Until now, plants have been the main source of new drugs. Morus nigra, which contains a rich complex of biologically active substances necessary for an organism (vitamins, anthocyanins, macro- and microelements, organic acids) is of great interest. We have conducted morphological and anatomical studies of stems of Morus nigra, identified the main diagnostic characters of the studied medicinal plants. Experimental studies have shown that the stems of Morus nigra are characterized by the presence of thick-walled epidermal cells with slightly convoluted walls and a large number of ordinary thick-walled fuzz.

The article presents the results of morphological and anatomical studies of Veronica spicata L. Macro- and microscopic features of the grass of Veronica spicata were described. We have determined the principal diagnostic features of leaves and stems of the plant’s active parts. We have found two types of trichomes in active parts of Veronica spicata L.: simple pluricellular fuzz and cephalated glandular fuzz with monocellular pedicle and monocellular or bicellular sphere-like capitulum, anomcytic stomatal apparatus.

The work is devoted to the review of the application of collagen and materials based on collagen in medicine and the pharmaceutical industry. We have taken into consideration the aspects of the use of “Collost” sterile bioplastic collagen material in surgery and options for further research areas of biomaterials on the basis of unreconstructed collagen.

This article reviews cellulose esters as important excipients in development of dosage forms with sustained release. We have studied modern methods of drug development, based on technological, and physical and chemical properties of excipients to provide a sustained release effect and the mechanism of interaction between active substance and excipients for justification of choice of the optimum prolonging agent in compliance with desirable result. Different cellulose esters were used as model excipients. They were hydroxypropylmethylcellulose (HPMC) and hydroxyethylcellulose (HEC). we have studied an effect of molecular weight and hydrophilic properties on dissolution rate of active substance from the tablets with sustained release.

We have carried out the analysis of antymicobacterial activity of PYATd10 diazinon derivative and dapsone. The capability of PYATd10 compound and dapsone drug to suppress the growth of M.lufu culture was studied by the method of serial dilutions. Visual evaluation of inoculations in medium Shkolnikova showed that there was no growth of mycobacteria with PYATd10 concentration 128 μg/ml, while minimum suppressing concentration of dapsone were equal to 32 μg/ml. Examining smears, colored according to Murohashi, under the influence of PYATd10 excipient and dapsone drug in the same concentrations, we have revealed the decrease of mycobacterial living forms content. A share of inviable bacteria decreased after the cultivation intensification, but amounts to less than 35%. Thus, the PYATd10 compound exhibits antimycobacterial activity towards M. lufu, being slightly inferior to the dapsone comparative drug by this type of activity.

Nowadays there is an active growth of veterinary pharmacy organizations and consumed medicinal drugs for veterinary use. Content-analysis showed that there was an insufficient number of studies devoted to the activity of veterinary pharmacies. The purpose of our work was the analysis of correspondence of range fullness of veterinary pharmacies to the contemporary state of pharmaceutical market of drugs for veterinary use. Veterinary clinics and pharmacies of Moscow and Moscow oblast were the object of our study. We have applied sociological methods (questionnaire, interview), marketing and statistic analysis methods. We have established that liquid dosage forms (53%) occupy the biggest part of drugs in the State Registry of Veterinary Drugs. Solutions occupy 68% of this amount. Antimicrobial drugs for systematic use (40%) are the most numerous drugs from pharmacotheraperutic group represented in the State Registry. Assortment of veterinary drugs is targeted mainly on a farm livestock (more than 50%). 58% of the market share is domestic drugs. Principal commodity groups which are released by veterinary pharmacies are feed-stuff (31%) and drugs (30%). Pharmacy organizations does not have sufficient number of drugs in their assortment (fullness coefficient 7.9%) which speaks about nonconformity of the assortment fullness.

The article describes the problems of development of an algorithm for state service outsourcing. On the basis of the expert evaluations method we have revealed the priority of factors for evaluation of reasonability of involvement of outsorter-organization with state services rendering.

We have studied a structure of a therapy with antibiotics which is applied for patients with acute and recidivous obstructive bronchitis. We have determined a clinical efficiency of each antibiotic used. We have presented a methodology of weight coefficients calculation efficiency by the Fishburn’s method. We have also presented a method for antibiotics distribution by the levels of clinical efficiency – high, medium, and low.

The article analyzes principal legal aspects of medical products storage, appointed for medical and sanitary consequences of emergencies mitigation. We have revealed that nowadays there is a whole range of legal gaps and uncertainties in the regulation of medical products storage. We have also offered the ways for their solution

Nowadays pharmacy organizations are actively introducing customer service standards into their activity. Efficiency of their introduction depends from the whole range of factors including the recognition of their significance and necessity by every expert. The purpose of the study is to compare the opinions of directors and pharmaceutical personnel about the use of pharmacy organizations activity standards of customer service. 50 directors and 50 pharmacy organization workers participated in the questionnaire. The study included the revelation of respondents’ attitude towards the service standards, estimation of their positive and negative sides, analysis of the necessary requirements and standards structure, revelation of the most hard- and easy-to-use sections of service standards. We have established that both categories of respondents noted a big number of positive sides of work following standards, including the influence on the goods turnover, service quality, and customer attraction. But some directors and personnel members were negative or neutral about the service standards. We have revealed that the implementation of standard sections about communication with a customer by the phone and conflict situations resolution were the biggest problem for the personnel. There are differences in opinions of directors and pharmaceutical personnel about the necessary structure and content of customer service standards in pharmacy organizations. The results obtained should be used for the management functions realization regarding the service standards.

Maintenance of the stock of medical property is an important strategic problem of Russian Federation Armed Forces nowadays. In the course of plan upgrading and reforming of a stock there is a necessity for theoretical elaboration of price formation process and realization of drugs and medical products discharged from the stocks. The conducted analysis of the requirements of current rules and regulations allowed the substantiation of the mechanism structure, which evaluates the price of drugs and medical products while formation, their keeping in a stock and reformation of medicinal property sets. We have created a model of price formation for drugs and medical products which are included into the medical property sets for theoretical substantiation of the mentioned processes. The study conducted allowed not only structuring of the price formation mechanism of discharged property, but also to isolate the prospective directions of its realization. So, we have established that the drugs and medical products discharged from the stock may be of great interest for consumers due to the medical property offer in low (optimal) costs.

Strategy of pharmaceutical goods (PG) promotion is a working out of methods of goods realization stimulation. To make PG promotion maximum effective, and to receive a sufficient result for pharmaceutical organization (PO) it is necessary to conduct marketing studies (MS), to work out a marketing plan for PG promotion and to offer marketing strategies for goods promotion. To resolve these problems we have formed a concept of marketing promotion of PG system for one of big retail PO of Kursk and Kursk oblast (code name “A”). With this purpose we have identified a problem of PG promotion organization, studied an influence of external and internal environment on the PO “A” activity, determined strong and weak sides of PO activity. We have systematized the results in SWOT-analysis, and formed the strategies of PO for the improvement of work efficiency on the market. On the basis of the results received we have worked out the recommendations for the marketing strategies of PG promotion for the certain PO.

Pharmacy organizations are an element of regional pharmaceutical market infrastructure formation. They have different character and activity type, organizational and legal forms, types of properties. The revelation of the features of retail pharmaceutical market of Yaroslavl oblast was the purpose of the study. The analysis of the data of regional department of Federal Service on Surveillance in Healthcare and Social Development of Russian Federation  n Yaroslavl oblast in the beginning of 2014 showed that there are 137 acting commercial entities, which have licenses for pharmaceutical activity. The region has 487  pharmacy organizations which implement pharmaceutical activity of state (14.6%), municipal (7.4%), and private (78.0%) forms of ownership. Some companies function in Yaroslavl (43.9%) and Rybinsk (22.4%) municipal district. The analysis of organization and legal forms revealed that 48.9% of pharmacy organizations are registered as ltd, 14.6% are state, and 14.2% are private entrepreneurs, public limited companies amount to 10.9%, the rest pharmacy organizations are included into municipal unitary enterprises and private limited companies – 7.39% and 4.1% correspondingly. The structure of retail market is represented by single pharmacy organizations (51.1%) as well as organizations joined into pharmacy chains from two and more PO (48.9%). The share of commercial entities which include one PO amounted to 14.4% of all PO. Share of pharmacy chains (42.3%) which include from 2 to 9 PO are 46.8% of all PO. Pharmacy chains, which have more than 9 retails spots amount to 6.6% of the total number of commercial entities. 38.8% of PO function within them. Pharmacy chains prevalence (42.3%), joined into 9 PO; pharmacy chains, which have more than 9 PO, and include state sector PO (14.6%) are the features of the regional market.

Stomatological market has actively developed recent years. Domestic experts received an access to contemporary technologies of dental diseases treatment in the world. This conditioned the appearance of new drugs and parapharmaceutical products applied in dental practice on the pharmaceutical market. In this connection, study of these drugs market, their price policy, demand and supply. Assortment of parapharmaceutical products applied in dental practice for oral cavity hygiene is represented mainly by liquid forms, such as mouth rinse, balms, elixirs, and a special place is occupied by toothpastes. Their assortment amounts to more than 700 types. Drugs, applied in dental practice are represented by the following groups: anti-inflammatory, antimicrobial, antiallergenic, anesthetics, drugs which stimulate tissues regeneration, fluoric drugs. The purpose of this study was the analysis of regional pharmaceutical market assortment, which offers parapharmaceutical goods and drugs for prevention and treatment of oral cavity diseases to the stomatological establishments. Pharmaceutical market of the Republic of North Ossetia – Alania is represented by a wide range of drugs for dental diseases treatment. This group is represented in the assortment of practically all distributors. The drugs for dental diseases treatment is not only supplied by domestic producers but also go from pharmaceutical companies of 29 foreign countries, which influences positively on the state of drug therapy of paradontum in the region.

The article is devoted to basic life milestones of Professor, Doctor of Pharmaceutical Science, Honored Scientist of Russia V.G. Belikov, who made a great contribution to the development of domestic pharmaceutical education and science, more than 30 years headed the leading pharmaceutical institution of the country.