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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">pmedpharm</journal-id><journal-title-group><journal-title xml:lang="ru">Фармация и фармакология</journal-title><trans-title-group xml:lang="en"><trans-title>Pharmacy &amp; Pharmacology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2307-9266</issn><issn pub-type="epub">2413-2241</issn><publisher><publisher-name>Pyatigorsk Medical and Pharmaceutical Institute - branch of Volgograd State Medical Univer</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.19163/2307-9266-2018-6-5-419-439</article-id><article-id custom-type="elpub" pub-id-type="custom">pmedpharm-324</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ, ЛЕКЦИИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS, LECTURES</subject></subj-group></article-categories><title-group><article-title>БИОЛОГИЧЕСКАЯ АКТИВНОСТЬ КОМПОНЕНТОВ ПЧЕЛИНОГО МАТОЧНОГО МОЛОЧКА И ПЧЕЛИНОГО ЯДА</article-title><trans-title-group xml:lang="en"><trans-title>BIOLOGICAL ACTIVITY OF THE COMPONENTS OF ROYAL JELLY AND BEE VENOM</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4556-135X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Марданлы</surname><given-names>С. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Mardanly</surname><given-names>S. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Марданлы Сейфаддин Гашимович – профессор кафедры фармакологии и фармацевтических дисциплин, доктор медицинских наук, Заслуженный работник здравоохранения Российской Федерации.</p><p>SPIN-код: 8284-0411, AuthorID: 772550.</p><p>142600 Московская обл., г. Орехово-Зуево, ул. Зеленая, 22;</p><p>142530. Московская обл., Электрогорск, ул. Будённого, д. 1.</p></bio><bio xml:lang="en"><p>Mardanly Seyfaddin Gashimovich – Professor of the Department of Pharmacology and Pharmaceutical Disciplines, Doctor of Medicine, Honored Employee of Health of the Russian Federation.  </p><p>SPIN-code: 8284-0411, AuthorID: 772550.</p><p>22, Zelenaya Str., Orekhovo-Zuyevo, Moscow region, Russia, 142600;</p><p>1, Budenny Str, Elektrogorsk, Moscow region, Russia, 142530.</p></bio><email xlink:type="simple">ekolab-president@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Помазанов</surname><given-names>В. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Pomazanov</surname><given-names>V. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Помазанов Владимир Васильевич – доктор технических наук, профессор кафедры фармакологии и фармацевтических дисциплин. Президент Ассоциации хроматографистов им. М.С.Цвета, специалист в области физико-химических методов анализа сложных смесей природного и искусственного происхождения.</p><p>SPIN-код: 3200-2407, AuthorID: 603793. </p><p>142600 Московская обл., г. Орехово-Зуево, ул. Зеленая, 22;</p><p>142530. Московская обл., Электрогорск, ул. Будённого, д. 1.</p></bio><bio xml:lang="en"><p>Pomazanov Vladimir Vasilyevich – Doctor of Technical Sciences, Professor of the Department of Pharmacology and Pharmaceutical Disciplines, President of the Association of chromatographists n.a. MS Tsvet, an expert in the field of physico-chemical methods for analyzing complex mixtures of natural and artificial origin.</p><p>SPIN-code: 3200-2407, AuthorID: 603793.</p><p>22, Zelenaya Str., Orekhovo-Zuyevo, Moscow region, Russia, 142600;</p><p>1, Budenny Str, Elektrogorsk, Moscow region, Russia, 142530.</p></bio><email xlink:type="simple">alliya2005@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Киселева</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Kiseleva</surname><given-names>V. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кисилева Валентина Алексеевна – декан фармацевтического факультета, доцент кафедры фармакологии и фармацевтических дисциплин, кандидат медицинских наук.</p><p>SPIN-код: 3412-2916, AuthorID: 342898.</p><p>142600 Московская обл., г. Орехово-Зуево, ул. Зеленая, 22</p></bio><bio xml:lang="en"><p>Kisileva Valentina Alekseevna – Candidate of Sciences (Medicine), Associate Professor of the Department of Pharmacology and Pharmaceutical Disciplines, State Educational Institution of Higher Education of the Moscow Region, Dean of the Faculty of Pharmacy.</p><p>SPIN-code: 3412-2916, AuthorID: 342898</p><p>22, Zelenaya Str., Orekhovo-Zuyevo, Moscow region, Russia, 142600</p></bio><email xlink:type="simple">fammgogi@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Нескородов</surname><given-names>Я. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Neskorodov</surname><given-names>Ya. B.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Нескородов Ярослав Борисович – кандидат биологических наук, научный сотрудник.</p><p>SPIN-код: 4104-2520, AuthorID: 630791. </p><p>142530. Московская обл., Электрогорск, ул. Будённого, д. 1.</p></bio><bio xml:lang="en"><p>Neskorodov Yaroslav Borisovich - Candidate of Sciences (Biology). Researcher of the company ECO Lab.</p><p>SPIN-code: 4104-2520, AuthorID: 630791.</p><p>1, Budenny Str, Elektrogorsk, Moscow region, Russia, 142530</p></bio><email xlink:type="simple">NeskorodovYB@gmail.com</email><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ГОУ ВО МО «Государственный гуманитарно-технологический университет»;&#13;
ЗАО «ЭКОлаб»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>State University of Humanities and Technology;&#13;
CJSC “Ecolab”</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ГОУ ВО МО «Государственный гуманитарно-технологический университет»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>State University of Humanities and Technology</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>ЗАО «ЭКОлаб»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>CJSC “Ecolab”</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2018</year></pub-date><pub-date pub-type="epub"><day>10</day><month>11</month><year>2018</year></pub-date><volume>6</volume><issue>5</issue><fpage>419</fpage><lpage>439</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Марданлы С.Г., Помазанов В.В., Киселева В.А., Нескородов Я.Б., 2018</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="ru">Марданлы С.Г., Помазанов В.В., Киселева В.А., Нескородов Я.Б.</copyright-holder><copyright-holder xml:lang="en">Mardanly S.G., Pomazanov V.V., Kiseleva V.A., Neskorodov Y.B.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.pharmpharm.ru/jour/article/view/324">https://www.pharmpharm.ru/jour/article/view/324</self-uri><abstract><p>Как сами продукты пчеловодства, так и их комбинации, широко представлены на отечественном фармацевтическом рынке, однако, современных экспериментальных исследований биологической активности этих соединений мало, а во многих имеющихся публикациях авторы описывают чрезвычайно широкий и противоречивый спектр терапевтических эффектов. Цель исследования – провести анализ экспериментальных работ по исследованию биологической активности продуктов пчеловодства. Материалы и методы. Исследование проводилось с использованием поисково-информационных (eLibrary, PubMed, CyberLeninka, ResearchGate) и библиотечных баз данных (Российская государственная библиотека, Центральная научная сельскохозяйственная библиотека). В обозначенных базах данных проводился поиск публикаций по таким терминам как «биологическая активность», «пчелиное маточное молочко» и т.д. Глубина поиска не ограничивалась. Результаты и обсуждение. Анализ опубликованных работ показывает, что экспериментально подтверждённой биологической активностью обладают такие субстанции, как пчелиный яд и пчелиное маточное молочко. Как в одном, так и другом случае были описаны действующие вещества и проведён обзор их известной биологической активности. Авторы предполагают, что при отработке метода лабораторного синтеза деценовых кислот, станет возможным их масштабное доклиническое исследование, которое может стать основой в создании какого-либо лекарственного средства с избирательным действием.</p></abstract><trans-abstract xml:lang="en"><p>Both bee products themselves and their combinations are widely represented in the domestic pharmaceutical market, however, modern experimental studies of the biological activity of these compounds are few, and in many of the existing publications the authors describe an extremely wide and controversial range of therapeutic effects. The aim of the study is to analyze the experimental works on the study of biological activity of bee products. Materials and methods. The study was conducted using search and information (eLibrary, PubMed, CyberLeninka, ResearchGate) and library databases (Russian State Library, Central Scientific Agricultural Library). In the designated databases, publications were searched by such terms as “biological activity”, “royal jelly”, etc. The depth of the search was not limited. Results and discussion. The analysis of the published works shows that such substances as bee venom and royal jelly have experimentally confirmed their biological activity. In both cases, the active substances have been described and a review of their detected biological activity has been carried out. Conclusion. The authors suggest that when developing the method of laboratory synthesis of decene acids, it can be possible to carry out their large-scale preclinical research, which may become the basis for the creation of a drug with a selective effect.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>биологическая активность</kwd><kwd>яд пчелиный</kwd><kwd>пчелиное маточное молочко</kwd><kwd>деценовые кислоты</kwd></kwd-group><kwd-group xml:lang="en"><kwd>biological activity</kwd><kwd>bee venom</kwd><kwd>royal jelly</kwd><kwd>decene acids</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Drews J. Drug discovery: a historical perspective // Science. – 2000. – Vol. 287. № 5460. – P. 1960–1964. DOI:10.1126/science.287.5460.1960.</mixed-citation><mixed-citation xml:lang="en">Drews  J.  Drug  discovery:  a  historical  perspective.  Science.  2000;  287(5460):1960–64.  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