STUDY FOR ANTIMYCOBACTERIAL ACTIVITY OF PYATD10 DIAZINON DERIVATIVE
https://doi.org/10.19163/2307-9266-2015-3-5(12)-26-30
Abstract
We have carried out the analysis of antymicobacterial activity of PYATd10 diazinon derivative and dapsone. The capability of PYATd10 compound and dapsone drug to suppress the growth of M.lufu culture was studied by the method of serial dilutions. Visual evaluation of inoculations in medium Shkolnikova showed that there was no growth of mycobacteria with PYATd10 concentration 128 μg/ml, while minimum suppressing concentration of dapsone were equal to 32 μg/ml. Examining smears, colored according to Murohashi, under the influence of PYATd10 excipient and dapsone drug in the same concentrations, we have revealed the decrease of mycobacterial living forms content. A share of inviable bacteria decreased after the cultivation intensification, but amounts to less than 35%. Thus, the PYATd10 compound exhibits antimycobacterial activity towards M. lufu, being slightly inferior to the dapsone comparative drug by this type of activity.
About the Authors
A. V. Voronkov
Pyatigorsk Medical and Pharmaceutical Institute – a branch of Volgograd State Medical
University, Pyatigorsk
Russian Federation
Russian Federation
S. A. Luzhnova
Leprosy Research Institute, Astrakhan
Russian Federation
Russian Federation
I. P. Kodonidi
Pyatigorsk Medical and Pharmaceutical Institute – a branch of Volgograd State Medical
University, Pyatigorsk
Russian Federation
Russian Federation
N. M. Gabitova
Leprosy Research Institute, Astrakhan
Russian Federation
Russian Federation
S. A. Lovyagina
Pyatigorsk Medical and Pharmaceutical Institute – a branch of Volgograd State Medical
University, Pyatigorsk
Russian Federation
Russian Federation
V. S. Sochnev
Pyatigorsk Medical and Pharmaceutical Institute – a branch of Volgograd State Medical
University, Pyatigorsk
Russian Federation
Russian Federation
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Review
For citations:
Voronkov A.V., Luzhnova S.A., Kodonidi I.P., Gabitova N.M., Lovyagina S.A., Sochnev V.S. STUDY FOR ANTIMYCOBACTERIAL ACTIVITY OF PYATD10 DIAZINON DERIVATIVE. Pharmacy & Pharmacology. 2015;3(5(12)):26-30. (In Russ.) https://doi.org/10.19163/2307-9266-2015-3-5(12)-26-30
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