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Фармация и фармакология

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Комплексный обзор фармакологических, терапевтических и токсикологических свойств борной кислоты и других борсодержащих соединений: текущее состояние и будущие перспективы

https://doi.org/10.19163/2307-9266-2025-13-3-202-238

Аннотация

Цель. В этом обзоре собрана информация, полученная в результате комплексного изучения научных ресурсов о последних достижениях в области здравоохранения, касающихся борных кислот и БСС, а также представлены текущие и будущие перспективы.

Материалы и методы. Источники литературы были собраны с использованием нескольких баз данных (WOS, PubMed, Scopus, Science Direct, SciVerse, SciELO, Cochrane Library, Embase и Академия Google). Были систематизированы данные о воздействии на здоровье борных кислот и БСС, используемых в доклинических и клинических исследованиях.

Результаты и залючение. Различные природные и синтетические борсодержащие соединения (БСС) все чаще используются в здравоохранении. На сегодняшний день 5 препаратов БСС (бортезомиб, крисаборол, иксазомиб, таваборол и ваборбактам) одобрены Управление по контролю качества пищевых продуктов и лекарственных средств США (FDA) для различных клинических целей. Также известно, что более 10 соединений на основе бора (алабостат, борокаптат натрия, воромицин, TOL-463 и другие) исследуются на различных этапах клинических испытаний. Кроме того, как видно, продолжаются клинические исследования комбинаций различных лекарственных средств с БСС для применения по новым показаниям. Кроме того, отмечается, что бор и борсодержащие соединения широко используются в качестве пищевых добавок. В этом обзоре также представлен анализ последних достижений в области фармакологической активности борных кислот и БСС, включая антиоксидантные, противовоспалительные, антиатеросклеротические, противоопухолевые, антимикробные, противопаразитарные, противовирусные, противопротозойные, кардиопротекторные, гепатопротекторные, нейропротекторные, остеопротекторные, противодиабетические, антиапоптотические, против ожирения, ферроптоз, влияние на иммунную систему, противоэпилептическую, антипаркинсоническую и альцгеймеровскую активность и соответствующие механизмы действия, полученные в ходе исследований как in vitro, так и in vivo.

Об авторах

О. Юнусоглу
Университет имени Болу Абант Иззет Байсал.
Турция

доцент кафедры медицинской фармакологии медицинского факультета Университета Болу Абант Иззет Байсал (Турция). 

14030, Турция, Болу Меркез/Болу, Кампус Гёлкёй.



И. Калфа
Университет имени Болу Абант Иззет Байсал.
Турция

магистрант кафедры медицинской фармакологии медицинского факультета Университета Болу Абант Иззет Байсал (Турция).

14030, Турция, Болу Меркез/Болу, Кампус Гёлкёй.



М. Э. Демирель
Университет имени Болу Абант Иззет Байсал.
Турция

доктор медицинских наук, преподаватель кафедры неотложной помощи медицинского факультета Университета Болу Абант Иззет Байсал (Турция).

14030, Турция, Болу Меркез/Болу, Кампус Гёлкёй.



М. А. Бинзет
Университет имени Болу Абант Иззет Байсал.
Турция

кандидат медицинских наук, доктор медицинского факультета Университета Болу Абант Иззет Байсал (Турция).

14030, Турция, Болу Меркез/Болу, Кампус Гёлкёй.



У. З. Севинч
Университет имени Болу Абант Иззет Байсал.
Турция

магистрант кафедры медицинской фармакологии медицинского факультета Университета Болу Абант Иззет Байсал (Турция).

14030, Турция, Болу Меркез/Болу, Кампус Гёлкёй.

 



И. Тюрель
Университет имени Болу Абант Иззет Байсал.
Турция

доктор медицинских наук, профессор, заведующий кафедрой медицинской фармакологии медицинского факультета Университета Болу Абант Иззет Байсал (Турция).

14030, Турция, Болу Меркез/Болу, Кампус Гёлкёй.

 



А. Х. Курт
Университет имени Болу Абант Иззет Байсал.
Турция

доктор медицинских наук, профессор, заведующий кафедрой медицинской фармакологии медицинского факультета Университета Болу Абант Иззет Байсал (Турция).

14030, Турция, Болу Меркез/Болу, Кампус Гёлкёй.



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Для цитирования:


Юнусоглу О., Калфа И., Демирель М., Бинзет М., Севинч У., Тюрель И., Курт А. Комплексный обзор фармакологических, терапевтических и токсикологических свойств борной кислоты и других борсодержащих соединений: текущее состояние и будущие перспективы. Фармация и фармакология. 2025;13(3):202-238. https://doi.org/10.19163/2307-9266-2025-13-3-202-238

For citation:


Yunusoglu O., Kalfa I., Demirel M., Binzet M., Sevinc U., Turel I., Kurt A. A Comprehensive Review of the Pharmacological, Therapeutic, and Toxicological Properties of Boric Acid and Other Boron-Containing Compounds: Current Landscape and Future Perspectives. Pharmacy & Pharmacology. 2025;13(3):202-238. https://doi.org/10.19163/2307-9266-2025-13-3-202-238

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