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Фармация и фармакология

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БИОЛОГИЧЕСКИ АКТИВНЫЕ СОЕДИНЕНИЯ ПОЛЫНИ ОДНОЛЕТНЕЙ. СЕСКВИТЕРПЕНОВЫЕ ЛАКТОНЫ

https://doi.org/10.19163/2307-9266-2016-4-5-4-35

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Аннотация

Полынь однолетняя (Artemisia annua L.) – однолетнее травянистое растение, используемое в народной медицине Китая более двух тысяч лет. В 70-х годах XX века из надземной части этого вида был выделен сесквитерпеновый лактон артемизинин. На сегодняшний день – это самое эффективное, среди известных природных и синтетических соединений, лекарственное средство для лечения малярии.

Целью исследования явился обзор информации, содержащейся в открытых источниках, об изучении сесквитерпеновых лактонов полыни однолетней и спектре их фармакологической активности.

Методы. Исследование проводилось с использованием информационно-поисковых (PubMed, ScholarGoogle), библиотечных баз данных (eLibrary, Cyberleninca), а также результатов собственных исследований.

Результаты. Установлено, что кроме эфирного масла и фенольных соединений надземная часть полыни однолетней содержит значительное количество различающихся по структуре сесквитерпеновых лактонов. Качественный состав и количественное содержание сесквитерпеновых лактонов варьирует в зависимости от эколого-географических факторов, фазы развития растений, технологии выращивания, способа сушки и т.д. Известные фармакологические исследования извлечений из травы полыни однолетней, содержащих сесквитерпеновые лактоны, а также индивидуальных соединений этой группы характеризуют данный вид сырья как перспективный источник для дальнейшего более глубокого исследования.

Заключение. Проведенный нами анализ, имеющихся в открытом информационном доступе, материалов по изучению сесквитерпеновых лактонов полыни однолетней, в том числе фитохимических и фармакологических, позволяют характеризовать траву полыни однолетней как перспективный источник для разработки новых лекарственных средств.

Об авторах

Д. А. Коновалов
Пятигорский медико-фармацевтический институт – филиал ВолгГМУ Минздрава России
Россия
доктор фармацевтических наук, профессор, заместитель директора по науке


О. М. Шевчук
ФГБУН «НБС-ННЦ»
Россия

доктор биологических наук, заведующий лабораторией ароматических и лекарственных растений,

 пгт. Никита, Республика Крым



Л. А. Логвиненко
ФГБУН «НБС-ННЦ»
Россия

научный сотрудник лаборатории ароматических и лекарственных растений,

пгт. Никита, Республика Крым



А. А. Хамилонов
Пятигорский медико-фармацевтический институт – филиал ВолгГМУ Минздрава России
Россия
аспирант кафедры фармакогнозии


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Для цитирования:


Коновалов Д.А., Шевчук О.М., Логвиненко Л.А., Хамилонов А.А. БИОЛОГИЧЕСКИ АКТИВНЫЕ СОЕДИНЕНИЯ ПОЛЫНИ ОДНОЛЕТНЕЙ. СЕСКВИТЕРПЕНОВЫЕ ЛАКТОНЫ. Фармация и фармакология. 2016;4(5):4-35. https://doi.org/10.19163/2307-9266-2016-4-5-4-35

For citation:


Konovalov D.A., Shevchuk O.M., Logvinenko L.A., Khamilo A.A. BIOLOGICALLY ACTIVE COMPOUNDS OF ARTEMISIA ANNUA. SESQUITERPENE LACTONES. Pharmacy & Pharmacology. 2016;4(5):4-35. (In Russ.) https://doi.org/10.19163/2307-9266-2016-4-5-4-35

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