pmedpharmФармация и фармакологияPharmacy & Pharmacology2307-92662413-2241Pyatigorsk Medical and Pharmaceutical Institute - branch of Volgograd State Medical Univer10.19163/2307-9266-2021-9-5-334-345pmedpharm-933Research ArticleОБЗОРЫ, ЛЕКЦИИREVIEWS, LECTURESPLGA – ПЕРСПЕКТИВНЫЙ ПОЛИМЕР ДЛЯ ДОСТАВКИ ЛЕКАРСТВЕННЫХ СРЕДСТВPLGA – THE SMART POLYMER FOR DRUG DELIVERYhttps://orcid.org/0000-0002-2844-3669СурьяН.SuryaN.

аспирант в области фармации, научный сотрудник фармацевтического колледжа 

Post Graduate in Pharmacy, Research Scholar

nagajyothisurya@gmail.comhttps://orcid.org/0000-0002-4013-4316БхаттачарьяС.BhattacharyyaS.

магистр фармацевтики, доцент фармацевтического колледжа 

Master in Pharmacy, Associate Professor

sayanibh@gmail.comФармацевтический колледж Крюпаниди 560035, Индия, Карнатака, Бангалор, Oфф Сарджапур Роуд Кармеларам Гунджур Роуд Вартур Хобли, Чикка Белландур, 12/1ИндияKrupanidhi College of Pharmacy 12/1, Chikka Bellandur, Carmelaram Gunjur Road Varthur Hobli Off Sarjapur Rd, Bengaluru, Karnataka, India, 560035India20212510202195334345Copyright © Сурья Н., Бхаттачарья С., 20212021Сурья Н., Бхаттачарья С.Surya N., Bhattacharyya S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pharmpharm.ru/jour/article/view/933

Полимеры стали неотъемлемой частью новой системы доставки лекарственных средств. Одним из успешных биоразлагаемых полимеров является PLGA, который состоит из сложных полиэфиров молочной и гликолевой кислот. Это один из одобренных «U. S. Food and Drugs Administration» (FDA, США) биоразлагаемых полимеров, который в последнее время широко используется в терапевтических целях.

Цель

Цель. Познакомить химиков-исследователей с новыми свойствами и применением PLGA в области фармации.

Материалы и методы

Материалы и методы. В качестве источников информации использовались различные базы данных, такие как Science Direct, Scopus, Web of Science, PubMed и Google Scholar. Поиск проводился по следующим ключевым словам и словосочетаниям: PLGA, доставка новых лекарств, наночастицы PLGA, биомедицинское применение PLGA.

Результаты

Результаты. Фармацевтическая и биомедицинская промышленность переполнены синтетическими и натуральными полимерами. Механические и вязкоэластичные свойства полимеров делают их пригодными для временной и пространственной доставки лекарственных препаратов в течение длительного периода. Применение методов сополимеризации приводит к модификации водорастворимости полимеров и делает их пригодными для различного использования системами доставки лекарственных веществ. Благодаря свойствам биосовместимости и биоразлагаемости полимеры стали использоваться в новых системах таргетной доставки лекарств. Сополимер молочной и гликолевой кислоты PLGA – представитель этих систем. PLGA универсален, так как может использоваться для инкапсуляции малых молекул, в тканевой инженерии, при восстановления костей и т. д., ввиду способности воспроизводить любой размер и принимать любую форму.

Заключение

Заключение. Сенситивность и способность к биоразложению PLGA делают этот сополимер интеллектуальным полимером для адресной и непрерывной доставки лекарств, а также в различных видах биомедицинского использования.

Polymers have become an integral part of novel drug delivery system. One such successful biodegradable polymer is poly lactic-co-glycolic acid (PLGA) which consists of polyesters of lactic acid and glycolic acid. It is one of the FDA-approved biodegradable polymers which is extensively used for therapeutic purposes in recent times.

The aim

The aim. To illuminate researchers on the chemistry, novel properties and applications of PLGA in pharmaceutical fields.

Materials and methods

Materials and methods. Various internet sources like Science Direct, Scopus, Web of Science, PubMed and google scholar were used as the data source. The key words search was carried out for the following words and combinations: PLGA, Novel drug delivery, PLGA Nano particles, biomedical applications of PLGA.

Results

Results. Pharmaceutical and biomedical industries are flooded with the use of synthetic and natural polymers. The mechanical and viscoelastic properties of the polymers make them suitable for the temporal and spatial delivery of therapeutic agents for an extended period. Employment of copolymerization techniques lead to the modification of water solubility of the polymers and make them suitable for various applications of drug delivery systems. Biodegradable polymers due to their biocompatibility and biodegradable property have attracted their use in novel drug delivery systems. PLGA is one of them. PLGA is versatile as it can be fabricated into any size, shape, and can be used to encapsulate small molecules, tissue engineering, and bone repair, etc.

Conclusion

Conclusion. The sensitivity and biodegradability of PLGA makes it a smart polymer for targeted and sustained delivery of drugs and in various biomedical applications.

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The authors declare that there are no conflicts of interest present.