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POSSIBILITIY OF SHORT-TERM STRESS INFLUENCES IMPLEMENTATION IN BIOLOGICALLY ACTIVE COMPOUNDS SCREENING

https://doi.org/10.19163/2307-9266-2015-3-3(10)-66-68

Abstract

This work presents the analysis of phobic anxiety behavioral reactions connected with short-term stress influences. We have established that 15 minutes forced swimming reduces locomotory and exploratory activity of animals without any connection with physical exhaustion. Short-term isolation provokes the increase of irrational searching activity connected with spatial disorder and agitation. During this work we have formed an algorithm which allowed fast screening of anxio-lytics and antidepressants

About the Authors

A. S. Tarasov
'Volgograd State Medical University, Volgograd SRI of pharmaclogy Volgograd State Medical University, Volgograd
Russian Federation


E. I. Morkovin
'Volgograd State Medical University, Volgograd SRI of pharmaclogy Volgograd State Medical University, Volgograd
Russian Federation


V. V. Stepanova
SRI of pharmaclogy Volgograd State Medical University, Volgograd
Russian Federation


References

1. Методические рекомендации по доклиническому изучению транквилизирующего (анксиолитического) действия лекарственных средств / Т.А. Воронина, СБ. Середенин, М.А. Яркова и др. // В кн.: Руководство по проведению доклинических исследований лекарственных средств. - М.: Гриф и К, 2012. - Ч. I. - 944 с.

2. Тюренков, И.Н. Влияние фенибута, его солей и композиций с органическими кислотами на физическую работоспособность / И.Н. Тюренков, Е.В. Болотова, В.Н. Перфи-лова // Вестник Волгоградского государственного медицинского университета. - 2007. -№ 1.-С. 65-67.

3. Levels of anxiety and depression as predictors of mortality: the HUNT study / A. Mykle-tun, O. Bjerkeset, S. Overland et al. // Br. J. Psychiatry. - 2009. - Vol. 195(2). - P. 118-125.


Review

For citations:


Tarasov A.S., Morkovin E.I., Stepanova V.V. POSSIBILITIY OF SHORT-TERM STRESS INFLUENCES IMPLEMENTATION IN BIOLOGICALLY ACTIVE COMPOUNDS SCREENING. Pharmacy & Pharmacology. 2015;3(3(10)):66-68. (In Russ.) https://doi.org/10.19163/2307-9266-2015-3-3(10)-66-68

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ISSN 2307-9266 (Print)
ISSN 2413-2241 (Online)