pmedpharmФармация и фармакологияPharmacy & Pharmacology2307-92662413-2241Pyatigorsk Medical and Pharmaceutical Institute - branch of Volgograd State Medical Univer10.19163/2307-9266-2021-9-1-4-16pmedpharm-792Research ArticleОБЗОРЫ, ЛЕКЦИИREVIEWS, LECTURESДЕНДРИМЕРЫ В ТАРГЕТНОЙ ДОСТАВКЕ ПРОТИВООПУХОЛЕВЫХ ПРЕПАРАТОВ: ДОСТИЖЕНИЯ, ПРОБЛЕМЫ И ПЕРСПЕКТИВЫ ДАЛЬНЕЙШИХ ИССЛЕДОВАНИЙDENDRIMERS IN ANTICANCER TARGETED DRUG DELIVERY: ACCOMPLISHMENTS, CHALLENGES AND DIRECTIONS FOR FUTUREhttps://orcid.org/0000-0002-5832-8602AмджадМ. В.AmjadA. M.

доцент кафедры фармацевтики фармацевтического факультета Университета Северных границ, Рафха, Саудовская Аравия

 

Assistant Professor, Department of Pharmaceutics, Faculty of Pharmacy, Northern Border University, Rafha, Saudi Arabia

mwbamjad@yahoo.comУниверситет Северных границ 76322, Рафха, Саудовская АравияСаудовская АравияNorthern Border University Rafha, Saudi Arabia, 76322Saudi Arabia20212306202191416Copyright © Aмджад М.В., 20212021Aмджад М.В.Amjad A.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pharmpharm.ru/jour/article/view/792

Дендримеры - это наночастицы с уникальными характеристиками, представляющими собой сферическую трехмерную форму и нанометровый размер. Доступность многочисленных концевых функциональных групп и модифицируемая инженерия поверхности позволяет изменить поверхность дендримеров с помощью нескольких терапевтических агентов, диагностических групп и таргетных веществ.

Цель статьи - ознакомить читателей с дизайном, разработкой, ограничениями, проблемами и перспективами дальнейших исследований противоопухолевых биодендримеров.

Материалы и методы

Материалы и методы. База данных была представлена такими системами как Medline, Cochrane Central Register of Controlled Trials, Scopus, Web of Science Core Collection, PubMed. gov, Google-Academy. Проведен поиск по следующим ключевым словам и сочетаниям: полипропиленимин, поли-L-лизин, Полиамидоамин - Polyamidoamine (PAMAM); рак; доставка лекарств; дендримеры.

Результаты

Результаты. Высокая инкапсуляция препарата и эффективное пассивное таргетирование относятся к числу его терапевтических применений. Были описаны последние разработки в области химиотерапевтической доставки лекарств с помощью дендримеров. По большей части, потенциал и эффективность дендримеров, как ожидается, окажут значительное прогрессивное влияние на таргетирование при доставке лекарств.

Заключение

Заключение. Новейшие открытия показали, что дендритные наноносители обладают многими уникальными свойствами, которые требуют дополнительных исследований и разработок.

Dendrimers are nanoparticles with unique features including globular 3D shape and nanometer size. The availability of numerous terminal functional groups and modifiable surface engineering permit modification of dendrimer surface with several therapeutic agents, diagnostic moieties and targeting substances.

The aim

The aim. To enlighten the readers regarding design, development, limitations, challenges and future directions regarding anticancer bio-dendrimers.

Materials and methods

Materials and methods. The data base was represented by such systems as Medline, Cochrane Central Register of Controlled Trials, Scopus, Web of Science Core Collection, PubMed. gov, Google-Academy. A search was carried out for the following keywords and combinations: Polypropylene imine (PPI); Poly-L-lysine (PLL); polyamidoamine (PAMAM); cancer; drug delivery; dendrimers.

Results

Results. High encapsulation of drug and effective passive targeting are also among their therapeutic uses. Herein, we have described latest developments in chemotherapeutic delivery of drugs by dendrimers. For the most part, the potential and efficacy of dendrimers are anticipated to have considerable progressive effect on drug targeting and delivery.

Conclusion

Conclusion. The newest discoveries have shown that the dendritic nanocarriers have many unique features that endorse more research and development.

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The authors declare that there are no conflicts of interest present.