IDENTIFICATION OF SOME COMPOSITE MEDICINAL DRUGS CONTAINING PARACETAMOL, WITH IR-SPECTROMETRY METHOD
https://doi.org/10.19163/2307-9266-2017-5-1-12-22
Abstract
A serious threat to the health of the population is falsified medicines. In a number of cases, they are identified in the process of incoming quality control for compliance
with the requirements of regulatory documents for indicators “Description”, “Packaging”, “Marking”. However, in order to identify sophisticated counterfeits, only a visual assessment of the drug is not enough. Purpose screening evaluation of potentially
counterfeited or poor-quality drugs using the IR spectrometry along the total spectrum.
Materials and methods. The objects of research were available in freely available
commercially available tablets produced by domestic and foreign manufacturers
“Paracetamol Extratab”, “Solpadein fast”, “Citrapac”, “Citramon P”, “Ascofen-P”, corresponding to the requirements of the current regulatory documents. The studies were carried out on a Fourier-Spectrophotometer infrared “FSM 1201”. Results and discussion. On the example of the tablets “Citramon P”, “Ascophen-P”, “Citrapac”, “Paracetamol Extratab”, “Solpadein Fast” the possibility of using the total IR spectra as a primary screening index of authenticity is shown. It was established that the total IR spectra of medicines of similar composition reflect the similarity of serial samples of the products of
one manufacturer and the difference in serial samples of products of different manufacturers.
with the requirements of regulatory documents for indicators “Description”, “Packaging”, “Marking”. However, in order to identify sophisticated counterfeits, only a visual assessment of the drug is not enough. Purpose screening evaluation of potentially
counterfeited or poor-quality drugs using the IR spectrometry along the total spectrum.
Materials and methods. The objects of research were available in freely available
commercially available tablets produced by domestic and foreign manufacturers
“Paracetamol Extratab”, “Solpadein fast”, “Citrapac”, “Citramon P”, “Ascofen-P”, corresponding to the requirements of the current regulatory documents. The studies were carried out on a Fourier-Spectrophotometer infrared “FSM 1201”. Results and discussion. On the example of the tablets “Citramon P”, “Ascophen-P”, “Citrapac”, “Paracetamol Extratab”, “Solpadein Fast” the possibility of using the total IR spectra as a primary screening index of authenticity is shown. It was established that the total IR spectra of medicines of similar composition reflect the similarity of serial samples of the products of
one manufacturer and the difference in serial samples of products of different manufacturers.
About the Authors
A. S. Saushkina
S.M. Kirov Military Medical Academy, St. Petersburg State Chemical-Pharmaceutical Academy
Russian Federation
Senior Lecturer, Department of Military Medical Supply and Pharmacy, candidate of pharmaceutical sciences, associate professor.
Russian Federation
Senior Lecturer, Department of Military Medical Supply and Pharmacy, candidate of pharmaceutical sciences, associate professor.
L. N. Zinchuk
St. Petersburg State Chemical-Pharmaceutical Academy
Russian Federation
chemist-analyst at the Testing Laboratory of the Center for Quality Control of Medicinal Products
Russian Federation
chemist-analyst at the Testing Laboratory of the Center for Quality Control of Medicinal Products
M. A. Denisov
STPF “Polysan”
Russian Federation
chemist
Russian Federation
chemist
V. A. Shokurov
S.M. Kirov Military Medical Academy
Russian Federation
cadet IV course of the pharmaceutical faculty
Russian Federation
cadet IV course of the pharmaceutical faculty
D. V. Goncharov
S.M. Kirov Military Medical Academy
Russian Federation
cadet IV course of the pharmaceutical faculty
Russian Federation
cadet IV course of the pharmaceutical faculty
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Review
For citations:
Saushkina A.S., Zinchuk L.N., Denisov M.A., Shokurov V.A., Goncharov D.V. IDENTIFICATION OF SOME COMPOSITE MEDICINAL DRUGS CONTAINING PARACETAMOL, WITH IR-SPECTROMETRY METHOD. Pharmacy & Pharmacology. 2017;5(1):12-22. (In Russ.) https://doi.org/10.19163/2307-9266-2017-5-1-12-22
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