ANALGETIC ACTIVITY OF SUBSTITUTED 1-(2-IMIDAZOLETHYL)-3- PYRROLINE-2-ONS
https://doi.org/10.19163/2307-9266-2014-2-6(7)-99-101
Abstract
The article presents the review of initial stage of carried out studies of an analgetic activity of substituted 1-(2-imidazolethyl)-3-pyrroline-2-ons. We have established that compound marked with laboratory cipher as GKN-1165 at a dose of 50 mg/kg has analgetic activity close to the activity of ethanol of nimesulid comparison taken at the same dose.
About the Authors
A. A. Ponomaryova
Perm State Pharmaceutical Academy, Perm
Russian Federation
Russian Federation
A. S. Yurchenko
Perm State Pharmaceutical Academy, Perm
Russian Federation
Russian Federation
N. N. Kasimova
Perm State Pharmaceutical Academy, Perm
Russian Federation
Russian Federation
References
1. Руководство по экспериментальному (доклиническому) изучению новых фармакологических веществ / Под общей редакцией члена-кореспондента РАМН, профессора Р.У. Хабриева. – 2 изд., перераб. и доп. – М.:ОАО «Издательство «Медицина», 2005. – 832с.
2. Зайцев А. А. Фармакология болеутоляющих средств в эксперименте и клинике. – Л., 1991. – С. 69.
Review
For citations:
Ponomaryova A.A., Yurchenko A.S., Kasimova N.N. ANALGETIC ACTIVITY OF SUBSTITUTED 1-(2-IMIDAZOLETHYL)-3- PYRROLINE-2-ONS. Pharmacy & Pharmacology. 2014;2(6(7)):99-101. (In Russ.) https://doi.org/10.19163/2307-9266-2014-2-6(7)-99-101
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