Pharmacy & Pharmacology

Advanced search


Full Text:


Rhodiola rosea is one of the most popular adaptogene agents. Apart from adaptogene, it has the whole range of other pharmaceutical properties: antioxidant, nootropic, antidepressant, immunomodulatory, and other. Russian industry manufactures liquid extract of Rhodiola rosea, as well as food BAS based on the Rhodiola rosea, but there are no dosage forms for external use.

The purpose of this work is to analyze scientific information about general characteristics of the pharmacological activity and possible use of Rhodiola rosea in external drugs and cosmetics.

Methods. The following resources were used for general characteristic of Rhodiola rosea, its pharmacological properties, particularly the usage of Rhodiola rosea in medical and cosmetic practices, as well prospects of its external use: eLIBRARY, PubMed, Cyberleninca, ResearchGate, information from manufacturers and dealers web-pages.

Results. Rhodiola drugs are considered prospective agents for depressions therapy, Parkinson disease treatment, memory, attention defects, for arrhythmia prevention, stamina increase, and stress level decrease in sport and space medicine, for acceptability and efficiency improvement of chemo- and radiotherapy, as immunostimulatory agent. Nowadays in the Russian Federation Rhodiola rosea liquid extract is used as a tonic agent and is prescribed for over-fatigue in healthy persons, and for the sick, weakened as the result of a long-term treatment. Literature has sufficient amount of data about possible effect of biologically active substances of Rhodiola rosea at external use: antioxidant and antimicrobial, bleaching, UV-protective, metabolism stimulating.

Conclusion. Thus, the data obtained give evidence about the prospect of Rhodiola use in cosmeceutics and prove the experience of its traditional use for withering and fat skin treatment, as well as acne.

About the Authors

E. F. Stepanova
Pyatigorsk Medical and Pharmaceutical Institute – branch of Volgograd State Medical University
Russian Federation
Doctor of Pharmaceutical Sciences, Professor, Professor of the Department of the Technology of Drugs

B. Shirzad
Pyatigorsk Medical and Pharmaceutical Institute – branch of Volgograd State Medical University
Russian Federation
graduate student of the Department of the Technology of Drugs

S. B. Evseeva
Biviteks ltd
Russian Federation

Candidate of Pharmaceutical Sciences,



1. Kurkin V.A. Rhodiola rosea (Golden root): drugs production and standardization: Monography. Samara: Ofort ltd, Samara State Medical University of the Ministry of Health of Russia, 2015. 240 p.

2. Galambosi B. Rhodiola rosea L. from wild collection to field production. Medicinal Plant Conservation. 2005. Vol. 11, no. 1. P. 31–35.

3. Galambosi B., Galambosi Zs., Slacanin I. Comparison of natural and cultivated roseroot (Rhodiola rosea L.) roots in Finland. Z Arznei-Gewurzpfla. 2007. Vol.12, no. 3. P. 141–147.

4. Galambosi B. et al. Importance and quality of roseroot growing in the European North. Z. Arznei-Gewurzpfla. 2010. Vol. 15, no. 4. P. 160–169.

5. Krylov G.V., Kazarinova N.V. Productiveness of the golden root and its efficient use. Protection of mountain landscapes of Siberia. Novosibirsk, 1973. P. 162–164.

6. Astafiev M.V. Ecological peculiarities of Rhodiola rosea introduction in Samara Oblast. Samara Scientific Center of Russian Academy of Science Bulletin. 2007. Vol. 9, no. 4. P. 1079–1084.

7. Buchwald W., Mscisz A., Krajewska-Patan A., Furmanowa M., Mielcarek S., Mrozikiewicz P.M. Contents of biologically active compounds in Rhodiola rosea roots during the vegetation period. Herba Polonica. 2006. Vol. 52, no. 4. P. 39–43.

8. Tasheva K., Kosturkova G. The role of biotechnology for conservation and biologically active substances production of Rhodiola rosea: endangered medicinal species. The Scientific World Journal. 2012; (access date: 20.03.2016).

9. Furmanowa M., Skopinska-Rozewska E., Rogala E., Malgorzata H. Rhodiola rosea in vitro culture: phytochemical analysis and antioxidant action. Acta Societis Botanicorum Poloniae. 1998. Vol. 76, no.1. P. 69–73.

10. Bykov V.A., Zapesochnaya G.G., Kurkin V.A. Rhodiola rosea L.: Traditional and Biotechnological Aspects of Drugs Production (review). Chemical and Pharmaceutical Journal. 1999. Vol. 33, no.1. P. 28–37.

11. Saratikov A.S., Krasnov E.A. Rhodiola rosea (golden root), 4th updated and revised edition. Tomsk: Publishing house of Tomsk University, 2004. 292 p.

12. Zapesochnaya G.G., Kurkin V.A. Glycosides of cinnamic alcohol from Rhodiola rosea roots. Chemistry of natural compounds. 1982. No. 6. P. 723-727.

13. Dascaliu A. et al. Chemical composition of golden root (Rhodiola rosea L.) rhizomes of Carpathian origin. Herba polonica. 2008. Vol. 54, no. 4. P. 17–27.

14. Rohloff J. Volatiles from rhizomes of Rhodiola rosea L. Phytochemistry. 2002. Vol. 59, no. 6. P. 655–661.

15. Register of drugs; URL: (access date: 19.05.2016).

16. Marina T.F. Influence of Rhodiola rosea drugs on conditioned activity of rats. Successes in natural and synthetic agents studies. Tomsk,1982. Р. 140–142.

17. Marina T.F., Alekseeva L.P. Influence of rhodosine and rhodioloside on electroencephalogram of rabbits. Stimulators of central nervous system. Tomsk, 1968. Vol. 2. P. 22–26.

18. Krasnov E.A., Veits L.A. Studies for essential oil of Rhodiola rosea L. Stimulators of the central nervous system. Tomsk, 1968. Vol. 2. P. 18–21.

19. Richard P. Brown, Patricia L. Gerbarg, Zakir Ramazanov. Rhodiola rosea: A phytomedicinal overview/; URL: publication/237469905 (access date: 20.04.2016).

20. Darbinyan V. et al. Rhodiola rosea in stress induced fatigue: a double blind cross-over study of a standardized extract SHR-5 with a repeated low-dose regimen on the mental performance of healthy physicians during night duty. Phytomedicine. 2000. Vol. 7, no. 5. P. 365–371.

21. Petkov V.D., Yonkov D., Mosharoff A., Kambourova T., Alova L., Petkov V.V. et al. Effects of alcohol aqueous extract from Rhodiola rosea L. roots on learning and memory. Acta Physiol Pharmacol Bulg. 1986. Vol. 12, no. 1. P. 3–16.

22. Mattson M.P., Pedersen W.A., Duan W., Culmsee C., Camandola S. Cellular and molecular mechanisms underlying perturbed energy metabolism and neuronal degeneration in Alzheimer’s and Parkin- son’s diseases. Ann N Y Acad Sc. 1999. Vol. 893. P. 154–175.

23. Salnik A.S., Cherdyntsev S.G., Eulusheva V.A., Kapustina V.A. To the mechanism of stimulating action of the extract of Eleuterococcus, rhodosine and piridrolum for muscular loads. Tomsk,1968. Vol. 2. P. 89–91.

24. Saratikov A.S., Marina T.F., Kaliko I.M. Stimulating action of golden root on upper brain. Siberian division of Academy of Science of USSR. Bulletin Biologic and Medical Sciences. 1965. Vol. 2, no. 8. P. 120–125.

25. Simonova N.V. Phytodrugs in correction of lipids peroxidation processes of biomembranes, induced by UV radiation. Reporter of Krasnoyarsk State Agrarian University, 2009. No. 2. P. 119–125.

26. Simonova N.V., Dorovskikh V.A., Shtarberg M.A. Adaptogenes in correction of lipids peroxidation processes of biomembranes, induced by cold and ultraviolet rays. Bulletin of physiology and pathology of respiration. 2011. No. 40. P. 66–71.

27. Kulagin O.L., Kurkin V.A., Tsaryova A.A., Dodonova N.A. Application of phytodrugs of Rhodiola rosea as possible hepatoprotectors. News of Samara Scientific Center of the Russian Academy of Science. 2010. Vol. 12, no. 1–8. P. 2065–2068.

28. Kozin S.V., Krendal F.P., Gretskiy S.V., Levina L.V. Hepatoprotectory component in protective action of Rhodiola rosea drugs in chronic intoxication of organophosphorous compounds treatment. Kursk Scientific and Practice Reporter “Human and his health”, 2014. No. 2. P. 12–19.

29. Udintsev S.N., Schakhov V.P. Decrease of cyclophosphamide haematotoxicity by Rhodiola rosea root extract in mice with Ehrlich and Lewis transplantable tumors. Eur. J. Cancer . 1991. Vol. 27, no. 9. P. 1182.

30. Stasyuk O.N., Alfonsova E.V. Experimental studies of the Rhodiola rosea influence on cognitive activity. Fundamental studies. 2012. No. 5-1. P. 193–196.

31. Sandberg F. Herbal Remedies and Herb Magic. Stockholm, Sweden: Det Basta; 1998. 223 p.

32. Sandberg F., Bohlin L. Remedies based on herbs. Stockholm, Sweden: Halsokostradets farlag AB; 1993. P. 131.

33. Study for the extract of Rhodiola rosea as a prescription component of non-alcoholic tonic beverages. Merchandiser of food products. 2015. No. 3. P. 20-17.

34. Register of Russian Federal Consumer Rights Protection and Human Health Control Service and Sanitary supervision of Russia products, which was registered officially; URL: (access date: 04.04.2016).

35. Kurkin V.A. at al. Rhodiola rosea: complex raw materials processing. Phamacy. 2006. No. 1. P. 40–42.

36. Stepanova E.F., Temirbulatova A.M., Pantyukhin A.V. Working out and pharmacotechnological studies of syrup with Rhodiola rosea complex extract. Materials of the Scientific program XII of special Exhibition “Pharmacy – 2005”. Moscow, 2005. P. 99–100.

37. Stepanova E.F. Development of the composition and technological studies of a complex adaptogenic syrup with Rhodiola rosea extract. News of the North Caucasus Institutions. Natural Sciences. 2006. No. 1. P. 67–69.

38. Molodozhnikova L.M., Rozhdestvenskaya O.S., Sotnik V.F. Forest Cosmetics. Resource book. Moscow: Ecology, 1991. 334 p.

39. Tootoo. Where Global Trade and China Connect; URL: category_list01280000-Plant-Extract. html (access date: 13.04.2016).

40. Terra Aromatica on-line store; URL: (access date: 24.05.2016).

41. Volshebnoe Kasanie (Magic Touch) online store; URL: (access date: 24.05.2016).

42. Green Mama on-line store; URL: http:// (access date: 24.05.2016).

43. Natura Siberica; URL: (access date: 24.05.2016).

44. Kalina group; URL: http://www.kalina. org/ (access date: 24.05.2016).

45. Yevseeva S.B., Sisuev B.B. Phyto and mineral components for correction of aging changes. International Journal of Applied and Fundamental Research. 2015. No. 12 (9). P. 1658–1662.

46. Akhtyamov S.N., Gerling Z.M., Butov Y.S. Skin Ageing. Nurse. 2006. No. 5. P. 11–13.

47. Miles E.A., Zoubouli P., Calder P.C. Differential anti-inflammatory effects of phenolic compounds from extra virgin olive oil identified in human whole blood cultures. Nutrition. 2005. Vol.21, no. 3. P. 389–394.

48. Dupon E. et al. From hydratation to cell turnover: an integral approach to antiaging. Cosmetics&Toiletries. 2010. Vol. 125, no. 3.

49. Pulok K. Mukherjee et al. Bioactive compounds from natural resources against skin aging. Phytomedicine. 2011. No. 19. P. 64–73.

50. Calcabrini C. et al. Rhodiola rosea ability to enrich cellular antioxidant defences of cultured human keratinocytes. Arch Dermatol Res. 2010. No.3. P. 191-200. Doi: 10.1007/s00403-009-0985-z.

51. Popov A.M. Mechanisms of biological activity of glycosides of ginseng: comparison with holothurian glycosides. Bulletin of the Far Eastern Branch of the Russian Academy of Sciences. 2006. No. 6. P. 9–104.

52. Puchkova T. Cosmeceutics: contemporary cosmetics of intensive action. Moscow: School of cosmetic chemists, 2010. 192 p.

53. Svobodová A., Walterová D., Psotová J. Influence of silymarin and its flavonolignans on H(2)O(2)-induced oxidative stress in human keratinocytes and mouse fibroblasts. Burns, 2006. No.8. P. 973-979.

54. Antoshechkin A. et al. Influence of the plant extract complex “AdMax” on global gene expression levels in cultured human fibroblasts. J Diet Suppl. 2008. Vol. 5, no. 3. P. 293–304. Doi: 10.1080/19390210802414337.

55. Albanova V.I., Zabnenkova O.V. Possibilities for restorative treatment and cosmetic curative treatment for acne patients. Expertise and clinical dermatocosmetology. 2011. No. 4. P. 45–50.

56. Margolina A.A., Ernandes E.I. New Cosmetology. Cosmetic products, ingredients, prescriptions, application. Moscow, 2015. 580 p.

57. You-Jung Kim. Antimelanogenic and antioxidant properties of gallic acid. Biol. Pharm. Bull. 2007. Vol. 30, no. 6. P. 1052–1055.

58. Kuo-Ching Wen et al. Tyrosol and its analogues inhibit alpha-melanocyte-stimulating hormone induced melanogenesis. Int. J. Mol. Sci. 2013. Vol. 14(12). P. 23420–23440. Doi: 10.3390/ ijms141223420.

59. Kondo T., Hearing V.J. Update on the regulation of melanocyte function and skin pigmentation. Expert Rev. Dermatol. 2011. No. 6. P. 97–108.

60. Chiang H.M., Chien Y.C., Wu C.H. et al. Hydroalcoholic extract of Rhodiola rosea L. (Crassulaceae) and its hydrolysate inhibit melanogenesis in B16F0 cells by regulating the CREB/MITF/tyrosinase pathway. Food Chem. Toxicol. 2014. Vol. 65, no. 3. P. 129–139.

61. Mao G.X., Xing W.M., Wen X.L. et al. Salidroside protects against premature senescence induced by ultraviolet B irradiation in human dermal fibroblasts. Int. J. Cosmet. Sci. 2015. Vol. 37, no. 3. P. 321-328.

62. Yevseeva S.B. Phytocomponents in cosmetic products for fat skin and acne treatment. International journal of Applied and fundamental studies. 2015. No. 10-5. P. 874-878.

63. Kapoor S., Saraf S. Topical herbal therapies an alternative and complementary choice to combat acne. Res. J. of Med. Plant. 2011. Vol. 5, no. 6. Р. 650–669.

64. Coenye T. et al. Eradication of Propionibacterium acnes biofilms by plant extracts and putative identification of icariin, resveratrol and salidroside as active compounds. Phytomedicine. 2012. Vol. 19, no. 5. P. 409–412. Doi: 10.1016/j. phymed.2011.10.005.


For citations:


Views: 3890

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.

ISSN 2307-9266 (Print)
ISSN 2413-2241 (Online)