pmedpharmФармация и фармакологияPharmacy & Pharmacology2307-92662413-2241Pyatigorsk Medical and Pharmaceutical Institute - branch of Volgograd State Medical Univer10.19163/2307-9266-2014-2-2(3)-23-33pmedpharm-24Research ArticleФАРМАКОГНОЗИЯ, БОТАНИКАPHARMACOGNOSY, BOTANYСЕСКВИТЕРПЕНОВЫЕ ЛАКТОНЫ ЛИСТЬЕВ И ПЛОДОВ LAURUS NOBILIS L. (ЛАВРА БЛАГОРОДНОГОSESQUITERPENE LACTONES OF LEAVES AND FRUITS OF LAURUS NOBILIS L.КоноваловД. А.KonovalovD. A.

доктор фармацевтических наук, заведующий кафедрой фармакогнозии, профессор Пятигорского медико-фармацевтического института–филиала ГБОУ ВПО ВолгГМУ Минздрава России. Область научных интересов – фитохимия, химия природных соединений, хемотаксономия.

konovalov_da@pochta.ruНасуховаН. М.NasuhovaN. M.

аспирант Дагестанского государственного университета, кафедра фармакогнозии.

Пятигорский медико-фармацевтический институт – филиал ГБОУ ВПО ВолгГМУ Минздрава России, г. ПятигорскРоссияPyatigorsk Medical-Pharmaceutical Institute – branch of the SGEI HPT VolgSMU of Minzdrav of Russia, PyatigorskRussian FederationДагестанский государственный университет, г. МахачкалаРоссияDagestan state university, MakhachkalaRussian Federation20141109201522(3)2333Copyright © Коновалов Д.А., Насухова Н.М., 20152015Коновалов Д.А., Насухова Н.М.Konovalov D.A., Nasuhova N.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pharmpharm.ru/jour/article/view/24

Лавр благородный (Laurus nobilis L.) распространен в Средиземноморском регионе, Европе и Америке. Широко культивируется также в странах Аравийского полуострова и Северной Африки.В качестве основных действующих веществ в растении описаны: компоненты эфирного масла, сесквитерпеновые лактоны, алкалоиды и фенольные соединения (флавоноиды, фенольные кислоты и лигнаны).В растении обнаружены более 30 сесквитерпеновых лактонов. Структурные типы этих соединений включают эвдесманолиды, гермакранолиды, гваянолиды. Сесквитерпеновые лактоны, выделенные из листьев и плодов Laurus nobilis, обладают антибактериальной, противогрибковой, антидиабетической, противоспалительной, гепатозащитной, нейрозащитной и цитотоксической активностью. Они ингибируют поглощение спирта, повышают активность печеночной глутатион-S-трансферазы. Большинство этих видов активности у сесквитерпеновых лактонов лавра обусловлены присутствием в их структуре α-метилен--бутиролактонной части.Таким образом, содержащие сесквитерпеновые лактоны листья и плоды Laurus nobilis могли бы быть важным источником сырья для создания новых лекарственных средств

Bay laurel (Laurus nobilis L.) is common in the Mediterranean region, Europe and America. Widely cultivated in the countries of the Arabian Peninsula and North Africa. As the basic active substances in plants: essential oil components, sesquiterpene lactones, alkaloids, and phenolic compounds (flavonoids, phenolic acids and lignans) are described.In the plant more than 30 sesquiterpene lactones are found. Structural types of these compounds include eudesmanolides, germacranolides, guaianolides.Sesquiterpene lactones isolated from the leaves and fruits of Laurus nobilis, possess antibacterial, antifungal, anti-diabetic, anti-inflammatory, hepatoprotective, neuroprotective and cytotoxic activity. They inhibit the absorption of alcohol increases the activity of hepatic glutathione-S-transferase. Most of these types of activity of sesquiterpene lactones from laurel due to the presence within their structure of α-methylene--butyrolactone part.Thus, sesquiterpene lactones-containing leaves and fruits Laurus nobilis could have been an important source of raw materials for the creation of new medicines

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The authors declare that there are no conflicts of interest present.