: 10.35229/jaes.881144Uzun Yaylacı E. Antibacterial Effects of Boric Acid Against Aquatic Pathogens. Journal of Anatolian Environmental and Animal Sciences. 2021;6(2):240–244. DOI: 10.35229/jaes.881144Hernandez-Patlan D., Solis-Cruz B., Latorre J.D., Maguey-Gonzalez J.A., Castellanos-Huerta I., Beyssac E., Garrait G., Vázquez-Durán A., López-Arellano R., Méndez-Albores A., Hargis B.M., Tellez-Isaias G. Evaluation of the Antimicrobial Activity of a Formulation Containing Ascorbic Acid and Eudragit FS 30D Microparticles for the Controlled Release of a Curcumin-Boric Acid Solid Dispersion in Turkey Poults Infected with Salmonella enteritidis: A Therapeutic Model // Int J Mol Sci. 2023;24(22):16186. DOI: 10.3390/ijms242216186Hernandez-Patlan D, Solis-Cruz B, Latorre JD, Maguey-Gonzalez JA, Castellanos-Huerta I, Beyssac E, Garrait G, Vázquez-Durán A, López-Arellano R, Méndez-Albores A, Hargis BM, Tellez-Isaias G. Evaluation of the Antimicrobial Activity of a Formulation Containing Ascorbic Acid and Eudragit FS 30D Microparticles for the Controlled Release of a Curcumin-Boric Acid Solid Dispersion in Turkey Poults Infected with Salmonella enteritidis: A Therapeutic Model. Int J Mol Sci. 2023;24(22):16186. DOI: 10.3390/ijms242216186Brittingham A., Wilson W.A. The antimicrobial effect of boric acid on Trichomonas vaginalis // Sex Transm Dis. – 2014. – Vol. 41, No. 12. – P. 718–722. DOI: 10.1097/OLQ.0000000000000203Brittingham A, Wilson WA. The antimicrobial effect of boric acid on Trichomonas vaginalis. Sex Transm Dis. 2014;41(12):718–722. DOI: 10.1097/OLQ.0000000000000203Trippier P.C., McGuigan C. Boronic acids in medicinal chemistry: anticancer, antibacterial and antiviral applications // Med Chem Commun. – 2010. – Vol. 1. – P. 183–198. DOI: 10.1039/C0MD00119HTrippier PC, McGuigan C. Boronic acids in medicinal chemistry: anticancer, antibacterial and antiviral applications. Med Chem Commun. 2010;1:183–198. DOI: 10.1039/C0MD00119HSchelenz S. Management of candidiasis in the intensive care unit // J Antimicrob Chemother. – 2008. – Vol. 61 Suppl 1. – P. i31–4. DOI: 10.1093/jac/dkm430Schelenz S. Management of candidiasis in the intensive care unit. J Antimicrob Chemother. 2008;61 Suppl 1:i31–4. DOI: 10.1093/jac/dkm430Talapko J., Juzbašić M., Matijević T., Pustijanac E., Bekić S., Kotris I., Škrlec I. Candida albicans-The Virulence Factors and Clinical Manifestations of Infection // J Fungi (Basel). – 2021. – Vol. 7, No. 2. – P. 79. DOI: 10.3390/jof7020079Talapko J, Juzbašić M, Matijević T, Pustijanac E, Bekić S, Kotris I, Škrlec I. Candida albicans-The Virulence Factors and Clinical Manifestations of Infection. J Fungi (Basel). 2021;7(2):79. DOI: 10.3390/jof7020079Çelikezen FÇ., İ. Şahin H. Investigation of Antimicrobial and Antifungal Effects of Some Boron Compounds // Bitlis Eren Üniversitesi Fen Bilimleri Dergisi. – 2023. – Vol. 12, No. 3. – P. 591–595. DOI: 10.17798/bitlisfen.1197472Çelikezen FÇ, İ. Şahin H. Investigation of Antimicrobial and Antifungal Effects of Some Boron Compounds. Bitlis Eren Üniversitesi Fen Bilimleri Dergisi. 2023;12(3):591–595. DOI: 10.17798/bitlisfen.1197472Van Slyke K.K., Michel V.P., Rein M.F. Treatment of vulvovaginal candidiasis with boric acid powder // Am J Obstet Gynecol. – 1981. – Vol. 141, No. 2. – P. 145–148. DOI: 10.1016/s0002-9378(16)32581-9Van Slyke KK, Michel VP, Rein MF. Treatment of vulvovaginal candidiasis with boric acid powder. Am J Obstet Gynecol. 1981;141(2):145–148. DOI: 10.1016/s0002-9378(16)32581-9De Seta F., Schmidt M., Vu B., Essmann M., Larsen B. Antifungal mechanisms supporting boric acid therapy of Candida vaginitis // J Antimicrob Chemother. – 2009. – Vol. 63, No. 2. – P. 325–336. DOI: 10.1093/jac/dkn486De Seta F, Schmidt M, Vu B, Essmann M, Larsen B. Antifungal mechanisms supporting boric acid therapy of Candida vaginitis. J Antimicrob Chemother. 2009;63(2):325–336. DOI: 10.1093/jac/dkn486Pointer B.R., Boyer M.P., Schmidt M. Boric acid destabilizes the hyphal cytoskeleton and inhibits invasive growth of Candida albicans // Yeast. – 2015. – Vol. 32, No. 4. – P. 389–398. DOI: 10.1002/yea.3066Pointer BR, Boyer MP, Schmidt M. Boric acid destabilizes the hyphal cytoskeleton and inhibits invasive growth of Candida albicans. Yeast. 2015;32(4):389–398. DOI: 10.1002/yea.3066Larsen B., Petrovic M., De Seta F. Boric Acid and Commercial Organoboron Products as Inhibitors of Drug-Resistant Candida albicans // Mycopathologia. – 2018. – Vol. 183, No. 2. – P. 349–357. DOI: 10.1007/s11046-017-0209-6Larsen B, Petrovic M, De Seta F. Boric Acid and Commercial Organoboron Products as Inhibitors of Drug-Resistant Candida albicans. Mycopathologia. 2018;183(2):349–357. DOI: 10.1007/s11046-017-0209-6Orak F., Nazik H., Yalcinkaya KT., Gundes A., Doganer A., Nazik S., Mulayim MK., Ozturk P. Antifungal efficacy of pure boron on yeast and mold isolates causing superficial mycosis // J Pak Med Assoc. – 2022. – Vol. 72, No. 7. – P. 1330–1334. DOI: 10.47391/JPMA.2219Orak F, Nazik H, Yalcinkaya KT, Gundes A, Doganer A, Nazik S, Mulayim MK, Ozturk P. Antifungal efficacy of pure boron on yeast and mold isolates causing superficial mycosis. J Pak Med Assoc. 2022;72(7):1330–1334. DOI: 10.47391/JPMA.2219Nemyatykh O.D., Maistrenko M.A., Demchenko D.D., Narkevich I.A., Okovityi S.V., Timchenko V.N. Principles of Rational COVID-19 Therapy in Pediatrics // J Clin Med. – 2023. – Vol. 12, No. 14. – P. 4731. DOI: 10.3390/jcm12144731Nemyatykh OD, Maistrenko MA, Demchenko DD, Narkevich IA, Okovityi SV, Timchenko VN. Principles of Rational COVID-19 Therapy in Pediatrics. J Clin Med. 2023;12(14):4731. DOI: 10.3390/jcm12144731Stebbing J., Phelan A., Griffin I., Tucker C., Oechsle O., Smith D., Richardson P. COVID-19: combining antiviral and anti-inflammatory treatments // Lancet Infect Dis. – 2020. – Vol. 20, No. 4. – P. 400–402. DOI: 10.1016/S1473-3099, No. – 20)30132-8Stebbing J, Phelan A, Griffin I, Tucker C, Oechsle O, Smith D, Richardson P. COVID-19: combining antiviral and anti-inflammatory treatments. Lancet Infect Dis. 2020;20(4):400–402. DOI: 10.1016/S1473-3099(20)30132-8Sarkar C., Mondal M., Torequl Islam M., Martorell M., Docea AO., Maroyi A., Sharifi-Rad J., Calina D. Potential Therapeutic Options for COVID-19: Current Status, Challenges, and Future Perspectives. Front Pharmacol. – 2020. – Vol. 11. – P. 572870. DOI: 10.3389/fphar.2020.572870Sarkar C, Mondal M, Torequl Islam M, Martorell M, Docea AO, Maroyi A, Sharifi-Rad J, Calina D. Potential Therapeutic Options for COVID-19: Current Status, Challenges, and Future Perspectives. Front Pharmacol. 2020;11:572870. DOI: 10.3389/fphar.2020.572870Akbari N., Ostadrahimi A., Tutunchi H., Pourmoradian S., Farrin N., Najafipour F., Soleimanzadeh H., Kafil B., Mobasseri M. Possible therapeutic effects of boron citrate and oleoylethanolamide supplementation in patients with COVID-19: A pilot randomized, double-blind, clinical trial // J Trace Elem Med Biol. – 2022. – Vol. 71. – P. 126945. DOI: 10.1016/j.jtemb.2022.126945Akbari N, Ostadrahimi A, Tutunchi H, Pourmoradian S, Farrin N, Najafipour F, Soleimanzadeh H, Kafil B, Mobasseri M. Possible therapeutic effects of boron citrate and oleoylethanolamide supplementation in patients with COVID-19: A pilot randomized, double-blind, clinical trial. J Trace Elem Med Biol. 2022;71:126945. DOI: 10.1016/j.jtemb.2022.126945Wanninger S., Lorenz V., Subhanb A., Edelmann F.T. Metal complexes of curcumin – synthetic strategies, structures and medicinal applications // Chem Soc Rev. – 2015. – Vol. 44. – P. 4986–5002. DOI: 10.1039/C5CS00088BWanninger S, Lorenz V, Subhanb A, Edelmann FT. Metal complexes of curcumin – synthetic strategies, structures and medicinal applications. Chem Soc Rev. 2015;44:4986–5002. DOI: 10.1039/C5CS00088BBellamy L.J., Spicer G.S., Strickland J.D.H. Compounds of curcumin and boric acid. Part III. Infra-red studies of rosocyanin and allied compounds // J Chem Soc. – 1952. – P. 4653–4656. DOI: 10.1039/JR9520004653Bellamy LJ, Spicer GS, Strickland JDH. Compounds of curcumin and boric acid. Part III. Infra-red studies of rosocyanin and allied compounds. J Chem. Soc. 1952:4653–4656. DOI: 10.1039/JR9520004653Sui Z., Salto R., Li J., Craik C., Ortiz de Montellano P.R. Inhibition of the HIV-1 and HIV-2 proteases by curcumin and curcumin boron complexes // Bioorg Med Chem. – 1993. – Vol. 1, No. 6. – P. 415–422. DOI: 10.1016/s0968-0896(00)82152-5Sui Z, Salto R, Li J, Craik C, Ortiz de Montellano PR. Inhibition of the HIV-1 and HIV-2 proteases by curcumin and curcumin boron complexes. Bioorg Med Chem. 1993;1(6):415–422. DOI: 10.1016/s0968-0896(00)82152-5Scorei IR., Biţă A., Mogoşanu G.D. Letter to the Editor: Boron enhances the antiviral activity of the curcumin against SARS-CoV-2 // Rom J Morphol Embryol. – 2020. – Vol. 61, No. 3. – P. 967–970. DOI: 10.47162/RJME.61.3.39Scorei IR, Biţă A, Mogoşanu GD. Letter to the Editor: Boron enhances the antiviral activity of the curcumin against SARS-CoV-2. Rom J Morphol Embryol. 2020;61(3):967–970. DOI: 10.47162/RJME.61.3.39Vega Valdez I.R., Santiago-Quintana J.M., Rosalez M., Farfan E., Soriano-Ursua M.A. Theoretical Evaluation of Bortezomib and Other Boron-Containing Compounds as Inhibitors of SARS-CoV-2 Main Protease // ChemRxiv. – 2020. DOI: 10.26434/chemrxiv.12047346.v1Vega Valdez IR, Santiago-Quintana JM, Rosalez M, Farfan E, Soriano-Ursua MA. Theoretical Evaluation of Bortezomib and Other Boron-Containing Compounds as Inhibitors of SARS-CoV-2 Main Protease. ChemRxiv. 2020. DOI: 10.26434/chemrxiv.12047346.v1Cetiner E., Sayin K., Tuzun B., Ataseven H. Could boron-containing compounds , No. BCCs) be effective against SARS-CoV-2 as anti-viral agent? // Bratisl Lek Listy. – 2021. – Vol. 122, No. 4. – P. 263–269. DOI: 10.4149/BLL_2021_044Cetiner E, Sayin K, Tuzun B, Ataseven H. Could boron-containing compounds (BCCs) be effective against SARS-CoV-2 as anti-viral agent? Bratisl Lek Listy. 2021;122(4):263–269. DOI: 10.4149/BLL_2021_044Momčilović S., Cantacessi C., Arsić-Arsenijević V., Otranto D., Tasić-Otašević S. Rapid diagnosis of parasitic diseases: current scenario and future needs // Clin Microbiol Infect. – 2019. – Vol. 25, No. 3. – P. 290–309. DOI: 10.1016/j.cmi.2018.04.028Momčilović S, Cantacessi C, Arsić-Arsenijević V, Otranto D, Tasić-Otašević S. Rapid diagnosis of parasitic diseases: current scenario and future needs. Clin Microbiol Infect. 2019;25(3):290–309. DOI: 10.1016/j.cmi.2018.04.028Thorley N., Ross J. Intravaginal boric acid: is it an alternative therapeutic option for vaginal trichomoniasis? // Sex Transm Infect. – 2018. – Vol. 94, No. 8. – P. 574–577. DOI: 10.1136/sextrans-2017-053343Thorley N, Ross J. Intravaginal boric acid: is it an alternative therapeutic option for vaginal trichomoniasis? Sex Transm Infect. 2018;94(8):574–577. DOI: 10.1136/sextrans-2017-053343Ugwu D.I., Eze F.U., Ezeorah C.J., Rhyman L., Ramasami P., Tania G., Eze C.C., Uzoewulu C.P., Ogboo B.C., Okpareke O.C. Synthesis, structure, hirshfeld surface analysis, non-covalent interaction, and in silico studies of 4-hydroxy-1-[(4-nitrophenyl)sulphonyl]pyrrolidine-2-carboxyllic acid // Research Square. – 2022. DOI: 10.21203/rs.3.rs-2217367/v1Ugwu DI, Eze FU, Ezeorah CJ, Rhyman L, Ramasami P, Tania G, Eze CC, Uzoewulu CP, Ogboo BC, Okpareke OC. Synthesis, structure, hirshfeld surface analysis, non-covalent interaction, and in silico studies of 4-hydroxy-1-[(4-nitrophenyl)sulphonyl]pyrrolidine-2-carboxyllic acid. Research Square. 2022. DOI: 10.21203/rs.3.rs-2217367/v1Mahmoud A., Zerhouni E. Neglected tropical diseases: moving beyond mass drug treatment to understanding the science. Health Aff (Millwood). – 2009. – Vol. 28, No. 6. – P. 1726–1733. DOI: 10.1377/hlthaff.28.6.1726Mahmoud A, Zerhouni E. Neglected tropical diseases: moving beyond mass drug treatment to understanding the science. Health Aff (Millwood). 2009;28(6):1726–1733. DOI: 10.1377/hlthaff.28.6.1726Croft S.L. Neglected diseases: progress in drug development // Curr Opin Investig Drugs. – 2007. – Vol. 8, No. 2. – P. 103–104.Croft SL. Neglected diseases: progress in drug development. Curr Opin Investig Drugs. 2007;8(2):103–104.Renslo A.R., McKerrow J.H. Drug discovery and development for neglected parasitic diseases // Nat Chem Biol. – 2006. – Vol. 2, No. 12. – P. 701–710. DOI: 10.1038/nchembio837Renslo AR, McKerrow JH. Drug discovery and development for neglected parasitic diseases. Nat Chem Biol. 2006;2(12):701–710. DOI: 10.1038/nchembio837Jacobs R.T., Plattner J.J., Keenan M. Boron-based drugs as antiprotozoals // Curr Opin Infect Dis. – 2011. – Vol. 24, No. 6. – P. 586–592. DOI: 10.1097/QCO.0b013e32834c630eJacobs RT, Plattner JJ, Keenan M. Boron-based drugs as antiprotozoals. Curr Opin Infect Dis. 2011;24(6):586–592. DOI: 10.1097/QCO.0b013e32834c630eLindenthal C., Weich N., Chia Y.S., Heussler V., Klinkert M.Q. The proteasome inhibitor MLN-273 blocks exoerythrocytic and erythrocytic development of Plasmodium parasites // Parasitology. – 2005. – Vol. 131, Pt 1. – P. 37–44. DOI: 10.1017/s003118200500747xLindenthal C, Weich N, Chia YS, Heussler V, Klinkert MQ. The proteasome inhibitor MLN-273 blocks exoerythrocytic and erythrocytic development of Plasmodium parasites. Parasitology. 2005;131(Pt 1):37–44. DOI: 10.1017/s003118200500747xReynolds J.M., El Bissati K., Brandenburg J., Günzl A., Mamoun C.B. Antimalarial activity of the anticancer and proteasome inhibitor bortezomib and its analog ZL3B // BMC Clin Pharmacol. – 2007. – Vol. 7. – P. 13. DOI: 10.1186/1472-6904-7-13Reynolds JM, El Bissati K, Brandenburg J, Günzl A, Mamoun CB. Antimalarial activity of the anticancer and proteasome inhibitor bortezomib and its analog ZL3B. BMC Clin Pharmacol. 2007;7:13. DOI: 10.1186/1472-6904-7-13Sørensen T.I.A., Martinez A.R., Jørgensen T.S.H. Epidemiology of Obesity // Handb Exp Pharmacol. – 2022. – Vol. 274. – P. 3–27. DOI: 10.1007/164_2022_581Sørensen TIA, Martinez AR, Jørgensen TSH. Epidemiology of Obesity. Handb Exp Pharmacol. 2022;274:3–27. DOI: 10.1007/164_2022_581Yunusoglu O., Türkmen Ö., Berkoz M., Yıldırım M., Yalın S. In Vitro Anti-Obesity Effect of Aloe vera Extract Through Transcription Factors and LipolysisAssociated Genes // East J Med. – 2022. – Vol. 27, No. 4. – P. 519–528. DOI: 10.5505/ejm.2022.13285Yunusoglu O, Türkmen Ö, Berkoz M, Yıldırım M, Yalın S. In Vitro Anti-Obesity Effect of Aloe vera Extract Through Transcription Factors and LipolysisAssociated Genes. East J Med. 2022;27(4):519–528. DOI: 10.5505/ejm.2022.13285Doğan A., Demirci S., Apdik H., Bayrak O.F., Gulluoglu S., Tuysuz E.C., Gusev O., Rizvanov A.A., Nikerel E., Şahin F. A new hope for obesity management: Boron inhibits adipogenesis in progenitor cells through the Wnt/β-catenin pathway // Metabolism. – 2017. – Vol. 69. – P. 130–142. DOI: 10.1016/j.metabol.2017.01.021Doğan A, Demirci S, Apdik H, Bayrak OF, Gulluoglu S, Tuysuz EC, Gusev O, Rizvanov AA, Nikerel E, Şahin F. A new hope for obesity management: Boron inhibits adipogenesis in progenitor cells through the Wnt/β-catenin pathway. Metabolism. 2017;69:130–142. DOI: 10.1016/j.metabol.2017.01.021Aysan E., Sahin F., Telci D., Yalvac M.E., Emre S.H., Karaca C., Muslumanoglu M. Body weight reducing effect of oral boric acid intake // Int J Med Sci. – 2011. – Vol. 8, No. 8. – P. 653–658. DOI: 10.7150/ijms.8.653Aysan E, Sahin F, Telci D, Yalvac ME, Emre SH, Karaca C, Muslumanoglu M. Body weight reducing effect of oral boric acid intake. Int J Med Sci. 2011;8(8):653–658. DOI: 10.7150/ijms.8.653Farrin N., Rezazadeh L., Pourmoradian S., Attari V.E., Tutunchi H., Zarezadeh M., Najafipour F., Ostadrahimi A. Boron compound administration; A novel agent in weight management: A systematic review and meta-analysis of animal studies // J Trace Elem Med Biol. – 2022. – Vol. 72. – P. 126969. DOI: 10.1016/j.jtemb.2022.126969Farrin N, Rezazadeh L, Pourmoradian S, Attari VE, Tutunchi H, Zarezadeh M, Najafipour F, Ostadrahimi A. Boron compound administration; A novel agent in weight management: A systematic review and meta- analysis of animal studies. J Trace Elem Med Biol. 2022;72:126969. DOI: 10.1016/j.jtemb.2022.126969Saeedi P., Petersohn I., Salpea P., Malanda B., Karuranga S., Unwin N., Colagiuri S., Guariguata L., Motala A.A., Ogurtsova K., Shaw J.E., Bright D., Williams R; IDF Diabetes Atlas Committee. Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: Results from the International Diabetes Federation Diabetes Atlas, 9th edition // Diabetes Res Clin Pract. – 2019. – Vol. 157. – P. 107843. DOI: 10.1016/j.diabres.2019.107843Saeedi P, Petersohn I, Salpea P, Malanda B, Karuranga S, Unwin N, Colagiuri S, Guariguata L, Motala AA, Ogurtsova K, Shaw JE, Bright D, Williams R; IDF Diabetes Atlas Committee. Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: Results from the International Diabetes Federation Diabetes Atlas, 9th edition. Diabetes Res Clin Pract. 2019;157:107843. DOI: 10.1016/j.diabres.2019.107843Weyer C., Bogardus C., Mott D.M., Pratley R.E. The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus // J Clin Invest. – 1999. – Vol. 104, No. 6. – P. 787–794. DOI: 10.1172/JCI7231Weyer C, Bogardus C, Mott DM, Pratley RE. The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus. J Clin Invest. 1999;104(6):787–794. DOI: 10.1172/JCI7231Cakir S., Eren M., Senturk M., Sarica Z.S. The Effect of Boron on Some Biochemical Parameters in Experimental Diabetic Rats // Biol Trace Elem Res. – 2018. – Vol. 184, No. 1. – P. 165–172. DOI: 10.1007/s12011-017-1182-0Cakir S, Eren M, Senturk M, Sarica ZS. The Effect of Boron on Some Biochemical Parameters in Experimental Diabetic Rats. Biol Trace Elem Res. 2018;184(1):165–172. DOI: 10.1007/s12011-017-1182-0Çakir S. Effect of Boric Acid on Metabolic Peptides and Some Biochemical Parameters in Experimental Diabetic Rats // Biol Trace Elem Res. – 2024. – Vol. 202, No. 3. – P. 1001–1008. DOI: 10.1007/s12011-023-03910-x. Epub 2023 Oct 23. Erratum in: Biol Trace Elem Res. – 2024. – Vol. 202, No. 8. – P. 3868–3869. DOI: 10.1007/s12011-023-03944-1Çakir S. Effect of Boric Acid on Metabolic Peptides and Some Biochemical Parameters in Experimental Diabetic Rats. Biol Trace Elem Res. 2024;202(3):1001–1008. DOI: 10.1007/s12011-023-03910-x. Epub 2023 Oct 23. Erratum in: Biol Trace Elem Res. 2024;202(8):3868–3869. DOI: 10.1007/s12011-023-03944-1Jin E., Li S., Ren M., Hu Q., Gu Y., Li K. Boron Affects Immune Function Through Modulation of Splenic T Lymphocyte Subsets, Cytokine Secretion, and Lymphocyte Proliferation and Apoptosis in Rats // Biol Trace Elem Res. – 2017. – Vol. 178, No. 2. – P. 261–275. DOI: 10.1007/s12011-017-0932-3Jin E, Li S, Ren M, Hu Q, Gu Y, Li K. Boron Affects Immune Function Through Modulation of Splenic T Lymphocyte Subsets, Cytokine Secretion, and Lymphocyte Proliferation and Apoptosis in Rats. Biol Trace Elem Res. 2017;178(2):261–275. DOI: 10.1007/s12011-017-0932-3Romero-Aguilar K.S., Arciniega-Martínez I.M., Farfán-García E.D., Campos-Rodríguez R., Reséndiz-Albor A.A., Soriano-Ursúa M.A. Effects of boron-containing compounds on immune responses: review and patenting trends // Expert Opin Ther Pat. – 2019. – Vol. 29, No. 5. – P. 339–351. DOI: 10.1080/13543776.2019.1612368Romero-Aguilar KS, Arciniega-Martínez IM, Farfán-García ED, Campos-Rodríguez R, Reséndiz-Albor AA, Soriano-Ursúa MA. Effects of boron-containing compounds on immune responses: review and patenting trends. Expert Opin Ther Pat. 2019;29(5):339–351. DOI: 10.1080/13543776.2019.1612368DeFrancesco H., Dudley J., Coca A. Boron Chemistry: An Overview // ACS Symposium Series. – 2016. – Vol. 1236. – P. 1–25. DOI: 10.1021/bk-2016-1236.ch001DeFrancesco H, Dudley J, Coca A. Boron Chemistry: An Overview. ACS Symposium Series. 2016;1236:1–25. DOI: 10.1021/bk-2016-1236.ch001Abdelnour S.A., Abd El-Hack M.E., Swelum A.A., Perillo A., Losacco C. The vital roles of boron in animal health and production: A comprehensive review // J Trace Elem Med Biol. – 2018. – Vol. 50. – P. 296–304. DOI: 10.1016/j.jtemb.2018.07.018Abdelnour SA, Abd El-Hack ME, Swelum AA, Perillo A, Losacco C. The vital roles of boron in animal health and production: A comprehensive review. J Trace Elem Med Biol. 2018;50:296–304. DOI: 10.1016/j.jtemb.2018.07.018Bhasker T.V., Gowda N.K., Mondal S., Krishnamoorthy P., Pal D.T., Mor A., Bhat S.K., Pattanaik A.K. Boron influences immune and antioxidant responses by modulating hepatic superoxide dismutase activity under calcium deficit abiotic stress in Wistar rats // J Trace Elem Med Biol. – 2016. – Vol. 36. – P. 73–79. DOI: 10.1016/j.jtemb.2016.04.007Bhasker TV, Gowda NK, Mondal S, Krishnamoorthy P, Pal DT, Mor A, Bhat SK, Pattanaik AK. Boron influences immune and antioxidant responses by modulating hepatic superoxide dismutase activity under calcium deficit abiotic stress in Wistar rats. J Trace Elem Med Biol. 2016;36:73–79. DOI: 10.1016/j.jtemb.2016.04.007Routray I., Ali S. Boron Induces Lymphocyte Proliferation and Modulates the Priming Effects of Lipopolysaccharide on Macrophages // PLoS One. – 2016. – Vol. 11, No. 3. – P. e0150607. DOI: 10.1371/journal.pone.0150607Routray I, Ali S. Boron Induces Lymphocyte Proliferation and Modulates the Priming Effects of Lipopolysaccharide on Macrophages. PLoS One. 2016;11(3):e0150607. DOI: 10.1371/journal.pone.0150607Asadi R., Raouf Sarshoori J., Ghorbani M., Mofid M. Evaluation of the Effect of Boron on Histopathological Changes of Atherosclerotic Plaque in Aortic Arch and Lipid Profiles in Hyperlipidemic New Zealand Male Rabbits // J Adv Med Biomed Res. – 2023. – Vol. 31, No. 145. – P. 197–203. DOI: 10.30699/jambs.31.145.197Asadi R, Raouf Sarshoori J, Ghorbani M, Mofid M. Evaluation of the Effect of Boron on Histopathological Changes of Atherosclerotic Plaque in Aortic Arch and Lipid Profiles in Hyperlipidemic New Zealand Male Rabbits. J Adv Med Biomed Res. 2023;31(145):197–203. DOI: 10.30699/jambs.31.145.197Yang H.Y., Liu M.L., Luo P., Yao X.S., Zhou H. Network pharmacology provides a systematic approach to understanding the treatment of ischemic heart diseases with traditional Chinese medicine // Phytomedicine. – 2022. – Vol. 104. – P. 154268. DOI: 10.1016/j.phymed.2022.154268Yang HY, Liu ML, Luo P, Yao XS, Zhou H. Network pharmacology provides a systematic approach to understanding the treatment of ischemic heart diseases with traditional Chinese medicine. Phytomedicine. 2022;104:154268. DOI: 10.1016/j.phymed.2022.154268Bittencourt M.S., Cerci R.J. Statin effects on atherosclerotic plaques: regression or healing? // BMC Med. – 2015. – Vol. 13. – P. 260. DOI: 10.1186/s12916-015-0499-9Bittencourt MS, Cerci RJ. Statin effects on atherosclerotic plaques: regression or healing? BMC Med. 2015;13:260. DOI: 10.1186/s12916-015-0499-9Toledo-Ibelles P., Mas-Oliva J. Antioxidants in the Fight Against Atherosclerosis: Is This a Dead End? // Curr Atheroscler Rep. – 2018. – Vol. 20, No. 7. – P. 36. DOI: 10.1007/s11883-018-0737-7Toledo-Ibelles P, Mas-Oliva J. Antioxidants in the Fight Against Atherosclerosis: Is This a Dead End? Curr Atheroscler Rep. 2018;20(7):36. DOI: 10.1007/s11883-018-0737-7Donoiu I., Militaru C., Obleagă O., Hunter J.M., Neamţu J., Biţă A., Scorei I.R., Rogoveanu O.C. Effects of boron-containing compounds on cardiovascular disease risk factors - A review // J Trace Elem Med Biol. – 2018. – Vol. 50. – P. 47–56. DOI: 10.1016/j.jtemb.2018.06.003Donoiu I, Militaru C, Obleagă O, Hunter JM, Neamţu J, Biţă A, Scorei IR, Rogoveanu OC. Effects of boron-containing compounds on cardiovascular disease risk factors - A review. J Trace Elem Med Biol. 2018;50:47–56. DOI: 10.1016/j.jtemb.2018.06.003Coban F.K., Ince S., Kucukkurt I., Demirel H.H., Hazman O. Boron attenuates malathion-induced oxidative stress and acetylcholinesterase inhibition in rats // Drug Chem Toxicol. – 2015. – Vol. 38, No. 4. – P. 391–399. DOI: 10.3109/01480545.2014.974109Coban FK, Ince S, Kucukkurt I, Demirel HH, Hazman O. Boron attenuates malathion-induced oxidative stress and acetylcholinesterase inhibition in rats. Drug Chem Toxicol. 2015;38(4):391–399. DOI: 10.3109/01480545.2014.974109Coban F.K., Liman R., Cigerci I.H., Ince S., Hazman OBozkurt M.F. The antioxidant effect of boron on oxidative stress and DNA damage in diabetic rats // J Fresenius Environ Bull. – 2015. – Vol. 24, No. 11. – P. 4059–4066.Coban FK, Liman R, Cigerci IH, Ince S, Hazman OBozkurt MF. The antioxidant effect of boron on oxidative stress and DNA damage in diabetic rats. J Fresenius Environ Bull. 2015;24(11):4059–4066.Zafar H., Ali S. Boron inhibits the proliferating cell nuclear antigen index, molybdenum containing proteins and ameliorates oxidative stress in hepatocellular carcinoma // Arch Biochem Biophys. – 2013. – Vol. 529, No. 2. – P. 66–74. DOI: 10.1016/j.abb.2012.11.008Zafar H, Ali S. Boron inhibits the proliferating cell nuclear antigen index, molybdenum containing proteins and ameliorates oxidative stress in hepatocellular carcinoma. Arch Biochem Biophys. 2013;529(2):66–74. DOI: 10.1016/j.abb.2012.11.008Sen C.K. Human Wound and Its Burden: Updated 2020 Compendium of Estimates // Adv Wound Care (New Rochelle). – 2021. – Vol. 10, No. 5. – P. 281–292. DOI: 10.1089/wound.2021.0026Sen CK. Human Wound and Its Burden: Updated 2020 Compendium of Estimates. Adv Wound Care (New Rochelle). 2021;10(5):281–292. DOI: 10.1089/wound.2021.0026Frykberg R.G., Banks J. Challenges in the Treatment of Chronic Wounds // Adv Wound Care (New Rochelle). – 2015. – Vol. 4, No. 9. – P. 560–582. DOI: 10.1089/wound.2015.0635Frykberg RG, Banks J. Challenges in the Treatment of Chronic Wounds. Adv Wound Care (New Rochelle). 2015;4(9):560–582. DOI: 10.1089/wound.2015.0635Tang N., Zhang R., Zheng Y., Wang J., Khatib M., Jiang X., Zhou C., Omar R., Saliba W., Wu W., Yuan M., Cui D., Haick H. Highly Efficient Self-Healing Multifunctional Dressing with Antibacterial Activity for Sutureless Wound Closure and Infected Wound Monitoring // Adv Mater. – 2022. – Vol. 34, No. 3. – P. e2106842. DOI: 10.1002/adma.202106842Tang N, Zhang R, Zheng Y, Wang J, Khatib M, Jiang X, Zhou C, Omar R, Saliba W, Wu W, Yuan M, Cui D, Haick H. Highly Efficient Self-Healing Multifunctional Dressing with Antibacterial Activity for Sutureless Wound Closure and Infected Wound Monitoring. Adv Mater. 2022;34(3):e2106842. DOI: 10.1002/adma.202106842Şahin F., Pirouzpanah M.B., Farshbaf-Khalili A., Ayşan E., Doğan A., Demirci S., Ostadrahimi A., Mobasseri M. The effect of the boron-based gel on the treatment of diabetic foot ulcers: A prospective, randomized controlled trial // J Trace Elem Med Biol. – 2023. – Vol. 79. – P. 127261. DOI: 10.1016/j.jtemb.2023.127261Şahin F, Pirouzpanah MB, Farshbaf-Khalili A, Ayşan E, Doğan A, Demirci S, Ostadrahimi A, Mobasseri M. The effect of the boron-based gel on the treatment of diabetic foot ulcers: A prospective, randomized controlled trial. J Trace Elem Med Biol. 2023;79:127261. DOI: 10.1016/j.jtemb.2023.127261Doğan A., Demirci S., Cağlayan AB., Kılıç E., Günal MY., Uslu U., Cumbul A., Sahin F. Sodium pentaborate pentahydrate and pluronic containing hydrogel increases cutaneous wound healing in vitro and in vivo // Biol Trace Elem Res. – 2014. – Vol. 162, No. 1-3. – P. 72–79. DOI: 10.1007/s12011-014-0104-7Doğan A, Demirci S, Cağlayan AB, Kılıç E, Günal MY, Uslu U, Cumbul A, Sahin F. Sodium pentaborate pentahydrate and pluronic containing hydrogel increases cutaneous wound healing in vitro and in vivo. Biol Trace Elem Res. 2014;162(1-3):72–79. DOI: 10.1007/s12011-014-0104-7Benderdour M., Van Bui T., Hess K., Dicko A., Belleville F., Dousset B. Effects of boron derivatives on extracellular matrix formation // J Trace Elem Med Biol. – 2000. – Vol. 14, No. 3. – P. 168–173. DOI: 10.1016/S0946-672X(00)80006-1Benderdour M, Van Bui T, Hess K, Dicko A, Belleville F, Dousset B. Effects of boron derivatives on extracellular matrix formation. J Trace Elem Med Biol. 2000;14(3):168–173. DOI: 10.1016/S0946-672X(00)80006-1Roy N., Saha N., Kitano T., Saha P. Development and Characterization of Novel Medicated Hydrogels for Wound Dressing // Soft Materials. – 2010. – Vol. 8, No. 2. – P. 130–148. DOI: 10.1080/15394451003756282Roy N, Saha N, Kitano T, Saha P. Development and Characterization of Novel Medicated Hydrogels for Wound Dressing. Soft Materials. 2010;8(2):130–148. DOI: 10.1080/15394451003756282Demirci S., Doğan A., Aydın S., Dülger E.Ç., Şahin F. Boron promotes streptozotocin-induced diabetic wound healing: roles in cell proliferation and migration, growth factor expression, and inflammation // Mol Cell Biochem. – 2016. – Vol. 417, No. 1-2. – P. 119–133. DOI: 10.1007/s11010-016-2719-9Demirci S, Doğan A, Aydın S, Dülger EÇ, Şahin F. Boron promotes streptozotocin-induced diabetic wound healing: roles in cell proliferation and migration, growth factor expression, and inflammation. Mol Cell Biochem. 2016;417(1-2):119–133. DOI: 10.1007/s11010-016-2719-9Shimikore S.S., Pawar Gaurav B. A Randomized Controlled Trial to Compare Efficacy of Collagen Granule-Based Dressing versus Conventional Dressing in the Management of Diabetic Foot Ulcers // Archives of Medicine and Health Sciences. – 2018. – Vol. 6, No. 1. – P. 28–31. DOI: 10.4103/amhs.amhs_30_17Shimikore SS, Pawar Gaurav B. A Randomized Controlled Trial to Compare Efficacy of Collagen Granule-Based Dressing versus Conventional Dressing in the Management of Diabetic Foot Ulcers. Archives of Medicine and Health Sciences. 2018;6(1):28–31. DOI: 10.4103/amhs.amhs_30_17Kırbaş O.K., Bozkurt B.T., Taşlı P.N., Hayal T.B., Özkan İ., Bülbül B., Beyaz S., Şahin F. Effective Scarless Wound Healing Mediated by Erbium Borate Nanoparticles // Biol Trace Elem Res. – 2021. – Vol. 199, No. 9. – P. 3262–3271. DOI: 10.1007/s12011-020-02458-4Kırbaş OK, Bozkurt BT, Taşlı PN, Hayal TB, Özkan İ, Bülbül B, Beyaz S, Şahin F. Effective Scarless Wound Healing Mediated by Erbium Borate Nanoparticles. Biol Trace Elem Res. 2021;199(9):3262–3271. DOI: 10.1007/s12011-020-02458-4Kurtoğlu A.H., Karataş A. Current approaches to wound therapy: modern wound dressings // J Fac Pharm Ankara. – 2009. – Vol. 38, No. 3. – P. 211–232. DOI: 10.1501/Eczfak_0000000562Kurtoğlu AH, Karataş A. Current approaches to wound therapy: modern wound dressings. J Fac Pharm Ankara. 2009;38(3):211–232. DOI: 10.1501/Eczfak_0000000562Chupakhin O.N., Khonina T.G., Kungurov N.V., Zilberberg N.V., Evstigneeva N.P., Kokhan M.M., Polishchuk A.I., Shadrina E.V., Larchenko E.Yu., Larionov L.P., Karabanalov M.S. Silicon–boron-containing glycerohydrogel having wound healing, regenerative, and antimicrobial activity // Russ Chem Bull. – 2017. – Vol. 66. – P. 558–563. DOI: 10.1007/s11172-017-1771-2Chupakhin ON, Khonina TG, Kungurov NV, Zilberberg NV, Evstigneeva NP, Kokhan MM, Polishchuk AI, Shadrina EV, Larchenko EYu, Larionov LP, Karabanalov MS. Silicon–boron-containing glycerohydrogel having wound healing, regenerative, and antimicrobial activity. Russ Chem Bull. 2017;66:558–563. DOI: 10.1007/s11172-017-1771-2Nzietchueng R.M., Dousset B., Franck P., Benderdour M., Nabet P., Hess K. Mechanisms implicated in the effects of boron on wound healing // J Trace Elem Med Biol. – 2002. – Vol. 16, No. 4. – P. 239–244. DOI: 10.1016/S0946-672X(02)80051-7Nzietchueng RM, Dousset B, Franck P, Benderdour M, Nabet P, Hess K. Mechanisms implicated in the effects of boron on wound healing. J Trace Elem Med Biol. 2002;16(4):239–244. DOI: 10.1016/S0946-672X(02)80051-7Sedighi-Pirsaraei N., Tamimi A., Sadeghi Khamaneh F., Dadras-Jeddi S., Javaheri N. Boron in wound healing: a comprehensive investigation of its diverse mechanisms // Front Bioeng Biotechnol. – 2024. – Vol. 12. – P. 1475584. DOI: 10.3389/fbioe.2024.1475584Sedighi-Pirsaraei N, Tamimi A, Sadeghi Khamaneh F, Dadras-Jeddi S, Javaheri N. Boron in wound healing: a comprehensive investigation of its diverse mechanisms. Front Bioeng Biotechnol. 2024;12:1475584. DOI: 10.3389/fbioe.2024.1475584Behera S.S., Pramanik K., Nayak M.K. Recent Advancement in the Treatment of Cardiovascular Diseases: Conventional Therapy to Nanotechnology // Curr Pharm Des. – 2015. – Vol. 21, No. 30. – P. 4479–4497. DOI: 10.2174/1381612821666150817104635Behera SS, Pramanik K, Nayak MK. Recent Advancement in the Treatment of Cardiovascular Diseases: Conventional Therapy to Nanotechnology. Curr Pharm Des. 2015;21(30):4479–4497. DOI: 10.2174/1381612821666150817104635Miljkovic D., Scorei R.I., Cimpoiaşu V.M., Scorei I.D. Calcium fructoborate: plant-based dietary boron for human nutrition // J Diet Suppl. – 2009. – Vol. 6, No. 3. – P. 211–226. DOI: 10.1080/19390210903070772Miljkovic D, Scorei RI, Cimpoiaşu VM, Scorei ID. Calcium fructoborate: plant-based dietary boron for human nutrition. J Diet Suppl. 2009;6(3):211–226. DOI: 10.1080/19390210903070772Shrivastava A.K., Singh H.V., Raizada A., Singh S.K. C-reactive protein, inflammation and coronary heart disease // Egypt Heart J. – 2015. – Vol. 94, No. 2. – P. 89–97. DOI: 10.1016/j.ehj.2014.11.005Shrivastava AK, Singh HV, Raizada A, Singh SK. C-reactive protein, inflammation and coronary heart disease. Egypt Heart J. 2015;94(2):89–97. DOI: 10.1016/j.ehj.2014.11.005Nielsen F.H. Historical and recent aspects of boron in human and animal health // J Boron. – 2017. – Vol. 2, No. 3. – P. 153–160.Nielsen FH. Historical and recent aspects of boron in human and animal health. J Boron. 2017;2(3):153–160.Karimkhani H., Özkoç M., Shojaolsadati P., Uzuner K., Donmez D.B., Kanbak G. Protective Effect of Boric Acid and Omega-3 on Myocardial Infarction in an Experimental Rat Model // Biol Trace Elem Res. – 2021. – Vol. 199, No. 7. – P. 2612–2620. DOI: 10.1007/s12011-020-02360-zKarimkhani H, Özkoç M, Shojaolsadati P, Uzuner K, Donmez DB, Kanbak G. Protective Effect of Boric Acid and Omega-3 on Myocardial Infarction in an Experimental Rat Model. Biol Trace Elem Res. 2021;199(7):2612–2620. DOI: 10.1007/s12011-020-02360-zBouchareb R., Katz M., Saadallah N., Sassi Y., Ali S., Lebeche D. Boron improves cardiac contractility and fibrotic remodeling following myocardial infarction injury // Sci Rep. – 2020. – Vol. 10, No. 1. – P. 17138. DOI: 10.1038/s41598-020-73864-wBouchareb R, Katz M, Saadallah N, Sassi Y, Ali S, Lebeche D. Boron improves cardiac contractility and fibrotic remodeling following myocardial infarction injury. Sci Rep. 2020;10(1):17138. DOI: 10.1038/s41598-020-73864-wDevarbhavi H., Asrani S.K., Arab J.P., Nartey Y.A., Pose E., Kamath P.S. Global burden of liver disease: 2023 update // J Hepatol. – 2023. – Vol. 79, No. 2. – P. 516–537. DOI: 10.1016/j.jhep.2023.03.017Devarbhavi H, Asrani SK, Arab JP, Nartey YA, Pose E, Kamath PS. Global burden of liver disease: 2023 update. J Hepatol. 2023;79(2):516–537. DOI: 10.1016/j.jhep.2023.03.017Berköz M., Aslan A., Yunusoğlu O., Krośniak M., Francik R. Hepatoprotective potentials of Usnea longissima Ach. and Xanthoparmelia somloensis (Gyelnik) Hale extracts in ethanol-induced liver injury // Drug Chem Toxicol. – 2025. – Vol. 48, No. 1. – P. 136–149. DOI: 10.1080/01480545.2024.2407867Berköz M, Aslan A, Yunusoğlu O, Krośniak M, Francik R. Hepatoprotective potentials of Usnea longissima Ach. and Xanthoparmelia somloensis (Gyelnik) Hale extracts in ethanol-induced liver injury. Drug Chem Toxicol. 2025;48(1):136–149. DOI: 10.1080/01480545.2024.2407867Wang R., Kong J., Wang D., Lien L.L., Lien E.J. A survey of Chinese herbal ingredients with liver protection activities // Chin Med. – 2007. – Vol. 2. – P. 5. DOI: 10.1186/1749-8546-2-5Wang R, Kong J, Wang D, Lien LL, Lien EJ. A survey of Chinese herbal ingredients with liver protection activities. Chin Med. 2007;2:5. DOI: 10.1186/1749-8546-2-5Kabu M., Uyarlar C., Żarczyńska K., Milewska W., Sobiech P. The role of boron in animal health // J Elem 2015. – Vol. 20, No. 2. – P. 535–541. DOI: 10.5601/jelem.2014.19.3.706Kabu M, Uyarlar C, Żarczyńska K, Milewska W, Sobiech P. The role of boron in animal health. J Elem 2015;20(2):535–541. DOI: 10.5601/jelem.2014.19.3.706Abdik H., Cumbul A., Hayal T.B., Avşar Abdik E., Taşlı P.N., Kırbaş O.K., Baban D., Şahin F. Sodium Pentaborate Pentahydrate ameliorates lipid accumulation and pathological damage caused by high fat diet induced obesity in BALB/c mice // J Trace Elem Med Biol. – 2021. – Vol. 66. – P. 126736. DOI: 10.1016/j.jtemb.2021Abdik H, Cumbul A, Hayal TB, Avşar Abdik E, Taşlı PN, Kırbaş OK, Baban D, Şahin F. Sodium Pentaborate Pentahydrate ameliorates lipid accumulation and pathological damage caused by high fat diet induced obesity in BALB/c mice. J Trace Elem Med Biol. 2021;66:126736. DOI: 10.1016/j.jtemb.2021Şahin E., Orhan C., Erten F., Şahin F., Şahin N., Şahin K. The effect of different boron compounds on nutrient digestibility, intestinal nutrient transporters, and liver lipid metabolism // Turk J Med Sci. – 2023. – Vol. 53, No. 3. – P. 619–629. DOI: 10.55730/1300-0144.5624Şahin E, Orhan C, Erten F, Şahin F, Şahin N, Şahin K. The effect of different boron compounds on nutrient digestibility, intestinal nutrient transporters, and liver lipid metabolism. Turk J Med Sci. 2023;53(3):619–629. DOI: 10.55730/1300-0144.5624Kucukkurt I., Ince S., Eryavuz A., Demirel H.H., Arslan-Acaroz D., Zemheri-Navruz F., Durmus I. The effects of boron-supplemented diets on adipogenesis-related gene expressions, anti-inflammatory, and antioxidative response in high-fat fed rats // J Biochem Mol Toxicol. – 2023. – Vol. 37, No. 2. – P. e23257. DOI: 10.1002/jbt.23257Kucukkurt I, Ince S, Eryavuz A, Demirel HH, Arslan-Acaroz D, Zemheri-Navruz F, Durmus I. The effects of boron-supplemented diets on adipogenesis-related gene expressions, anti-inflammatory, and antioxidative response in high-fat fed rats. J Biochem Mol Toxicol. 2023;37(2):e23257. DOI: 10.1002/jbt.23257Bhushan B., Apte U. Liver Regeneration after Acetaminophen Hepatotoxicity: Mechanisms and Therapeutic Opportunities // Am J Pathol. – 2019. – Vol. 189, No. 4. – P. 719–729. DOI: 10.1016/j.ajpath.2018.12.006Bhushan B, Apte U. Liver Regeneration after Acetaminophen Hepatotoxicity: Mechanisms and Therapeutic Opportunities. Am J Pathol. 2019;189(4):719–729. DOI: 10.1016/j.ajpath.2018.12.006Çelik M., Aydın P. 4-hidroksifenilboronik asitin HEPG2 hücre hattında asetaminofen ile indüklenen karaciğer hücre hasarı üzerine etkisinin araştırılması // J Boron. – 2022. – Vol. 7, No. 3. – P. 507–513. DOI: 10.30728/boron.1079589Çelik M, Aydın P. 4-hidroksifenilboronik asitin HEPG2 hücre hattında asetaminofen ile indüklenen karaciğer hücre hasarı üzerine etkisinin araştırılması. J Boron. 2022;7(3):507–513. DOI: 10.30728/boron.1079589Olufunmilayo E.O., Gerke-Duncan M.B., Holsinger R.M.D. Oxidative Stress and Antioxidants in Neurodegenerative Disorders // Antioxidants (Basel). – 2023. – Vol. 12, No. 2. – P. 517. DOI: 10.3390/antiox12020517Olufunmilayo EO, Gerke-Duncan MB, Holsinger RMD. Oxidative Stress and Antioxidants in Neurodegenerative Disorders. Antioxidants (Basel). 2023;12(2):517. DOI: 10.3390/antiox12020517Pizzorno L. Nothing Boring About Boron. Integr Med (Encinitas). – 2015. – Vol. 14, No. 4. – P. 35–48.Pizzorno L. Nothing Boring About Boron. Integr Med (Encinitas). 2015;14(4):35–48.Nakmode D.D., Day C.M., Song Y., Garg S. The Management of Parkinson's Disease: An Overview of the Current Advancements in Drug Delivery Systems // Pharmaceutics. – 2023. – Vol. 15, No. 5. – P. 1503. DOI: 10.3390/pharmaceutics15051503Nakmode DD, Day CM, Song Y, Garg S. The Management of Parkinson's Disease: An Overview of the Current Advancements in Drug Delivery Systems. Pharmaceutics. 2023;15(5):1503. DOI: 10.3390/pharmaceutics15051503Yang P., Liu Y., Tong Z.W., Huang Q.H., Xie X.H., Mao S.Y., Ding J.H., Lu M., Tan R.X., Hu G. The marine-derived compound TAG alleviates Parkinson's disease by restoring RUBCN-mediated lipid metabolism homeostasis // Acta Pharmacol Sin. – 2024. – Vol. 45, No. 7. – P. 1366–1380. DOI: 10.1038/s41401-024-01259-yYang P, Liu Y, Tong ZW, Huang QH, Xie XH, Mao SY, Ding JH, Lu M, Tan RX, Hu G. The marine-derived compound TAG alleviates Parkinson's disease by restoring RUBCN-mediated lipid metabolism homeostasis. Acta Pharmacol Sin. 2024;45(7):1366–1380. DOI: 10.1038/s41401-024-01259-yOzdemir H.S., Yunusoglu O., Sagmanligil V., Yasar S., Colcimen N., Goceroglu R., Catalkaya E. Investigation of the pharmacological, behavioral, and biochemical effects of boron in parkinson-indicated rats: Effects of Boron on Rotenone-Induced Parkinson’s Disease // Cellular and Molecular Biology. – 2022. – Vol. 68, No. 8. – P. 13–21. DOI: 10.14715/cmb/2022.68.8.3Ozdemir HS, Yunusoglu O, Sagmanligil V, Yasar S, Colcimen N, Goceroglu R, Catalkaya E. Investigation of the pharmacological, behavioral, and biochemical effects of boron in parkinson-indicated rats: Effects of Boron on Rotenone-Induced Parkinson’s Disease. Cellular and Molecular Biology. 2022;68(8):13–21. DOI: 10.14715/cmb/2022.68.8.3Küçükdoğru R., Türkez H., Arslan M.E., Tozlu ÖÖ., Sönmez E., Mardinoğlu A., Cacciatore I., Di Stefano A. Neuroprotective effects of boron nitride nanoparticles in the experimental Parkinson's disease model against MPP+ induced apoptosis // Metab Brain Dis. – 2020. – Vol. 35, No. 6. – P. 947–957. DOI: 10.1007/s11011-020-00559-6Küçükdoğru R, Türkez H, Arslan ME, Tozlu ÖÖ, Sönmez E, Mardinoğlu A, Cacciatore I, Di Stefano A. Neuroprotective effects of boron nitride nanoparticles in the experimental Parkinson's disease model against MPP+ induced apoptosis. Metab Brain Dis. 2020;35(6):947–957. DOI: 10.1007/s11011-020-00559-6Yavuz E., Çevik G., Çevreli B., Serdaroğlu Kaşıkçı E. Effect of boric acid and quercetin combination on oxidative stress/ cognitive function in parkinson model // J Boron. – 2023. – Vol. 8, No. 3. – P. 85–91. DOI: 10.30728/boron.1215949Yavuz E, Çevik G, Çevreli B, Serdaroğlu Kaşıkçı E. Effect of boric acid and quercetin combination on oxidative stress/ cognitive function in parkinson model. J Boron. 2023;8(3):85–91. DOI: 10.30728/boron.1215949Revi M. Alzheimer's Disease Therapeutic Approaches // Adv Exp Med Biol. – 2020. – Vol. 1195. – P. 105–116. DOI: 10.1007/978-3-030-32633-3_15Revi M. Alzheimer's Disease Therapeutic Approaches. Adv Exp Med Biol. 2020;1195:105–116. DOI: 10.1007/978-3-030-32633-3_15Shin J.H. Dementia Epidemiology Fact Sheet 2022 // Ann Rehabil Med. – 2022. – Vol. 46, No. 2. – P. 53–59. DOI: 10.5535/arm.22027Shin JH. Dementia Epidemiology Fact Sheet 2022. Ann Rehabil Med. 2022;46(2):53–59. DOI: 10.5535/arm.22027Murphy M.P., LeVine H. 3rd. Alzheimer's disease and the amyloid-beta peptide // J Alzheimers Dis. – 2010. – Vol. 19, No. 1. – P. 311–323. DOI: 10.3233/JAD-2010-1221Murphy MP, LeVine H 3rd. Alzheimer's disease and the amyloid-beta peptide. J Alzheimers Dis. 2010;19(1):311–323. DOI: 10.3233/JAD-2010-1221Paudel P., Seong S.H., Zhou Y., Park H.J., Jung H.A., Choi J.S. Anti-Alzheimer's Disease Activity of Bromophenols from a Red Alga, Symphyocladia latiuscula (Harvey) Yamada // ACS Omega. – 2019. – Vol. 4, No. 7. – P. 12259–12270. DOI: 10.1021/acsomega.9b01557Paudel P, Seong SH, Zhou Y, Park HJ, Jung HA, Choi JS. Anti-Alzheimer's Disease Activity of Bromophenols from a Red Alga, Symphyocladia latiuscula (Harvey) Yamada. ACS Omega. 2019;4(7):12259–12270. DOI: 10.1021/acsomega.9b01557Özdemir Ç., Arslan M., Küçük A., Yığman Z., Dursun A.D. Therapeutic Efficacy of Boric Acid Treatment on Brain Tissue and Cognitive Functions in Rats with Experimental Alzheimer's Disease // Drug Des Devel Ther. – 2023. – Vol. 17. – P. 1453–1462. DOI: 10.2147/DDDT.S405963Özdemir Ç, Arslan M, Küçük A, Yığman Z, Dursun AD. Therapeutic Efficacy of Boric Acid Treatment on Brain Tissue and Cognitive Functions in Rats with Experimental Alzheimer's Disease. Drug Des Devel Ther. 2023;17:1453–1462. DOI: 10.2147/DDDT.S405963Colak S., Geyikoglu F., Keles O.N., Türkez H., Topal A., Unal B. The neuroprotective role of boric acid on aluminum chloride-induced neurotoxicity // Toxicol Ind Health. – 2011. – Vol. 27, No. 8. – P. 700–710. DOI: 10.1177/0748233710395349Colak S, Geyikoglu F, Keles ON, Türkez H, Topal A, Unal B. The neuroprotective role of boric acid on aluminum chloride-induced neurotoxicity. Toxicol Ind Health. 2011;27(8):700–710. DOI: 10.1177/0748233710395349Lu C.J., Hu J., Wang Z., Xie S., Pan T., Huang L., Li X. Discovery of boron-containing compounds as Aβ aggregation inhibitors and antioxidants for the treatment of Alzheimer's disease // Medchemcomm. – 2018. – Vol. 9, No. 11. – P. 1862–1870. DOI: 10.1039/c8md00315gLu CJ, Hu J, Wang Z, Xie S, Pan T, Huang L, Li X. Discovery of boron-containing compounds as Aβ aggregation inhibitors and antioxidants for the treatment of Alzheimer's disease. Medchemcomm. 2018;9(11):1862–1870. DOI: 10.1039/c8md00315gAnam A.K., Insogna K. Update on Osteoporosis Screening and Management // Med Clin North Am. – 2021. – Vol. 105, No. 6. – P. 1117–1134. DOI: 10.1016/j.mcna.2021.05.016Anam AK, Insogna K. Update on Osteoporosis Screening and Management. Med Clin North Am. 2021;105(6):1117–1134. DOI: 10.1016/j.mcna.2021.05.016Curtis E.M., van der Velde R., Moon R.J., van den Bergh J.P., Geusens P., de Vries F., van Staa T.P., Cooper C., Harvey N.C. Epidemiology of fractures in the United Kingdom 1988-2012: Variation with age, sex, geography, ethnicity and socioeconomic status // Bone. – 2016. – Vol. 87. – P. 19–26. DOI: 10.1016/j.bone.2016.03.006Curtis EM, van der Velde R, Moon RJ, van den Bergh JP, Geusens P, de Vries F, van Staa TP, Cooper C, Harvey NC. Epidemiology of fractures in the United Kingdom 1988-2012: Variation with age, sex, geography, ethnicity and socioeconomic status. Bone. 2016;87:19–26. DOI: 10.1016/j.bone.2016.03.006Kanis J.A. Diagnosis of osteoporosis and assessment of fracture risk // Lancet. – 2002. – Vol. 359, No. 9321. – P. 1929–1936. DOI: 10.1016/S0140-6736(02)08761-5Kanis JA. Diagnosis of osteoporosis and assessment of fracture risk. Lancet. 2002;359(9321):1929–1936. DOI: 10.1016/S0140-6736(02)08761-5Rosen H.N., Vokes T.J., Malabanan A.O., Deal C.L., Alele J.D., Olenginski T.P., Schousboe J.T. The Official Positions of the International Society for Clinical Densitometry: vertebral fracture assessment // J Clin Densitom. – 2013. – Vol. 16, No. 4. – P. 482–488. DOI: 10.1016/j.jocd.2013.08.003Rosen HN, Vokes TJ, Malabanan AO, Deal CL, Alele JD, Olenginski TP, Schousboe JT. The Official Positions of the International Society for Clinical Densitometry: vertebral fracture assessment. J Clin Densitom. 2013;16(4):482–488. DOI: 10.1016/j.jocd.2013.08.003Egorova E.A., Beitullaev A.M., Matveev A.V., Koryanova K.N. Review of publications on drug-related problems investigations in osteoporosis patients // Pharmacy & Pharmacology. – 2023. – Vol. 11, No. 5. – P. 412–421. DOI: 10.19163/2307-9266-2023-11-5-412-421Egorova EA, Beitullaev AM, Matveev AV, Koryanova KN. Review of publications on drug-related problems investigations in osteoporosis patients. Pharmacy & Pharmacology. 2023;11(5):412–421. DOI: 10.19163/2307-9266-2023-11-5-412-421Xu B., Dong F., Yang P., Wang Z., Yan M., Fang J., Zhang Y. Boric Acid Inhibits RANKL-Stimulated Osteoclastogenesis In Vitro and Attenuates LPS-Induced Bone Loss In Vivo // Biol Trace Elem Res. – 2023. – Vol. 201, No. 3. – P. 1388–1397. DOI: 10.1007/s12011-022-03231-5Xu B, Dong F, Yang P, Wang Z, Yan M, Fang J, Zhang Y. Boric Acid Inhibits RANKL-Stimulated Osteoclastogenesis In Vitro and Attenuates LPS-Induced Bone Loss In Vivo. Biol Trace Elem Res. 2023;201(3):1388–1397. DOI: 10.1007/s12011-022-03231-5Toker H., Ozdemir H., Balci Yuce H., Goze F. The effect of boron on alveolar bone loss in osteoporotic rats // J Dent Sci. – 2016. – Vol. 11, No. 3. – P. 331–337. DOI: 10.1016/j.jds.2016.03.011Toker H, Ozdemir H, Balci Yuce H, Goze F. The effect of boron on alveolar bone loss in osteoporotic rats. J Dent Sci. 2016;11(3):331–337. DOI: 10.1016/j.jds.2016.03.011Eltzschig H.K., Eckle T. Ischemia and reperfusion--from mechanism to translation // Nat Med. – 2011. – Vol. 17, No. 11. – P. 1391–1401. DOI: 10.1038/nm.2507Eltzschig HK, Eckle T. Ischemia and reperfusion--from mechanism to translation. Nat Med. 2011;17(11):1391–1401. DOI: 10.1038/nm.2507Frangogiannis N.G. Pathophysiology of Myocardial Infarction // Compr Physiol. – 2015. – Vol. 5, No. 4. – P. 1841–1875. DOI: 10.1002/cphy.c150006Frangogiannis NG. Pathophysiology of Myocardial Infarction. Compr Physiol. 2015;5(4):1841–1875. DOI: 10.1002/cphy.c150006Zhao Y., Zhang X., Chen X., Wei Y. Neuronal injuries in cerebral infarction and ischemic stroke: From mechanisms to treatment (Review) // Int J Mol Med. – 2022. – Vol. 49, No. 2. – P. 15. DOI: 10.3892/ijmm.2021.5070Zhao Y, Zhang X, Chen X, Wei Y. Neuronal injuries in cerebral infarction and ischemic stroke: From mechanisms to treatment (Review). Int J Mol Med. 2022;49(2):15. DOI: 10.3892/ijmm.2021.5070Wu M.Y., Yiang G.T., Liao W.T., Tsai A.P., Cheng Y.L., Cheng P.W., Li C.Y., Li C.J. Current Mechanistic Concepts in Ischemia and Reperfusion Injury // Cell Physiol Biochem. – 2018. – Vol. 46, No. 4. – P. 1650–1667. DOI: 10.1159/000489241Wu MY, Yiang GT, Liao WT, Tsai AP, Cheng YL, Cheng PW, Li CY, Li CJ. Current Mechanistic Concepts in Ischemia and Reperfusion Injury. Cell Physiol Biochem. 2018;46(4):1650–1667. DOI: 10.1159/000489241Yapca O.E., Borekci B., Suleyman H. Ischemia-reperfusion damage // Eurasian J Med. – 2013. – Vol. 45, No. 2. – P. 126–127. DOI: 10.5152/eajm.2013.24Yapca OE, Borekci B, Suleyman H. Ischemia-reperfusion damage. Eurasian J Med. 2013;45(2):126–127. DOI: 10.5152/eajm.2013.24Güler S., Aslaner A., Ellidağ H.Y., Yıldırım Ş., Çakır T. The protective effect of boric acid on cholestatic rat liver ischemia reperfusion injury // Turk J Med Sci. – 2021. – Vol. 51, No. 5. – P. 2716–2726. DOI: 10.3906/sag-2101-153Güler S, Aslaner A, Ellidağ HY, Yıldırım Ş, Çakır T. The protective effect of boric acid on cholestatic rat liver ischemia reperfusion injury. Turk J Med Sci. 2021;51(5):2716–2726. DOI: 10.3906/sag-2101-153Çolak S., Koc K., Yıldırım S., Geyikoğlu F. Effects of boric acid on ovarian tissue damage caused by experimental ischemia/reperfusion // Biotech Histochem. – 2022. – Vol. 97, No. 6. – P. 415–422. DOI: 10.1080/10520295.2021.2012823Çolak S, Koc K, Yıldırım S, Geyikoğlu F. Effects of boric acid on ovarian tissue damage caused by experimental ischemia/reperfusion. Biotech Histochem. 2022;97(6):415–422. DOI: 10.1080/10520295.2021.2012823Allahverdiyev O., Dzhafar S., Berköz M., Yıldırım M. Advances in current medication and new therapeutic approaches in epilepsy // East J Med. – 2018. – Vol. 23, No. 1. – P. 48–59. DOI: 10.5505/ejm.2018.62534Allahverdiyev O, Dzhafar S, Berköz M, Yıldırım M. Advances in current medication and new therapeutic approaches in epilepsy. East J Med. 2018;23(1):48–59. DOI: 10.5505/ejm.2018.62534Berköz M., Yunusoğlu O., Aslan A., Bozkurt A. Investigation of antiepileptic potentials of usnic acid and some lichen species on the behavioral and biochemical levels in pentylenetetrazole-induced kindling model of epilepsy // J Res Pharm. – 2024. – Vol. 28, No. 5. – P. 1378–1390. DOI: 10.29228/jrp.816Berköz M, Yunusoğlu O, Aslan A, Bozkurt A. Investigation of antiepileptic potentials of usnic acid and some lichen species on the behavioral and biochemical levels in pentylenetetrazole-induced kindling model of epilepsy. J Res Pharm. 2024;28(5):1378–1390. DOI: 10.29228/jrp.816Kurt A.H., Bosnak M., Inan S.Y., Celik A., Uremis M.M. Epileptogenic effects of G protein-coupled estrogen receptor 1 in the rat pentylenetetrazole kindling model of epilepsy // Pharmacol Rep. – 2016. – Vol. 68, No. 1. – P. 66–70. DOI: 10.1016/j.pharep.2015.07.001Kurt AH, Bosnak M, Inan SY, Celik A, Uremis MM. Epileptogenic effects of G protein-coupled estrogen receptor 1 in the rat pentylenetetrazole kindling model of epilepsy. Pharmacol Rep. 2016;68(1):66–70. DOI: 10.1016/j.pharep.2015.07.001Engel J. Jr. Concepts of epilepsy // Epilepsia. – 1995. – Vol. 36, Suppl 1. – P. S23–29. DOI: 10.1111/j.1528-1157.1995.tb01648.xEngel J Jr. Concepts of epilepsy. Epilepsia. 1995;36 Suppl 1:S23–29. DOI: 10.1111/j.1528-1157.1995.tb01648.xFisher R.S., van Emde Boas W., Blume W., Elger C., Genton P., Lee P., Engel J. Jr. Epileptic seizures and epilepsy: definitions proposed by the International League Against Epilepsy (ILAE) and the International Bureau for Epilepsy (IBE) // Epilepsia. – 2005. – Vol. 46, No. 4. – P. 470–472. DOI: 10.1111/j.0013-9580.2005.66104.xFisher RS, van Emde Boas W, Blume W, Elger C, Genton P, Lee P, Engel J Jr. Epileptic seizures and epilepsy: definitions proposed by the International League Against Epilepsy (ILAE) and the International Bureau for Epilepsy (IBE). Epilepsia. 2005;46(4):470–472. DOI: 10.1111/j.0013-9580.2005.66104.xKarademir M., Arslan G. The effect of boric acid on penicillin induced experimental epilepsy // CMJ. – 2019. – Vol. 41, No. 1. – P. 150–157. DOI: 10.7197/223.vi.543145Karademir M, Arslan G. The effect of boric acid on penicillin induced experimental epilepsy. CMJ. 2019;41(1):150–157. DOI: 10.7197/223.vi.543145Akdere Ö.E., Shikhaliyeva İ., Gümüşderelioğlu M. Boron mediated 2D and 3D cultures of adipose derived mesenchymal stem cells // Cytotechnology. – 2019. – Vol. 71, No. 2. – P. 611–622. DOI: 10.1007/s10616-019-00310-9Akdere ÖE, Shikhaliyeva İ, Gümüşderelioğlu M. Boron mediated 2D and 3D cultures of adipose derived mesenchymal stem cells. Cytotechnology. 2019;71(2):611–622. DOI: 10.1007/s10616-019-00310-9Lu L., Zhang Q., Ren M., Jin E., Hu Q., Zhao C., Li S. Effects of Boron on Cytotoxicity, Apoptosis, and Cell Cycle of Cultured Rat Sertoli Cells In vitro // Biol Trace Elem Res. – 2020. – Vol. 196, No. 1. – P. 223–230. DOI: 10.1007/s12011-019-01911-3Lu L, Zhang Q, Ren M, Jin E, Hu Q, Zhao C, Li S. Effects of Boron on Cytotoxicity, Apoptosis, and Cell Cycle of Cultured Rat Sertoli Cells In vitro. Biol Trace Elem Res. 2020;196(1):223–230. DOI: 10.1007/s12011-019-01911-3Yilmaz H., Özbek E.N., İşel E., Debeleç-Bütüner B., Yetik‐Anacak G., Tansu Koparal A., Ulus G. Evaluation of Borax Pentahydrate as a Novel Antiangiogenic Agent. – 2023. DOI: 10.21203/rs.3.rs-3267555/v1Yilmaz H, Özbek EN, İşel E, Debeleç-Bütüner B, Yetik‐Anacak G, Tansu Koparal A, Ulus G. Evaluation of Borax Pentahydrate as a Novel Antiangiogenic Agent. 2023. DOI: 10.21203/rs.3.rs-3267555/v1Bolt H.M., Duydu Y., Başaran N., Golka K. Boron and its compounds: current biological research activities // Arch Toxicol. – 2017. – Vol. 91, No. 8. – P. 2719–2722. DOI: 10.1007/s00204-017-2010-1Bolt HM, Duydu Y, Başaran N, Golka K. Boron and its compounds: current biological research activities. Arch Toxicol. 2017;91(8):2719–2722. DOI: 10.1007/s00204-017-2010-1Demircan B., Velioğlu Y.S. Toxicological Evaluation of Boron Compounds Taken from Food and Environment // Akademik Gıda. – 2020. – Vol. 18, No. 3. – P. 312–322. DOI: 10.24323/akademik-gida.818193Demircan B, Velioğlu YS. Toxicological Evaluation of Boron Compounds Taken from Food and Environment. Akademik Gıda. 2020;18(3):312–322. DOI: 10.24323/akademik-gida.818193Duydu Y., Başaran N., Üstündağ A., Aydin S., Ündeğer Ü., Ataman O.Y., Aydos K., Düker Y., Ickstadt K., Waltrup B.S., Golka K., Bolt H.M. Reproductive toxicity parameters and biological monitoring in occupationally and environmentally boron-exposed persons in Bandirma, Turkey // Arch Toxicol. – 2011. – Vol. 85, No. 6. – P. 589–600. DOI: 10.1007/s00204-011-0692-3Duydu Y, Başaran N, Üstündağ A, Aydin S, Ündeğer Ü, Ataman OY, Aydos K, Düker Y, Ickstadt K, Waltrup BS, Golka K, Bolt HM. Reproductive toxicity parameters and biological monitoring in occupationally and environmentally boron-exposed persons in Bandirma, Turkey. Arch Toxicol. 2011;85(6):589–600. DOI: 10.1007/s00204-011-0692-3Hunt C.D., Herbel J.L., Nielsen F.H. Metabolic responses of postmenopausal women to supplemental dietary boron and aluminum during usual and low magnesium intake: boron, calcium, and magnesium absorption and retention and blood mineral concentrations // Am J Clin Nutr. – 1997. – Vol. 65, No. 3. – P. 803–813. DOI: 10.1093/ajcn/65.3.803Hunt CD, Herbel JL, Nielsen FH. Metabolic responses of postmenopausal women to supplemental dietary boron and aluminum during usual and low magnesium intake: boron, calcium, and magnesium absorption and retention and blood mineral concentrations. Am J Clin Nutr. 1997;65(3):803–813. DOI: 10.1093/ajcn/65.3.803

The authors declare that there are no conflicts of interest present.