POSSIBILITIY OF SHORT-TERM STRESS INFLUENCES IMPLEMENTATION IN BIOLOGICALLY ACTIVE COMPOUNDS SCREENING

A. S. Tarasov; E. I. Morkovin; V. V. Stepanova

doi:10.19163/2307-9266-2015-3-3(10)-66-68

POSSIBILITIY OF SHORT-TERM STRESS INFLUENCES IMPLEMENTATION IN BIOLOGICALLY ACTIVE COMPOUNDS SCREENING

A. S. Tarasov, E. I. Morkovin, V. V. Stepanova

https://doi.org/10.19163/2307-9266-2015-3-3(10)-66-68

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Abstract

This work presents the analysis of phobic anxiety behavioral reactions connected with short-term stress influences. We have established that 15 minutes forced swimming reduces locomotory and exploratory activity of animals without any connection with physical exhaustion. Short-term isolation provokes the increase of irrational searching activity connected with spatial disorder and agitation. During this work we have formed an algorithm which allowed fast screening of anxio-lytics and antidepressants

Keywords

stress, anxiety, forced swimming, isolation, immobilization, pre-clinical studies methods.

About the Authors

A. S. Tarasov

'Volgograd State Medical University, Volgograd SRI of pharmaclogy Volgograd State Medical University, Volgograd
Россия

E. I. Morkovin

'Volgograd State Medical University, Volgograd SRI of pharmaclogy Volgograd State Medical University, Volgograd
Россия

V. V. Stepanova

SRI of pharmaclogy Volgograd State Medical University, Volgograd
Россия

References

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For citations:

Tarasov A.S., Morkovin E.I., Stepanova V.V. POSSIBILITIY OF SHORT-TERM STRESS INFLUENCES IMPLEMENTATION IN BIOLOGICALLY ACTIVE COMPOUNDS SCREENING. Pharmacy & Pharmacology. 2015;3(3(10)):66-68. (In Russ.) https://doi.org/10.19163/2307-9266-2015-3-3(10)-66-68

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