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Фармация и фармакология

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БИОЛОГИЧЕСКАЯ АКТИВНОСТЬ HYPERICUM PERFORATUM L. (HYPERICACEAE): ОБЗОР

https://doi.org/10.19163/2307-9266-2021-9-1-17-31

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Аннотация

Hypericum perforatum L. (зверобой продырявленный) является лекарственным растением, которое в последнее время интенсивно изучается клиницистами, фармакологами и химиками. Результатами этого являются публикации как оригинальных статей, так и ряда обзоров, посвященных спектру биологической активности экстрактов и отдельных химических компонентов этого вида. В отличие от многих других известных лекарственных растений, фармакологическое изучение которых сопровождается установлением структур новых (или вновь обнаруженных) химических соединений, динамика современного изучения H. perforatum по большей части связана с детальным изучением механизмов его терапевтического действия и, в меньшей степени, с поиском новых компонентов.

Цель. Обзор сведений по биологической активности экстрактов и отдельных компонентов Hypericum perforatum L. (Hypericaceae) — зверобоя продырявленного, опубликованных в научной литературе за последние 10 лет.

Материалы и методы. Для сбора и анализа сведений использовали электронные базы данных PubMed, Scopus, Web of Science, Google Scholar и др. доступные ресурсы. Поиск в базах данных производился по публикациям за 2010-2020 гг. по таким ключевым словам, как: Hypericum perforatum, зверобой продырявленный, St. John's wort, биологическая активность зверобоя.

Результаты. В обзоре представлены сведения об антидепрессивной, нейропротекторной, ноотропной, анксиолитической активности, антибактериальным, цитотоксическим, противовоспалительным свойствам, анальгезирующем, гипогликемическом действии и других видах активности экстрактов H. perforatum, а также индивидуальных соединений (гиперицина, гиперфорина, аментофлавона и др.), выделенных из этого вида. Как известно, пул вторичных метаболитов этого вида включает нафтодиантроны, флавоноиды и другие фенольные соединения, несколько классов липофильных веществ, в том числе производных флороглюцина и терпеноиды. При этом наиболее подробно (помимо экстрактов и их фракций) изучалась биологическая активность фотореактивного нафтодиантрона гиперицина и гиперфорина — производного флороглюцина. Данный обзор посвящен анализу сведений по биологической активности зверобоя продыявленного, опубликованных в литературе с 2010 по 2020 годы. В настоящее время популярность H. perforatum связана прежде всего с его антидепрессивными свойствами, которые подтверждены многочисленными доклиническими исследованиями и клиническими испытаниями, хотя до сих пор нет единого мнения о возможности эффективности использования зверобоя для лечения как тяжелой, так и даже умеренной депрессии. Кроме того, в данном обзоре приведены сведения о нейропротекторной, ноотропной, противоэпилептической, анксиолитической, антибактериальной, антивирусной, противопротозойной активности, противоопухолевых, цитотоксических, анальгезирующих, противовоспалительных и других свойств экстрактов и индивидуальных компонентов этого вида.

Заключение. Несмотря на известность H. perforatum, зверобоя продырявленного, как растения с антидепрессивной активностью, продолжаются интенсивные исследования, направленные на выяснение молекулярных механизмов действия экстрактов и индивидуальных соединений при патологиях нервной системы. Кроме этого, весьма перспективными могут стать исследования его антибактериальной, антивирусной, цитотоксической активности, наряду с определением возможности применения з. продырявленного при нарушениях обмена веществ, функций мочеполовой системы и в других областях медицины.

Об авторах

А. Л. Буданцев
Федеральное государственное бюджетное учреждение науки Ботанический институт им. В.Л. Комарова Российской академии наук (БИН РАН) 197376, Россия, г. Санкт-Петербург, ул. проф. Попова, 2
Россия

доктор биологических наук, профессор, заведующий лабораторией растительных ресурсов ФГБУ «Ботанический институт им. В. Л. Комарова» РАН



В. А. Приходько
Федеральное государственное бюджетное образовательное учреждение высшего образования «Санкт-Петербургский государственный химико-фармацевтический университет» Министерства здравоохранения Российской Федерации 197376, Россия, г. Санкт-Петербург, ул. проф. Попова, 14
Россия


И. В. Варганова
Федеральное государственное бюджетное учреждение науки Ботанический институт им. В.Л. Комарова Российской академии наук (БИН РАН) 197376, Россия, г. Санкт-Петербург, ул. проф. Попова, 2
Россия

научный сотрудник лаборатории растительных ресурсов ФГБУ «Ботанический институт им. В. Л. Комарова» РАН



С. В. Оковитый
Федеральное государственное бюджетное образовательное учреждение высшего образования «Санкт-Петербургский государственный химико-фармацевтический университет» Министерства здравоохранения Российской Федерации 197376, Россия, г. Санкт-Петербург, ул. проф. Попова, 14
Россия

доктор медицинских наук, профессор, заведующий кафедрой фармакологии и клинической фармакологии ФГБОУ ВО «Санкт-Петербургский государственный химико-фармацевтический университет» Минздрава России



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Для цитирования:


Буданцев А.Л., Приходько В.А., Варганова И.В., Оковитый С.В. БИОЛОГИЧЕСКАЯ АКТИВНОСТЬ HYPERICUM PERFORATUM L. (HYPERICACEAE): ОБЗОР. Фармация и фармакология. 2021;9(1):17-31. https://doi.org/10.19163/2307-9266-2021-9-1-17-31

For citation:


Budantsev A.L., Prikhodko V.A., Varganova I.V., Okovityi S.V. BIOLOGICAL ACTIVITY OF HYPERICUM PERFORATUM L. (HYPERICACEAE): A REVIEW. Pharmacy & Pharmacology. 2021;9(1):17-31. https://doi.org/10.19163/2307-9266-2021-9-1-17-31

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