THE POSSIBILITY OF CREATING MULTIFUNCTIONAL SILVER-CONTAINING DRUGS WITH DETOXIFYING EFFECT

Modern technology and the level of fundamental studies allow us to create the medical sorbents with the predetermined structural, mechanical and adsorptional properties. Sorption materials are interesting not only as detoxicants that are used to remove toxic agents from the liquid media, but also as carriers for a delivery in zones a therapeutic effect of biologically active substances. The aim of this work is the substantiation of structure of the multifunctional drug with anti-bacterial and detoxifying effects due to the complex of silver and the sorption component – alumina-silica-containing sorbent. Materials and methods. We used physico-chemical (sorption activity of methylene blue dye, specific surface, pH in contact with water, atomic emission spectrometry with inductively coupled plasma) and pharmaceutical methods (bulk density, dissolution test for solid dosage forms). Results and discussion. The two-stage method of immobilization of a complex of silver and water repellent on the surface sorption
matrix was justified. The sample of the optimum composition of silver-containing drugs was selected: aluminium oxide-hydroxide – 99.2%, clustered silver (Argovit – C – 2%) – 0.3 %, based on silver and subsidiary substance (repellents – brand PMS P – 841) – 0.5 %. The output of silver into the solution from the specified sample composition for 8 hours did not exceed 1,6 ± 0,3%, the value of specific surface area of 90 m2/ g, the value of pH to 8.1 ± 0.02, bulk density 1.12 ± 0.11 g/cm3. Conclusion. An experimentally substantiated composition of silver-containing drug AlSi/Ag was received, a comprehensive scientific data of its physico-chemical and technological properties were obtained.

silver, sorbents, immobilization

1. Fenelonov V. B. Poristyj uglerod [Porous carbon]. Novosibirsk: izdatelstvo institutata kataliza SO RAN [Novosibirsk: Siberian Branch of the Russian Academy of Sciences], 1995. 518 p. (In Russ.)

2. Borodin Yu.I., Konenkov V.I., Parmon V.N., Lyubarsky M.S., Rachkovskaya L.N., Bgatova N.P., Letyagin A.Yu. BIOLOGICHESKIE SVOJSTVA SORBENTOV I PERSPEKTIVY IH PRIMENENIYA [BIOLOGICAL PROPERTIES OF SORBENTS AND PERSPECTIVES OF THEIR APPLICATION]. Uspekhi sovremennoj biologii [Advances in modern biology]. 2014. Vol. 134. N 3. P. 236-248. (In Russ.)

3. Nikova M.I., Petrova I.V. SORBENTY DLYA OCHISTKI BIOLOGICHESKIH ZHIDKOSTEJ OT TYAZHELYH METALLOV [SORBENTS FOR CLEANING BIOLOGICAL FLUIDS FROM HEAVY METALS]. Sovremennaya nauka aktualnye problemy teorii i praktiki. Seriya: poznanie [ Modern Science: Actual Problems of Theory and Practice. Series: knowledge]. 2012. N 12 (15). P. 11 -14. (In Russ.)

4. Borodin Y.I., Rachkovskaya L.N., Darneva I.S., Novoselova T.I. Enterosorbent Noolit. Dlya fizicheskoj i psihologicheskoj reabilitacii [Enterosorbent Nolite. For physical and psychological rehabilitation]. Novosibirsk izdatelstovo «Sova» [Novosibirsk: “The Owl”], 2006. 221 p. (In Russ.)

5. Rachkovskaya L.N., Letyagin A.Yu., Burmistrov V.A., Korolev M.A., Gelfond N.E., Borodin Y.I., Konenkov V.I. MODIFICIROVANNYE SORBENTY DLYA PRAKTICHESKOGO ZDRAVOOHRANENIYA [MODIFIED SORBENTS FOR PRACTICAL PUBLIC HEALTH]. Sibirskij nauchnyj medicinskij zhurnal [Siberian Scientific Medical Journal]. 2015. Т.35, N 2. С 47 – 54. (In Russ.)

6. Belousova E.A., Volchkova E.V., Rusanova E.V., Tsodikova O.M. ANTIBIOTIKO-ASSOCIIROVANNYE PORAZHENIYA KISHECHNIKA [ANTIBIOTIC-ASSOCIATED INTESTINAL LESIONS]. Effektivnaya farmakoterapiya [Effective pharmacotherapy]. 2011. N 8. P. 12-17. (In Russ.)

7. Burmistrov V.A. (RU), Pestryakov A.N. (RU), Olegova G.V. (RU), Burmistrov I.V. (RU), Burmistrov A.V. (RU), Bogdanchikova N.E. (MX). Kompleksnyj preparat dlya profilaktiki i lecheniya kishechnyh infekcij [Complex preparation for the prevention and treatment of intestinal infections]. Pat. 2519659, Russia. Publ. 06/20/2014. (In Russ.)

8. Sladkov A.V., Ignatova V.A., Polonskaya A.A., Samedova A.E. Razrabotka i vnedrenie na rynok naturalnogo antibiotika kolloidnoe serebro v usloviyah vstupleniya v vto [Development and introduction of a natural antibiotic (colloidal silver) to the market in the context of accession to the WTO]. / Aktualnye problemy ekonomicheskogo razvitiya sbornik dokladov mezhdunarodnoj zaochnoj nauchno-prakticheskoj konferencii posvyashchennoj 20-letiyu instituta ekonomiki i menedzhmenta sb nauch tr [Actual problems of economic development: a collection of reports of an international correspondence scientific-practical conference on the 20th anniversary of the Institute of Economics and Management: coll. Sci. Tr.] Belgorodskij gosudarstvennyj tekhnologicheskij universitet im V G SHuhova Belgorod [Belgorod State Technological University. V.G. Shukhova]. Belgorod, 2013. P. 206-208. (In Russ.)

9. Shub G.M., Shapoval O.G., Velmakin S.E., Sakulina L.B. IZMENENIE ADGEZIVNOJ AKTIVNOSTI ESCHERICHIA COLI I PSEUDOMONAS AERUGINOSA POD VLIYANIEM NANOCHASTIC SEREBRA [CHANGE IN THE ADHESIVE ACTIVITY OF ESCHERICHIA COLI AND PSEUDOMONAS AERUGINOSA UNDER THE INFLUENCE OF SILVER NANOPARTICLES]. Fundamentalnye issledovaniya [Fundamental research]. 2013. N 6 -6. P. 1453-1455. (In Russ.)

10. Alexandrova S.V., Atamanov I.V., Sadvokasova A.A. ISPOLZOVANIE KOLLOIDNOGO SEREBRA V KACHESTVE ALTERNATIVY ANTIBIOTIKAM V PTICEVODSTVE [USE OF COLLOIDAL SILVER AS AN ALTERNATIVE TO ANTIBIOTICS IN POULTRY FARMING]. Vestnik gosudarstvennogo agrarnogo universiteta Severnogo Zauralya [Bulletin of the State Agrarian University of the Northern Zauralye]. 2016. N 4 (35). P.41-46. (In Russ.)

11. Bowler P.G., Welsby S., Towers V. IN VITRO ANTIMICROBIAL EFFICACY OF A SILVER-CONTAINING WOUND DRESSING AGAINST MYCOBACTERIA ASSOCIATED WITH ATYPICAL SKIN ULCERS. Wounds. 2013. Vol. 25. No. 8. P. 225–230.

12. Martin N.L., Bass P., Liss S.N. ANTIBACTERIAL PROPERTIES AND MECHANISM OF ACTIVITY OF A NOVEL SILVER-STABILIZED HYDROGEN PEROXIDE. PLoS One. 2015. Vol. 10. No. 7. DOI: 10.1371/journal.pone.0131345.

13. Gosudarstvennyj reestr lekarstvennyh sredstv [The State Register of Medicinal Products], 2017. URL: http://grls. rosminzdrav.ru/. (Date access data: 22.04.2017). (In Russ.)

14. Blagitko E.M., Burmistrov V.A., Kolesnikov A.P., Mikhailov Yu. I., Rodionov P.P. Serebro v medicine [Silver in medicine]. Novosibirsk: Nauka – Centr [Novosibirsk: Science – Center], 2004. 254 c. (In Russ.)

15. Mashkovsky M.D. Lekarstvennye sredstva [Medicines]. T.1. – 14 ed., Rev. And additional. Мockva: «Izdatelstvo Novaya Volna» [Moscow: Open Company “Publishing house the New Wave”], 2002. 354 p. (In Russ.)

16. Gosudarstvennaya farmakopeya RF, XIII izd [State Pharmacopoeia of the Russian Federation, XIII ed.] T. 1-3. Mockva [Moscow], 2015. URL: // femb.ru-feml. (In Russ.)

17. Vorontsov I.I. Sposob lecheniya erozivnogo gastrita [Method of treatment of erosive gastritis]. Pat. 2183479, Russia; Publ. 20.06.2002. (In Russ.)

18. Belyakov N.A. Enterosorbciya [Enterosorption]. Leningrad: Centr sorbcionnyh tekhnologij [Leningrad: Sorption Technologies Center], 1991. 328 p. (In Russ.)

19. Rachkovskaya L.N., Popova T.V., Letyagin A.Y., Tolstikova T.G., Korolyov M.A., Bogdanchikova N., Pestryakov A.N., Kotlyarova A.A., Burmistrov V., Konenkov V.I. SILVER CONTAINING SORBENTS: PHYSICOCHEMICAL AND BIOLOGICAL PROPERTIES. Resource-Efficient Technologies. 2016. Vol. 2. Is. 2. P. 43–49. DOI: 10.1016/j.reffit.2016.06.001

20. Rachkovskaya L.N., Gelfond N.E., Gubina V.I., Erimbaeva A.T., Bulavchenko, Podlipskaya T.U. Podhody k konstruirovaniyu sorbentov [Approaches to the design of sorbents]. Fundamentalnye problemy limfologii i kletochnoj biologii sb nauch tr [Fundamental problems of lymphology and cell biology: Sat. Sci. Tr.] NIIKEL SO RAMN [NIIKEL SB RAMS]. Novosibirsk, 2013. P. 269 – 271. (In Russ.)