Comparative analysis of bioequivalence, safety, and tolerability of semaglutide (tablets): results of an open-label randomized crossover comparative study

A. S. Ametov; L. A. Balykova; K. Ya. Zaslavskaya; I. E. Shokhin; T. G. Bodrova; L. A. Zorina; V. S. Shcherbakova; D. V. Kurkin; K. N. Koryanova; E. S. Mishchenko; M. L. Maksimov; A. V. Matveev; L. I. Shcherbakova; I. N. Dyakova; E. D. Kozlov; D. N. Andreev; Yu. G. Kazaishvili; S. M. Noskov; P. A. Bely

Pharmacy & Pharmacology
Farmaciâ i farmakologiâ

ISSN 2307-9266 (Print)
ISSN 2413-2241 (Online)

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Ametov A.S., Balykova L.A., Zaslavskaya K.Ya., Shokhin I.E., Bodrova T.G., Zorina L.A., Shcherbakova V.S., Kurkin D.V., Koryanova K.N., Mishchenko E.S., Maksimov M.L., Matveev A.V., Shcherbakova L.I., Dyakova I.N., Kozlov E.D., Andreev D.N., Kazaishvili Yu.G., Noskov S.M., Bely P.A. Comparative analysis of bioequivalence, safety, and tolerability of semaglutide (tablets): results of an open-label randomized crossover comparative study. Pharmacy & Pharmacology. 2026;14(4):387-409. (In Russ.) https://doi.org/10.19163/2307-9266-2026-14-4-387-409

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ISSN 2307-9266 (Print)
ISSN 2413-2241 (Online)

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About the Authors

A. S. Ametov
Russian Medical Academy of Continuing Professional Education.
Russian Federation

Doctor of Sciences (Medicine), Professor, Head of the Department of Endocrinology, Head of the UNESCO Network Department on the topic "Bioethics of Diabetes Mellitus as a global problem", Russian Medical Academy of Continuing Professional Education; Honored Scientist of the Russian Federation.

Bld. 1, 2/1, Barrikadnaya Str., Moscow, Russia, 125993.

L. A. Balykova
National Research Ogarev Mordovia State University.
Russian Federation

Doctor of Sciences (Medicine), Professor, Head of the Department of Pediatrics, Corresponding Member of the Russian Academy of Sciences, Director of the Medical Institute, National Research Ogarev Mordovia State University; Corresponding Member of the Russian Academy of Sciences.

68, Bolshevistskaya Str., Saransk, Russia, 430005.

K. Ya. Zaslavskaya
National Research Ogarev Mordovia State University.
Russian Federation

Assistant of the Department of Biological and Pharmaceutical Chemistry with the course of organization and management of pharmacy, National Research Ogarev Mordovia State University.

68, Bolshevistskaya Str., Saransk, Russia, 430005.

I. E. Shokhin
Limited Liability Company “Center for Pharmaceutical Analytics”.
Russian Federation

Doctor of Sciences (Pharmacy), General Director, Center for Pharmaceutical Analytics LLC, Moscow, Russia.

8, Simferopolsky Blvd, Moscow, Russia, 117638.

T. G. Bodrova
Russian University of Medicine.
Russian Federation

PhD candidate of the Scientific and Educational Institute of Pharmacy n.a. K.M. Lakin, Russian University of Medicine.

4, Dolgorukovskaya Str., Moscow, Russia, 127006

L. A. Zorina
Federal Scientific and Clinical Center for Specialized Types of Medical Care and Medical Technologies.
Russian Federation

Candidate of Sciences (Medicine), clinical pharmacologist, obstetrician-gynecologist, dietitian, lecturer of the Department of Therapy, Geriatrics, and Anti-Aging Medicine, Federal Scientific and Clinical Center for Specialized Types of Medical Care and Medical Technologies.

28 Orekhovy Blvd, Russia, Moscow, 115682.

V. S. Shcherbakova
Tver State Medical University.
Russian Federation

Candidate of Sciences (Biology), Assistant Professor of the Department of Pharmacology, Tver State Medical University.

4 Sovetskaya Str., Tver, Russia, 170100.

D. V. Kurkin
1. Russian University of Medicine. 2. Volgograd State Medical University.
Russian Federation

Doctor of Sciences (Pharmacy), Assistant Professor, Director of the Scientific and Educational Institute of Pharmacy n.a. K.M. Lakin, Russian University of Medicine; Professor of the Department of Clinical Pharmacology and Intensive Care of the Volgograd State Medical University.

1. 4, Dolgorukovskaya Str., Moscow, Russia, 127006.

2. 1 Pavshikh Bortsov Sq., Volgograd, Russia, 400066.

K. N. Koryanova
1. Pyatigorsk Medical and Pharmaceutical Institute – branch of Volgograd State Medical University. 2. Russian Medical Academy of Continuing Professional Education.
Russian Federation

Candidate of Sciences (Pharmacy), Assistant Professor of the Department of Pharmacy, Faculty of Postgraduate Education of the Pyatigorsk Medical and Pharmaceutical Institute — branch of Volgograd State Medical University; Assistant Professor of the Department of Pharmacy, General Pharmacology and Pharmaceutical Consulting of the Russian Medical Academy of Continuing Professional Education.

1. 11 Kalinin Ave., Pyatigorsk, Russia, 357532.

2. Bld. 1, 2/1, Barrikadnaya Str., Moscow, Russia, 125993.

E. S. Mishchenko
Pyatigorsk Medical and Pharmaceutical Institute – branch of Volgograd State Medical University.
Russian Federation

Candidate of Sciences (Pharmacy), Assistant Professor of the Department of Toxicological and Analytical Chemistry, Pyatigorsk Medical and Pharmaceutical Institute – branch of Volgograd State Medical University.

11 Kalinin Ave., Pyatigorsk, Russia, 357532.

M. L. Maksimov
Russian Medical Academy of Continuing Professional Education.
Russian Federation

Doctor of Sciences (Medicine), Professor, Dean of the Faculty of Preventive Medicine and Healthcare Organization, Head of the Department of Pharmacy, General Pharmacology and Pharmaceutical Consulting, Russian Medical Academy of Continuing Professional Education.

Bld. 1, 2/1, Barrikadnaya Str., Moscow, Russia, 125993.

A. V. Matveev
Russian Medical Academy of Continuing Professional Education.
Russian Federation

Candidate of Sciences (Medicine), Assistant Professor, Assistant Professor of the Department of Clinical Pharmacology and Therapy named after Academician B. E. Votchal, Russian Medical Academy of Continuous Professional Education.

Bld. 1, 2/1, Barrikadnaya Str., Moscow, Russia, 125993.

L. I. Shcherbakova
Pyatigorsk Medical and Pharmaceutical Institute – branch of Volgograd State Medical University.
Russian Federation

Candidate of Sciences (Pharmacy), Assistant Professor, Deputy Director for Educational Work, Head of the Department of Inorganic, Physical and Colloidal Chemistry, Pyatigorsk Medical and Pharmaceutical Institute – branch of Volgograd State Medical University.

11 Kalinin Ave., Pyatigorsk, Russia, 357532.

I. N. Dyakova
Pyatigorsk Medical and Pharmaceutical Institute – branch of Volgograd State Medical University.
Russian Federation

Candidate of Sciences (Pharmacy), Assistant Professor, Head of the Department of Biology and Physiology, Acting Dean of the Faculty of Postgraduate Education, Pyatigorsk Medical and Pharmaceutical Institute – branch of Volgograd State Medical University.

11 Kalinin Ave., Pyatigorsk, Russia, 357532.

E. D. Kozlov
National Research Ogarev Mordovia State University.
Russian Federation

senior lecturer of the Department of Outpatient Therapy of the Medical Institute, National Research Ogarev Mordovia State University.

68, Bolshevistskaya Str., Saransk, Russia, 430005.

D. N. Andreev
Russian University of Medicine.
Russian Federation

Candidate of Sciences (Medicine), Assistant Professor, Assistant Professor of the Department of Propaedeutics of Internal Diseases and Gastroenterology, Russian University of Medicine.

4, Dolgorukovskaya Str., Moscow, Russia, 127006.

Yu. G. Kazaishvili
Tver State Medical University.
Russian Federation

Candidate of Sciences (Biology), Assistant Professor of the Department of Pharmacology, Tver State Medical University.

4 Sovetskaya Str., Tver, Russia, 170100.

S. M. Noskov
1. Yaroslavl State Medical University. 2. Clinical Hospital No. 3.
Russian Federation

Doctor of Sciences (Medicine), Professor, Head of the Department of Hospital Therapy, Yaroslavl State Medical University; internist, Chief Researcher, Clinical Hospital No. 3, Yaroslavl, Russia.

1. 5 Revolutionary Str., Yaroslavl, Russia, 150000.

2. 61 Mayakovskogo Str., Yaroslavl, Russia, 150007.

P. A. Bely
Russian University of Medicine
Russian Federation

Doctor of Sciences (Medicine), Professor of the Department of Internal Medicine and Gastroenterology, Russian University of Medicine.

4, Dolgorukovskaya Str., Moscow, Russia, 127006.

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