pmedpharmФармация и фармакологияPharmacy & Pharmacology2307-92662413-2241Pyatigorsk Medical and Pharmaceutical Institute - branch of Volgograd State Medical Univer10.19163/2307-9266-2016-4-5-4-35pmedpharm-214Research ArticleОБЗОРЫ, ЛЕКЦИИREVIEWS, LECTURESБИОЛОГИЧЕСКИ АКТИВНЫЕ СОЕДИНЕНИЯ ПОЛЫНИ ОДНОЛЕТНЕЙ. СЕСКВИТЕРПЕНОВЫЕ ЛАКТОНЫBIOLOGICALLY ACTIVE COMPOUNDS OF ARTEMISIA ANNUA. SESQUITERPENE LACTONESКоноваловД. А.KonovalovD. A.

доктор фармацевтических наук, профессор, заместитель директора по науке

Doctor of Pharmaceutical Sciences, Professor, Deputy Director of Research

d.a.konovalov@pmedpharm.ruШевчукО. М.ShevchukO. M.

доктор биологических наук, заведующий лабораторией ароматических и лекарственных растений,

 пгт. Никита, Республика Крым

Doctor of Biological Sciences, Head of the Laboratory of Aromatic and Medicina Plants,

Nikita, Republic of Crimea

oksana_shevchuk1970@mail.ruЛогвиненкоЛ. А.LogvinenkoL. A.

научный сотрудник лаборатории ароматических и лекарственных растений,

пгт. Никита, Республика Крым

scientific worker of the laboratory of aromatic medicinal plants,

Nikita, Republic of Crimea

ХамилоновА. А.KhamiloA. A.

аспирант кафедры фармакогнозии

postgraduate student at the Chair of Pharmacognosy

spartan400@yandex.ruПятигорский медико-фармацевтический институт – филиал ВолгГМУ Минздрава РоссииРоссияPyatigorsk Medical and Pharmaceutical Institute – branch of Volgograd State Medical University of the Ministry of Health of RussiaRussian FederationФГБУН «НБС-ННЦ»РоссияNikitsky Botanic GardenRussian Federation20162911201645435Copyright © Коновалов Д.А., Шевчук О.М., Логвиненко Л.А., Хамилонов А.А., 20162016Коновалов Д.А., Шевчук О.М., Логвиненко Л.А., Хамилонов А.А.Konovalov D.A., Shevchuk O.M., Logvinenko L.A., Khamilo A.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pharmpharm.ru/jour/article/view/214

Полынь однолетняя (Artemisia annua L.) – однолетнее травянистое растение, используемое в народной медицине Китая более двух тысяч лет. В 70-х годах XX века из надземной части этого вида был выделен сесквитерпеновый лактон артемизинин. На сегодняшний день – это самое эффективное, среди известных природных и синтетических соединений, лекарственное средство для лечения малярии.

Целью исследования явился обзор информации, содержащейся в открытых источниках, об изучении сесквитерпеновых лактонов полыни однолетней и спектре их фармакологической активности.

Методы

Методы. Исследование проводилось с использованием информационно-поисковых (PubMed, ScholarGoogle), библиотечных баз данных (eLibrary, Cyberleninca), а также результатов собственных исследований.

Результаты

Результаты. Установлено, что кроме эфирного масла и фенольных соединений надземная часть полыни однолетней содержит значительное количество различающихся по структуре сесквитерпеновых лактонов. Качественный состав и количественное содержание сесквитерпеновых лактонов варьирует в зависимости от эколого-географических факторов, фазы развития растений, технологии выращивания, способа сушки и т.д. Известные фармакологические исследования извлечений из травы полыни однолетней, содержащих сесквитерпеновые лактоны, а также индивидуальных соединений этой группы характеризуют данный вид сырья как перспективный источник для дальнейшего более глубокого исследования.

Заключение

Заключение. Проведенный нами анализ, имеющихся в открытом информационном доступе, материалов по изучению сесквитерпеновых лактонов полыни однолетней, в том числе фитохимических и фармакологических, позволяют характеризовать траву полыни однолетней как перспективный источник для разработки новых лекарственных средств.

Artemisia annua is an herblike annual plant which has been used in Chinese folk medicine for more than 2,000 years. In 1970-s sesquiterpene lactones of artemisinin was isolated from the aboveground part of this plant. Today it is the most efficient known natural and synthetic compound for malaria treatment.

The purpose of the study was the review of the information from the open sources about the study for sesquiterpene lactones of Artemisia annua referring to its pharmacological activity.

Methods

Methods. The study was carried out using informational and search engines (PubMed, ScholarGoogle), library databases (eLibrary, Cyberleninca), and the results of our own researches.

Results

Results. It was established that apart from the essential oil and phenolic compounds, aboveground part of Artemisia annua, it contains a significant amount of sesquiterpene lactones. Qualitative content and quantitative composition of sesquiterpene lactones varies depending on the ecological and geographic factors, plants growing phase, cultivation technology, drying methods etc. Well-known pharmacological studies of the extracts from Artemisia annua herb with sesquiterpene lactones, as well as individual compounds of this group characterize this type of raw materials as a perspective source for more profound research.

Conclusion

Conclusion. Our analysis of the open materials on the sesquiterpene lactones of Artemisia annua, including phytochemical and pharmacological ones, allows characterization of the Artemisia annua herb as a perspective source for new drugs working out.

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The authors declare that there are no conflicts of interest present.