MODERN ASSORTMENT, PROPERTIES AND PERSPECTIVES OF MEDICAL DRESSINGS IMPROVEMENT OF WOUND TREATMENT

The effectiveness of reparation is now characterized not only in terms of wound healing. The aesthetic result is also of great significance. Besides, it is important to ensure the comfort of medication, in order to combine the optimal therapy and the quality of life of the patient. The aim of the study was the literature review on the effective wound treatment with the help of modern dressings, including their assortment and prospects for improvement. Materials and methods. The materials of the study were reliable literary sources containing information about wounds, pathogenesis, the stages of the wound process and its possible violations; the assortment of modern wound coverings and the composition of biologically active substances that have a pharmacological effect; the results of preclinical and clinical trials and their prospects of use in aesthetic medicine. The research was carried out using the information retrieval and library databases (eLIBRARY, Cyberleninka), technical information. The research methods used in the work are: informational, analytical, descriptive. Results and discussion. As a result of generalization and analysis of modern publications devoted to the effective wound treatment, modern views on the wound process, wound coverings, their assortment and compositions are described. The results of pharmacological tests as well as the properties of biologically active substances and carrier polymers used are also presented. It is noted that the prospective compounds for including with the wound coverings and external drugs affecting the repair process at different stages of the wound process are tizol, bischofite, peptides (1-β-interleukin), ectoin. Conclusion. Thus, it has been established that modern wound dressings and dressings containing the substances of different pharmacological groups are offered for effective therapy: antiseptics, anesthetics, repair stimulators, antioxidants that affect different stages and elements of the wound process. Their use can be required in cosmetology. Improving the composition of wound coverings is relevant. The wound coverings based on biopolymers containing interleukins-1, ectoin, hyaluronic acid, bischofite and tizol are of great interest.

1. Boateng JS, Matthews KH, Stevens HNE, Eccleston GM. Wound Healing Dressings and Drug Delivery Systems: A Review. Journal of pharmaceutical sciences. 2008 Aug;97(8):2892–923. DOI: 10.1002/jps.21210

2. Privolnev VV, Karakulina EV. Osnovnye principy mestnogo lecheniya ran i ranevoj infekcii [Basic principles of the local treatment of wounds and wound infection]. Clinical Microbiology and Antimicrobiology Chemotherapy. 2011;13(3):214–22. Russian.

3. Gosudarstvennyj reestr medicinskih izdelij i organizacij, osushchestvlyayushchih proizvodstvo i izgotovlenie medicinskih izdelij [The state register of medical products and organizations that manufacture and manufacture products]. [Internet]. [cited 2017 Iun 23]. Available from: http://www.roszdravnadzor.ru/services/misearch. Russian.

4. Radhika PV, Arun Kumar KV. Herbal Hydrogel for Wound Healing: A Review. International Journal of Pharma Research and Health Sciences. 2017;5(2):1616–22. DOI: 10.21276/ijprhs.2017.02.02

5. Caló E, Khutoryanskiy VV. Biomedical applications of hydrogels: A review of patents and commercial products. European Polymer Journal. 2015 Apr;65:252–67. DOI: 10.1016/j.eurpolymj.2014.11.024

6. Gluhov AA, Aralova MV. Patofiziologiya dlitel’no nezazhivayushchih ran i sovremennye metody stimulyacii ranevogo processa [Pathophysiology of persistent chronic and current methods of stimulation of wound process]. Novosti Khirurgii. 2015 Nov–Dec;23(6):673–9. DOI: 10.18484/2305-0047.2015.6.673. Russian.

7. Gosudarstvennyj reestr medicinskih izdelij [State Register of Medical Devices]. [Internet]. Oficial’noe izdanie (po sostoyaniyu na 1 yanvarya 2005 g.). [cited 2017 Iun 23]. Available from: http://durex-promo.ru/index. php?ds=1422430. Russian.

8. Dopolnenie №3 k gosudarstvennomu reestru medicinskih izdelij [Supplement No. 3 to the state register of medical devices]. [Internet]. Oficial’noe izdanie (po sostoyaniyu na 1 yanvarya 2001 g.). [cited 2017 Iun 23]. Available from: http://www.worklib.ru/laws/ml03/pages/10001708.php. Russian.

9. Goossens An, Cleenewerck MB. New wound dressings: classification, tolerance. Eur. J. Dermatol. 2010;20(1):24–6. DOI: 10.1684/ejd.2010.0835

10. Shablin DV, Pavlenko SG, Yevglevsky AA, Bondarenko PP, Khuranov AA. Sovremennye ranevye pokrytiya v mestnom lechenii ran razlichnogo geneza [Modern wound dressings in local treatments of different wounds]. [Internet]. Fundamental research. 2013;12:361–5. [cited 2017 Auv 25]. Available from: https://fundamental-research.ru/ru/article/view?id=33335. Russian.

11. CHekmareva IA, Adamyan AA, Vtyurin BV, Dobysh SV, Gordienko EN, Kochergina EV. Elektronnomikroskopicheskij analiz dejstviya ranevogo pokrytiya s preparatom «Flamena®D» na regeneratornye processy v rane [Electron microscopic analysis of the action of the wound coating with the preparation “Flamena® D” on the regenerative processes in the wound]. Almanac of the Institute of Surgery A.V. Vishnevsky. 2008;3(2 Pt 1):11–2. Russian.

12. Artyuhov AA (RU), Shtil’man MI (RU), Voskanyan PS (AM), Tsatsakis A. Makroporistyj gelevyj material i izdeliya na ego osnove [Macroporous gel material and products based on it]. Russian Federation patent 2328313; A61L 15/22, A61L 15/44(54), № 2006125842/15. [Internet]. 2008 Iul 10 [cited 2017 Iul 26]. Available from: http://www.fips.ru. Russian.

13. Paramonov BA, Karpuhina LG, Andreev DYu, Karpova RG, Maksimov VN, Fokin YuN, Novozhilov AA, Karnovich AA, Antonov SF, Zolina NN. Opyt primeneniya ranevyh pokrytij serii «Foliderm-gel’» (mul’ticentrovoe issledovanie) [Experience in the application of wound coatings of the “Foliderm-gel” series (multicenter study)]. Sovremennye perspektivy v issledovanii hitina i hitozana: materialy VIII mezhdunarodnoj konferencii (Kazan’, 12-17 iyunya 2006 g.). Mockva; 2006. P. 236–7. Russian.

14. Lazarenko VA, Bezhin AI, Gusejnov AZ, Cherdakov AV, Ivanov AV, Zhukovskij VA. Lechenie gnojnyh ran s primeneniem ranevyh pokrytij «Biatravm» i «Resorb» (eksperimental’noe issledovanie) [The treatment of pu-

15. rulent wounds with application wound coverings “Biatravm” and “Resorb” (experimental research)]. Journal of New Medical Technologies. 2010;XVII(3):200–3. Russian.

16. Fronchek EV, Kriger AG, Adamyan AA, Dobysh SV, Kilimchuk LE, Golovanova PM. Biologicheskaya kompoziciya dlya lecheniya ran «Kollahit» [Biological composition for the treatment of wounds “Collage”]. Russian Federation patent 2108114; A61L15/28, № 96124444/14. [Internet]. 1998 Apr 10 [cited 2017 Iul 26]. Available from: http://www.fips.ru. Russian.

17. Antonov SF, Nikonov BA, Churilova IV, Paramonov BA, Teslenko AYa. Ranevoe pokrytie i sposob ego polucheniya [Wound cover and method of its preparation]. Russian Federation patent 2240830; A61L 15/44, № 2003138256/15. [Internet]. 2003 Dec 23 [cited 2017 Iul 26]. Available from: http://www.fips.ru. Russian.

18. Fominyh EM. Perspektivnye perevyazochnye sredstva v hirurgii gnojnyh ran [Perspective bandages in surgery of purulent wounds]. Rany i ranevye infekcii: materialy I mezhdunarodnogo kongressa (Moskva, 11–13 oktyabrya 2012 g.). Mockva; 2012. P. 332–3. Russian.

19. TU 9393-008-52708501-2004 Pokrytiya travmaticheskie ranevye formoustojchivye gelevye steril’nye «PRG Gelepran» [Coverage traumatic wound form-stable gel-sterile “PGG Gelepran”]. Russian.

20. Borisov VS, Chernega EN. Principy etapnogo mestnogo lecheniya ozhogovoj rany s ispol’zovaniem atravmatichnyh gelevyh povyazkok «Appolo» raznonapravlennogo dejstviya [Principles of localized local treatment of a burn wound with the use of atraumatic gel dressings “Appolo” of different directions]. Emergency medical care. 2006;3:111–2. Russian.

21. Vinnik IS, Markelova NM, Solov’eva NS, Shishatskaya EI, Kuznetsov MN, Zuev AP. Sovremennye ranevye pokrytiya v lechenii gnojnyh ran [The current dressings for wound care in the treatment of purulent wounds]. Novosti Khirurgii. 2015 Sep-Oct;23(5):552–8. Russian.

22. Zargarova NI, Grebenyuk AN, Legeza VI. Eksperimental’naya ocenka effektivnosti primeneniya ranevyh pokrytij v kachestve sredstv konservativnoj terapii luchevyh ozhogov pri mestnyh i sochetannyh radiacionnyh porazheniyah [Experimental evaluation of the effectiveness of wound coatings as a means of conservative therapy of radiation burns in local and combined radiation injuries]. Radiacionnaya biologiya. Radioekologiya. 2013;53(5):481–86. Russian.

23. Kolaeva AV, Gusev IV, Lipatova IM, Oltarzhevskaya ND. Osobennosti sozdaniya steril’nyh materialov «Kole-gel’» i «Kolegel’-disk» dlya napravlennoj dostavki lekarstvennyh preparatov [Features of the creation of sterile materials “Kolegel” and “Kolegel-disk” for the targeted delivery of medicinal products]. Rossijskij bioterapevticheskij zhurnal. 2016;15(10):601–4. Russian.

24. Kharkova NA. Eksperimental’naya ocenka svojstv perevyazochnyh sredstv «Koleteks-ADL» i «Kolegel’-ADL-CH-disk» dlya primeneniya v posleoperacionnom lechenii LOR-organov [An experimental assessment of properties of dressing means of «Koleteks-ADL» and «Kolegel-ADL-CH-disk» for application in treatment of otorhinolaryngology]. Fundamental research. 2015;12(Pt 5):964–8. Russian.

25. Chattopadhyay S, Raines RT. Collagen-Based Biomaterials for Wound Healing. Biopolymers. 2014 Aug;101(8):821–33. DOI: 10.1002/bip.22486

26. Antipova LV, Storublevcev SA, Bolgova SB, Suhov IV, Matasova KV, Zhdanova IYu, Majorova KV. Primenenie kollagenovyh substancij v otraslyah ekonomiki [The use of collagen substances in industries]. Mezhdunarodnyj zhurnal prikladnyh i fundamental’nyh issledovanij. 2015;10:601–4. Russian.

27. Obydenko VI, Baranchugova LM, Rusaeva NS. Regeneraciya eksperimental’nyh polnoslojnyh ploskostnyh ran kozhi krys pri ispol’zovanii produktov rastvoreniya kollagena [Regeneration of experimental full-layer planar wounds of skin of rats with the use of collagen dissolution products]. Bulletin of medical internet conferences. 2015;5(5):649–51. Russian.

28. Chai Q, Jiao Y, Yu X. Hydrogels for biomedical applications: their characteristics and the mechanisms behind them. Gels. 2017;3(1):6. DOI: 10.3390/gels3010006

29. Kokorina OV, Dvorjanchikov VV, Solovjeva TS, Kasatkin AN. Primenenie gelya na osnove hitozana: osobennosti regeneracii posleoperacionnoj rany na slizistoj obolochke polosti rta [The chitosan gel implementation: regenerative specificity of surgical wound on buccal mucous]. Vestnik of Russian military medical Academy. 2016;4(56):122–6. Russian.

30. Belova SV, Babushkina IV, Gladkova EV, Mamonova IA, Karyakina EV, Korshunov GV. Regeneraciya eksperimental’noj gnojnoj rany i processy svobodnoradikal’nogo okisleniya pri ispol’zovanii nanochastic metallov i hitozana [Regeneration of the experimental septic wound and processes of free-radical oxidation using nanoparticles of metals and chitosan]. Far East Medical Journal. 2014;3:79–82. Russian.

31. Sataev CB. Strukturnaya organizaciya hirurgicheskoj rany v dinamike posle primeneniya gialuronovoj kisloty v vozrastnom aspekte [Organization of the surgical wound in dynamics after application hyaluronic of the acid in age aspect]. Ulyanovsk Medico-Biological Journal. 2013;2:29–35. Russian.

32. Gabitov VH, Umetalieva AB. Morfologiya kozhi posle termicheskogo vozdejstviya v usloviyah kompleksnogo primeneniya hitozana, gialuronovoj kisloty i angiogenina [Morphology of the leather after thermal influence in conditions of complex application chitozan, hyaluronic acids and angiogenin]. Ulyanovsk Medico-Biological Journal. 2013;2:63–8. Russian.

33. Belova OV, Arion VYa, Sergienko VI. Rol’ citokinov v immunologicheskoj funkcii kozhi [The role of cytokines in the immunological function of the skin]. International Journal of Immunopathology, Allergology, Infectology. 2008;1:41–55. Russian.

34. Varyushina EA, Roslomy VL, Aleksandrov GV, Rybalchenko OV, Potokin IL, Isaeva EN, Simbirtsev AS. Vliyanie mestnogo primeneniya interlejkina 1β na citologicheskie parametry zazhivleniya kozhnoj rany [Influence of interleukin 1ß topical application on cytological parameters of skin wound healing]. Cytokines and Inflammation. 2010;9(2):7–12. Russian.

35. Simbirtsev AS. Novye vozmozhnosti primeneniya citokinov v dermatologii i kosmetologii [New cytokine application abilities in dermatology and cosmetology]. Vestnik esteticheskoj mediciny. 2010;9(2):44–50. Russian.

36. Birincioğlu İ, Akbaba M, Alver A, Kul S, Özer E, Turan N, Şentürk A, İnce İ. Determination of skin wound age by using cytokines as potential markers // Journal of Forensic and Legal Medicine. 2016 Nov;44:14–19. DOI: 10.1016/j.jflm.2016.08.011

37. Serebrennikova SN, Seminskij IZh, Semenov NV, Guzovskaya EV. Interlejkin-1, interlejkin-10 v regulyacii vospalitel’nogo processa [Interleukin-1, Interleukin-10 in regulation of inflammatory process]. Siberian Medical Journal (Irkutsk). 2012;8:5–7. Russian.

38. Shah HU, Gul H, Khan MM, Khan R. Outcome of second-degree burns in paediatric patients: Efficacy of antibiotic coating dressing. Pak J Surg. 2017;33(1):64–9.

39. Varyushina EA, Moskalenko EA, Lebedeva TP, Bubnov AN, Simbirtsev AS. Ispol’zovanie interlejkina-1β dlya mestnogo lecheniya gnojno-nekroticheskih porazhenij nizhnih konechnostej [Interleukin-1β application for local treatment of purulent and necrotic lesions of lower extremities]. Meditsinskaya immunologiya. 2008;10(4-5):439–448. DOI: 10.15789/1563-0625-2008-4-5-439-448. Russian.

40. Isamulaeva AZ, Kunin AA, Spicyna AV, Sergienko DF, Isamulaeva AI. Kliniko-immunologicheskaya ocenka effektivnosti primeneniya interlejkin-1β v gelevoj forme u bol’nyh s porazheniem parodonta [Clinical and immunological evaluation of the effectiveness of interleukin-1β in gel form in patients with periodontal disease]. Periodontics. 2014;4(73):63–7. Russian.

41. Petrov SV, Simbircev AS, Bubnova NA, Rybakova EV, Fionik OV, Volkova ES. Ispol’zovanie interlejkina-1 dlya mestnogo lecheniya bol’nyh s troficheskimi yazvami nizhnih konechnostej venoznoj etiologii [The use of interleukin-1 for local treatment of patients with trophic ulcers of the lower extremities of venous etiology]. Med-itsinskaya immunologiya. 2001;3(4):533–9. Russian.

42. Bownik A, Stępniewska Z. Protective effects of ectoine on behavioral, physiological and biochemical parameters of Daphnia magna subjected to hydrogen peroxide. Comp Biochem Physiol C Toxicol Pharmacol. 2015 Apr;170:38–49. DOI: 10.1016/j.cbpc.2015.02.002

43. Kunte HJ, Lentzen G, Galinski EA. Industrial Production of the Cell Protectant Ectoine: Protection Mechanisms, Processes and Products. Current Biotechnology. 2014;3(1):10-25. DOI: 10.2174/22115501113026660037

44. Šaranović V. Ectoine nasal spray in treatment of allergic rhinitis. Macedonian pharmaceutical bulletin. 2016;62(suppl):545-6.

45. Unfried K, Sydlik U, Krutmann J, Bilstein A. Therapeutic uses of ectoine / Patent US 20140315869 AA61K-31505FI; 2014 Nov 23.

46. Bilstein A, Scherner O, Lentzen G. Composition containing ecotine or hydroxyecotine as an active substances for promoting the regeneration of injured body tissue / Patent US 20150297592 A1; 2012 Iul 09.

47. Krut UA, Korokin MV. Farmakologicheskaya korrekciya gnojnogo ranevogo processa fitomineralsorbentami u krys [Pharmacological correction of the purulent process of wound by phytomineralsorbentum in rats]. Kubanskij nauchnyj medicinskij vestnik. 2017;2(163)91–5. Russian.

48. Spasov AA, Mazanova LS, Motov AA, Zajchenko SI, Lutoshkina IN, Orobinskaya TA, Sysuev BB. Vliyaniya mazi minerala bishofit na prochnost’ rubca inficirovannyh i neinficirovannyh ran kozhi [Effects of ointment mineral bischofite on the rumen strength of infected and uninfected skin wounds]. Experimental and Clinical Pharmacology. 2009;72(4):43–5. Russian.

49. Spasov AA, Orobinskaya TA, Mazanova LS, Motov AA, Sysuev BB. Protivovospalitel’noe dejstvie bishofitnoj mazi [Anti-inflammatory effect of bischofite ointment]. Experimental and Clinical Pharmacology. 2007;70(6):32–5. Russian.

50. Sysuev BB, Smirnov AV, Mitrofanova IU. Izuchenie morfologicheskih osobennostej processov reparacii kozhnyh ran pod vliyaniem glaznyh kapel’ bishofita [The morphologic characteristics research of the dermal injuries’reparative process as affected the bischofite eye drops]. Modern problems of science and education. 2011;5:4. Russian.

51. Mokhova OS, Glukhov AA. Klinicheskaya ocenka effektivnosti primeneniya oksitocina i akvakompleksa glicerosol’vata titana v kompleksnom lechenii ran myagkih tkanej [Clinical evaluation of the use oxytocin and aqua-complex of titanium glycerolsolvate (tisolium) in complex treatment of the wounds soft tissue]. Journal of New Medical Technologies. 2013;1:182. Russian.

52. Mokhova OS, Glukhov AA. Osobennosti techeniya ranevogo processa pri regional’nom primenenii akvakompleksa glicerosol’vata titana i oksitocina [Features of the course of the wound process in the regional application of the aquacomplex of glycerol solvate of titanium and oxytocin]. Journal of experimental and clinical surgery. 2014;7(4):419–23. DOI: 10.18499/2070-478X-2014-7-4-419–423. Russian.

53. Mokhova OS, Glukhov AA, Mikulich EV. Ocenka effektivnosti kompleksnogo lecheniya ran myagkih tkanej s primeneniem oksitocina i akvakompleksa glicerosol’vata titana v eksperimente [Assessment of efficiency of complex treatment of soft tissue wounds by means of oxytocin and titanium aquacomplex glycerolsolvate in experiment]. Journal of New Medical Technologies. 2014;1:46. Russian.

54. Kryuchkova NA, Temkin ES, Poroshin AV. Ocenka effektivnosti primeneniya gelya polikatan i akvakompleksa titana glicerosol’vata v lechenii zabolevanij parodonta [To assess the efficacy of the application of the gel polycat-an and aqua-complex of titanium glicerosolvate in the treatment of periodontal diseases]. The Journal of scientific articles “Health and Education Millenium”. 2017;19(7):40–3. Russian.

55. Temkin ES, Kryuchkova NA, Sysuev BB. Izmenenie klinicheskoj kartiny polosti rta u bol’nyh s vospalitel’nymi zabolevaniyami parodonta pri primenenii gelya «Polikatan» v kombinacii s preparatom «Tizol’» [Changes in clinical manifestations of the inflammatory periodontal diseases in patients treated with Polycatan gel and Tizol]. Volgograd scientific medical journal. 2015;4:39–40. Russian.

56. Mitrofanova IY, Sysuev BB, Ozerov AA, Samoshina EA, Ahmedov NM. Innovacionnye lekarstvennye preparaty na osnove minerala bishofit glubokoj ochistki: perspektivy i problemy primeneniya [Innovative drugs on the high purification mineral bischofite: prospects and problems of administration]. Fundamental research. 2014;9(7):1554–7. Russian.

57. Glubokova IB. Reparaciya kozhi posle mekhanicheskoj dermabrazii [Skin repair after mechanical dermabrasion]. Experimental and Clinical Dermatocosmetology. 2005;6:55–60. Russian.

58. Lapatina NG. Himicheskaya eksfoliaciya: novye vozmozhnosti povysheniya effektivnosti [Chemical exfoliation: new ways to increase effectiveness]. Vestnik esteticheskoj mediciny. 2010;9(2):77–82. Russian.

59. Shevchenko NA, Bazarenko RA, Dodohova MA, Chebotarev VV, Berezovskij DP. Defekty okazaniya medicinskih kosmetologicheskih uslug [Defects in the provision of medical cosmetology services]. Medical news of the North Caucasus. 2013;8(2):85–9. Russian.