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SESQUITERPENE LACTONES OF LEAVES AND FRUITS OF LAURUS NOBILIS L.

https://doi.org/10.19163/2307-9266-2014-2-2(3)-23-33

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Abstract

Bay laurel (Laurus nobilis L.) is common in the Mediterranean region, Europe and America. Widely cultivated in the countries of the Arabian Peninsula and North Africa. As the basic active substances in plants: essential oil components, sesquiterpene lactones, alkaloids, and phenolic compounds (flavonoids, phenolic acids and lignans) are described.
In the plant more than 30 sesquiterpene lactones are found. Structural types of these compounds include eudesmanolides, germacranolides, guaianolides.
Sesquiterpene lactones isolated from the leaves and fruits of Laurus nobilis, possess antibacterial, antifungal, anti-diabetic, anti-inflammatory, hepatoprotective, neuroprotective and cytotoxic activity. They inhibit the absorption of alcohol increases the activity of hepatic glutathione-S-transferase. Most of these types of activity of sesquiterpene lactones from laurel due to the presence within their structure of α-methylene--butyrolactone part.Thus, sesquiterpene lactones-containing leaves and fruits Laurus nobilis could have been an important source of raw materials for the creation of new medicines

About the Authors

D. A. Konovalov
Pyatigorsk Medical-Pharmaceutical Institute – branch of the SGEI HPT VolgSMU of Minzdrav of Russia, Pyatigorsk
Russian Federation


N. M. Nasuhova
Dagestan state university, Makhachkala
Russian Federation


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Review

For citations:


Konovalov D.A., Nasuhova N.M. SESQUITERPENE LACTONES OF LEAVES AND FRUITS OF LAURUS NOBILIS L. Pharmacy & Pharmacology. 2014;2(2(3)):23-33. (In Russ.) https://doi.org/10.19163/2307-9266-2014-2-2(3)-23-33

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ISSN 2307-9266 (Print)
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