pmedpharmФармация и фармакологияPharmacy & Pharmacology2307-92662413-2241Pyatigorsk Medical and Pharmaceutical Institute - branch of Volgograd State Medical Univer10.19163/2307-9266-2020-8-1-4-28pmedpharm-620Research ArticleОБЗОРЫ, ЛЕКЦИИREVIEWS, LECTURESПредставители семейства Lamiaceae Lindl. как источники лекарственного растительного сырья для получения нейротропных средств (обзор)Members of the family Lamiaceae Lindl. as sources of medicinal plant raw materials to obtain neurotropic drugshttps://orcid.org/0000-0001-5708-3407ЗвездинаЕ. В.ZvezdinaЕ. V.

Звездина Екатерина Владимировна – аспирант очной формы обучения

117216, Российская Федерация, г. Москва, ул. Грина, д. 7, стр. 1

Ekaterina V. Zvezdina – Post-graduate Student, Senior Researcher of the Department of Phytochemistry and Standardization

7 (Bldg 1), Green St., Moscow, Russian Federation, 117216

catterina@inbox.ruhttps://orcid.org/0000-0002-1274-4512ДайронасЖ. В.DayronasJ. V.

Дайронас Жанна Владимировна – доктор фармацевтических наук, профессор кафедры фармакогнозии, ботаники и технологии фитопрепаратов

357532, Российская Федерация, г. Пятигорск, пр. Калинина, 11

Zhanna V. Dayronas – Doctor of Sciences (Pharmacy), Professor, Head of the Department of Pharmacognosy, Botany and Technology of Phytopreparations

11, Kalinin Ave., Pyatigorsk, Russia, 357532

daironas@mail.ruБочкареваИ. И.BochkarevaI. I.

Бочкарева Инна Ивановна – кандидат фармацевтических наук, доцент, заведующий кафедрой фармации

385000, Республика Адыгея, г. Майкоп, ул. Первомайская, д. 191

Inna I. Bochkareva – Candidate of Sciences (Pharmacy), Associate Professor, Head of the Department of Pharmacy

191, May Day St., Maykop, Republic of Adygea, Russian Federation, 385000

bochkarevainna@gmail.comhttps://orcid.org/0000-0002-8638-9963ЗилфикаровИ. Н.ZilfikarovI. N.

Зилфикаров Ифрат Назимович – доктор фармацевтических наук, профессор РАН, главный научный сотрудник отдела фитохимии и стандартизации, ВИЛАР

117216, Российская Федерация, г. Москва, ул. Грина, д. 7, стр. 1; 385000, Республика Адыгея, г. Майкоп, ул. Первомайская, д. 191

Ifrat N. Zilfikarov – Doctor of Sciences (Pharmacy), Professor of RAS, Chief Researcher, Department of Phytochemistry and Standardization

7 (Bldg 1), Green St., Moscow, Russian Federation, 117216; 191, May Day St., Maykop, Republic of Adygea, Russian Federation, 385000

dagfarm@mail.ruhttps://orcid.org/0000-0002-4992-6926БабаеваЕ. Ю.BabaevaE. Yu.

Бабаева Елена Юрьевна – кандидат биологических наук, ведущий научный сотрудник лаборатории Ботанический сад

SPIN-код: 4230-0443

117216, Российская Федерация, г. Москва, ул. Грина, д. 7, стр. 1

Elena Yu. Babaeva – Candidate of Sciences (Biology), Senior Research Officer

SPIN-code: 4230-0443

7 (Bldg 1), Green St., Moscow, Russian Federation, 117216

babaevaelena@mail.ruФерубкоЕ. В.FerubkoE. V.

Ферубко Екатерина Владимировна – кандидат медицинских наук, заведующий отделом экспериментальной и клинической фармакологии

117216, Российская Федерация, г. Москва, ул. Грина, д. 7, стр. 1

Ekaterina V. Ferubko – Candidate of Sciences (Medicine) Head of the Department of Experimental and Clinical Pharmacology

7 (Bldg 1), Green St., Moscow, Russian Federation, 117216

eferubko@yandex.ruhttps://orcid.org/0000-0003-0355-4132ГусейноваЗ. А.GuseynovaZ. A.

Гусейнова Зиярат Агамирзоевна – кандидат биологических наук, старший научный сотрудник лаборатории флоры и растительных ресурсов

367000, Российская Федерация, Республика Дагестан, г. Махачкала, ул. М. Гаджиева, д. 45

Ziyarat A. Guseynova – Candidate of Sciences (Biology), Senior Researcher, Laboratory of Flora and Plant Resources

45, M. Gadzhiev St., Makhachkala, Republic of Dagestan, Russian Federation, 367000

guseinovaz@mail.ruhttps://orcid.org/0000-0001-9409-9344СеребрянаяФ. К.SerebryanayaF. K.

Серебряная Фатима Казбековна – кандидат фармацевтических наук, доцент кафедры фармаогнозии, ботаники и технологии фитопрепаратов, научный сотрудник Эколого-ботанической станции БИН РАН (Перкальский денрологический парк)

357532, Российская Федерация, г. Пятигорск, пр. Калинина, 11

Fatima K. Serebryanaya – Candidate of Sciences (Pharmacy), Associate Professor of the Department of Pharmacognosy, Botany and Technology of Phytopreparations

11, Kalinin Ave., Pyatigorsk, Russia, 357532

f.k.serebryanaya@pmedpharm.ruhttps://orcid.org/0000-0003-2773-6387КаибоваС. Р.KaibovaS. R.

Каибова Сабина Равидиновна – кандидат фармацевтических наук, доцент кафедры фармации

367000, Российская Федерация, Республика Дагестан, г. Махачкала, пл. Ленина, д. 1

Sabina R. Kaibova – Candidate of Sciences (Pharmacy), Associate Professor, Department of Pharmacy

1, Lenin Square, Makhachkala, Republic of Dagestan, Russian Federation, 367000

kaibova.00@mail.ruhttps://orcid.org/0000-0001-9809-1120ИбрагимовТ. А.IbragimovT. A.

Ибрагимов Тимур Алгасанович – кандидат фармацевтических наук, доцент кафедры аналитической и фармацевтической химии

367000, Российская Федерация, Республика Дагестан, г. Махачкала, пл. Ленина, д. 1; 367000, Российская Федерация, Республика Дагестан, г. Махачкала, ул. Батырая, д. 4

Timur A. Ibragimov – Candidate of Sciences (Pharmacy), Associate Professor, Department of Analytical and Pharmaceutical Chemistry

1, Lenin Square, Makhachkala, Republic of Dagestan, Russian Federation, 367000; 4, Batyraya St., Makhachkala, Republic of Dagestan, Russian Federation, 367000

aloefarm@mail.ruФГБНУ «Всероссийский научно-исследовательский институт лекарственных и ароматических растений» (ВИЛАР)РоссияAll-Russia Scientific Research Institute of Medicinal and Aromatic Plants (VILAR)Russian FederationПятигорский медико-фармацевтический институт – филиал ФГБОУ ВО «Волгоградский государственный медицинский университет» Минздрава РоссииРоссияPyatigorsk Medical and Pharmaceutical Institute – a branch of Volgograd State Medical UniversityRussian FederationФГБОУ ВО «Майкопский государственный технологический университет»РоссияMaykop State Technological UniversityRussian FederationФГБНУ «Всероссийский научно-исследовательский институт лекарственных и ароматических растений» (ВИЛАР); ФГБОУ ВО «Майкопский государственный технологический университет»РоссияAll-Russia Scientific Research Institute of Medicinal and Aromatic Plants (VILAR); Maykop State Technological UniversityRussian FederationФГБУН «Горный ботанический сад» Дагестанского ФИЦ РАНРоссияMountain Botanical Garden, Dagestan FIC RASRussian FederationФГБОУ ВО «Дагестанский государственный медицинский университет» Минздрава РоссииРоссияDagestan State Medical UniversityRussian FederationФГБОУ ВО «Дагестанский государственный медицинский университет» Минздрава России; ФГБОУ ВО «Дагестанский государственный университет» Минобрнауки РоссииРоссияDagestan State Medical University; Dagestan State UniversityRussian Federation20200305202081428Copyright © Звездина Е.В., Дайронас Ж.В., Бочкарева И.И., Зилфикаров И.Н., Бабаева Е.Ю., Ферубко Е.В., Гусейнова З.А., Серебряная Ф.К., Каибова С.Р., Ибрагимов Т.А., 20202020Звездина Е.В., Дайронас Ж.В., Бочкарева И.И., Зилфикаров И.Н., Бабаева Е.Ю., Ферубко Е.В., Гусейнова З.А., Серебряная Ф.К., Каибова С.Р., Ибрагимов Т.А.Zvezdina Е.V., Dayronas J.V., Bochkareva I.I., Zilfikarov I.N., Babaeva E.Y., Ferubko E.V., Guseynova Z.A., Serebryanaya F.K., Kaibova S.R., Ibragimov T.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pharmpharm.ru/jour/article/view/620

Цель работы – обзор и анализ опубликованных в современной научной литературе данных, полученных в ходе фармакологических, фармакогностических и фармако-технологических исследований образцов лекарственного растительного сырья (ЛРС), заготавливаемого от различных представителей сем. Lamiaceae Lindl. (яснотковые), из которых получены биологически активные вещества (БАВ), фармацевтические субстанции, суммарные извлечения и лекарственные препараты, обладающие нейротропной активностью.

Материалы и методы

Материалы и методы. Для обзора использовали сведения научной литературы из открытых и доступных источников последних двадцати лет, размещенных в научно-технических библиотеках учреждений, а также в электронных базах данных: Elibrary, PubMed, Scopus, Киберленинка, Google-академия, J-stage. Поисковые запросы – названия видов растений сем. Lamiaceae (русские и латинские), заготавливаемых от них образцов ЛРС, а также наименования фармацевтических субстанций, лекарственных препаратов и БАВ.

Результаты

Результаты. При работе с источниками научной информации основное внимание уделено фармакологическим тестам, проведенным в ходе специализированных исследований на лабораторных животных, подтверждающим наличие нейротропной активности у исследуемых объектов – эфирных масел и извлечений из ЛРС (водных, водно-спиртовых, метанольных). Установлено, что потенциал лечебного и лечебно-профилактического применения фармацевтических субстанций и лекарственных препаратов, получаемых из ЛРС представителей 30 родов семейства Lamiaceae, остается нереализованным, несмотря на пристальное внимание исследователей.

Заключение

Заключение. Данный обзор охватил 71 вид из 30 родов. При значительном уровне изученности, который можно отметить при анализе данной публикации, остается не затронутым огромный пласт ресурсных видов данного семейства. В дальнейшем они могут представлять фармакогностический интерес и иметь практическое использование, в частности, для создания на их основе новых лекарственных препаратов нейротропного действия.

The aim of this work is to review and analyze the data published in the modern scientific literature obtained in pharmacological, pharmacognostic and pharmacotechnological studies of various types of raw materials obtained from members of the family Lamiaceae L., which were sources of biologically active substances, pharmaceutical substances, total extracts and the drugs – with a neurotropic activity.

Materials and methods

Materials and methods. For the review, we used the information of scientific literature from open and accessible sources of the last twenty years, located in the scientific and technical libraries of institutions, as well as in electronic databases: Elibrary, PubMed, Scopus, Cyberleninka, GoogleAcademy, J-Stage. The search inquiries were: the species of the family Lamiaceae (Russian and Latin), the samples of medicinal plant materials based on them as well as the names of the drugs and biologically active substances obtained from these raw materials.

Results

Results. When working with the sources of scientific information, the main attention was paid to pharmacologic tests performed during the studies on laboratory animals and proving the presence of neurotropic activity in the studied objects – essential oils and extracts from plant raw materials: aqueous, aqueous alcoholic, and methanol ones. It has been established that the potential of the therapeutic and preventive application of pharmaceutical substances and drugs based on the medicinal plant materials obtained from 30 genera members of the Lamiaceae family, remains unrealized despite the close attention of various researchers.

Conclusion

Conclusion. This review comprised 71 species from 30 genera. Despite the significant level of the previous study presented in the analysis of this publication, an enormous potential of this family’s species remains unexplored. In the future, they can be of both – pharmacognostic and practical interest, in particular, in creation of new medicinal preparations of the neurotropic action based on them.

обзор литературыяснотковыеLamiaceaeфитотерапиялекарственное растительное сырье (ЛРС)экстрактфитопрепаратлекарственный препаратфармакогнозияфармакологиястресснейротропная активностьанксиолитический эффектседативное действиеантидепрессивное действиеГАМК-α-рецепторыбензодиазепиновые рецепторыLiterature reviewLamiaceae L.herbal medicinemedicinal plant materialsextractherbal formulation фитопрепаратmedicinal preparationpharmacognosypharmacologystressneurotropic activityanxiolytic effectsedative actionantidepressant actionGABA-α-receptorsbenzodiazepine receptorsReferencesФедоров Б.М. Стресс и система кровообращения. М.: Медицина, 1991. 319 с.Fedorov BМ. Stress i sistema krovoobrashcheniya [Stress and circulatory system]. М.: Medicina.1991; 319. RussianКрыжановский Г.Н., Магаева С.В., Макаров С.В. Нейроимунопатология. М.: Медицина, 1997. 282 с.Kryzhanovsky GN, Magaeva SV, Makarov SV. Neuropatologiya [Neuroimunopathology]. M.: Medicina; 1997. 282 p. RussianСелье Г. 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The authors declare that there are no conflicts of interest present.