pmedpharmФармация и фармакологияPharmacy & Pharmacology2307-92662413-2241Pyatigorsk Medical and Pharmaceutical Institute - branch of Volgograd State Medical Univer10.19163/2307-9266-2026-14-1-31-80pmedpharm-1813Research ArticleОБЗОРЫREVIEWЛекарственное растительное сырье и фитопрепараты в терапии хронических инфекционно-воспалительных заболеваний почек и мочевыводящих путейMedicinal plant raw materials and phytopreparations in the therapy of chronic infectious and inflammatory diseases of the kidneys and urinary tracthttps://orcid.org/0000-0001-9558-5336ШишкаловД. И.ShishkalovD. I.

аспирант кафедры фармации, преподаватель кафедры медицинской и фармацевтической химии ФГБОУ ВО «Майкопский государственный технологический университет (МГТУ)». 

385000, Россия, Республика Адыгея, г. Майкоп, ул. Первомайская, д. 191.

 

191 Pervomayskaya Str., Maykop, Russia, 385000.

hitmanapp@mail.ruhttps://orcid.org/0000-0001-8467-2899АртемьеваВ. В.ArtemyevaV. V.

старший преподаватель кафедры медицинской и фармацевтической химии ФГБОУ ВО «Майкопский государственный технологический университет (МГТУ)». 

 

385000, Россия, Республика Адыгея, г. Майкоп, ул. Первомайская, д. 191.

senior lecturer at the Department of Medical and Pharmaceutical Chemistry, Maykop State Technological University. 

191 Pervomayskaya Str., Maykop, Russia, 385000.

denis7radnet.ru@mail.ruhttps://orcid.org/0000-0002-8638-9963ЗилфикаровИ. Н.ZilfikarovI. N.

доктор фармацевтических наук, профессор РАН, заведующий кафедрой медицинской и фармацевтической химии ФГБОУ ВО «Майкопский государственный технологический университет (МГТУ)», главный научный сотрудник отдела химии и технологии природных соединений ФГБНУ «Всероссийский научно-исследовательский институт лекарственных и ароматических растений (ВИЛАР)». 

385000, Россия, Республика Адыгея, г. Майкоп, ул. Первомайская, д. 191.

117216, Россия, г. Москва, ул. Грина, д. 7, стр. 1.

Doctor of Sciences (Pharmacy), Professor of the Russian Academy of Sciences, Head of the Department of Medical and Pharmaceutical Chemistry, Maykop State Technological University; Chief Scientist, All-Russian Scientific Research Institute of Medicinal and Aromatic Plants.

1. 191 Pervomayskaya Str., Maykop, Russia, 385000.

2. 7 Grin Str., Bldg. 1, Moscow, Russia, 117216.

dagfarm@mail.ruhttps://orcid.org/0000-0003-3425-7157АвдееваЕ. В.AvdeevaE. V.

доктор фармацевтических наук, профессор, заведующий кафедрой фармакологии имени заслуженного деятеля науки РФ профессора А.А. Лебедева ФГБОУ ВО СамГМУ Минздрава России.

Doctor of Sciences (Pharmacy), Professor, Head of the Department of Pharmacology named after the Honored Scientist of the Russian Federation Professor A.A. Lebedev, Samara State Medical University. 

89 Chapaevskaya Str., Samara, Russia, 443099. 

e.v.avdeeva@samsmu.ruhttps://orcid.org/0000-0002-7513-9352КуркинВ. А.KurkinV. A.

доктор фармацевтических наук, профессор, заведующий кафедрой фармакогнозии с ботаникой и основами фитотерапии ФГБОУ ВО СамГМУ Минздрава России. 

443099, Россия, г. Самара, ул. Чапаевская, д. 89.

Doctor of Sciences (Pharmacy), Professor,  Head of the Department of Pharmacognosy with Botany and the Basics of Phytotherapy, Samara State Medical University. 

89 Chapaevskaya Str., Samara, Russia, 443099.

v.a.kurkin@samsmu.ruФедеральное государственное бюджетное образовательное учреждение высшего образования «Майкопский государственный технологический университет».РоссияMaykop State Technological University.Russian Federation1. Федеральное государственное бюджетное образовательное учреждение высшего образования «Майкопский государственный технологический университет». 2. Федеральное государственное бюджетное научное учреждение «Всероссийский научно-исследовательский институт лекарственных и ароматических растений».Россия1. Maykop State Technological University. 2. All-Russian Scientific Research Institute of Medicinal and Aromatic Plants.Russian FederationФедеральное государственное бюджетное образовательное учреждение высшего образования «Самарский государственный медицинский университет» Министерства здравоохранения Российской Федерации.РоссияSamara State Medical University.Russian Federation2026220320261413180Copyright © Шишкалов Д.И., Артемьева В.В., Зилфикаров И.Н., Авдеева Е.В., Куркин В.А., 20262026Шишкалов Д.И., Артемьева В.В., Зилфикаров И.Н., Авдеева Е.В., Куркин В.А.Shishkalov D.I., Artemyeva V.V., Zilfikarov I.N., Avdeeva E.V., Kurkin V.A.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pharmpharm.ru/jour/article/view/1813Цель

Цель. Проанализировать и обобщить современные научные данные о применении лекарственного растительного сырья как источника биологически активных веществ и лекарственных средств растительного происхождения (фитопрепаратов) в терапии хронических инфекционно-воспалительных заболеваний почек и мочевыводящих путей.

Материалы и методы

Материалы и методы. Поиск научных данных осуществляли в международных электронных базах Google Scholar, Science Direct, PubMed, elibrary.ru и cyberleninka.ru. Основной массив научных публикаций охватывал оригинальные статьи за период с 2010 по 2025 гг. В настоящий обзор включено 446 источников научной информации.

Результаты

Результаты. Хронические инфекционно-воспалительные заболевания почек и мочевыводящих путей (ХИВЗПМП) становятся все более актуальной проблемой и требуют особого внимания. В арсенале современной медицины и фармации имеется разнообразное официнальное лекарственное растительное сырье (ЛРС), являющееся источником биологически активных веществ (БАВ) и фитопрепаратов для терапии и профилактики заболеваний почек. Кроме того, активно изучаются новые перспективные растительные объекты. Представленные результаты доклинических фитохимических и фармакологических, а также клинических исследований достоверно указывают на наличие существенного влияния выявленных БАВ, в частности, компонентов эфирных масел и фенольных соединений на основные звенья патогенеза и на развитие диуретического, противовоспалительного, уросептического, литолитического и антилитогенного эффектов. Все указанное стимулирует разработку новых комбинированных фитопрепаратов, для которых отмечены различные подходы в их стандартизации, выборе методов анализа ведущих и сопутствующих БАВ.

Заключение

Заключение. В обзоре рассмотрено и проанализировано современное состояние исследований в области применения ЛРС как источника БАВ фитопрепаратов в терапии ХИВЗПМП. Показано, что ключевые классы БАВ терпеноидной и фенольной природы обладают противовоспалительным, антибактериальным, диуретическим, литолитическим и антилитогенным эффектами. Выделен ряд перспективных нефармакопейных видов ЛРС: подмаренника настоящего трава, подсолнечника однолетнего корни, шиповника корни, дудника лекарственного корневища и корни, клюквы плоды, имеющие обширный эмпирический опыт применения в народной медицине, а также результаты лабораторных химических и доклинических исследований.

The aim

The aim. To analyze and summarize modern scientific data on the use of medicinal plant raw materials as a source of biologically active substances and herbal medicines (phytopreparations) in the therapy of chronic infectious and inflammatory diseases of the kidneys and urinary tract.

Materials and methods

Materials and methods. The search for scientific data was carried out in international scientific electronic databases Google Scholar, Science Direct, PubMed, elibrary.ru and cyberleninka.ru. Publications for the period from 2010 to 2025 were studied. This review includes 446 sources of scientific information.

Results

Results. Chronic infectious and inflammatory diseases of the kidneys and urinary tract (CIDKUT) are becoming an increasingly important problem and require special attention. Modern medicine and pharmacy have a variety of official medicinal plant raw materials (MPRMs) at their disposal, which are a source of biologically active substances (BASs) and phytopreparations for the treatment and prevention of kidney diseases. In addition, new promising plant objects are being actively studied. The presented results of preclinical phytochemical and pharmacological, as well as clinical studies, reliably indicate the presence of a significant influence of the identified BASs, in particular, components of essential oils and phenolic compounds, on the main links of pathogenesis and on the development of diuretic, anti-inflammatory, uroseptic, litholytic and antilithogenic effects. All of the above stimulates the development of new combined phytopreparations, for which various approaches have been noted in their standardization, the choice of methods for analyzing leading and related BAS.

Conclusion

Conclusion. The review examines and analyzes the current state of research in the field of using MPRM as a source of BASs of phytopreparations in the treatment of CIDKUT. It is shown that key classes of BAS of terpenoid and phenolic nature have anti-inflammatory, antibacterial, diuretic, litholytic and antilithogenic effects. A number of promising non-pharmacopoeial types of MPRMs have been identified: true bedstraw herb, annual sunflower roots, rosehip roots, angelica rhizomes and roots, cranberry fruits, which have extensive empirical experience in folk medicine, as well as the results of laboratory chemical and preclinical studies.

хронические инфекционно-воспалительные заболевания почек и мочевыводящих путейбиологически активные веществакомпоненты эфирных маселфенольные соединенияоднокомпонентные фитопрепаратыкомбинированные фитопрепаратыфитотерапиядиуретическая активностьантибактериальная активностьпротивовоспалительная активностьлитолитическая активностьантилитогенная активностьперспективные источники фитопрепаратовchronic infectious and inflammatory diseases of the kidneys and urinary tractbiologically active substancescomponents of essential oilsphenolic compoundssingle-component phytopreparationscombined phytopreparationsphytotherapydiuretic activityantibacterial activityanti-inflammatory activitylitholytic activityantilithogenic activitypromising sources of phytopreparationsДанное исследование не имело финансовой поддержки от сторонних организаций.This study did not have financial support from third-party organizations.ReferencesКоролёв С.В., Зенков И.Б. 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The authors declare that there are no conflicts of interest present.